Chitin derivative and its preparation and its uses in preparation of medicines
By chemically modifying chitosan to form N-long-chain alkyl-O-sulfonate chitosan, the problems of limited selection of amphiphilic components and poor safety of chemical coupling methods in the existing technology are solved, and the problem is achieved The preparation of nanoscale micelles with low toxicity and no hemolytic reaction can be used to solubilize and encapsulate poorly soluble drugs, thereby improving the therapeutic effect.
Patent Information
- Application Number
- CN03112981.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2003-03-14
- Publication Date
- 2003-09-03
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
In the existing research on biodegradable polymer micelles, the selection of amphiphilic components is limited, resulting in the hydrophobic components being limited to certain synthetic polymer materials, and the chemical coupling method has challenges in preparation and safety, making it difficult to form suitable Nanoscale micelles as drug nanocarriers.
By modifying the chemical structure of chitosan, N-long-chain alkyl-O-sulfonate chitosan is formed to form an amphiphilic polymer molecule, which is used to prepare nano-scale micelles and is suitable for use in poorly soluble Solubilization and encapsulation of drugs and their biodegradation in the body.
Nano-sized micelles with low toxicity and no hemolytic reaction have been realized, which can prolong the circulation in the body, reduce phagocytosis of reticuloendothelial cells, improve the therapeutic effect, and provide a preparation method for industrial application.