An absorbable anchoring vascular puncture site closure device

Abstract

The application discloses a blood vessel puncture port closure device, and relates to the technical field of medical devices, which comprises a closure assembly, a delivery and release assembly, an anchor, a blocking piece and a suture, wherein the suture is connected with the anchor and the blocking piece; the delivery and release assembly is used for delivering and releasing the closure assembly to a blood vessel puncture port; the anchor is used for being unfolded in a blood vessel cavity and being attached to an inner wall of the blood vessel; the blocking piece is used for being placed in a puncture channel of an outer wall of the blood vessel; and the suture is used for providing a pulling force, so that the anchor and the blocking piece clamp the blood vessel wall between the anchor and the blocking piece, thereby solving the problems of slow hemostasis speed, poor hemostasis effect on anticoagulation patients, complicated operation and the risk of permanent retention of metal clips in the body to cause foreign body residue of the existing blood vessel closure device.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a vascular puncture site closure device with an absorbable anchor. Background Technology

[0002] Currently, endovascular surgeries such as percutaneous coronary intervention often use the femoral artery approach. The traditional method of hemostasis after the procedure is manual compression, which requires the doctor to manually apply pressure to the puncture site for 30 to 40 minutes, and the patient must be immobilized in bed for more than 12 hours to prevent bleeding.

[0003] To shorten hemostasis time and bed rest time, several vascular closure devices have emerged in the current technology, mainly divided into two categories: The first category is suture devices, which suture the vascular puncture site with sutures, similar to surgical suturing techniques, but require precise suture operation, have high technical requirements, and improper operation can easily lead to vascular stenosis or occlusion; The second category is clamping devices, which use nickel-titanium alloy clamps to clamp the puncture site from the outside of the blood vessel, but the metal clamps will remain permanently in the body, causing some patients to experience a foreign body sensation, and may affect subsequent punctures of the same side of the blood vessel.

[0004] Furthermore, manual compression and partial closure devices primarily rely on the patient's own blood clots for occlusion. For patients receiving anticoagulation therapy such as heparin during the procedure, hemostasis is poor and the failure rate is high. In some pure collagen embolic devices, if mispositioned, the collagen may protrude into the blood vessel, causing embolism. Summary of the Invention

[0005] The purpose of this invention is to provide a vascular puncture site closure device to solve the problems existing in the prior art. By combining mechanical anchoring and physical filling, it can achieve reliable hemostasis that does not depend on the patient's coagulation status and reduce the risk of foreign body residue in blood vessels.

[0006] To achieve the above objectives, the present invention provides the following solution: The present invention provides a vascular puncture site closure device, comprising: A closure assembly includes an anchor, a sealing element, and a suture connecting the anchor and the sealing element; and... A delivery and release assembly for delivering the closure assembly to the vascular puncture site; The anchor is deployed within the blood vessel lumen, and after deployment, it unfolds and adheres to the inner wall of the blood vessel. The radial dimension of the deployed anchor is larger than the inner diameter of the puncture site. The occlusion device is deployed in the puncture channel outside the blood vessel lumen, and after deployment, it unfolds at the outer wall of the blood vessel and seals the puncture site. The suture provides traction force to clamp the blood vessel wall between the anchor and the occlusion device. A locking knot is provided on the suture line. The locking knot is located on the side of the occluder away from the anchor. When the locking knot is subjected to an external force in the direction of the occluder, it slides along the suture line and locks in position after the external force is removed. This is used to maintain the clamping force of the anchor and the occluder on the blood vessel wall.

[0007] Optionally, the anchoring element, when unfolded, is at least T-shaped, umbrella-shaped, basket-shaped, or trident-shaped.

[0008] Optionally, the occlusion element is a hemostatic sponge, which expands upon contact with blood to seal the puncture site. Optionally, the anchor, the sealing element, and the suture are all made of absorbable material.

[0009] Optionally, the material used to make the anchor is at least a lactide-glycolic acid polymer or polyglycolic acid.

[0010] Optionally, the material used to make the sealing element is at least oxidized regenerated cellulose, bovine collagen, or recombinant collagen.

[0011] Optionally, the material used to make the suture is at least polyglycolic acid or polylactic acid.

