Micro-infusion patch

Abstract

The utility model discloses a trace infusion patch which comprises an injection assembly, a medicine storage assembly, a piston button, a liquid inlet one-way valve and a liquid outlet one-way valve, a plurality of sets of variable pressure cavities and medicine storage channels are arranged in the medicine storage assembly, and each medicine storage channel is connected into a liquid inlet of the corresponding variable pressure cavity. The injection assembly is communicated with liquid outlets of the variable-pressure cavities, the volume of each variable-pressure cavity is controlled by pressing of the piston button, the variable-pressure cavities can be matched with the liquid inlet one-way valve and the liquid outlet one-way valve to jointly pump liquid medicine into the injection assembly from the corresponding medicine storage channels, the whole structure is simple, no electronic component exists, the size is small, and carrying is easy. Time-sharing infusion or simultaneous infusion of various medicines can be achieved, and the infusion requirements of patients for different medicines are met.

Description

[Technical field]

[0001] The utility model relates to the technical field of infusion devices, in particular to the technical field of micro-infusion patches. [Background technology]

[0002] At present, one of the effective treatment measures for diabetes is to inject insulin (a hypoglycemic hormone). As an intelligent infusion device, the infusion pump can use mechanical driving force to accurately control the number of infusion drops or the infusion flow rate, ensuring that the dosage enters the patient's body accurately and safely, thereby greatly improving the accuracy and safety of the infusion. It is recognized as the preferred medical device for insulin injection. Traditional infusion pumps usually infuse insulin through an infusion needle inserted subcutaneously, such as a new type of infusion line for an insulin pump and a micro-infusion pump disclosed in the invention patent with publication number CN109481781A. However, this type of output pump has a problem that the pain of the infusion needle is strong when the infusion needle is inserted, and on the other hand, there is also a problem that the infusion needle is prone to discomfort during the later retention period.

[0003] Since the infusion pump is used by the patient to actively input the injection parameters based on experience, and the human body has different responses to insulin based on factors such as menstruation, diet, and activity level, the patient may experience excessive insulin infusion after completing the injection, which in turn causes hypoglycemia, and in severe cases causes dizziness, coma, and even sudden death. The most common method for treating hypoglycemia is for the patient to replenish sugar or inject glucagon (a blood sugar-raising hormone) in time when the blood sugar is perceived to be low. However, the existing infusion pumps usually adopt a single-channel design, which can only realize the infusion of one liquid medicine, resulting in the patient needing to be equipped with an additional infusion pump for the infusion of glucagon, and there is a problem that the entire blood sugar regulation method is more troublesome. In addition, in addition to diabetes, there are many diseases that require patients to infuse two or more drugs simultaneously or in different time periods for control and regulation.

[0004] In order to meet the needs of patients who want to be able to infuse two kinds of liquid medicine at the same time during treatment, some manufacturers choose to design the infusion pump as a dual-channel structure, such as a dual-channel injection pump disclosed in the utility model patent with announcement number CN215023925U. However, this type of dual-channel infusion pump usually requires two motors to control the infusion of liquid medicine in the two channels respectively, resulting in a large volume of the whole machine and inconvenient portability. In addition, some manufacturers have adopted a multi-channel design with more than two channels, such as a new type of multi-channel combined micro-injection pump disclosed in the utility model patent with announcement number CN209004910U. However, each channel still needs to be equipped with a dedicated motor one by one, and there are the same technical problems as the dual-channel infusion pump. [Contents of the utility model]

[0005] The purpose of the utility model is to solve the problems in the prior art and to propose a micro-infusion patch with a simple overall structure, without any electronic components, small size, easy to carry, and capable of time-sharing infusion or simultaneous infusion of multiple drugs to meet the patient's infusion needs for different drugs.

