Hemicellulose-based antibacterial agent as well as preparation method and application thereof

By modifying hemicellulose through acetylation, Hantz reaction, and enamineation, a hemicellulose-based antibacterial agent was prepared, which solved the problems of poor biocompatibility and weak antibacterial performance of existing antibacterial agents and achieved a safe and efficient antibacterial effect.

CN122444894APending Publication Date: 2026-07-24SOUTH CHINA UNIV OF TECH
0 Cites 0 Cited by

Patent Information

Application Number
CN202610489374.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-14
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing antibacterial agents have poor biocompatibility, poor biodegradability, and high toxicity. Furthermore, native hemicellulose has weak antibacterial properties, making it difficult to apply in fields requiring high antibacterial performance.

Method used

By acetylation, Hantz reaction and enamine modification of hemicellulose, a hemicellulose-based antibacterial agent with easily controllable degree of substitution, suitable hydrophilicity and hydrophobicity and safety was prepared. Acetyl groups and long-chain alkyl aldehydes were introduced, and aminoglycoside antibiotics were covalently bound to the hemicellulose backbone.

Benefits of technology

It enhances the antibacterial properties of hemicellulose, giving it a synergistic antibacterial effect in complex biological environments, while maintaining the biological activity of antibiotics, thus achieving a safe and efficient antibacterial effect.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention belongs to the field of biological medicines and fine chemicals, and particularly relates to a hemicellulose-based antibacterial agent as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out acetylation modification reaction on hemicellulose to obtain acetylated hemicellulose; dissolving the obtained acetylated hemicellulose in a solvent, adding aldehydes and a nitrogen source, and carrying out a Hanzz reaction to obtain multi-component modified hemicellulose; the multi-component modified hemicellulose is dissolved in a modified solvent system, aminoglycoside antibiotics are added for enamination modification, and the enamination modified hemicellulose is obtained. Acetylated hemicellulose is subjected to multi-component reaction modification by using an aldehyde component and a nitrogen source, so that modified hemicellulose of which the substitution degree is easy to regulate and control and the antibacterial property is proper is obtained. The multi-component reaction modified enaminated hemicellulose prepared by the preparation method disclosed by the invention is used as an antibacterial agent, has good antibacterial property, proper hydrophilic and hydrophobic properties and safety, and also has the advantages of simple preparation and low cost.
Need to check novelty before this filing date? Find Prior Art