Synthesis reactor for levamlodipine besylate

Abstract

The utility model discloses a synthesis reactor for levamlodipine besylate, which relates to the technical field of medical equipment, and comprises a tank body, a mounting shaft is rotatably connected in the tank body, a plurality of groups of stirring arms are fixedly connected on the outer side of the mounting shaft, and a first mounting ring and a second mounting ring are fixedly connected in the tank body. The first mounting ring is arranged above the second mounting ring, a scraping rod is arranged in the tank body, the upper end and the lower end of the scraping rod are slidably connected to the interiors of the first mounting ring and the second mounting ring correspondingly, the side face of the scraping rod is attached to the inner wall of the tank body, and a driving assembly is arranged at the top of the scraping rod; the driving assembly drives the scraping rod to do circular motion between the first installation ring and the second installation ring, in the moving process of the scraping rod, the outer side face of the scraping rod acts on the inner wall of the tank body, residues on the inner wall of the tank body are scraped away, and equipment cleaning is more convenient.

Description

Technical Field

[0001] The utility model relates to the technical field of medical equipment, in particular to a synthesis reactor for levamlodipine besylate. Background Art

[0002] Levoamlodipine besylate, as a third-generation dihydropyridone calcium ion antagonist, is mainly used for the treatment of hypertension and angina pectoris. It is currently the first choice drug for the treatment of hypertension. Levoamlodipine besylate is mainly achieved by synthetic reactions.

[0003] A Chinese patent (publication number: CN212632655U) discloses a synthesis reactor for levamlodipine besylate, comprising a rotating motor, a feed inlet, a stirring impeller, a reactor shell, a mounting bracket, a discharge port, a thermal insulation layer, a three-way valve, a temperature control system, a cooling system, a heating system, a nitrogen filling interface, a nitrogen system, a tail gas port, a vacuum system, and a compressed air interface; the thermal insulation layer is respectively connected to the heating and cooling systems through a three-way valve; the temperature control system is respectively connected to the cooling system and the heating system, the temperature control system comprises a single-chip microcomputer, a display module, an alarm module, a temperature sensor can provide nitrogen for the reactor, ensure that the environment in the reactor meets the requirements, monitor the reaction temperature in the reactor in real time, and control the introduction of cooling or heating working medium in the thermal insulation layer through the three-way valve, the thermal insulation layer is provided with a compressed air interface, and the thermal insulation layer can be flushed by compressed air, but after the equipment is completed and the obtained product is discharged, part of it will still remain on the inner wall of the equipment, and it needs to be manually cleaned, which is inconvenient to use.

[0004] In order to solve the above problems, we have made improvements and proposed a synthesis reactor for amlodipine besylate. Utility Model Content

[0005] In order to solve the above technical problems, the utility model provides the following technical solutions:

[0006] The utility model provides a synthesis reactor for levamlodipine besylate, comprising a tank body, wherein a mounting shaft is rotatably connected inside the tank body, a plurality of stirring arms are fixedly connected to the outer side of the mounting shaft, a first mounting ring and a second mounting ring are fixedly connected inside the tank body, and the first mounting ring is arranged above the second mounting ring, a scraper rod is arranged inside the tank body, and the upper and lower ends of the scraper rod are respectively slidably connected to the inside of the first mounting ring and the second mounting ring, the side surface of the scraper rod is fitted with the inner wall of the tank body, and a driving component is arranged on the top of the scraper rod.

[0007] As a preferred technical solution of the utility model, the driving assembly includes a second motor, and the second motor is fixedly connected to the inside of the tank body, the output end of the second motor is fixedly connected to a second driving gear, the side of the second driving gear is meshingly connected to a gear ring, and the side of the gear ring is fixedly connected to the scraper rod, and the gear ring is rotatably connected to the bottom of the first mounting ring.

