A bone regeneration kit and implant system for immediate implantation
By integrating a personalized abutment with a rigid barrier membrane and plasma matrix bone blocks, the problems of maintaining bone space and soft tissue closure in immediate implantation are solved, enabling autologous bone regeneration and aesthetic shaping, providing a systematic solution, and reducing surgical complexity and the risk of complications.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HUBEI PRIME SHIELD BIOTECHNOLOGY CO LTD
- Filing Date
- 2026-05-13
- Publication Date
- 2026-07-24
AI Technical Summary
Existing technologies lack systematic and complete solutions, making it difficult to effectively maintain bone space, close soft tissue, and achieve aesthetic shaping during immediate implantation, and also pose risks of immunogenicity and disease transmission.
The system integrates a personalized abutment with components such as a rigid barrier membrane and plasma matrix bone blocks. It uses digital scanning to design the transgingival molding section and titanium mesh fixation section to form a three-level rigid support. It combines autologous bone chips with plasma matrix to form autologous bone blocks, which enhances mechanical strength and resistance to degradation.
It achieves rigid maintenance of bone space, simultaneous shaping of soft tissue and aesthetic results, avoids secondary surgery, reduces patient pain and risk of complications, and improves surgical efficiency and aesthetic results.
Smart Images
Figure CN122440344A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of dental implant medical device technology, and more specifically, to a bone regeneration kit and implantation system for immediate implantation. Background Technology
[0002] The resorption and collapse of the alveolar bone socket, especially the labial bone plate in the aesthetic zone, after tooth extraction is a long-standing core challenge in the field of dental implantology. Bundle bone is a metabolically active bone tissue that relies on the periodontal ligament for blood supply, and its thickness is typically only 0.2-0.4 mm. Once a tooth is lost, the blood supply to the bundle bone is interrupted, leading to rapid resorption and remodeling within weeks post-surgery. This directly results in the loss of alveolar width and contour, severely hindering the ideal three-dimensional placement of implants and the final aesthetic outcome of the restoration. Clinical studies have shown that when the labial bone plate thickness is ≤1 mm, the average vertical bone resorption after extraction can reach 7.5 mm, while for bone plates >1 mm thick, the vertical bone resorption is only 1.1 mm. Therefore, for patients with severely insufficient labial bone width before extraction (e.g., labial bone plate thickness less than 1 mm), effectively maintaining bone regeneration space and preventing bone resorption and collapse during extraction has become a pressing problem to be solved in immediate implantation techniques.
[0003] Currently, for these challenging cases, the commonly used clinical solution is to perform guided bone regeneration surgery on the labial side simultaneously with immediate implantation. This involves filling the space between the implant and the labial bone plate, as well as the lateral side, with granular bone repair material and covering it with a barrier membrane. However, this method faces significant challenges in maintaining space: granular bone material, lacking complete bone wall support and implant support on the labial side, is highly susceptible to displacement or absorption due to soft tissue pressure, making it difficult to stably maintain the ideal three-dimensional contour around the implant neck, especially on the labial side. While collagen membranes are biocompatible, their low mechanical strength makes them prone to folding and collapse under pressure from the buccal muscles, failing to maintain a stable osteogenic space. To increase space maintenance, rigid barrier membranes such as titanium mesh are sometimes used clinically. However, existing titanium meshes require multiple bone screws for fixation to the jawbone, which is not only complex and invasive but also requires a second surgery for flap removal after healing, increasing patient suffering and the risk of soft tissue complications.
[0004] In recent years, autologous blood extracts, known as "plasma matrix," have been widely used to guide bone regeneration due to their rich content of growth factors and three-dimensional fibrin scaffolds. By mixing plasma matrix with bone repair materials, it can be molded into "plasma matrix bone blocks" with a certain mechanical strength. However, existing methods for preparing plasma matrix bone blocks mostly use commercially available xenogeneic or allogeneic bone as bone phase components, posing risks of immunogenicity, disease transmission, and ethical controversies. Furthermore, their internal fiber cross-linking is insufficient, resulting in low mechanical strength and rapid degradation, making it difficult to meet the long-term spatial maintenance requirements for bone defects in load-bearing areas. In addition, existing immediate implantation-related products are mostly simple assembly of individual components (such as purchasing blood collection tubes, bone powder, and collagen membranes separately), lacking a complete solution that systematically and deeply couples bone augmentation components, barrier membranes, and implant fixation structures.
