A rapid positioning device for chromatographic columns and a method for installing same

Abstract

The application discloses a kind of chromatographic column quick positioning device and its installation method, belong to liquid chromatograph accessory installation technical field, to the existing chromatographic column installation mode dismounting is complicated, single-point clamping axial constraint force is insufficient and lead to the problem that chromatographic column is prone to axial channeling under high pressure working condition, the device includes two mounting seats, fixed with internal thread pipe in mounting seat, internal thread pipe is connected with external thread pipe with internal thread, external thread pipe bottom end is equipped with sealing cap component, clamping component is equipped in mounting seat, by screwing external thread pipe, first inclined plane clamping plate is gathered under the extrusion of limit cover inclined plane groove, realize first re-clamping, after sealing cap and connecting pipe are connected by hook elastic clamping, second inclined plane clamping plate is gathered under the extrusion of butt joint snap ring, realize second re-clamping, to form up and down double clamping positioning to chromatographic column body, and realize quick dismounting by push ring driving top rod and hook inclined plane chamfer transmission.

Description

Technical Field

[0001] This invention relates to the field of liquid chromatograph accessory installation technology, and in particular to a rapid column positioning device and its installation method. Background Technology

[0002] Chromatographic columns are the core separation components in analytical instruments such as liquid chromatographs and gas chromatographs. The accuracy and convenience of their installation and positioning directly affect the stability of chromatographic analysis results and experimental efficiency. In actual chromatographic analysis, chromatographic columns usually need to be frequently changed between different analytical tasks. At the same time, it is also necessary to ensure that the chromatographic column is in a stable axial positioning state during use to prevent problems such as dead volume changes, flow path obstruction, or abnormal peak shape caused by axial displacement. Currently, the main methods for installing and positioning chromatographic columns in existing technologies include the following: One method is to use flange nuts and sealing washers to fix both ends of the chromatographic column to the mounting base. Although this method provides a relatively secure connection, the disassembly and assembly are cumbersome, requiring the use of wrenches and other tools to tighten or loosen the nuts one by one. This is extremely inefficient in experimental scenarios where chromatographic columns need to be frequently replaced. Another method is to use a ferrule-type connector, which fixes the column by inserting it into the ferrule and tightening the ferrule nut. Although this method is relatively simple to operate, the ferrule-type connector has high requirements for the dimensional accuracy of the outer diameter of the chromatographic column, and the clamping force of the ferrule is limited. It is prone to loosening after long-term use or when subjected to external vibration, resulting in axial displacement of the chromatographic column. Yet another method is to use a simple sleeve-type mounting base, where the chromatographic column passes directly through the sleeve and is fixed by friction. Although this method is the most convenient for disassembly and assembly, the clamping force is insufficient, and the chromatographic column is prone to slippage during use, making it impossible to guarantee the stability of the positioning. In addition, although some existing quick-installation devices have improved the efficiency of disassembly and assembly to a certain extent, most of them only have a clamping mechanism at one end of the chromatographic column and only use a simple open sleeve at the other end. The overall clamping structure is simple and the axial constraint force on the chromatographic column is insufficient. Especially in high-performance liquid chromatography systems, due to the high back pressure inside the system, the chromatographic column is prone to axial movement under pressure, which in turn affects the separation effect and detection sensitivity. To address the aforementioned problems, this technical solution proposes a rapid column positioning device and its installation method. Summary of the Invention

[0003] The purpose of this invention is to solve the problems of cumbersome disassembly and assembly of existing chromatographic columns and insufficient axial constraint force of single-point clamping, which makes the chromatographic column prone to axial movement under high pressure conditions. Therefore, a rapid positioning device for chromatographic columns and its installation method are proposed.

[0004] To achieve the above objectives, the present invention adopts the following technical solution: A rapid positioning device for a chromatographic column includes two mounting bases and a chromatographic column body. An internally threaded tube is fixedly mounted within each mounting base. An externally threaded tube is internally threadedly connected to the internally threaded tube, and the bottom end of the externally threaded tube extends below the mounting base. The positioning device further includes: A capping component is installed at the bottom end of the externally threaded tube, and the chromatographic column body passes through the capping component and the externally threaded tube; A clamping component is installed within the mounting base, and the chromatographic column body passes through the clamping component; Specifically, by screwing the external threaded tube to move it axially relative to the internal threaded tube, the clamping component performs a first clamping and positioning of the chromatographic column body; when the capping component is engaged with the external threaded tube, the clamping assembly within the capping component performs a second clamping and positioning of the chromatographic column body.

