Multistage biomimetic spine-like micro-robot for lung sampling and method of making the same

By designing a multi-level biomimetic spiky microrobot, and utilizing the synergistic effect of micron-level microspiky and nano-level gold spike structures, the lung sampling problem in existing technologies has been solved, achieving stable scraping of airway tissue and cells and adjustable sampling depth.

CN122398375APending Publication Date: 2026-07-17HARBIN INSTITUTE OF TECHNOLOGY (SHENZHEN) (INSTITUTE OF SCIENCE AND TECHNOLOGY INNOVATION HARBIN INSTITUTE OF TECHNOLOGY SHENZHEN)

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HARBIN INSTITUTE OF TECHNOLOGY (SHENZHEN) (INSTITUTE OF SCIENCE AND TECHNOLOGY INNOVATION HARBIN INSTITUTE OF TECHNOLOGY SHENZHEN)
Filing Date
2026-04-20
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing microrobots have difficulty effectively scraping airway epithelial tissue or cells from the lungs, and lack the ability to control the sampling depth, resulting in easy sample detachment and making it difficult to meet clinical diagnostic needs.

Method used

A multi-level biomimetic spiky microrobot is designed, combining micron-level microspiky and nano-level gold spike structures. It utilizes magnetically driven rotational motion to achieve mechanical scraping and micro/nano entanglement. By integrating a magnetically driven inner cylinder with a multifunctional sampling outer shell, it achieves multi-level interactive sampling of airway tissues and stable sample anchoring.

Benefits of technology

It achieves effective scraping of airway tissue and cells, and the sample remains stably attached during the robot's movement. It can adjust the sampling depth according to the depth of the lesion to obtain samples with histological diagnostic value.

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Abstract

本发明提供了一种用于肺部取样的多级仿生刺状微型机器人,包括集成磁驱动内筒与多功能取样外壳,所述集成磁驱动内筒设置在所述多功能取样外壳的内部,所述集成磁驱动内筒掺杂有磁性颗粒,使其在外部磁场作用下具有良好的磁响应能力,所述多功能取样外壳的一端面为取样面,所述取样面上设有实现与气道组织的多级交互的多级仿生刺状结构和用于毛细吸附与样本暂存的微凹槽。本发明还提供了一种用于肺部取样的多级仿生刺状微型机器人的制备方法。本发明的有益效果是:通过在微型机器人取样外壳表面构建微米级刺状结构并在其表面形成纳米级金刺结构,使机器人在磁驱动旋转过程中形成稳定的机械刮取与结构锚定作用。
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