[0012] Optionally, the delivery and release assembly includes a catheter sheath, a loading tube, a positioner, and a push rod; The loading tube is movably inserted into the catheter sheath. In the initial state, the anchor and the plug are housed in the distal lumen of the loading tube, with the anchor located at the farthest end of the loading tube and the plug located at the proximal end of the anchor. The locator is used to provide resistance feedback indicating that the anchor has been attached to the inner wall of the blood vessel by retracting and contacting the anchor after the anchor is released, deployed, and attached to the inner wall of the blood vessel. The push rod is movably inserted into the loading tube and sleeved on the suture. The distal end of the push rod is initially located on the proximal side of the occlusion element. It is used to push the occlusion element along the suture into the puncture channel on the outer wall of the blood vessel and compact it after the loading tube is retracted to expose the occlusion element. At the same time, it pushes the locking knot to slide along the suture towards the occlusion element.

[0013] Optionally, the delivery and release assembly further includes an operating handle connected to the proximal end of the catheter sheath; The proximal ends of the loading tube, the locator, and the push rod all extend to the operating handle, which is equipped with control elements for axially moving the loading tube, the locator, and the push rod, respectively.

[0014] Optionally, the delivery and release assembly further includes a suture cutting mechanism disposed within the operating handle, located near the proximal end of the push rod; The suture cutting mechanism includes a drive member and a cutting blade. The cutting blade is installed at the output end of the drive member, and the cutting edge of the cutting blade faces the suture thread passing through the push rod. The drive member is used to drive the cutting blade to move and cut the suture thread.

[0015] The present invention achieves the following technical effects compared to the prior art: The vascular puncture site closure device disclosed in this invention employs a sandwich closure method combining internal anchoring and external sealing. The anchoring element unfolds and adheres to the inner wall of the blood vessel, while the sealing element is placed on the outer wall of the blood vessel to seal the puncture site. Both elements are clamped together by sutures to form a stable mechanical seal. Because a locking knot is provided on the suture, after the push rod pushes the sealing element to compact against the outer wall of the blood vessel, the locking knot locks the suture tension, maintaining a stable clamping force between the anchoring element and the sealing element on the blood vessel wall, preventing the sealing element from shifting postoperatively. This design does not rely on the patient's coagulation function and can achieve immediate hemostasis even in a strongly anticoagulant state. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a schematic diagram of the overall structure of a vascular puncture site closure device in one example of the present invention; Figure 2 This is a partial structural schematic diagram of a vascular puncture site closure device in one example of the present invention; Figure 3 This is a schematic diagram of the sealing element, anchoring element, and suture extending out of the loading tube in an example disclosed in this invention; Figure 4 This is a schematic diagram of the structure of an anchoring element in one example disclosed in this invention; Figure 5 This is a schematic diagram of the structure of a catheter sheath in one example disclosed in this invention; Figure 6 This is a schematic diagram of the structure of a loading tube in one example disclosed in this invention; Figure 7 This is a schematic diagram of the operation of a vascular puncture site closure device in one example of the present invention; Among them, 1-operating handle, 2-catheter sheath, 3-loading tube, 4-sealing component, 5-anchoring component, and 6-suture. Detailed Implementation

[0018] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0019] The purpose of this invention is to provide a vascular puncture site closure device to solve the problems existing in the prior art. By combining mechanical anchoring and physical filling, it can achieve reliable hemostasis that does not depend on the patient's coagulation status and reduce the risk of foreign body residue in blood vessels.

[0020] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0021] like Figures 1 to 7 As shown, the present invention provides a vascular puncture site closure device, including a closure assembly and a delivery and release assembly. The closure assembly includes an anchor 5, a sealing element 4, and a suture 6, with the suture 6 connecting the anchor 5 and the sealing element 4. The delivery and release assembly is used to deliver the closure assembly to the vascular puncture site. The anchor 5 is released within the vascular lumen, unfolding and adhering to the inner wall of the vessel after release. The radial dimension of the unfolded anchor 5 is larger than the inner diameter of the vascular puncture site. The sealing element 4 is released in the puncture channel outside the vascular lumen, unfolding at the outer wall of the vessel and sealing the vascular puncture site after release. The suture 6 provides traction force to clamp the vessel wall between the anchor 5 and the sealing element 4. The suture 6 is provided with a locking knot, which is located on the side of the occlusion member 4 away from the anchor member 5. When the locking knot is subjected to an external force in the direction of the occlusion member 4, it slides along the suture 6 and locks in position after the external force is removed, in order to maintain the clamping force of the anchor member 5 and the occlusion member 4 on the blood vessel wall.

