Nervonic acid derivative as well as preparation method and application thereof
By chemically modifying nervonic acid, a white solid nervonic acid derivative was prepared, which solved the problems of low extraction rate, high cost and complicated preparation. It achieved efficient penetration of the blood-brain barrier, exerted a dual mechanism to treat Alzheimer's disease and significantly improved cognitive function.
Patent Information
- Application Number
- CN202610644178.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-05-11
- Publication Date
- 2026-07-24
AI Technical Summary
The current nervonic acid has a low extraction rate, high cost, poor stability, and complex preparation process and low purity of derivatives, resulting in limited efficacy and significant side effects in the treatment of Alzheimer's disease, as well as low blood-brain barrier penetration.
A nervonic acid derivative was prepared by modifying its chemical structure using specific methods, including activating the carboxyl group with 1-hydroxybenzotriazole (HOBT) and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI), adding 4-(2-aminoethyl)phenyl-1,2-diol hydrochloride and N,N-diisopropylethylamine, and quenching the reaction with distilled water, extraction and purification by column chromatography to obtain a white solid product.
It significantly improves the stability and targeting of nervonic acid, enabling it to penetrate the blood-brain barrier and accumulate in the hippocampus. By inhibiting neuroinflammation and hippocampal neuronal ferroptosis, it significantly improves cognitive impairment caused by Alzheimer's disease, providing a novel treatment option.