[0005] In terms of soft tissue management, immediate implantation commonly faces the challenge of sealing the extraction socket. While some studies have attempted to use personalized healing abutments concurrently with immediate implantation, their function is limited to supporting gingival shaping and cannot simultaneously address the issues of maintaining bone augmentation space and securing the barrier membrane. Clinically, a multifunctional abutment capable of simultaneously achieving "bone space rigidity maintenance, soft tissue sealing, and aesthetic shaping" during implant placement is still lacking.
[0006] The inventors recognized that by designing a personalized abutment with a transgingival shaping section that precisely matches the transgingival morphology of the natural tooth neck, ideal support and closure of soft tissue can be provided immediately after implant placement, guiding the gingival cuff to heal along a pre-defined contour. This transgingival shaping section not only effectively closes the wound and prevents exposure and infection of bone augmentation material, but also directly forms the transgingival contour required for the final restoration during the healing process. This design significantly shortens the treatment cycle, reduces patient suffering, and avoids cumulative damage to soft tissue from multiple surgeries, thus contributing to better aesthetic results.
[0007] Therefore, the purpose of this invention is to provide a bone regeneration kit and implantation system for immediate implantation. By systematically integrating a personalized abutment with a transgingival shaping section with components such as a rigid barrier membrane and plasma matrix bone blocks, it achieves multiple clinical goals, including maintaining bone space rigidity, complete autologous bone regeneration, simultaneous soft tissue shaping, and eliminating the need for secondary surgery, thus solving the technical problem of the lack of such a systematic complete solution in the prior art. Summary of the Invention
[0008] To address the aforementioned technical problems, this invention provides a bone regeneration kit and implantation system for immediate implantation. First, a rigid barrier membrane is directly fixed to the titanium mesh fixation part of a personalized abutment, forming a three-tiered rigid support system of "implant, abutment, and titanium mesh," eliminating the need for titanium screw fixation, facilitating surgical procedures, and reducing the flap area. Second, the transgingival shaping part of the abutment is designed based on digital scanning, completing soft tissue closure and aesthetic shaping simultaneously with implantation. Third, a thickness-limited bone scraper is used to scrape autologous bone fragments from the bundle of bone in the extraction socket, mixing them with autologous plasma matrix to form a completely autologous bone block without adding any exogenous materials. Furthermore, surface modification of the mold and heat treatment enhance its mechanical strength and resistance to degradation. These three aspects synergistically achieve the clinical goals of maintaining bone space rigidity, completely autologous bone regeneration, simultaneous soft tissue shaping, and avoiding secondary surgery.
[0009] In a first aspect, the present invention provides a bone regeneration kit for immediate implantation, the kit comprising patient-personalized components and universal components.
[0010] The patient-personalized component includes a personalized abutment and a rigid barrier membrane. The personalized abutment has a segmented structure, consisting, from top to bottom, of a transgingival shaping section, a titanium mesh fixation section, and an implant connector. The implant connector is used to connect to the implant, and the titanium mesh fixation section is located between the implant connector and the transgingival shaping section, and the titanium mesh fixation section is equipped with at least one fixation structure. The rigid barrier membrane has a porous structure, and its shape and size are adapted to the labial contour of the patient's extraction socket and bone defect area. The rigid barrier membrane is equipped with at least one mounting hole that matches the fixation structure.
[0011] The general-purpose components include: a plasma matrix preparation component and a bone fragment collector. The plasma matrix preparation component includes at least a blood collection container and a plasma matrix molding mold. The bone fragment collector is used to scrape autologous bone fragments.
[0012] In a preferred embodiment, the personalized abutment is fixedly connected to the implant via a fixing screw passing through the central channel of the transgingival shaping part, the titanium mesh fixation part, and the implant connection part; when the mounting hole of the rigid barrier membrane is connected to the fixation structure on the titanium mesh fixation part, the rigid barrier membrane forms a spatial match with the labial contour of the patient's extraction socket and bone defect area, and can be non-destructively removed from the personalized abutment by releasing the fixation structure after the healing period; the transgingival shaping part has a three-dimensional shape that matches the transgingival morphology of the patient's natural tooth neck, and the three-dimensional shape is obtained based on preoperative digital scanning data.
[0013] In a preferred embodiment, the bone scraper has a thickness-limiting scraping structure, with the scraping depth limited to 0.5-1.2 mm; the bone scraper is used to scrape autologous bone scrapings from the area of the labial bone plate of the extraction socket with a coronal thickness of less than 1 mm and / or the bundle-like bone area of the inner wall of the alveolar socket.