[0022] Understandably, after endovascular surgeries such as percutaneous coronary intervention, traditional manual compression methods rely on the patient's coagulation function, which is ineffective for patients receiving anticoagulation therapy and requires prolonged bed rest. Existing suture devices are complex to operate and have long learning curves, while clamping devices use metal clips permanently left in the body. The vascular puncture site closure device disclosed in this invention employs a dissecting closure method combining internal anchoring and external occlusion. The anchor 5 unfolds and adheres to the inner wall of the blood vessel, while the occlusion element 4 is placed on the outer wall of the blood vessel to seal the puncture site. Both are clamped to the blood vessel wall by sutures 6, forming a stable mechanical seal. Because the suture 6 has a locking knot, after the pusher pushes the occlusion element 4 to compact against the outer wall of the blood vessel, the locking knot locks the tension of the suture 6, maintaining a stable clamping force between the anchor 5 and the occlusion element 4 on the blood vessel wall and preventing the occlusion element 4 from shifting postoperatively. This design does not rely on the patient's coagulation function and can achieve immediate hemostasis even in a strongly anticoagulant state.

[0023] In some specific examples, using this vascular puncture closure device, the average hemostasis time is about 1 to 2 minutes, and the patient's postoperative immobilization time is shortened to about 2 hours, allowing for same-day discharge.

[0024] In one embodiment, the anchor 5, when unfolded, is at least T-shaped, umbrella-shaped, basket-shaped, or trident-shaped. Anchors 5 of different shapes all have a large radial projection area, effectively covering the inner edge of the puncture site, providing mechanical support by being held inside the puncture site, and the gaps in their structure allow for normal blood flow around them, without causing vascular stenosis or occlusion. When the device is retracted, the unfolded anchor 5 will be held inside the puncture site, providing clear mechanical feedback, allowing the operator to confirm that the anchor 5 has been properly attached.

[0025] In one embodiment, the occlusion element 4 is a hemostatic sponge, which expands upon contact with blood to seal the puncture site. After release, the hemostatic sponge unfolds and expands, tightly filling the puncture channel in the outer wall of the blood vessel, sealing the puncture site from the outside. Simultaneously, the anchoring element 5 clamps the blood vessel wall from the inside, and the two work together to form a closed structure with internal and external clamping, achieving a reliable seal of the puncture site.

[0026] In one embodiment, the anchor 5, the occlusion element 4, and the suture 6 are all made of absorbable material, designed to be degraded and absorbed by the body within a certain period after the puncture site is closed, leaving no permanent foreign body residue. This avoids the foreign body sensation and chronic inflammatory reactions that may be caused by the long-term retention of permanent implants such as metal clips in the body, and preserves the possibility of the patient undergoing another puncture on the same side of the blood vessel in the future.

[0027] As a preferred example, after the entire closure assembly is implanted into the human body, the hemostatic sponge degrades and is absorbed within 2 to 6 weeks, and the anchor 5 and suture 6 are completely degraded and absorbed within 60 to 90 days.

[0028] In one embodiment, the material used to fabricate the anchor 5 is at least a lactide-glycolic acid polymer or polyglycolic acid. Both lactide-glycolic acid polymers and polyglycolic acid have excellent biocompatibility and predictable degradation rates, enabling them to stably perform their occlusion function after implantation and degrade and be absorbed within a specified period. Of course, the anchor 5 can also be made of other biodegradable polymers.

[0029] In one embodiment, the material used to fabricate the occlusion element 4 is at least oxidized regenerated cellulose, bovine collagen, or recombinant collagen. Hemostatic sponges made of different materials can be flexibly selected according to clinical needs; all can rapidly expand upon contact with blood, tightly filling the puncture channel and providing reliable physical occlusion.