[0006] To achieve the above-mentioned purpose, the utility model proposes a micro-infusion patch, including an injection component, a drug storage component, a piston button, a liquid inlet check valve and a liquid outlet check valve, wherein the drug storage component is respectively provided with a plurality of groups of pressure-changing chambers and drug storage channels, each of the drug storage channels is respectively connected to the liquid inlet of the corresponding pressure-changing chamber, the injection component is respectively connected to the liquid outlet of each pressure-changing chamber, the volume of each pressure-changing chamber is respectively controlled by pressing the piston button and can cooperate with the liquid inlet check valve and the liquid outlet check valve to pump the drug liquid from the corresponding drug storage channel into the injection component.

[0007] Preferably, the medicine storage assembly comprises an upper cover, a lower cover, a sealing plate and a spacer, the upper cover and the lower cover are assembled and fixed and are provided with interlocking positioning holes, a plurality of the piston buttons and the liquid outlet one-way valves are respectively installed at the two ends of the positioning holes in a one-to-one correspondence, a plurality of the medicine storage channels respectively penetrate the hole wall of the positioning hole at one end at the joint surface of the upper cover and the lower cover and are installed with a liquid inlet one-way valve and are closed by a sealing plate at the other end, and the spacer separates the chamber enclosed by the various piston buttons, the liquid inlet one-way valve and the liquid outlet one-way valve in the positioning hole to form various variable pressure chambers.

[0008] Furthermore, each of the sealing sheets is a breathable film for waterproofing and dustproofing.

[0009] Furthermore, each of the drug storage channels is arranged in a spiral shape that winds in sequence, in a serpentine shape, or directly arranged in separate areas. When the separate areas are arranged in separate areas, each area can be divided equally or unequally.

[0010] Furthermore, the bottom surface of the upper cover and / or the top surface of the lower cover are respectively provided with a plurality of spiral grooves to form each drug storage channel, and the cross section of each drug storage channel is one or a combination of a circle, a rectangle, a trapezoid and a triangle. Taking the case where the cross section of each drug storage channel is a circle and is in a spiral shape that is wound in sequence as an example, each drug storage channel can be formed by combining spiral grooves with semicircular cross sections that are respectively arranged on the bottom surface of the upper cover and the top surface of the lower cover, or can be directly formed by spiral grooves with circular cross sections that are individually arranged on the bottom surface of the upper cover or the top surface of the lower cover.

[0011] Furthermore, the volume of each of the drug storage channels is 1-2 mL (100-200 U), the volume of each of the variable pressure chambers is 0.025-0.05 mL, the upper cover is a transparent cover, and each of the drug storage channels is provided with spiral scale lines divided by length. Among them, the volume of each of the drug storage channels is the cross-sectional area * spiral length, and each of the spiral scale lines is used to calculate and indicate the use and remaining capacity of the drug and can be divided into 20-40 scales according to the total length. With such a design, for insulin patients, they can generally meet the dosage requirements of three meals by pressing 2-4 times.

[0012] Preferably, the positioning hole is a stepped hole, each of the piston buttons comprises a button and a spring, each of the buttons comprises a press plate and a guide column, each of the guide columns is connected to the corresponding press plate at one end and extends into the small hole section of the positioning hole after passing through the corresponding spring at the other end, and each of the springs is against the corresponding press plate at one end and against the step portion of the positioning hole at the other end.

[0013] Furthermore, a plurality of cylindrical annular grooves are respectively arranged on the outer wall of each guide column, and a sealing ring is respectively installed in each cylindrical annular groove.

[0014] Furthermore, each sealing ring is a rubber ring or a silicone ring.

[0015] Furthermore, the free end of the large hole section of the positioning hole is provided with a cover annular groove, the outer edge of each of the push plates is provided with a groove, and a retaining ring is placed in the cover annular groove and each groove. The retaining ring is used to prevent each button from falling out of the medicine storage assembly.

[0016] Furthermore, an annular convex edge is provided on the step portion of the positioning hole and is arranged around each spring at the same time. The annular convex edge can cooperate with the spacer to isolate and guide each spring, thereby ensuring that each spring can be normally extended and retracted.

