A traditional Chinese medicine composition with the functions of activating blood circulation and warming meridians and its preparation method and application

Abstract

This invention discloses a traditional Chinese medicine composition with functions of promoting blood circulation, removing blood stasis, warming the meridians, and unblocking collaterals, as well as its preparation method and application. The composition consists of three types of medicinal materials in specific weight ranges: those for warming the meridians and dispelling cold, promoting blood circulation and removing blood stasis, and those for tonifying the liver and kidneys. These materials are soaked in 50-65 degree liquor for 90-270 days, then air-dried and pulverized. The resulting powder is mixed with aged mugwort floss at a ratio of 5%-15% to make moxa cones. This invention, through a unique liquor-processing technique, effectively reduces the warming and drying properties of the medicinal materials and the finished product. While significantly enhancing the effects of warming the meridians and dispelling cold, promoting blood circulation and removing blood stasis, and unblocking collaterals and relieving pain, it greatly reduces the "heatiness" side effects easily caused by traditional moxibustion, broadening the applicable population. It is suitable for the adjunctive treatment of joint pain, shoulder, neck, waist, and knee strain, and dysmenorrhea caused by cold and dampness stagnation.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a traditional Chinese medicine composition for moxibustion therapy, and in particular to a traditional Chinese medicine formula with the effects of promoting blood circulation, removing blood stasis, warming the meridians and unblocking collaterals, and its application in moxa sticks. Background Technology

[0002] While traditional pure moxibustion with moxa cones has the effect of warming the meridians and dispelling cold, its nature is warm and drying, easily causing discomfort such as "internal heat" (dry mouth, insomnia). It is unsuitable for those with a constitution prone to heat, yin deficiency with excessive fire, or those in the acute inflammatory phase, severely limiting its application. Existing moxa cone products with added medicinal herbs often fail to systematically address the warming and drying issues arising from the herbs themselves and the combined effects of moxibustion; in fact, improper formulation may even exacerbate the "internal heat" reaction. Therefore, there is an urgent need for a traditional Chinese medicine moxa cone composition that can enhance efficacy while effectively overcoming or significantly reducing the warming and drying side effects of traditional moxibustion. Summary of the Invention

[0003] The present invention aims to overcome the shortcomings of the prior art and provide a traditional Chinese medicine composition and its moxa cones. Through scientific formulation and unique processing technology, it can enhance the effects of promoting blood circulation, removing blood stasis, warming the meridians and unblocking collaterals, while significantly reducing its warming and drying properties, thus broadening the applicable population.

[0004] This invention provides a traditional Chinese medicine composition, characterized in that it is composed of the following three types of medicinal materials: (1) The following are the ingredients of herbs for warming the meridians and dispelling cold, dispelling wind and dampness: 10-20 parts of *Shenjincao*, 10-20 parts of *Tougucao*, 10-20 parts of *Xungufeng*, 2-6 parts of *Qianghuo*, 2-6 parts of *Duhuo*, 6-15 parts of *Chuanjiao*, 10-20 parts of *Guizhi*, 6-15 parts of *Gaoliangjiang*, and 3-9 parts of *Mahuang*.

[0005] (2) The proportion of the following medicinal materials in terms of weight are: 3-10 parts of ground beetle, 6-15 parts of clematis, 2-6 parts of achyranthes bidentata, 3-10 parts of safflower or salvia miltiorrhiza, 3-10 parts of peach kernel, 3-10 parts of angelica sinensis, 3-10 parts of chuanxiong rhizome, and 5-15 parts of mugwort leaf.

[0006] (3) The weight ratio of medicinal materials for tonifying the liver and kidneys and strengthening tendons and bones is as follows: Cyperus rotundus 5-12 parts, Chaenomeles speciosa 5-12 parts, Acanthopanax senticosus 10-20 parts, Cicadae periostracum 2-6 parts, Eucommia ulmoides 3-10 parts.

