Highly transdermally absorbable colchicine alcohol liposome gel, its preparation method and application
By combining lecithin with a gel matrix, the problems of low transdermal efficiency and poor stability of colchicine topical preparations have been solved, resulting in a colchicine lecithin gel with high transdermal permeability and high skin retention, which is suitable for industrial production and has important clinical value.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- GUANGZHOU HUIYUAN PHARM TECH CO LTD
- Filing Date
- 2026-06-03
- Publication Date
- 2026-07-17
AI Technical Summary
Existing colchicine oral preparations have significant toxic side effects, topical preparations have low transdermal efficiency and insufficient skin retention, and proton pump formulations have poor stability and are difficult to industrialize. Existing proton pump formulations also have problems such as unregistered raw materials, excipients, and packaging materials, poor compatibility with gel matrix, uncontrollable dosage, and lack of investigation into stability effects.
The colchicine-based gel is formed by combining an alcohol body and a gel matrix. The alcohol body contains colchicine, phospholipids, transdermal penetration enhancers, antioxidants, metal ion chelators, and water. The gel matrix is carbomer. This results in a colchicine-based gel with high transdermal penetration and high skin retention. The gel is prepared and filled into shape using a specific process.
A colchicine alcohol gel with high transdermal efficiency, good stability, controllable process, and suitable for industrial production was achieved, which significantly improved the transdermal ability and skin retention time of the drug and reduced the risk of systemic adverse reactions.
Smart Images
Figure CN122398718A_ABST