[0014] In a preferred embodiment, the plasma matrix preparation assembly includes a liquid plasma matrix preparation tube and a solid plasma matrix preparation tube; the solid plasma matrix preparation tube has a hydrophilic inner surface, and the liquid plasma matrix preparation tube has a hydrophobic inner surface.
[0015] In a preferred embodiment, the plasma matrix molding mold is used for the preparation of plasma matrix bone blocks and is made of medical metal material, which is selected from titanium, titanium alloy or stainless steel; the inner surface roughness Rsm of the plasma matrix molding mold is 0.1-0.2 μm, and the inner surface is acid-etched to form micropits.
[0016] Secondly, the present invention provides a bone regeneration implant system for immediate implantation, the system comprising: a bone regeneration kit for immediate implantation as described in any of the preceding claims; an implant pre-implanted into the patient's extraction socket, wherein the implant connector of the personalized abutment is detachably fixedly connected to the implant; and a plasma matrix bone block, the plasma matrix bone block being prepared by mixing autologous bone fragments collected by the bone fragment collector with plasma matrix material prepared by the plasma matrix preparation component, and filling the bone augmentation space formed between the rigid barrier membrane and the extraction socket wall. The autologous bone fragments are derived from autologous bone with a coronal thickness of less than 1 mm on the labial side of the extraction socket and / or bundles of bone from the alveolar socket wall; the plasma matrix bone block does not contain any bone repair materials other than autologous tissue.
[0017] In a preferred embodiment, the plasma matrix bone block has a dense layer formed by surface heat treatment, the dense layer being located on the side of the plasma matrix bone block facing the soft tissue, for enhancing anti-degradation capacity and cell barrier function.
[0018] Thirdly, the present invention also provides a method for preparing a plasma matrix bone block using the above-mentioned kit, comprising: scraping autologous bone fragments from the area with a coronal thickness of less than 1 mm on the labial side of the extraction socket and / or the inner wall of the alveolar socket using the bone fragment collector; mixing the autologous bone fragments with plasma matrix material prepared by the plasma matrix preparation component; and shaping the plasma matrix bone block in the plasma matrix molding mold to form a completely autologous plasma matrix bone block, wherein the plasma matrix bone block does not contain any bone repair materials other than autologous tissue.
[0019] Fourthly, the present invention also provides an operational method for assembling an implant system using the above-mentioned kit, comprising: scraping autologous bone fragments from the area with a coronal thickness of less than 1 mm on the labial side of the extraction socket and / or from the inner wall of the alveolar socket using the bone fragment collector; mixing the autologous bone fragments with plasma matrix material prepared by the plasma matrix preparation component, and shaping them in the plasma matrix molding mold to form a completely autologous plasma matrix bone block; fixing the personalized abutment to the pre-implanted implant; fixing the rigid barrier membrane to the titanium mesh fixation part of the abutment through the fixation structure to form a stable local regeneration space; and filling the bone increment space between the rigid barrier membrane and the extraction socket wall with the plasma matrix bone block.
[0020] Compared with the prior art, the present invention has the following beneficial effects: (1) Achieve rigidity maintenance of bone space. By directly fixing the rigid barrier membrane to the titanium mesh fixation part of the personalized abutment, a three-level rigid support chain of "implant, abutment, titanium mesh" is formed, which eliminates the need for titanium screws to fix to the bone surface, facilitates clinical operation, and reduces flap area; (2) Achieve simultaneous shaping and closure of soft tissue. The transgingival shaping part of the personalized abutment is customized based on preoperative digital scanning. After implantation, it can precisely support and close the soft tissue, guide the gingival cuff to heal according to the preset contour, completely eliminate the need for conventional second-stage surgery, shorten the treatment cycle, and improve the aesthetic effect; (3) Achieve complete autologous bone regeneration. Autologous bone fragments are obtained from the bundle of bone in the extraction socket using a thickness-limited bone fragment collector and mixed with autologous plasma matrix to form plasma matrix bone blocks without the addition of any exogenous bone materials, thus avoiding the immunogenicity and disease transmission risks of allogeneic / xenogeneic materials; (4) Improve the mechanical strength and degradation resistance of plasma matrix bone blocks. Using acid-etched medical metal molding dies promotes dense cross-linking of fibrin, and combined with surface heat treatment to form a dense layer, significantly enhancing the degradation resistance and cell barrier function of the bone blocks; (5) Provide a systematic complete solution. Integrate patient-specific components with general components into an all-in-one kit, covering the entire process from bone scraping and bone block shaping to abutment and titanium mesh fixation, to achieve standardized operation and improve surgical efficiency. Attached Figure Description
[0021] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments consistent with the invention and, together with the description, serve to explain the principles of the invention.