[0017] Preferably, the injection assembly includes a base plate and a needle plate, the base plate and the needle plate are assembled and fixed, the side of the base plate away from the needle plate is set close to the lower cover and is provided with a notch, a plurality of drug through holes are evenly arranged above the notch, and a hollow microneedle connected to each drug through hole is evenly arranged on the side of the needle plate away from the base plate, and a plurality of indwelling needles connected to the notch can also be directly provided on the side of the needle plate away from the base plate. Specifically, only one hollow microneedle can be provided, or a hollow microneedle array composed of multiple hollow microneedles can be provided; only one indwelling needle can be provided, or multiple indwelling needles can be provided.

[0018] Furthermore, a thickened portion is provided on one side of the upper cover away from the lower cover and around each piston button.

[0019] Furthermore, the length of each hollow microneedle is 50-1500 μm, and the diameter of the needle opening of each hollow microneedle is 1-20 μm. Each hollow microneedle can be inserted into an appropriate part of the human body and pass through the epidermis for drug infusion.

[0020] Beneficial effects of the utility model:

[0021] 1) By adding several groups of drug storage channels storing drug liquid and a variable pressure chamber controlled by a piston button, a liquid inlet check valve and a liquid outlet check valve in the drug storage component, on the one hand, the injection component can infuse the drug liquid subcutaneously at a very slow speed under normal conditions, and on the other hand, the drug liquid in the variable pressure chamber can be quickly pressed into the body when the piston button is pressed, so as to achieve rapid micro-infusion of the drug liquid. When the piston button is released, the variable pressure chamber can automatically replenish the drug liquid from the drug storage channel. The overall structure is simple, without any electronic components, small in size, easy to carry, and can achieve time-sharing infusion or simultaneous infusion of multiple drugs, meeting the infusion needs of patients for different drugs;

[0022] 2) By using a substrate with a notch and a drug through hole and a needle plate with hollow microneedles to form an injection assembly, a microneedle array can be used to painlessly form multiple infusion channels between the drug storage assembly and the human body, and then the notch is used to first receive the drug solution released by the drug storage assembly, and then the microneedle array is gradually used to complete the painless infusion of the drug solution, effectively improving the comfort of infusion;

[0023] 3) By providing a plurality of spiral grooves on the bottom surface of the upper cover and / or the top surface of the lower cover to form various drug storage channels, the space can be fully utilized and the volume of the micro-infusion patch can be further reduced;

[0024] 4) By combining a key, a spring, a sealing ring and a retaining ring to form a piston button, the elastic force of the spring can be used to automatically push the key back to its original position after the key is released. At the same time, the retaining ring is used to prevent the key from popping out excessively, and the sealing ring can ensure the stable sealing of the key during the lifting process.

[0025] The features and advantages of the present invention will be described in detail through embodiments in conjunction with the accompanying drawings.

Brief Description of the Drawings

[0026] Figure 1 is an exploded schematic diagram of the first embodiment;

[0027] Figure 2 is a top view of the first embodiment;

[0028] Figure 3 yes Figure 2 AA section view;

[0029] Figure 4 yes Figure 3 An enlarged schematic diagram of point B;

[0030] Figure 5 is a schematic diagram of the three-dimensional structure of the substrate of the first embodiment;

[0031] Figure 6 is a schematic diagram of the three-dimensional structure of the needle plate of the first embodiment;

[0032] Figure 7 is a schematic diagram of the three-dimensional structure of the key of the first embodiment;

[0033] Figure 8 is a top view of the lower cover of the first embodiment;

[0034] Fig. 9 is an exploded schematic diagram of the second embodiment;

[0035] Fig.10 is a top view of the second embodiment;

[0036] Fig.11 yes Fig.10 CC section view;

[0037] Fig.12 yes Fig.11 An enlarged schematic diagram of D;

[0038] Fig.13 is a top view of the lower cover of the second embodiment;

[0039] Fig.14 is an exploded schematic diagram of Embodiment 3;

[0040] Fig.15 is a top view of the third embodiment;

[0041] Fig.16 yes Fig.15 EE section view;

[0042] Fig.17 yes Fig.16 An enlarged schematic diagram of point F;

[0043] Fig.18 is a top view of the lower cover of the third embodiment;

[0044] Fig.19 is a top view of the fourth embodiment;

[0045] Fig. 20 yes Fig.19 GG section view.

