Cervus elaphus-derived hexapeptide and application thereof
By extracting and modifying hexapeptides from sika deer antler, the problem of small peptide purification was solved, and four hexapeptides with lipid-lowering and anti-atherosclerotic activities were obtained for the treatment of hyperlipidemia and inflammation-related diseases.
CN122404484APending Publication Date: 2026-07-17HUBEI UNIV FOR NATITIES
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HUBEI UNIV FOR NATITIES
- Filing Date
- 2026-05-25
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing technologies are insufficient to effectively isolate and purify small peptides from natural products, and the application of small peptides in lowering blood lipids and preventing atherosclerosis is limited.
Method used
Hexapeptides were extracted and modified from sika deer antler, and four hexapeptides with lipid-lowering and anti-atherosclerotic activities were obtained through specific purification steps. They were then prepared into pharmaceutically acceptable salt forms.
Benefits of technology
It significantly reduced blood lipid levels and MCP-1 content in high-fat fed mice, protected vascular endothelial cells, and has the potential to treat hyperlipidemia and inflammation-related diseases.
✦ Generated by Eureka AI based on patent content.
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Abstract
本发明涉及4种马鹿茸源六肽及应用。所述马鹿茸源六肽的氨基酸序列如SEQ IDNo .1‑ SEQ IDNo .4 所示。所述六肽由马鹿茸中纯化测序得到的六肽，再改构，经化学合成得到。具有降血脂、保护血管内皮细胞的作用，可用于治疗高血脂和抗动脉粥样硬化。
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