[0007] Preferably, the weight parts of each medicinal material in the traditional Chinese medicine composition are as follows: 15 parts of *Shenjincao*, 15 parts of *Tougucao*, 15 parts of *Xungufeng*, 3 parts of *Qianghuo*, 3 parts of *Duhuo*, 10 parts of *Chuanjiao*, 15 parts of *Guizhi*, 10 parts of *Gaoliangjiang*, 6 parts of *Mahuang*; 6 parts of *Tubiechong*, 10 parts of *Weilingxian*, 3 parts of *Niuxi*, 6 parts of *Honghua*, 6 parts of *Taoren*, 6 parts of *Danggui*, 6 parts of *Chuanxiong*, 10 parts of *Aiye*; 8 parts of *Xiangfu*, 8 parts of *Mugua*, 15 parts of *Wujiapi*, 3 parts of *Chantui*, and 6 parts of *Duzhong*.

[0008] The preparation method of the traditional Chinese medicine composition is as follows: mix the medicinal materials in the above proportion, soak them in 50-65 degree liquor, the mass-volume ratio (g / mL) of the medicinal materials to the liquor is 1:1 to 1:3, the soaking time is 90-270 days, take out the medicinal materials, air dry them, and then pulverize them into 80-200 mesh powder.

[0009] The present invention also provides an moxa cone comprising moxa wool and the above-mentioned traditional Chinese medicine composition powder, wherein the traditional Chinese medicine composition powder accounts for 5%-15% of the total mass of the moxa cone, preferably 8%. The moxa wool is made from aged moxa leaves stored for 3-5 years by low-temperature and low-speed grinding.

[0010] Beneficial effects Synergistic combination for enhanced efficacy: The scientific combination of three types of medicinal materials takes into account the effects of warming the meridians and dispelling cold, promoting blood circulation and removing blood stasis, and tonifying the liver and kidneys, thus addressing both the symptoms and the root cause of the disease caused by cold and dampness stagnation.

[0011] Proper processing results in a milder medicinal property and significantly reduced side effects: Prolonged soaking in medium-to-high-proof liquor effectively counteracts the medicinal properties, greatly reducing the warming and drying nature of the herbs and the final product. Clinical observations show that the incidence of "heatiness" reactions caused by using the moxa sticks of this invention is significantly lower than that caused by traditional pure moxa sticks, demonstrating superior safety and tolerability.

[0012] The process is meticulous to ensure efficacy: the moxa wool is made from aged moxa and ground at low temperature and low speed to retain the effective ingredients to the maximum extent; the medicinal materials are processed with wine and then dried and pulverized in the shade, which facilitates the continuous release and transdermal absorption of the effective ingredients under the heat of moxibustion.

[0013] Flexible in application and wide in indication: The formula can be finely adjusted based on specific symptoms to achieve personalized treatment. Detailed Implementation

[0014] The present invention will be further illustrated by the following examples, but the present invention is not limited thereto.

[0015] Example 1 Weigh the following medicinal materials according to the following weights: 150g of *Shenjincao*, 150g of *Tougucao*, 150g of *Xun Gu Feng*, 30g of *Qianghuo*, 30g of *Duhuo*, 100g of *Chuanjiao*, 150g of *Guizhi*, 100g of *Gaoliangjiang*, 60g of *Mahuang*, 60g of *Tubiechong*, 100g of *Weilingxian*, 30g of *Huai Niuxi*, 60g of *Honghua*, 60g of *Taoren*, 60g of *Danggui*, 60g of *Chuanxiong*, 100g of *Aiye*, 80g of *Xiangfu*, 80g of *Mugua*, 150g of *Wujiapi*, 30g of *Chantui*, and 60g of *Duzhong*.

[0016] Mix the above medicinal materials evenly, put them into a ceramic vat, add pure sorghum liquor at 60 degrees until the medicinal materials are completely submerged (about 4.5L of liquor is needed), seal it, and soak it in a cool place for 180 days. After the expiration, filter out the medicinal materials, spread them out in a bamboo tray and dry them in the shade until they reach a constant weight. Then, crush them with a traditional Chinese medicine grinder and sieve them through a 100-mesh sieve to obtain the traditional Chinese medicine composition powder A.

