System for evaluating the activity state of vitiligo with cx3cr1 as a target
By using flow cytometry to detect the proportion of CX3CR1+CD8+ T cells, the subjectivity and complexity of assessing vitiligo activity have been resolved. This enables rapid and accurate assessment of vitiligo activity, optimizing treatment plans, reducing medical costs, and improving quality of life.
CN122409435APending Publication Date: 2026-07-17AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
- Filing Date
- 2026-04-21
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing methods for assessing vitiligo activity are highly subjective and difficult to quantify. Traditional biomarker detection is complex and easily affected by biological factors, and flow cytometry indicators are insufficient to accurately reflect the degree of disease activity.
Method used
Flow cytometry was used to detect the proportion of CX3CR1+CD8+ T cells. A standardized operating procedure was established for sample collection, processing, staining, detection, and data analysis to assess the activity status of vitiligo.
Benefits of technology
It enables rapid and accurate assessment of vitiligo activity, improves diagnostic precision and repeatability, reduces the risk of misdiagnosis, optimizes treatment plans, lowers medical costs, and improves quality of life.
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Figure CN122409435A_ABST
Abstract
本发明属于生物医学检测技术领域，具体为以CX3CR1为靶点的白癜风活动状态评估系统。本发明系统具体包括：样本采集处理模块，从白癜风患者中采集抗凝血样本；试剂盒，包含一组用于检测目标细胞群的高特异性、荧光标记的流式抗体组合；流式细胞检测仪，对裂红后的细胞进行染色、重悬、进行检测；数据分析模块，计算CX3CR1+的CD8+T细胞的比例，通过分析比例变化，评估白癜风的活动状态，为临床治疗提供参考。本发明操作方便，减少人为误差，在多批次样本检测表明测试结果具有很高的一致性和重复性。本发明填补了当前白癜风活动状态客观评估的空缺。
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