[0005] In one possible design, the capping component includes a connecting tube fixedly installed at the bottom end of the externally threaded tube, and a cap that snaps into the connecting tube. A protective sleeve is fixedly installed at the bottom of the cap, the chromatographic column body passes through the protective sleeve, the clamping assembly is installed inside the cap, and the top of the clamping assembly extends into the connecting tube and mates with the inner wall of the connecting tube.

[0006] In one possible design, the clamping assembly includes a plurality of second inclined clamping plates fixedly installed at equal intervals within the cover, an anti-slip pad fixedly installed on the inner side of the second inclined clamping plates, a limiting groove provided on the outer side of the second inclined clamping plates, and a docking snap ring fixedly installed on the inner wall of the connecting tube, the docking snap ring engaging with the plurality of the limiting grooves; When the cap is engaged with the connecting tube, the docking ring presses against the limiting groove to bring the multiple second inclined clamps closer together, thereby clamping the chromatographic column body through the anti-slip pad.

[0007] In one possible design, the clamping assembly further includes a plurality of elastic connecting strips, each elastic connecting strip being located between two adjacent second inclined clamping plates, and both sides of the elastic connecting strip being fixedly connected to the two second inclined clamping plates respectively, the elastic connecting strip being used to provide an outward resetting elastic force for the second inclined clamping plates.

[0008] In one possible design, a docking ring is fixedly installed at the bottom of the connecting pipe, a first docking recess is fixedly installed at the bottom of the docking ring, a second docking recess is fixedly installed inside the cover, and the second docking recess is engaged with the first docking recess; multiple hooks are fixedly installed at equal intervals on the cover, and the tops of the multiple hooks are engaged with the docking ring. During the process of attaching the cap to the connecting tube, the hook is supported by the docking ring and bends outward elastically, and then resets and is attached after passing the docking ring.

[0009] In one possible design, multiple push rods are slidably connected at equal intervals through the bottom inner wall of the cover. The bottom ends of the multiple push rods extend to the bottom of the cover and are fixedly installed with the same push ring. A compression spring located below the cover is sleeved on each push rod. The top end of the compression spring is connected to the bottom of the cover, and the bottom end is connected to the top of the push ring. Multiple through holes are equally spaced on the mating ring, and the positions of the push rods and the through holes correspond to each other. The bottom of the hook is provided with a chamfered edge. Specifically, pushing the push ring upwards can drive the top rod through the through hole and drive the chamfered surface, causing the hook to bend outwards to release the engagement with the docking ring.

[0010] In one possible design, the clamping component includes an inner packing tube fixedly installed inside the externally threaded tube, and a plurality of first inclined clamps fixedly installed at equal intervals on the top of the inner packing tube, wherein the chromatographic column body passes through the inner packing tube and the plurality of first inclined clamps. The plurality of the first inclined clamps are used to come together with each other to clamp the chromatographic column body when under pressure.

[0011] In one possible design, the positioning device further includes a limiting cover fixedly installed on the inner wall of the mounting base, and the inner wall of the limiting cover is provided with a sloping groove. When the externally threaded tube is screwed into the internally threaded tube, multiple first inclined clamping plates move into the limiting cover, and the inclined groove squeezes the first inclined clamping plates to bring them closer together, thereby achieving the first clamping and positioning of the chromatographic column body.