[0017] Example 2 Weigh the lower limits of the weight parts of each medicinal material in the basic formula: 100g of Lycopodium clavatum, 100g of Speranskia tuberculata, 100g of Aristolochia mollissima, 20g of Notopterygium incisum, 20g of Heracleum hemsleyanum, 60g of Zanthoxylum bungeanum, 100g of Cinnamomum cassia, 60g of Alpinia officinarum, 30g of Ephedra sinica; 30g of Eupolyphaga seu Steleophaga, 60g of Clematis chinensis, 20g of Cyathula officinalis, 30g of Salvia miltiorrhiza, 30g of Prunus persica, 30g of Angelica sinensis, 30g of Ligusticum chuanxiong, 50g of Artemisia argyi; 50g of Cyperus rotundus, 50g of Chaenomeles sinensis, 100g of Acanthopanax gracilistylus, 20g of Cryptotympana pustulata, 30g of Eucommia ulmoides. The preparation method is the same as that in Example 1, soak it with 55-degree liquor for 90 days to obtain the traditional Chinese medicine composition powder B.

[0018] Example 3 Weigh the upper limits of the weight parts of each medicinal material in the basic formula: 200g of Lycopodium clavatum, 200g of Speranskia tuberculata, 200g of Aristolochia mollissima, 60g of Notopterygium incisum, 60g of Heracleum hemsleyanum, 150g of Zanthoxylum bungeanum, 200g of Cinnamomum cassia, 150g of Alpinia officinarum, 90g of Ephedra sinica; 100g of Eupolyphaga seu Steleophaga, 150g of Clematis chinensis, 60g of Achyranthes bidentata, 100g of Carthamus tinctorius, 100g of Prunus persica, 100g of Angelica sinensis, 100g of Ligusticum chuanxiong, 150g of Artemisia argyi; 120g of Cyperus rotundus, 120g of Chaenomeles sinensis, 200g of Acanthopanax gracilistylus, 60g of Cryptotympana pustulata, 100g of Eucommia ulmoides. The preparation method is the same as that in Example 1, soak it with 65-degree liquor for 270 days to obtain the traditional Chinese medicine composition powder C.

[0019] Example 4 Take the aged Artemisia argyi stored for 4 years, grind it repeatedly 4 times with a low-speed stone mill (rotation speed <50 revolutions per minute) to obtain delicate golden moxa floss. Respectively take the traditional Chinese medicine composition powders A, B, and C prepared in Examples 1, 2, and 3, and gently stir them with the moxa floss in a mixer at a ratio of 8% of the total mass of the moxa floss until they are uniform. Use a rolling machine to roll the mixed medicinal moxa floss into a column with a diameter of 1.8 cm and a length of 20 cm, and wrap it with mulberry paper externally to obtain the medicinal moxa column of the present invention.

[0020] Example 5 On the basis of the basic formula in Example 1, add 50g of Pueraria lobata and 30g of Curcuma longa, and the preparation method is the same as that in Example 1 to obtain the special medicinal powder D. Mix it with the moxa floss at a ratio of 10% of the mass of the moxa floss and roll it into a moxa column.

[0021] Example 6 Sixty patients with cold-dampness type knee joint pain were randomly divided into two groups. The experimental group received moxibustion with moxa cones containing powder A from Example 1, while the control group received commercially available pure moxa wool moxa cones. Both groups received the same treatment course and moxibustion method for 4 weeks.

[0022] Results: The overall effective rate of pain relief and joint mobility improvement in the experimental group was significantly higher than that in the control group (P<0.05). Regarding adverse reactions, 4 cases (approximately 13.3%) in the control group experienced varying degrees of "heatiness" reactions such as dry mouth and insomnia; while only 1 case (approximately 3.3%) in the experimental group experienced mild dry mouth, and none experienced insomnia. The incidence of "heatiness" reactions was significantly lower in the experimental group than in the control group (P<0.05). These results verify that the wine-processing technique of this invention, while enhancing therapeutic efficacy, can significantly reduce the "heatiness" side effects easily induced by traditional moxibustion.

