Functional coating with anticoagulant and antioxidant functions and preparation method thereof

By introducing an aminated layer and grafting TEMPO free radical scavenger onto the surface of biomaterials, a covalently grafted coating with both anticoagulant and antioxidant functions was constructed, solving the problems of thrombosis and oxidative stress on the surface of biomaterials and achieving a highly efficient and stable bidirectional regulatory effect.

CN122440907APending Publication Date: 2026-07-24CHENGDU MEDICAL COLLEGE
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Patent Information

Application Number
CN202610574529.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-28
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing biomaterial surface modification technologies cannot effectively address both thrombosis and oxidative stress simultaneously, and single-function modification strategies cannot meet clinical needs.

Method used

By introducing an aminated layer on the substrate surface and grafting a highly reactive epoxy group onto the efficient free radical scavenger TEMPO, a covalently grafted coating with anticoagulant and antioxidant functions is constructed, achieving bidirectional regulation of the coating.

Benefits of technology

It achieves a synergistic enhancement of anticoagulant and antioxidant properties, with high coating stability, wide applicability, and good biocompatibility. It can effectively inhibit platelet adhesion and scavenge reactive oxygen species in the long term, reducing oxidative damage.

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Abstract

The invention discloses a preparation method of a coating with anticoagulation and antioxidation functions. The preparation method comprises the following steps: step 1, carrying out amination treatment on the surface of a substrate; step 2, carrying out double-bond modification on the aminated surface; step 3, constructing an anticoagulant functional layer through in-situ copolymerization; and step 4, grafting an antioxidant by utilizing an epoxy group ring-opening reaction. The invention also discloses a functional coating with both anticoagulation and antioxidation functions. Through reasonable chemical structural design, excellent anticoagulation performance and oxidation resistance are achieved in the same coating system, and the limitation of an existing coating with a single function is effectively overcome. Meanwhile, the coating is firmly combined with the substrate through multi-layer chemical covalent bonds, has higher bonding strength and stability, is not easy to fall off, and can meet the requirements of long-term implantation or long-term use.
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