Preparation method and application of microneedle patch for repairing radioactive skin injury

By combining microneedle patches made of gelatin and mangiferin that form a gel through heating and cooling, along with keratin nanoparticles, the problem of poor drug penetration is solved, enabling precise treatment of radiation-induced skin damage and significantly improving the efficiency of damage repair.

CN122440540APending Publication Date: 2026-07-24ARMY MEDICAL UNIV
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Patent Information

Application Number
CN202610469422.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-10
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing methods for treating radiation-induced skin damage suffer from poor drug penetration, insufficient targeting, and unsatisfactory treatment effects, leading to exacerbated skin damage and a lack of effective treatment options.

Method used

A microneedle patch that uses gelatin and mangiferin to form a gel by heating and cooling is combined with human hair keratin nanoparticles. The microneedles penetrate the stratum corneum of the skin, first releasing mangiferin to scavenge reactive oxygen species, and then releasing keratin nanoparticles to promote cell proliferation and tissue repair.

Benefits of technology

It achieves precise drug delivery and programmed release, significantly improving the repair efficiency of radiation-induced skin damage, clearing reactive oxygen species, inhibiting inflammation, resisting cell apoptosis, and promoting epidermal regeneration, thereby enhancing the healing effect of skin damage.

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Abstract

The invention discloses a preparation method and application of a microneedle for repairing radioactive skin injury, the microneedle is prepared by adopting a physical cross-linking mode, residues of an organic solvent and a micromolecular cross-linking agent are avoided, and the microneedle has good biocompatibility and degradability. The microneedle can penetrate through the cuticle of the skin to accurately deliver the medicine to the epidermal layer, the medicine is rapidly gelatinized in the skin, and programmed release of the medicine is achieved: mangiferin is firstly released, active oxygen generated by radiation outbreak is removed, and oxidative DNA damage is prevented; keratin nanoparticles are continuously released, inflammatory reaction is inhibited by regulating and controlling an NF-kappa B signal channel, meanwhile, the anti-apoptosis effect is achieved, expression of cell keratin is up-regulated, and barrier reconstruction and hair follicle regeneration are promoted. The micro-needle system realizes staged synergistic treatment of early-stage anti-oxidation prevention and later-stage anti-inflammatory, anti-apoptosis and regeneration promotion, has the effects of removing active oxygen, inhibiting inflammation, resisting apoptosis and promoting epidermal regeneration, and can remarkably improve the repair efficiency of radioactive skin injury.
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