[0022] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, for those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0023] Figure 1 This is a schematic diagram of the structure of the personalized base provided in an embodiment of the present invention.
[0024] Figure 2 This is a schematic diagram of a rigid barrier membrane structure provided in an embodiment of the present invention.
[0025] Figure 3 This is a schematic diagram of the bone fragment collector provided in an embodiment of the present invention. Detailed Implementation
[0026] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. It should be noted that the following embodiments are only for explaining the invention and do not constitute any limitation on the invention.
[0027] Example 1: Preparation of a bone regeneration kit for immediate implantation This embodiment provides a bone regeneration kit for immediate implantation.
[0028] 1. Preparation of patient-personalized components (1) Fabrication of personalized substrates (structure as follows) Figure 1 (As shown): Preoperatively, CBCT and intraoral scan data of the patient's oral cavity were collected and imported into 3D design software to reconstruct the 3D morphology of the extraction socket and the labial bone defect area. The transgingival shaping section was designed based on the transgingival contour of the natural tooth neck. The titanium mesh fixation section and implant connection section were designed based on the bone defect area and implant placement location. The titanium mesh fixation section is located between the implant connection section and the transgingival shaping section, and its hexagonal shape serves as the fixation structure. The design data was transmitted to a CNC machining center and machined using titanium alloy material to obtain a segmented, personalized abutment. A central channel runs through the center of the abutment. (2) Preparation of rigid barrier membranes (structure as follows) Figure 2 As shown): Based on the labial contour of the patient's bone defect area, a three-dimensional arched titanium mesh model matching the morphology of the defect area was generated using 3D design software. The titanium mesh has multiple through holes (center diameter 0.3-0.6 mm, perimeter diameter 2-3 mm, porosity 30%), with hexagonal mounting holes in the central area matching the fixing structure. Selective laser melting 3D printing technology was used, with pure titanium powder as the raw material, to print the model to a thickness of 0.2 mm, with passivated edges.
[0029] 2. Preparation of general-purpose components (1) Plasma matrix preparation components: including tubes for solid plasma matrix preparation and tubes for liquid plasma matrix preparation. The tubes for solid plasma matrix preparation are made of glass, and the inner surface is treated with vacuum plasma (argon first, then oxygen, flow rate 1 L / min, power 300 W, each treatment for 60 s) to form a hydrophilic surface; the tubes for liquid plasma matrix preparation are made of plastic. The plasma matrix molding mold is made of medical titanium alloy, and the inner surface is treated with acid etching (10% nitric acid combined with 1% hydrofluoric acid, 50℃ treatment for 60 min) to form micropits, with a roughness Rsm of 0.15 μm; (2) Bone scraper collector (structure as follows) Figure 3 As shown): It is made of medical-grade stainless steel in one piece, with a curved scraper at the front end. The scraper has a turning and limiting scraping structure, and the scraping depth is limited to 0.8 mm.
[0030] Example 2: Method for preparing completely autologous plasma matrix bone blocks using a kit This embodiment provides a method for preparing plasma matrix bone blocks using the kit of Example 1. (1) Collection of autologous blood: 20 mL of blood was collected from the patient’s elbow crease using both solid plasma matrix preparation tubes and liquid plasma matrix preparation tubes, for a total of 40 mL; (2) Centrifugation: Immediately place the preparation tube into the plasma matrix preparation platform and centrifuge at 700 g for 8 minutes. A solid plasma matrix gel forms in the upper layer of the tube used for solid plasma matrix preparation, and a liquid plasma matrix forms in the upper layer of the tube used for liquid plasma matrix preparation. (3) Collection of autologous bone fragments: After tooth extraction, use a bone fragment collector to gently scrape autologous bone fragments from the area with a thickness of less than 1 mm on the coronal side of the extraction socket and from the bundle of bone on the inner wall of the alveolar socket, and collect them for later use. The scraping depth is automatically controlled within 0.8 mm by the turning scraping structure to avoid damage to the root support bone plate; (4) Mixing and molding: Take the obtained autologous bone fragments, add the chopped solid plasma matrix and liquid plasma matrix, mix and compact them thoroughly in the plasma matrix molding mold, let stand for 5-10 minutes to solidify, and form a plasma matrix bone block that matches the defect shape; (5) Surface heat treatment: The side of the formed plasma matrix bone block facing the soft tissue is heated at 80°C for 5 minutes to form a dense layer.