[0012] An installation method, applied in a rapid positioning device for a chromatographic column as described above, includes the following steps: S1. Fix the two mounting brackets in the required positions, check whether the internal threaded tube, external threaded tube, capping component and clamping component are intact, and ensure that the elastic connecting strip is in the natural state and the compression spring is in the compressed energy storage state. S2. Take the chromatographic column body, first pass it downward from the top opening of the mounting base, then pass it through the inner packing tube and multiple first inclined clamping plates in the clamping component, then pass it through the external threaded tube, continue downward through the connecting tube and the clamping assembly in the cap, and finally pass it out from the protective sleeve, so that the top end of the chromatographic column body extends to the top of the mounting base and the bottom end extends to the bottom of the mounting base. S3. Rotate the external threaded tube downwards and screw it into the internal threaded tube in the mounting base. As the external threaded tube moves downwards, multiple first inclined clamping plates gradually move into the limiting cover. The inclined groove on the inner wall of the limiting cover is used to squeeze and limit the first inclined clamping plates, so that multiple first inclined clamping plates come together. The friction force is used to achieve the first clamping and positioning of the upper part of the chromatographic column body. S4. After the external threaded tube is moved down to the bottom, the cap is put on the connecting tube from bottom to top, so that the chromatographic column body passes through the protective sleeve. The second mating concave ring inside the cap is engaged with the first mating concave ring at the bottom of the connecting tube. At the same time, the multiple hooks on the cap are elastically bent outward by the support of the mating ring during the upward movement. After the top of the hook passes the mating ring, it automatically resets, so that the hook and the mating ring are engaged and positioned, thereby completing the stable connection between the cap and the connecting tube. S5. After the cap and connecting tube are installed, the multiple second inclined clamps and anti-slip pads inside the cap are moved into the connecting tube along with the cap. At this time, the docking ring on the inner wall of the connecting tube is engaged with the limiting groove on the outer side of each second inclined clamp. Under the support and squeezing action of the docking ring, the multiple second inclined clamps move closer to each other. The multiple anti-slip pads on the inner side are used to achieve the second clamping and positioning of the chromatographic column body at the bottom. Thus, the double clamping and positioning of the chromatographic column body is completed. S6. After the double clamping and positioning is completed, the elastic connecting strip provides elastic support to the adjacent second inclined clamping plate to prevent the second inclined clamping plate from shrinking excessively. The inclined groove in the limiting cover limits the first inclined clamping plate to prevent the first inclined clamping plate from loosening, thereby keeping the chromatographic column body in a stable positioning state on the mounting base. Beneficial effects:

[0013] 1. A double clamping structure is adopted, which combines the upper clamping component with the lower capping component. While the external threaded tube moves down and locks, the capping and connecting tube are quickly connected through the snapping of the second docking concave ring and the first docking concave ring, as well as the elastic snapping of multiple hooks with the docking ring. This allows the multiple second inclined clamping plates inside the cap to automatically retract under the support and compression of the docking rings on the inner wall of the connecting tube, providing a second round of clamping and positioning for the lower part of the chromatographic column body. The multiple first inclined clamping plates at the top are clamped and positioned under the compression and limitation of the inclined grooves on the inner wall of the limiting cover. The double clamping structure significantly improves the axial constraint force on the chromatographic column body, effectively preventing axial displacement of the chromatographic column body under high pressure or external vibration, avoiding abnormal peak shape caused by dead volume changes or flow path obstruction, and ensuring the accuracy and repeatability of chromatographic analysis results. 2. The cap and connecting tube are connected by multiple hooks and a flexible snap-fit ​​ring. As the multiple hooks move upward, they automatically bend outward elastically under the support of the snap-fit ​​ring. After passing the snap-fit ​​ring, they automatically reset and snap-fit. When disassembling or assembling, simply push the push ring upward to drive multiple push rods through the through holes and the chamfered edges at the bottom of the hooks. This will cause the multiple hooks to bend outward synchronously and disengage from the snap-fit ​​ring. The operation is simple and quick, and the cap can be disassembled with one hand. At the same time, the snap-fit ​​between the second and first snap-fit ​​rings provides a reliable axial positioning reference for the cap, ensuring the stability and positioning accuracy of the connection between the cap and the connecting tube. This invention enables rapid assembly and disassembly through the combination of an external threaded tube and an internal threaded tube. It also utilizes a double clamping structure consisting of an upper first inclined clamping plate and a lower second inclined clamping plate to effectively solve the problems of cumbersome assembly and disassembly and insufficient axial constraint force of single-point clamping in the prior art. This prevents the chromatographic column from axially shifting under high pressure conditions. At the same time, the design of the hook elastic clip and the elastic connecting strip takes into account both connection stability and ease of disassembly. Attached Figure Description

[0014] Figure 1 This is a first-view schematic diagram of the connection structure between the two mounting bases and the chromatographic column of the rapid positioning device for the chromatographic column proposed in this invention. Figure 2 This is a second-view schematic diagram of the two mounting bases and the column connection structure of a rapid column positioning device proposed in this invention. Figure 3 This is a three-dimensional schematic diagram of the mounting base and external threaded tube separation structure of a rapid positioning device for a chromatographic column proposed in this invention; Figure 4 This is a schematic diagram showing the separation of the mounting base and the external threaded tube of a rapid positioning device for a chromatographic column proposed in this invention. Figure 5 This is a three-dimensional schematic diagram of the connecting pipe, external threaded pipe and cap connection structure of a rapid positioning device for a chromatographic column proposed in this invention. Figure 6 This is a three-dimensional schematic diagram of the cap and multiple second inclined clamping plate connection structure of a rapid positioning device for a chromatographic column proposed in this invention. Figure 7 This is a three-dimensional schematic diagram of the connection structure of multiple second inclined clamps and multiple elastic connecting strips of a rapid positioning device for a chromatographic column proposed in this invention.

