A method for detecting the content of acetaminophen vitamin C effervescent tablets

The high-performance liquid chromatography (HPLC) method for detecting acetaminophen and vitamin C effervescent tablets solves the problem of difficulty in determining the endpoint of existing detection methods, and achieves rapid, sensitive and accurate content detection.

CN122754367APending Publication Date: 2026-09-15CHONGQING CONQUER PHARML
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Patent Information

Application Number
CN202611048491.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-07-15
Publication Date
2026-09-15

AI Technical Summary

Technical Problem

Existing detection methods for acetaminophen and vitamin C effervescent tablets have difficulty in determining the endpoint, and suffer from low sensitivity and accuracy.

Method used

High-performance liquid chromatography (HPLC) was used, with specific mobile phase and chromatographic conditions, in conjunction with a reference solution, to analyze the contents of acetaminophen and vitamin C.

Benefits of technology

It enables rapid, sensitive, and accurate detection of acetaminophen and vitamin C effervescent tablet content, and features simplicity, precision, good reproducibility, ease of operation, high sensitivity, and strong specificity.

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Abstract

The present application belongs to the technical field of content detection of paracetamol vitamin C effervescent tablets, and particularly relates to a method for detecting the content of paracetamol vitamin C effervescent tablets, which comprises the following steps: preparing a mobile phase by using a phosphate buffer-tetrabutylammonium bromide-methanol mixed solution as the mobile phase; preparing a control solution by using paracetamol and vitamin C and a solvent; preparing a sample solution by using a product to be detected and a solvent; and injecting the control solution and the sample solution into a liquid chromatograph for analysis. The method can quickly, sensitively and accurately detect the content of paracetamol vitamin C effervescent tablets, and has the advantages of simple operation, high sensitivity, strong specificity, and the ability to simultaneously detect the content of paracetamol and vitamin C.
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