[0031] Example 3: Assembly and implantation method of integrated immediate implantation system This embodiment provides a method for constructing an integrated immediate implantation system using the above-described kit and implant, and for performing immediate implantation surgery. (1) Minimally invasive tooth extraction and implant placement: After routine disinfection and anesthesia, the affected tooth was extracted minimally invasively, and the granulation tissue in the alveolar socket was thoroughly scraped off and rinsed with saline. According to the preoperative design, the extraction socket was prepared step by step on the palatal side, and the implant was placed. The implantation torque was controlled at 25-35 Ncm to ensure initial stability; (2) Personalized abutment fixation: Align the implant connection part of the personalized abutment prepared in Example 1 with the internal hexagonal interface of the implant and install it in place; (3) Rigid barrier membrane fixation: Align the hexagonal mounting holes of the rigid barrier membrane prepared in Example 1 with the fixation structure (titanium mesh fixation part) of the abutment. After positioning, pass the fixing screws through the transgingival shaping part, the titanium mesh fixation part and the implant connection part to lock the abutment onto the implant. The torque is controlled at 20 Ncm. At this time, a bone increment space is formed between the titanium mesh and the extraction socket wall, and the transgingival shaping part of the abutment is exposed above the gingival soft tissue. (4) Filling the plasma matrix bone block: Fill the bone increment space with the plasma matrix bone block prepared in Example 2, ensuring that the bone block is in close contact with the inner wall of the titanium mesh, the implant neck and the alveolar bone wall; (5) Soft tissue sealing and healing: The gingival soft tissue around the perforated area was sutured without tension to ensure it closely adhered to the outer contour of the perforated area. Since the perforated area was digitally customized based on the morphology of the patient's natural tooth neck, the sutured gingival cuff already had an ideal perforated shape. Six months postoperatively, the patient's local healing was good, and new bone formation occurred within the bone augmentation space; (6) Removal of titanium mesh and final restoration: After local anesthesia, the fixing screws are loosened through the central channel, and the titanium mesh is removed together with the fixing screws. Since the transgingival shaping part of the abutment has formed a mature gingival cuff, a digital impression can be taken directly, and the final restoration can be installed to complete the implant restoration.
[0032] Five patients with labial coronal bone plate thickness < 1 mm and total bone width < 7 mm in the anterior aesthetic zone underwent immediate implant treatment using the method described in Example 3. Six months post-operation, CBCT measurements showed an average increase in labial bone width of 2.1 ± 0.6 mm, with a bone volume preservation rate of 78.6 ± 4.1%. The width of the peri-implant keratinized gingiva remained above 3.0 mm, and the gingival papillae were well-filled. The average red aesthetic score was 13.2 ± 1.1 (out of 14). All patients experienced good soft tissue healing without complications such as infection or titanium mesh exposure. Post-operative visual analog scale (VAS) scores showed significantly better pain perception and treatment satisfaction compared to traditional guided bone regeneration surgery.
[0033] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.
[0034] The above description is merely a specific embodiment of the present invention, enabling those skilled in the art to understand or implement the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the present invention is not to be limited to the embodiments described herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims
1. A bone regeneration kit for immediate implantation, characterized in that, include: Patient personalization components, the patient personalization components including: A personalized abutment, which has a segmented structure, consisting of a transgingival shaping section, a titanium mesh fixation section, and an implant connection section from top to bottom; the implant connection section is used to connect to the implant, and the titanium mesh fixation section is located between the implant connection section and the transgingival shaping section, and the titanium mesh fixation section is equipped with at least one fixation structure. A rigid barrier membrane, wherein the rigid barrier membrane has a porous structure and its shape and size are adapted to the labial contour of the patient's extraction socket and bone defect area, and the rigid barrier membrane is provided with at least one mounting hole that matches the fixing structure. A general component, comprising: A plasma matrix preparation assembly, comprising at least a blood collection container and a plasma matrix molding mold; Bone scraper, used to scrape off autologous bone fragments.