[0015] In the diagram: 1. Mounting base; 2. Column body; 3. Internally threaded tube; 4. Externally threaded tube; 5. Liner packing tube; 6. First inclined clamp; 7. Limiting cover; 8. Connecting tube; 81. Docking ring; 9. Hand ring; 10. Cap; 11. First docking recess; 12. Second docking recess; 13. Perforation; 14. Hook; 15. Second inclined clamp; 16. Anti-slip pad; 17. Limiting groove; 18. Elastic connecting strip; 19. Protective sleeve; 20. Docking retainer; 21. Push rod; 22. Push ring; 23. Compression spring; 24. Inclined chamfer. Detailed Implementation

[0016] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0017] In one embodiment: Refer to Figure 1-7 A positioning device includes two mounting bases 1 and a chromatographic column body 2.

[0018] like Figure 1-3 As shown, the two mounting bases 1 are typically made of aluminum alloy and are fixed to the flow path interface plate of the chromatography instrument through mounting holes on their sides. The mounting base 1 has a stepped hole running vertically through its center. An internally threaded tube 3 is press-fitted into the upper part of the stepped hole in the mounting base 1 via an interference fit; its internal thread is an M20×1.5 fine thread. An externally threaded tube 4 is a section of 304 stainless steel round tube with the same specification external thread on its outer wall, which is screwed into the internally threaded tube 3 via a threaded connection. The bottom end of the externally threaded tube 4 extends to the bottom of the mounting base 1.

[0019] like Figure 3 As shown, the limiting cover 7 is fixed to the lower inner wall of the stepped hole of the mounting base 1 by multiple screws. The inner cavity of the limiting cover 7 is a frustum-shaped cone, which is larger at the top and smaller at the bottom. Its inner wall forms a continuous inclined groove with a cone angle of 8 degrees.

[0020] like Figure 3 As shown, the inner liner tube 5 is fixedly embedded in the inner hole of the externally threaded tube 4, and its inner diameter is slightly larger than the standard outer diameter of the column body 2 (for example, for a 4.6 mm outer diameter column, the inner diameter of the inner liner tube 5 is approximately 4.8 mm), and the material is polyetheretherketone (PEEK). The roots of multiple first inclined clamps 6 (e.g., three, evenly distributed circumferentially) are integrally formed with or fixed to the top of the inner liner tube 5. The outer surface of the first inclined clamp 6 is an inclined surface that matches the inclined groove of the inner wall of the limiting cover 7, and a silicone rubber gasket with a thickness of approximately 0.5 mm is bonded to its inner surface. The column body 2 passes sequentially through the space enclosed by the inner liner tube 5 and the multiple first inclined clamps 6.

[0021] like Figure 3-4As shown, the connecting pipe 8 is fixed to the bottom end of the externally threaded pipe 4 by welding. A wristband 9 is fitted over the connecting pipe 8 for easy gripping and rotation. A radially outwardly extending mating ring 81 is provided on the outer bottom of the connecting pipe 8. A first mating recess 11 is fixedly connected to the bottom of the mating ring 81. An annular mating retaining ring 20 with a rectangular cross-section is fixed to the inner wall of the connecting pipe 8 near the bottom.

[0022] like Figure 4 As shown, the main body of the cap 10 is injection molded from engineering plastic. A second mating recess 12 is fixed to its inner top, which can engage with the first mating recess 11. Multiple flexible hooks 14 are evenly distributed circumferentially on the sidewalls of the cap 10. Each hook 14 has an outwardly chamfered edge 24. A downwardly extending protective sleeve 19 is located at the bottom center of the cap 10. The inner diameter of the protective sleeve 19 is slightly larger than the outer diameter of the chromatographic column body 2, and it is made of flexible rubber to protect the end of the chromatographic column. Multiple second inclined clamping plates 15 are fixedly embedded at equal intervals at the base of the cap 10's inner cavity. The outer side of each second inclined clamping plate 15 has a limiting groove 17, and the inner side is bonded with an anti-slip pad 16. Adjacent second inclined clamping plates 15 are connected by a rectangular cross-section silicone rubber elastic connecting strip 18, which, in its natural state, keeps the second inclined clamping plates 15 tending to separate from each other. In this embodiment, if the elastic connecting strip 18 is not provided, the second inclined clamp 15 may not be able to automatically return to the open state after the cap 10 is detached from the connecting tube 8, affecting the loading of the chromatographic column next time.