[0030] As a preferred example, the hemostatic sponge is made from oxidized regenerated cellulose. Oxidized regenerated cellulose is a plant-based component, eliminating the risk of cross-infection from animal-derived viruses or pathogens such as bovine spongiform encephalopathy. It exhibits excellent biocompatibility and significantly reduces postoperative immune rejection. Its degradation and absorption cycle is 2 to 6 weeks, far superior to the 6 to 12 weeks of traditional collagen, facilitating rapid tissue healing. Furthermore, it contains no animal components, overcoming dietary restrictions and making it suitable for all population groups.

[0031] In one embodiment, the material used to make the suture 6 is at least polyglycolic acid or polylactic acid. After implantation, the suture 6 needs to maintain sufficient tension for a certain period of time to ensure that the anchor 5 and the occlusion element 4 clamp tightly against the blood vessel wall, and then gradually degrade and be absorbed. The degradation cycles of polyglycolic acid and polylactic acid match the degradation cycles of the anchor 5 and the occlusion element 4, enabling them to work together to complete the entire process of occlusion and degradation.

[0032] In one embodiment, the delivery and release assembly includes a catheter sheath 2, a loading tube 3, a locator, and a pusher. The loading tube 3 is movably inserted within the catheter sheath 2. In its initial state, the anchor 5 and the occlusion element 4 are housed within the distal lumen of the loading tube 3, with the anchor 5 located at the distal end of the loading tube 3 and the occlusion element 4 located proximal to the anchor 5. The locator is used to provide resistance feedback indicating that the anchor 5 has adhered to the vessel wall after the anchor 5 has been released, deployed, and adhered to the vessel wall. In one specific configuration, the locator is a flexible claw or stepped structure. When the anchor 5 is deployed and the loading tube 3 is retracted, the locator contacts the anchor 5, generating a noticeable resistance sensation. The operator can then determine that the anchor 5 has adhered to the vessel wall without relying on X-ray fluoroscopy for confirmation. The pusher is movably inserted within the loading tube 3 and fitted onto the suture 6. The distal end of the push rod is initially located on the proximal side of the occlusion element 4. It is used to push the occlusion element 4 along the suture 6 into the puncture channel on the outer wall of the blood vessel and compact it after the loading tube 3 is retracted to expose the occlusion element 4. At the same time, it pushes the locking knot to slide along the suture 6 toward the occlusion element 4.

[0033] The loading tube 3, locator, and pusher work together. The loading tube 3 carries the closure assembly and precisely delivers it, exposing it step by step. The locator provides tactile feedback through contact with the anchor 5 during retraction, allowing the positioning operation to proceed without X-ray fluoroscopy. The pusher pushes and presses the occlusion element 4 against the vessel wall, while simultaneously sliding the locking knot to the locked position. The catheter sheath 2 provides a delivery channel from outside the body to the vessel. The movement of the loading tube 3 within the catheter sheath 2 enables the step-by-step release of the anchor 5 and the occlusion element 4. This step-by-step design ensures that each component is released sequentially, guaranteeing the precision and controllability of the entire closure process.

[0034] As a preferred example, the distal end of the catheter sheath 2 has a smooth, tapered tip for easy insertion into the blood vessel along the guidewire, and its wall is marked to indicate the depth position under fluoroscopy.

[0035] In one embodiment, the delivery and release assembly further includes an operating handle 1, which is connected to the proximal end of the catheter sheath 2. The proximal ends of the loading tube 3, the locator, and the push rod all extend to the operating handle 1. The operating handle 1 is equipped with control elements for controlling the axial movement of the loading tube 3, the locator, and the push rod, respectively. All control elements are centrally arranged on the operating handle 1, allowing the operator to complete all operations of retracting the loading tube 3, retracting the locator, and pushing the push rod with a single hand gripping the handle. There is no need to change instruments or alter hand gestures, making operation simple and with a short learning curve.

[0036] As a preferred example, each control element is a slide button or knob, etc., and the operator controls the axial movement of the loading tube 3, the positioner and the push rod by pushing different control elements.

[0037] In one embodiment, the delivery and release assembly further includes a suture cutting mechanism disposed within the operating handle 1, near the proximal end of the push rod. The suture cutting mechanism includes a drive member and a cutting blade. The cutting blade is mounted at the output end of the drive member, with its cutting edge facing the suture 6 passing through the push rod. The drive member drives the cutting blade to cut the suture 6. The suture cutting mechanism is integrated into the operating handle 1, allowing the suture cutting operation to be completed on the same handle as other control steps, eliminating the need for additional cutting tools or steps and improving operational continuity.

