Rhabdovirus g protein having one or more cysteine-rich regions and uses thereof
By introducing a cysteine-rich region of the rhabdovirus G glycoprotein that binds to LDLR into the lentiviral vector, the difficulty of targeting specific cell types with lentiviral vectors was solved, achieving broader cell infection and stability.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- WILLIARD CORP
- Filing Date
- 2024-11-09
- Publication Date
- 2026-07-17
AI Technical Summary
Existing lentiviral vectors face challenges such as difficulty in binding to cell receptors, poor in vivo compatibility, and limited targeting range when targeting specific cell types, making it difficult to achieve reproducible high viral incorporation levels.
Recombinant proteins, including cysteine-rich regions of the rhabdovirus G glycoprotein or its functional fragments that bind to the low-density lipoprotein receptor (LDLR), are used to enhance the targeting and cellular infection capabilities of viral vectors through covalent binding or fusion protein methods.
It improved the viral vector's ability to target different cell types, enhanced the efficiency and stability of viral entry into cells, and achieved a wider range of cell infection.
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