[0008] As a preferred technical solution of the utility model, a temperature detector is fixedly connected to the bottom end of the mounting shaft, a heat pipe is fixedly connected to the outside of the tank body, and both ends of the heat pipe are connected to the temperature control system, a wire is fixedly connected to the top end of the temperature detector, and the wire passes through the mounting shaft to be electrically connected to the temperature control system.

[0009] As a preferred technical solution of the utility model, the top of the tank body is fixedly connected to a first motor, the output end of the first motor is fixedly connected to a first driving gear, the side of the first driving gear is meshingly connected to a driven gear, and the driven gear is fixedly connected to the top of the mounting shaft.

[0010] As a preferred technical solution of the utility model, a connecting ring is fixedly connected to the bottom end of the installation shaft, a protective cover is rotatably connected to the outer side of the connecting ring, and the temperature detector is arranged inside the protective cover.

[0011] As a preferred technical solution of the utility model, a plurality of side panels are fixedly connected to the side of the protective cover, and the plurality of side panels are arranged in a circle.

[0012] The beneficial effects of the utility model are:

[0013] 1. In the utility model, the driving assembly drives the scraper rod to make a circular motion between the first mounting ring and the second mounting ring. During the movement of the scraper rod, the outer side surface of the scraper rod acts on the inner wall of the tank body to scrape off the residue on the inner wall of the tank body, making the cleaning equipment more convenient.

[0014] 2. In the utility model, the protective cover is installed at the bottom of the installation shaft through the connecting ring to protect the temperature detector and extend the service life of the temperature detector. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0016] Figure 1 It is a three-dimensional diagram of the utility model;

[0017] Figure 2 The utility model Figure 1 Enlarged view of point A in the middle;

[0018] Figure 3 It is a cross-sectional view of the utility model;

[0019] Figure 4 The utility model Figure 3 Enlarged view of point B in the middle;

[0020] Figure 5 It is a schematic diagram of the installation shaft of the utility model;

[0021] In the figure: 1, tank body; 2, heat pipe; 3, first motor; 4, first driving gear; 5, driven gear; 6, mounting shaft; 7, wire; 8, first mounting ring; 9, second mounting ring; 10, scraper rod; 11, stirring arm; 12, second motor; 13, second driving gear; 14, gear ring; 15, connecting ring; 16, temperature sensor; 17, protective cover; 18, side plate. DETAILED DESCRIPTION

[0022] The preferred embodiments of the present invention are described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described herein are only used to illustrate and explain the present invention, and are not used to limit the present invention.

[0023] Example: Figure 1-5 As shown, a synthesis reactor for levamlodipine besylate comprises a tank body 1, wherein a mounting shaft 6 is rotatably connected inside the tank body 1, and a plurality of stirring arms 11 are fixedly connected to the outer side of the mounting shaft 6, and a first mounting ring 8 and a second mounting ring 9 are fixedly connected inside the tank body 1, and the first mounting ring 8 is arranged above the second mounting ring 9, and a scraper rod 10 is arranged inside the tank body 1, and the upper and lower ends of the scraper rod 10 are respectively slidably connected to the inside of the first mounting ring 8 and the second mounting ring 9, and the side surface of the scraper rod 10 is in contact with the inner wall of the tank body 1, and a driving assembly is arranged on the top of the scraper rod 10, and the top of the first mounting ring 8 is provided with a chamfer inclined toward the center of gravity of the tank body 1, so that the material can just fall, and the bottom end of the second mounting ring 9 is provided with a plurality of through holes for the material to fall, so as to reduce or avoid the material remaining in the second mounting ring 9;

[0024] After the product has completed its reaction in the tank body 1, the discharge port is opened to discharge the material from the discharge port. In the final stage of discharge, the drive assembly drives the scraper rod 10 to make a circular motion between the first mounting ring 8 and the second mounting ring 9. During the movement of the scraper rod 10, the outer side surface of the scraper rod 10 acts on the inner wall of the tank body 1 to scrape off the residue on the inner wall of the tank body 1, making the cleaning equipment more convenient.