[0046] In the figure: 1-injection component, 11-base plate, 111-recess, 112-drug through hole, 12-needle plate, 121-hollow microneedle, 122-indwelling needle, 2-drug storage component, 21-upper cover, 22-lower cover, 23-drug storage channel, 231-spiral scale line, 24-positioning hole, 25-sealing plate, 26-annular groove of cover body, 27-spacer, 28-annular convex edge, 3-piston button, 31-button, 311-press plate, 3111-cutting groove, 312-guide column, 3121-column annular groove, 32-spring, 33-sealing ring, 34-retaining ring, 4-liquid inlet one-way valve, 5-liquid outlet one-way valve. [Specific implementation method]

[0047] Embodiment 1:

[0048] See also Figures 1 to 8 The present embodiment comprises an injection assembly 1, a drug storage assembly 2, a piston button 3, a liquid inlet check valve 4 and a liquid outlet check valve 5. The drug storage assembly 2 is provided with two sets of variable pressure chambers (i.e. Figure 4 The two dotted line frame parts) and the drug storage channel 23, the two drug storage channels 23 are respectively connected to the liquid inlets of the corresponding pressure-changing chambers, the injection assembly 1 is respectively connected to the liquid outlets of the two pressure-changing chambers, the volumes of the two pressure-changing chambers are respectively controlled by pressing the piston button 3 and can cooperate with the liquid inlet check valve 4 and the liquid outlet check valve 5 to pump the drug liquid from the corresponding drug storage channel 23 into the injection assembly 1.

[0049] The medicine storage assembly 2 includes an upper cover 21, a lower cover 22, a sealing sheet 25 and a spacer 27. The upper cover 21 and the lower cover 22 are assembled and fixed and are provided with interlocking positioning holes 24. The two piston buttons 3 and the liquid outlet one-way valve 5 are respectively installed at the two ends of the positioning hole 24 in a one-to-one correspondence. The two medicine storage channels 23 respectively penetrate the hole wall of the positioning hole 24 at one end at the joint surface of the upper cover 21 and the lower cover 22 and are installed with a liquid inlet one-way valve 4, while the other end is closed by the sealing sheet 25 after spirally winding around the positioning hole 24. The spacer 27 separates the chamber enclosed by the two piston buttons 3, the liquid inlet one-way valve 4 and the liquid outlet one-way valve 5 in the positioning hole 24 to form two variable pressure chambers.

[0050] The bottom surface of the upper cover 21 and the top surface of the lower cover 22 are respectively provided with two spiral grooves to form two medicine storage channels 23 .

[0051] The cross sections of the two drug storage channels 23 are respectively circular.

[0052] The volumes of the two drug storage channels 23 are both 1 mL (100 U), the volumes of the two pressure-changing chambers are both 0.025 mL, the upper cover 21 is a transparent cover, and the two drug storage channels 23 are respectively provided with spiral scale lines 231 equally divided according to length.

[0053] The positioning hole 24 is a stepped hole, and the two piston buttons 3 respectively include a button 31 and a spring 32. The two buttons 31 respectively include a pressing plate 311 and a guide column 312. One end of the two guide columns 312 is connected to the corresponding pressing plate 311 and the other end extends into the small hole section of the positioning hole 24 after passing through the corresponding spring 32. The two springs 32 respectively have one end against the corresponding pressing plate 311 and the other end against the stepped portion of the positioning hole 24.

[0054] A circle of cylindrical annular grooves 3121 are respectively formed on the outer walls of the two guide pillars 312 , and sealing rings 33 are respectively installed in the two circles of cylindrical annular grooves 3121 .

[0055] A cover annular groove 26 is provided at the free end of the large hole section of the positioning hole 24 , and grooves 3111 are respectively provided at the outer edges of the two pressing plates 311 . A retaining ring 34 is placed in the cover annular groove 26 and the two grooves 3111 .