[0023] like Figure 3-4 As shown, the bottom of the cover 10 is also slidably connected to multiple push rods 21 (the number corresponding to the hooks 14). The top end of each push rod 21 slidably passes through a guide hole in the bottom wall of the cover 10, and the bottom end is fixedly connected to a push ring 22. Each push rod 21 is fitted with a compression spring 23. The top end of the compression spring 23 is limited by a retaining ring fixed to the bottom of the cover 10, and the bottom end presses against the push ring 22, thereby putting the compression spring 23 in a pre-compressed state and providing a downward holding force for the push ring 22. The mating ring 81 has through holes 13 corresponding to the positions of the push rods 21.

[0024] During installation, the column body 2 is first passed from above through the inner packing tube 5, the external threaded tube 4, the connecting tube 8, the space between multiple second inclined clamps 15 inside the cap 10, and the protective sleeve 19 of a mounting base 1. Then, the external threaded tube 4 is rotated (or the connecting tube 8 is rotated via the hand ring 9) to screw it into the internal threaded tube 3 of the mounting base 1. As the external threaded tube 4 moves downward, the inner packing tube 5 and the first inclined clamp 6 fixed thereon move downward together. When the first inclined clamp 6 enters the frustum-shaped inner cavity of the limiting cover 7, the inner wall of the inclined groove exerts a radially inward squeezing force on the outer surface of the first inclined clamp 6. This squeezing force compels multiple first inclined clamps 6 to converge towards the center simultaneously, gripping the column body 2 tightly through the silicone rubber pads on their inner sides, completing the first clamping and positioning. The use of a conical surface fit instead of a straight cylindrical surface is based on practical assembly considerations. If the inner wall of the limiting cover 7 is a straight cylinder, the first inclined clamping plate 6 lacks the driving force for radial contraction when it moves downward, and cannot form an effective clamping; however, by using inclined surface cooperation, the axial rotational motion is naturally converted into radial clamping motion, which simplifies the operation logic.

[0025] After the first clamping is completed, the cap 10 is pushed upwards, causing the second mating ring 12 to engage with the first mating ring 11. During this process, the chamfered edge 24 of the hook 14 on the side wall of the cap 10 will first contact the lower edge of the mating ring 81. Continuing to push upwards, the hook 14 elastically bends outwards under the resistance of the mating ring 81 until its top hook-shaped portion passes over the upper surface of the mating ring 81. Subsequently, the hook 14 returns to its original position due to its own elasticity, and its hook-shaped portion hooks onto the top of the mating ring 81, thereby locking the cap 10 onto the connecting tube 8. Simultaneously, as the cap 10 moves upwards, the multiple second inclined clamping plates 15 and the limiting groove 17 fixed inside it enter the interior of the connecting tube 8. When the docking ring 20 engages with the limiting groove 17 of the second inclined clamping plate 15, the inner wall of the docking ring 20 generates a radially inward component force on the inclined surface of the limiting groove 17, forcing the multiple second inclined clamping plates 15 to overcome the tension of the elastic connecting strip 18 and move closer together. This, in turn, allows the anti-slip pads 16 on the inner side to grip the chromatographic column body 2, completing the second round of clamping and positioning. At this point, the chromatographic column body 2 is subjected to dual radial clamping from the first inclined clamping plate 6 and the second inclined clamping plate 15 near both ends, ensuring reliable axial constraint.

[0026] During disassembly, push the push ring 22 upwards, further compressing the compression spring 23. The push ring 22 drives multiple push rods 21 upwards through the through hole 13. The top of the push rods 21 abuts against the chamfered edge 24 on the inner side of the hook 14, applying an outward force to bend the hook 14 outwards again, thus disengaging its hook-shaped part from the docking ring 81. At this time, the cap 10 can be pulled downwards to separate it from the connecting tube 8. The second inclined clamp 15 resets and opens under the action of the elastic connecting strip 18, releasing the second clamping. Then, rotate the external threaded tube 4 in the opposite direction to move the first inclined clamp 6 upwards and out of the limiting cover 7. The first inclined clamp 6 slightly opens under its own elasticity or the reaction force of the internal chromatographic column, releasing the first clamping, allowing the chromatographic column body 2 to be removed.

[0027] This application can be used in the field of liquid chromatograph accessory installation technology, and can also be used in other fields applicable to this application.

