Targeted drug-loaded liposome combined functionalized hydrogel as well as preparation method and application thereof

By combining targeted drug-loaded liposomes with functionalized gelatin hydrogels, active targeted drug delivery and long-lasting sustained release for rheumatoid arthritis have been achieved, solving the problems of poor targeting and large side effects in existing treatments and providing a more effective RA treatment option.

CN122440547APending Publication Date: 2026-07-24CHONGQING HAOYUAN BIOPHARMACEUTICAL CO LTD
0 Cites 0 Cited by

Patent Information

Application Number
CN202610709975.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-22
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Current treatments for rheumatoid arthritis with methotrexate monotherapy suffer from poor targeting, significant systemic side effects, and insufficient regulation of the joint immune microenvironment. Furthermore, conventional drug-loaded nanoparticles are difficult to achieve long-term sustained release of drugs locally in the joint.

Method used

A combined system of targeted drug-loaded liposomes and functionalized gelatin hydrogels was adopted. Through the synergistic effect of RGD peptide-modified drug-loaded liposomes and methacrylic anhydride and gallic acid-grafted gelatin hydrogels, active targeted drug delivery and long-term sustained release were achieved, forming a local drug reservoir and combining with immune-modulating functions.

Benefits of technology

It significantly improves treatment efficacy, reduces side effects, achieves precise enrichment and long-term release of drugs at the lesion site, reverses the imbalance of the immune microenvironment, and provides a more targeted and durable RA treatment approach.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention provides a targeted drug-loaded liposome combined functionalized hydrogel and a preparation method and application thereof, the targeted drug-loaded liposome combined functionalized hydrogel comprises an active targeted liposome and a functionalized gelatin hydrogel, and the active targeted liposome is dispersed in the functionalized gelatin hydrogel, and performing ultraviolet cross-linking curing under a photoinitiator to obtain the targeted drug-loaded liposome combined functional hydrogel. The functionalized gelatin hydrogel comprises methacrylic anhydride grafted gelatin hydrogel and gallic acid grafted gelatin hydrogel, and the active targeting liposome is an RGD peptide modified drug-loaded liposome. The defects that in existing rheumatoid arthritis treatment, methotrexate single-drug therapy is poor in targeting, large in systemic toxic and side effects and insufficient in joint immune microenvironment regulation and control are overcome.
Need to check novelty before this filing date? Find Prior Art