[0038] In one scenario, the driving mechanism is a push-button or rotary knob, and the cutting blade is a microblade or scissor structure. After the occlusion component 4 is compacted and locked in place, the surgeon presses the push button to drive the cutting blade, neatly cutting the suture 6, separating the closure component from the delivery and release component. The delivery and release component can then be completely removed from the body, leaving only the closure component at the puncture site to complete the occlusion.

[0039] To facilitate understanding, we will explain how the above device performs the closure of the vascular puncture site in a specific clinical scenario. For example, consider a coronary intervention patient receiving dual antiplatelet therapy: Following percutaneous coronary intervention (PCI), the femoral artery guidewire was kept in place while the arterial sheath was removed. The loading tube 3, along with the catheter sheath 2, was inserted into the blood vessel along the indwelling guidewire until the distal end of the loading tube 3 was marked as entering the vascular lumen. Blood return was observed at this point, confirming that the distal end of the loading tube 3 had entered the vascular lumen.

[0040] The guidewire is withdrawn, and the operator retracts the loading tube 3 a first distance using the control on the operating handle 1. The anchoring element 5, no longer radially constrained by the wall of the loading tube 3, automatically unfolds into a pre-shaped T-shape within the blood vessel lumen, with its radial dimension larger than the inner diameter of the puncture site. At this point, the occlusion element 4 is still contained within the distal lumen of the loading tube 3 and has not yet been exposed.

[0041] The entire device is retracted, causing the deployed anchor 5 to move towards the puncture site until it adheres to the inner wall of the blood vessel. The operator then retracts the locator, causing the distal end of the locator to contact the proximal end of the anchor 5, generating a clear locking resistance feedback. This feedback indicates that the anchor 5 has adhered to the inner wall of the blood vessel and is locked inside the puncture site.

[0042] After confirming that the anchor 5 is attached to the inner wall of the blood vessel, the operator continues to retract the loading tube 3 a second distance. The occlusion element 4, no longer constrained by the loading tube 3, is exposed in the puncture channel on the outer wall of the blood vessel and unfolds. The operator pushes the plunger, and the distal end of the plunger pushes the occlusion element 4 along the suture 6 into the puncture channel on the outer wall of the blood vessel and presses it firmly against the outer wall. At the same time, the locking knot on the suture 6 is pushed along the suture 6 towards the occlusion element 4. The pusher force is maintained for 3 to 5 seconds to ensure that the occlusion element 4 is tightly attached to the outer wall of the blood vessel.

[0043] After the pusher force is removed, the locking knot is locked in position by the friction between it and the suture 6, preventing the suture 6 from sliding in the opposite direction, maintaining the clamping force of the anchor 5 and the occlusion 4 on the blood vessel wall, and clamping the blood vessel wall between the anchor 5 and the occlusion 4.

[0044] After confirming that the locking mechanism is secure, the operator presses the suture cutting mechanism button on the operating handle 1. The drive unit moves the cutting blade to cut the suture 6 inside the push rod. After the suture 6 is cut, the closing assembly separates from the delivery and release assembly. The operator removes the delivery and release assembly and the push rod, leaving only the anchor 5, the sealing element 4, and the suture 6 at the puncture site.

[0045] Gently press the skin puncture site for about 1 minute to confirm that there is no bleeding.

[0046] After completing the above steps, the patient should be immobilized for approximately 2 hours post-surgery, and can get out of bed and move around after 4 hours. They can be discharged the following day. Clinical data shows that this method has no complications such as hematoma or pseudoaneurysm, and the complication rate is comparable to or even lower than that of manual compression.

[0047] In some cases, ultrasound guidance can be used for puncture site localization and device release to improve success rates in patients with calcified lesions. For example, the loading tube 3 is first withdrawn to expose the anchor 5 and allow it to unfold and adhere to the inner wall of the blood vessel. Then, the loading tube 3 is withdrawn further to expose the occlusion element 4 and allow it to unfold on the outer wall of the blood vessel. The occlusion element 4 is then compacted by the push rod, and the locking knot is pushed to lock the clamping force. Finally, the suture 6 is cut to withdraw the delivery and release assembly. The entire process is independent of the patient's coagulation function, and hemostasis can be achieved within approximately 1 to 2 minutes even if the patient is in a heparin anticoagulant state. The operator can complete all operations—retraction of the loading tube 3, retraction of the locator, push rod advancement, and suture 6 cutting—with a single hand holding the operating handle 1. The learning curve is short, which facilitates its promotion in primary healthcare institutions.