[0028] In another embodiment: an improvement on the above embodiment: a rapid positioning device for chromatographic columns, which is applied to the field of liquid chromatograph accessory installation technology. The structure of this embodiment is basically the same as that of the previous embodiment, except that the material and size parameters of some components are adapted to accommodate chromatographic columns of different specifications.

[0029] In this embodiment, the dimensions of relevant components are adjusted accordingly for a micro-column with an outer diameter of 2.1 mm. The inner diameter of the packing tube 5 is set to 2.3 mm. The number of the first inclined clamping plate 6 and the second inclined clamping plate 15 is increased to four to provide uniform clamping force despite the reduced circumference. The anti-slip pad 16 is replaced with a slightly harder fluororubber to provide sufficient friction while avoiding excessive compression that could damage the micro-column. The connection thread between the connecting tube 8 and the external threaded tube 4 is changed to M12×1. The cone angle of the inclined groove on the inner wall of the limiting cover 7 is adjusted to 10 degrees to obtain the required radial contraction within a shorter axial stroke.

[0030] Furthermore, the cross-sectional shape of the elastic connecting strip 18 is changed to a circle. While the material remains silicone rubber, its Shore hardness is adjusted to 40A to provide a moderate restoring force. In high-pressure infusion systems, the system pressure may reach 40 MPa. If the limiting cover 7 does not provide continuous constraint on the first inclined clamping plate 6, relying solely on its initial clamping force, under long-term pressure pulsation impact, slight slippage may occur between the first inclined clamping plate 6 and the chromatographic column body 2, leading to loosening of the clamping point. In this embodiment, the rigid inclined groove structure of the limiting cover 7 provides a rigid external support environment for the first inclined clamping plate 6, effectively resisting the loosening tendency caused by internal pressure fluctuations.

[0031] As an alternative implementation, the wristband 9 can also be designed as a separate unit from the connecting tube 8, secured by a set screw. This structure is suitable for scenarios requiring frequent changes of different column lengths, and the axial position of the wristband 9 on the connecting tube 8 can be adjusted to suit the operator's habits. However, it should be noted that the separate structure may experience relative slippage at the set screw connection point under significant torque, making it more suitable for applications requiring less manual force.

[0032] This invention proposes an installation method for use in a rapid positioning device for chromatographic columns as described above, comprising the following steps: S1. Fix the two mounting bases 1 in the required positions, check whether the internal threaded tube 3, external threaded tube 4, capping component and clamping component are intact, and ensure that the elastic connecting strip 18 is in the natural state and the compression spring 23 is in the compressed energy storage state. S2. Take the chromatographic column body 2, first pass it downward from the top opening of the mounting base 1, then pass it through the inner packing tube 5 and multiple first inclined clamping plates 6 in the clamping component, then pass it through the external threaded tube 4, continue downward through the connecting tube 8 and the clamping assembly in the cap 10, and finally pass it out from the protective sleeve 19, so that the top end of the chromatographic column body 2 extends to the top of the mounting base 1 and the bottom end extends to the bottom of the mounting base 1. S3. Rotate the external threaded tube 4 downward and screw it into the internal threaded tube 3 in the mounting base 1. As the external threaded tube 4 moves downward, multiple first inclined clamping plates 6 gradually move into the limiting cover 7. The inclined groove on the inner wall of the limiting cover 7 is used to squeeze and limit the first inclined clamping plates 6, so that multiple first inclined clamping plates 6 come together with each other. The friction force is used to achieve the first clamping and positioning of the upper part of the chromatographic column body 2. S4. After the external threaded tube 4 is moved down to the bottom, the cap 10 is put on the connecting tube 8 from bottom to top, so that the chromatographic column body 2 passes through the protective sleeve 19. The second mating concave ring 12 inside the cap 10 is engaged with the first mating concave ring 11 at the bottom of the connecting tube 8. At the same time, the multiple hooks 14 on the cap 10 are elastically bent outward by the support of the mating ring 81 during the upward movement. After the top of the hook 14 passes the mating ring 81, it automatically resets, so that the hook 14 is engaged and positioned with the mating ring 81, thereby completing the stable connection between the cap 10 and the connecting tube 8. S5. After the cap 10 and the connecting tube 8 are engaged, the multiple second inclined clamping plates 15 and anti-slip pads 16 inside the cap 10 are moved into the connecting tube 8 together with the cap 10. At this time, the docking ring 20 on the inner wall of the connecting tube 8 is engaged with the limiting groove 17 on the outer side of each second inclined clamping plate 15. Under the support and compression of the docking ring 20, the multiple second inclined clamping plates 15 move closer to each other. The multiple anti-slip pads 16 on the inner side are used to achieve the second clamping and positioning of the chromatographic column body 2 at the bottom. Thus, the double clamping and positioning of the chromatographic column body 2 is completed. S6. After the double clamping and positioning is completed, the elastic connecting strip 18 provides elastic support to the adjacent second inclined clamping plate 15 to prevent the second inclined clamping plate 15 from shrinking excessively. The inclined groove in the limiting cover 7 limits the first inclined clamping plate 6 to prevent the first inclined clamping plate 6 from loosening, so that the chromatographic column body 2 maintains a stable positioning state on the mounting base 1.