Claims

1. A traditional Chinese medicine composition with the functions of promoting blood circulation, removing blood stasis, warming the meridians, and unblocking collaterals, characterized in that, Made from the following parts by weight of raw materials: Herbs for warming the meridians and dispelling cold, dispelling wind and dampness: 10-20 parts of *Shenjincao*, 10-20 parts of *Tougucao*, 10-20 parts of *Xungufeng*, 2-6 parts of *Qianghuo*, 2-6 parts of *Duhuo*, 6-15 parts of *Chuanjiao*, 10-20 parts of *Guizhi*, 6-15 parts of *Gaoliangjiang*, and 3-9 parts of *Mahuang*. Blood-activating, stasis-removing, meridian-clearing, and pain-relieving herbs: 3-10 parts of ground beetle, 6-15 parts of clematis root, 2-6 parts of achyranthes root, 3-10 parts of safflower or salvia root, 3-10 parts of peach kernel, 3-10 parts of angelica root, 3-10 parts of chuanxiong rhizome, and 5-15 parts of mugwort leaf. Herbs for tonifying the liver and kidneys and strengthening muscles and bones: Cyperus rotundus 5-12 parts, Chaenomeles speciosa 5-12 parts, Acanthopanax senticosus 10-20 parts, Cicadae periostracum 2-6 parts, Eucommia ulmoides 3-10 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The weight proportions of each ingredient are as follows: 15 parts of *Shenjincao*, 15 parts of *Tougucao*, 15 parts of *Xungufeng*, 3 parts of *Qianghuo*, 3 parts of *Duhuo*, 10 parts of *Chuanjiao*, 15 parts of *Guizhi*, 10 parts of *Gaoliangjiang*, and 6 parts of *Mahuang*. 6 parts of ground beetle, 10 parts of clematis root, 3 parts of achyranthes root, 6 parts of safflower, 6 parts of peach kernel, 6 parts of angelica root, 6 parts of chuanxiong rhizome, 10 parts of mugwort leaf; 8 parts of cyperus rhizome, 8 parts of papaya, 15 parts of eleutherococcus root bark, 3 parts of cicada molting, and 6 parts of eucommia bark.

3. A method for preparing the traditional Chinese medicine composition as described in claim 1 or 2, characterized in that, The process includes the following steps: mixing the raw medicinal materials, soaking them in 50-65 degree liquor for 90-270 days, removing the medicinal materials, air-drying them, and then pulverizing them into 80-200 mesh powder.

4. The method according to claim 3, characterized in that, The alcohol content of the liquor is 58-60 degrees, and the soaking time is 180 days.

5. A moxa stick, characterized in that, The mixture comprises moxa wool and a powder of the traditional Chinese medicine composition as described in claim 1 or 2, wherein the powder of the traditional Chinese medicine composition accounts for 5%-15% of the total mass of the moxa stick.

6. The moxa stick according to claim 5, characterized in that, The herbal composition powder accounts for 8% of the total mass of the moxa sticks.

7. The moxa stick according to claim 5 or 6, characterized in that, The mugwort floss is made from aged mugwort leaves that have been stored for 3-5 years, which are then ground at low temperature and low speed.

8. A method for preparing moxa sticks as described in any one of claims 5-7, characterized in that, include: The powdered traditional Chinese medicine composition is mixed evenly with the mugwort floss in a certain proportion and then rolled into shape.

9. The use of the traditional Chinese medicine composition as described in claim 1 or 2 in the preparation of external moxibustion products for treating joint pain, stiff neck and shoulders, lumbar muscle strain or dysmenorrhea caused by cold and dampness stagnation.

10. The application of the moxa cones as described in any one of claims 5-7 in moxibustion therapy for warming the meridians and dispelling cold, promoting blood circulation and removing blood stasis, and relieving pain by unblocking the meridians.