2. The bone regeneration kit for immediate implantation according to claim 1, characterized in that, The personalized abutment is fixedly connected to the implant via a fixing screw passing through the central channel of the transgingival shaping part, the titanium mesh fixation part, and the implant connection part; when the mounting hole of the rigid barrier membrane is connected to the fixation structure on the titanium mesh fixation part, the rigid barrier membrane forms a spatial match with the labial contour of the patient's extraction socket and bone defect area, and can be non-destructively removed from the personalized abutment by releasing the fixation structure after the healing period; the transgingival shaping part has a three-dimensional shape that matches the transgingival morphology of the patient's natural tooth neck, and the three-dimensional shape is based on preoperative digital scanning data.
3. The bone regeneration kit for immediate implantation according to claim 1, characterized in that, The bone scraper has a thickness-limiting scraping structure, and its scraping depth is limited to 0.5-1.2 mm; the bone scraper is used to scrape autologous bone scrapers from the area of the labial bone plate of the extraction socket with a coronal thickness of less than 1 mm and / or the bundle-like bone area of the inner wall of the alveolar socket.
4. The bone regeneration kit for immediate implantation according to claim 1, characterized in that, The plasma matrix preparation assembly includes a liquid plasma matrix preparation tube and a solid plasma matrix preparation tube; the solid plasma matrix preparation tube has a hydrophilic inner surface, and the liquid plasma matrix preparation tube has a hydrophobic inner surface.
5. The bone regeneration kit for immediate implantation according to claim 1, characterized in that, The plasma matrix molding mold is used for the preparation of plasma matrix bone blocks and is made of medical metal material, which is selected from titanium, titanium alloy or stainless steel; the inner surface roughness Rsm of the plasma matrix molding mold is 0.1-0.2 μm, and the inner surface is acid etched to form micropits.
6. A bone regeneration implantation system for immediate implantation, characterized in that, include: Bone regeneration kit for immediate implantation according to any one of claims 1-5; An implant, which is pre-inserted into the patient's extraction socket, wherein the implant connector of the personalized abutment is detachably and fixedly connected to the implant; Plasma matrix bone block, wherein the plasma matrix bone block is prepared by mixing autologous bone fragments collected by the bone fragment collector with plasma matrix material prepared by the plasma matrix preparation component, and fills the bone increment space formed between the rigid barrier membrane and the tooth socket wall; The autologous bone fragments are derived from autologous bone with a thickness of less than 1 mm on the coronal side of the extraction socket and / or bundles of bone from the inner wall of the alveolar socket; the plasma matrix bone block does not contain any bone repair materials other than autologous tissue.
7. The bone regeneration implant system for immediate implantation according to claim 6, characterized in that, The plasma matrix bone block has a dense layer formed by surface heat treatment, which is located on the side of the plasma matrix bone block facing the soft tissue, and is used to enhance the resistance to degradation and cell barrier function.
8. The bone regeneration implant system for immediate implantation according to claim 6, characterized in that, The surfaces of the rigid barrier membrane and the personalized substrate are coated with a bioactive coating.
9. A method for preparing plasma-derived bone blocks using the bone regeneration kit for immediate implantation as described in any one of claims 1-5, characterized in that, Includes the following steps: The bone scraper scrapes autologous bone fragments from the area with a coronal thickness of less than 1 mm on the labial side of the extraction socket and / or from the inner wall of the alveolar socket. The autologous bone fragments are mixed with the plasma matrix material prepared by the plasma matrix preparation component, and then shaped in the plasma matrix molding mold to form a completely autologous plasma matrix bone block, wherein the plasma matrix bone block does not contain any bone repair materials other than autologous tissue.
10. A method of assembling an implantation system using the bone regeneration kit for immediate implantation as described in any one of claims 1-5, characterized in that, Includes the following steps: The bone scraper scrapes autologous bone fragments from the area with a coronal thickness of less than 1 mm on the labial side of the extraction socket and / or from the inner wall of the alveolar socket. The autologous bone fragments are mixed with the plasma matrix material prepared by the plasma matrix preparation component, and then shaped in the plasma matrix molding mold to form a completely autologous plasma matrix bone block. The personalized abutment is fixed to the pre-implanted implant; The rigid barrier membrane is fixed to the titanium mesh fixing part of the base through the fixing structure to form a stable local regeneration space; The plasma matrix bone block is filled into the bone increment space between the rigid barrier membrane and the tooth extraction socket wall.