[0033] The accompanying drawings in this application are for illustrative purposes only. The dimensions and shapes of the components shown are not actual limitations but are merely schematic representations. In actual implementation, the components can be reasonably configured and adjusted according to specific needs and actual conditions.

[0034] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A rapid positioning device for a chromatographic column, comprising two mounting bases (1) and a chromatographic column body (2), characterized in that, An internally threaded tube (3) is fixedly installed inside the mounting base (1). An externally threaded tube (4) is internally threaded to the internally threaded tube (3). The bottom end of the externally threaded tube (4) extends to the bottom of the mounting base (1). The positioning device further includes: A capping component is installed at the bottom end of the external threaded tube (4), and the chromatographic column body (2) passes through the capping component and the external threaded tube (4). A clamping component is installed in the mounting base (1), and the chromatographic column body (2) passes through the clamping component; In this process, by screwing the external threaded tube (4) to move it axially relative to the internal threaded tube (3), the clamping component performs a first clamping and positioning of the chromatographic column body (2); when the capping component is engaged with the external threaded tube (4), the clamping assembly inside the capping component performs a second clamping and positioning of the chromatographic column body (2).

2. The rapid column positioning device according to claim 1, characterized in that, The sealing component includes a connecting pipe (8) fixedly installed at the bottom end of the external threaded pipe (4) and a sealing cap (10) that is snapped into the connecting pipe (8). A protective sleeve (19) is fixedly installed at the bottom of the sealing cap (10). The chromatographic column body (2) passes through the protective sleeve (19). The clamping assembly is installed inside the sealing cap (10), and the top of the clamping assembly extends into the connecting pipe (8) and cooperates with the inner wall of the connecting pipe (8).

3. The rapid column positioning device according to claim 2, characterized in that, The clamping assembly includes multiple second inclined clamping plates (15) fixedly installed at equal intervals inside the cover (10). Anti-slip pads (16) are fixedly installed on the inner side of the second inclined clamping plates (15), and limiting grooves (17) are provided on the outer side of the second inclined clamping plates (15). A docking ring (20) is fixedly installed on the inner wall of the connecting pipe (8), and the docking ring (20) is engaged with the multiple limiting grooves (17). When the cap (10) is engaged with the connecting tube (8), the docking ring (20) squeezes the limiting groove (17) to bring the multiple second inclined clamps (15) closer together, and then the anti-slip pad (16) clamps the chromatographic column body (2).

4. The rapid column positioning device according to claim 3, characterized in that, The clamping assembly also includes a plurality of elastic connecting strips (18), each elastic connecting strip (18) being located between two adjacent second inclined clamping plates (15), and the two sides of the elastic connecting strip (18) being fixedly connected to the two second inclined clamping plates (15) respectively. The elastic connecting strip (18) is used to provide the second inclined clamping plates (15) with an outward resetting elastic force.

5. The rapid column positioning device according to claim 2, characterized in that, A docking ring (81) is fixedly installed at the bottom of the connecting pipe (8), and a first docking concave ring (11) is fixedly installed at the bottom of the docking ring (81). A second docking concave ring (12) is fixedly installed inside the cover (10), and the second docking concave ring (12) is engaged with the first docking concave ring (11). A plurality of hooks (14) are fixedly installed at equal intervals on the cover (10), and the tops of the plurality of hooks (14) are engaged with the docking ring (81). During the process of the cap (10) and the connecting tube (8) being fitted together, the hook (14) is supported by the docking ring (81) and bends outward elastically, and is reset and fitted after passing the docking ring (81).

