A hair growth promoting plant exosome preparation and a preparation method and application thereof
By using a freeze-thaw mixing technique involving ginger vesicles and minoxidil solution, the problems of poor biocompatibility and high immunogenicity of minoxidil formulations have been solved, achieving efficient transdermal absorption and low-dose hair regrowth effects of minoxidil, while reducing the risk of adverse reactions.
CN122398751APending Publication Date: 2026-07-17CHANGSHA SHIHAO BIOTECHNOLOGY CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- CHANGSHA SHIHAO BIOTECHNOLOGY CO LTD
- Filing Date
- 2026-05-09
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing minoxidil formulations suffer from poor biocompatibility and high immunogenicity during delivery, resulting in low transdermal absorption efficiency and adverse reactions.
Method used
A hair growth-promoting plant vesicle formulation with a particle size of 168.5±22.1 nm was prepared by mixing ginger vesicles with minoxidil solution and repeatedly freezing and thawing. The freeze-thaw process improved drug loading efficiency and achieved efficient targeted delivery of minoxidil.
Benefits of technology
It improves the transdermal absorption efficiency of minoxidil, reduces the dosage, decreases the occurrence of adverse reactions, and has good biocompatibility and low immunogenicity.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN122398751A_ABST
Abstract
本发明属于生物医药技术领域，具体涉及一种促生发植物外囊泡制剂及其制备方法与应用；所述促生发植物外囊泡制剂是由促生发植物的外囊泡和米诺地尔溶液经（0.8~1.2）:1的体积比混合和反复冻融3~5次制备得到的；所述促生发植物的外囊泡粒径为168.5±22.1nm，浓度为2.0×1010particle / mL~2.5×1010particle / mL；所述米诺地尔溶液的浓度为（0.8~1.2）mg / mL；米诺地尔和生姜外囊泡联合应用能实现协同增效，在达到相同生发效果的同时降低米诺地尔用量进而减少因高剂量药物所伴随的潜在不良反应；具有良好的生物相容性以及低免疫原性。
Need to check novelty before this filing date? Find Prior Art