[0048] Any adaptive changes made according to actual needs are within the scope of protection of this invention.

[0049] It should be noted that, for those skilled in the art, it is obvious that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0050] Specific examples have been used to illustrate the principles and implementation methods of this invention. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of this invention. Furthermore, those skilled in the art will recognize that, based on the ideas of this invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of this invention.

Claims

1. A device for closing a vascular puncture site, characterized in that, include: A closure assembly includes an anchor, a sealing element, and a suture connecting the anchor and the sealing element; and... A delivery and release assembly for delivering the closure assembly to the vascular puncture site; The anchor is deployed within the blood vessel lumen, and after deployment, it unfolds and adheres to the inner wall of the blood vessel. The radial dimension of the deployed anchor is larger than the inner diameter of the puncture site. The occlusion device is deployed in the puncture channel outside the blood vessel lumen, and after deployment, it unfolds at the outer wall of the blood vessel and seals the puncture site. The suture provides traction force to clamp the blood vessel wall between the anchor and the occlusion device. A locking knot is provided on the suture line. The locking knot is located on the side of the occluder away from the anchor. When the locking knot is subjected to an external force in the direction of the occluder, it slides along the suture line and locks in position after the external force is removed. This is used to maintain the clamping force of the anchor and the occluder on the blood vessel wall.

2. The vascular puncture site closure device according to claim 1, characterized in that, The anchoring element, when unfolded, is at least T-shaped, umbrella-shaped, basket-shaped, or trident-shaped.

3. The vascular puncture site closure device according to claim 1, characterized in that, The occlusion element is a hemostatic sponge, which expands upon contact with blood to seal the puncture site.

4. The vascular puncture site closure device according to claim 1, characterized in that, The anchor, the sealing element, and the suture are all made of absorbable material.

5. The vascular puncture site closure device according to claim 4, characterized in that, The material used to make the anchor is at least a lactide-glycolic acid polymer or polyglycolic acid.

6. The vascular puncture site closure device according to claim 4, characterized in that, The material used to make the sealing component is at least oxidized regenerated cellulose, bovine collagen, or recombinant collagen.

7. The vascular puncture site closure device according to claim 4, characterized in that, The material used to make the suture is at least polyglycolic acid or polylactic acid.

8. The vascular puncture site closure device according to claim 1, characterized in that, The delivery and release assembly includes a catheter sheath, a loading tube, a positioner, and a push rod; The loading tube is movably inserted into the catheter sheath. In the initial state, the anchor and the plug are housed in the distal lumen of the loading tube, with the anchor located at the farthest end of the loading tube and the plug located at the proximal end of the anchor. The locator is used to provide resistance feedback indicating that the anchor has been attached to the inner wall of the blood vessel by retracting and contacting the anchor after the anchor is released, deployed, and attached to the inner wall of the blood vessel. The push rod is movably inserted into the loading tube and sleeved on the suture. The distal end of the push rod is initially located on the proximal side of the occlusion element. It is used to push the occlusion element along the suture into the puncture channel on the outer wall of the blood vessel and compact it after the loading tube is retracted to expose the occlusion element. At the same time, it pushes the locking knot to slide along the suture towards the occlusion element.

9. The vascular puncture site closure device according to claim 8, characterized in that, The delivery and release assembly also includes an operating handle connected to the proximal end of the catheter sheath; The proximal ends of the loading tube, the locator, and the push rod all extend to the operating handle, which is equipped with control elements for axially moving the loading tube, the locator, and the push rod, respectively.

10. The vascular puncture site closure device according to claim 9, characterized in that, The delivery and release assembly also includes a suture cutting mechanism, which is disposed within the operating handle and located near the end of the push rod; The suture cutting mechanism includes a drive member and a cutting blade. The cutting blade is installed at the output end of the drive member, and the cutting edge of the cutting blade faces the suture thread passing through the push rod. The drive member is used to drive the cutting blade to move and cut the suture thread.

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