6. The rapid column positioning device according to claim 5, characterized in that, Multiple push rods (21) are slidably connected at equal intervals through the bottom inner wall of the cover (10). The bottom ends of the multiple push rods (21) extend to the bottom of the cover (10) and are fixedly installed with the same push ring (22). A compression spring (23) located below the cover (10) is sleeved on the push rod (21). The top end of the compression spring (23) is connected to the bottom of the cover (10), and the bottom end is connected to the top of the push ring (22). Multiple through holes (13) are opened at equal intervals on the docking ring (81). The positions of the push rods (21) and the through holes (13) are corresponding. The bottom of the hook (14) is provided with a chamfered edge (24). Pushing the push ring (22) upwards can drive the top rod (21) through the through hole (13) and drive the chamfer (24) to bend the hook (14) outwards to release the engagement with the docking ring (81).

7. The rapid column positioning device according to claim 1, characterized in that, The clamping component includes an inner packing tube (5) fixedly installed inside the external threaded tube (4), and a plurality of first inclined clamps (6) fixedly installed at equal intervals on the top of the inner packing tube (5). The chromatographic column body (2) passes through the inner packing tube (5) and the plurality of first inclined clamps (6). The plurality of the first inclined clamps (6) are used to come together with each other to clamp the chromatographic column body (2) when under pressure.

8. The rapid column positioning device according to claim 7, characterized in that, The positioning device also includes a limiting cover (7) fixedly installed on the inner wall of the mounting base (1), and the inner wall of the limiting cover (7) is provided with a sloping groove. When the external threaded tube (4) is screwed into the internal threaded tube (3), multiple first inclined clamps (6) move into the limiting cover (7), and the inclined groove squeezes the first inclined clamps (6) to make them close together, thereby achieving the first clamping and positioning of the chromatographic column body (2).

9. An installation method, applied in the rapid positioning device for a chromatographic column as described in any one of claims 1-8, characterized in that, Includes the following steps: S1. Fix the two mounting bases (1) in the required position, check whether the internal threaded tube (3), external threaded tube (4), capping component and clamping component are intact, and ensure that the elastic connecting strip (18) is in the natural state and the compression spring (23) is in the compressed energy storage state. S2. Take the chromatographic column body (2), first pass it down from the top opening of the mounting base (1), then pass it through the inner lining packing tube (5) and multiple first inclined clamping plates (6) in the clamping component, then pass it through the external threaded tube (4), continue to pass it down through the connecting tube (8) and the clamping assembly in the cap (10), and finally pass it out from the protective sleeve (19), so that the top end of the chromatographic column body (2) extends to the top of the mounting base (1) and the bottom end extends to the bottom of the mounting base (1); S3. Rotate the external threaded tube (4) downward and screw it into the internal threaded tube (3) in the mounting base (1). As the external threaded tube (4) moves downward, multiple first inclined clamps (6) gradually move into the limiting cover (7). The inclined groove on the inner wall of the limiting cover (7) is used to squeeze and limit the first inclined clamps (6), so that multiple first inclined clamps (6) come together with each other. The friction force is used to achieve the first clamping and positioning of the upper part of the chromatographic column body (2). S4. After the external threaded tube (4) is moved down to the bottom, the cap (10) is put on the connecting tube (8) from bottom to top, so that the chromatographic column body (2) passes through the protective sleeve (19). The second mating concave ring (12) inside the cap (10) is engaged with the first mating concave ring (11) at the bottom of the connecting tube (8). At the same time, the multiple hooks (14) on the cap (10) are elastically bent outward by the support of the mating ring (81) during the upward movement. After the top of the hook (14) passes the mating ring (81), it automatically resets, so that the hook (14) is engaged and positioned with the mating ring (81), thereby completing the stable connection between the cap (10) and the connecting tube (8). S5. After the cap (10) and the connecting tube (8) are fitted together, the multiple second inclined clamps (15) and anti-slip pads (16) inside the cap (10) are moved into the connecting tube (8) together with the cap (10). At this time, the docking ring (20) on the inner wall of the connecting tube (8) is engaged with the limiting groove (17) on the outer side of each second inclined clamp (15). Under the support and squeezing action of the docking ring (20), the multiple second inclined clamps (15) move closer to each other. The multiple anti-slip pads (16) on the inner side are used to achieve the second clamping and positioning of the chromatographic column body (2) at the bottom. Thus, the double clamping and positioning of the chromatographic column body (2) is completed. S6. After the double clamping and positioning is completed, the elastic connecting strip (18) provides elastic support to the adjacent second inclined clamp (15) to prevent the second inclined clamp (15) from shrinking excessively. The inclined groove in the limiting cover (7) limits the first inclined clamp (6) to prevent the first inclined clamp (6) from loosening, so that the chromatographic column body (2) maintains a stable positioning state on the mounting base (1).

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