[0056] An annular flange 28 is also provided on the step portion of the positioning hole 24 and surrounds the two springs 32 .

[0057] The injection assembly 1 includes a base plate 11 and a needle plate 12, and the base plate 11 and the needle plate 12 are assembled and fixed together. The side of the base plate 11 away from the needle plate 12 is arranged close to the lower cover 22 and is provided with a recess 111, and a plurality of drug through holes 112 are evenly arranged on the recess 111, and hollow microneedles 121 respectively connected to each drug through hole 112 are evenly arranged on the side of the needle plate 12 away from the base plate 11.

[0058] The working process of this embodiment:

[0059] When in use, the needle plate 12 is directly pressed on the skin surface to make each hollow microneedle 121 penetrate into the subcutaneous tissue. At this time, under the influence of osmotic pressure, the drug can gradually enter the body at a very slow speed, so as to be infused as a basal rate of medicine such as insulin.

[0060] When the patient presses one of the buttons 31, the liquid medicine (assuming it is insulin) in the drug storage channel 23 corresponding to the button 31 will enter the body at a faster speed, thereby achieving the infusion of three meals of insulin. Specifically, when the patient presses one of the buttons 31, the liquid outlet check valve 5 corresponding to the button 31 automatically opens under the action of pressure, and the liquid inlet check valve 4 corresponding to the button 31 automatically closes under the action of pressure, so that the volume of the variable pressure chamber corresponding to the button 31 gradually decreases and the liquid medicine penetrates into the patient's subcutaneous tissue through the microneedle array of the injection assembly 1 (the maximum infusion amount of a single press is the volume of the variable pressure chamber); when the patient releases the button 31, the liquid outlet check valve 5 corresponding to the button 31 automatically closes under the action of pressure, and the liquid inlet check valve 4 corresponding to the button 31 automatically opens under the action of pressure, so that the volume of the variable pressure chamber corresponding to the button 31 gradually increases and the liquid medicine is inhaled from the corresponding drug storage channel 23. In addition, during the above operation, the patient can understand the actual drug solution infusion situation in real time through the spiral scale line 231.

[0061] In this embodiment, taking the use of diabetics as an example, the two drug storage channels 23 can store insulin and glucagon respectively. If the patient finds that the blood sugar is low, glucagon can be infused to increase the blood sugar; if the patient finds that the blood sugar is high, insulin can be infused to lower the blood sugar.

[0062] Embodiment 2:

[0063] See also Figures 9 to 13 (in, Fig.13 The spiral scale line 231 is omitted, and the number of the pressure-changing chamber, the drug storage channel 23, the piston button 3, the liquid inlet check valve 4 and the liquid outlet check valve 5 is one. The rest is the same as in the first embodiment.

[0064] Embodiment three:

[0065] See also Figures 14 to 18 (in, Fig.18 The spiral scale line 231 is omitted, and the number of the pressure-changing chamber, the drug storage channel 23, the piston button 3, the liquid inlet check valve 4 and the liquid outlet check valve 5 are all three. The rest is the same as in the first embodiment.

[0066] Embodiment 4:

[0067] See also Figure 19 to Figure 20 A plurality of indwelling needles 122 connected to the recesses 111 are directly disposed on the side of the needle plate 12 away from the base plate 11. Other features are the same as those of the second embodiment.

[0068] The above embodiments are intended to illustrate the present invention, not to limit the present invention. Any solution that is a simple transformation of the present invention falls within the protection scope of the present invention.

Claims

1. Micro-infusion patch, Features: The invention comprises an injection assembly (1), a drug storage assembly (2), a piston button (3), a liquid inlet check valve (4) and a liquid outlet check valve (5); the drug storage assembly (2) is provided with a plurality of groups of pressure-changing chambers and drug storage channels (23); each of the drug storage channels (23) is connected to the liquid inlet of the corresponding pressure-changing chamber; the injection assembly (1) is connected to the liquid outlet of each pressure-changing chamber; the volume of each pressure-changing chamber is controlled by pressing the piston button (3) and can cooperate with the liquid inlet check valve (4) and the liquid outlet check valve (5) to pump the drug liquid from the corresponding drug storage channel (23) into the injection assembly (1).

2. The micro-infusion patch according to claim 1, Features: The medicine storage assembly (2) comprises an upper cover (21), a lower cover (22), a sealing sheet (25) and a spacer (27); the upper cover (21) and the lower cover (22) are joined and fixed together and are provided with interlinked positioning holes (24); a plurality of the piston buttons (3) and the liquid outlet one-way valves (5) are respectively installed at two ends of the positioning holes (24) in a one-to-one correspondence; a plurality of the medicine storage channels (23) respectively penetrate the hole wall of the positioning hole (24) at one end at the joining surface of the upper cover (21) and the lower cover (22) and are installed with the liquid inlet one-way valve (4) and are closed by the sealing sheet (25) at the other end; the spacer (27) separates the chambers enclosed by the piston buttons (3), the liquid inlet one-way valves (4) and the liquid outlet one-way valves (5) in the positioning hole (24) to form various variable pressure chambers.

3. The micro-infusion patch as claimed in claim 2, Features: Each of the drug storage channels (23) is arranged in a spiral shape that winds in sequence, in a serpentine shape, or is directly and independently arranged in partitions.

4. The micro-infusion patch as claimed in claim 3, It is characterized in that The bottom surface of the upper cover (21) and / or the top surface of the lower cover (22) are respectively provided with a plurality of line grooves to form medicine storage channels (23), and the cross-section of each medicine storage channel (23) is one or a combination of circular, rectangular, trapezoidal and triangular.

5. The micro-infusion patch as claimed in claim 4, Features: The volume of each drug storage channel (23) is 1-2 mL, the volume of each pressure-changing chamber is 0.025-0.05 mL, the upper cover (21) is a transparent cover, and each drug storage channel (23) is provided with a spiral scale line (231) divided equally according to the length.

6. The microinfusion patch according to any one of claims 2 to 5, Features: The positioning hole (24) is a stepped hole. Each of the piston buttons (3) comprises a button (31) and a spring (32). Each of the buttons (31) comprises a pressing plate (311) and a guide column (312). One end of each of the guide columns (312) is connected to the corresponding pressing plate (311), and the other end thereof extends into the small hole section of the positioning hole (24) after passing through the corresponding spring (32). One end of each of the springs (32) abuts against the corresponding pressing plate (311), and the other end abuts against the stepped portion of the positioning hole (24).

7. The micro-infusion patch according to claim 6, Features: A plurality of cylindrical annular grooves (3121) are respectively arranged on the outer wall of each guide column (312), and a sealing ring (33) is respectively installed in each cylindrical annular groove (3121).

8. The micro-infusion patch according to claim 6, Features: A cover body annular groove (26) is provided at the free end of the large hole section of the positioning hole (24), and a cutting groove (3111) is provided at the outer edge of each of the pressing plates (311). A retaining ring (34) is placed in the cover body annular groove (26) and each of the cutting grooves (3111).

9. The micro-infusion patch according to claim 6, Features: An annular convex edge (28) is also provided on the step portion of the positioning hole (24) and is arranged around each spring (32).

10. The microinfusion patch according to any one of claims 2 to 5, Features: The injection assembly (1) comprises a base plate (11) and a needle plate (12), wherein the base plate (11) and the needle plate (12) are assembled and fixed together, and the side of the base plate (11) away from the needle plate (12) is arranged close to the lower cover (22) and is provided with a recess (111), and a plurality of drug passing holes (112) are evenly arranged above the recess (111), and a hollow microneedle (121) respectively connected to each drug passing hole (112) is evenly arranged on the side of the needle plate (12) away from the base plate (11), and a plurality of indwelling needles (122) connected to the recess (111) can also be directly arranged on the side of the needle plate (12) away from the base plate (11).

Images