[0025] Specifically, Figure 4As shown, the driving assembly includes a second motor 12, and the second motor 12 is fixedly connected to the inside of the tank body 1, and the output end of the second motor 12 is fixedly connected to the second driving gear 13, and the side of the second driving gear 13 is meshedly connected to the gear ring 14, and the side of the gear ring 14 is fixedly connected to the scraper rod 10, and the gear ring 14 is rotatably connected to the bottom of the first mounting ring 8. The second motor 12 drives the second driving gear 13 to rotate when it works, and the rotating second driving gear 13 drives the gear ring 14 to rotate at the bottom of the first mounting ring 8, thereby driving the scraper rod 10 to move.

[0026] Specifically, Figure 2 and Figure 5 As shown, the bottom end of the mounting shaft 6 is fixedly connected with a thermometer 16, the outer side of the tank body 1 is fixedly connected with a heat pipe 2, and both ends of the heat pipe 2 are connected to the temperature control system, the top end of the thermometer 16 is fixedly connected with a wire 7, and the wire 7 passes through the mounting shaft 6 and is electrically connected to the temperature control system. The thermometer 16 is moved to the bottom of the mounting shaft 6 so that the thermometer 16 is always at the center of gravity of the material, so that the measured temperature is more accurate, and the thermometer 16 is prevented from being installed on the inner wall of the tank body 1 to interfere with the operation of the scraper 10. The thermometer 16 measures the temperature of the material. When there is a difference between the measured temperature and the set temperature, the thermometer 16 transmits a signal to the temperature control system, and the temperature control system sends cold water or hot water into the heat pipe 2 to cool down or heat up the tank body 1 to maintain the reaction environment of the material.

[0027] Specifically, Figure 2 As shown, a first motor 3 is fixedly connected to the top of the tank body 1, and a first driving gear 4 is fixedly connected to the output end of the first motor 3. A driven gear 5 is meshedly connected to the side of the first driving gear 4, and the driven gear 5 is fixedly connected to the top of the mounting shaft 6. The first motor 3 drives the first driving gear 4 to rotate, and the rotating first driving gear 4 drives the mounting shaft 6 to rotate through the driven gear 5, thereby rotating the stirring arm 11 to stir the material, and leaving the top of the mounting shaft 6 empty for the wire 7 to pass through the central axis of the mounting shaft 6, so as to avoid the wire 7 following the rotation during the rotation of the mounting shaft 6, so that the wire 7 is not torn off due to entanglement.

[0028] Specifically, Figure 1As shown, a connecting ring 15 is fixedly connected to the bottom end of the mounting shaft 6, a protective cover 17 is rotatably connected to the outer side of the connecting ring 15, and a temperature detector 16 is arranged inside the protective cover 17, the temperature detector 16 is tightly attached to the inside of the protective cover 17, and a plurality of side plates 18 are fixedly connected to the side of the protective cover 17, and the plurality of side plates 18 are arranged in a circle, and the protective cover 17 is mounted on the bottom of the mounting shaft 6 through the connecting ring 15 to protect the temperature detector 16 and extend the service life of the temperature detector 16. The side plates 18 arranged on the outer side of the protective cover 17 receive resistance from the material during the rotation of the mounting shaft 6 due to the existence of the side plates 18, so that the connecting ring 15 rotates inside the protective cover 17, and the protective cover 17 receives resistance and can remain relatively still, or rotate to a lesser extent, to avoid the entanglement of the wire 7.

[0029] Working principle: the first motor 3 drives the first driving gear 4 to rotate, and the rotating first driving gear 4 drives the mounting shaft 6 to rotate through the driven gear 5, thereby rotating the stirring arm 11 to stir the material in the tank body 1, and the temperature detector 16 measures the temperature of the material. When there is a difference between the measured temperature and the set temperature, the temperature detector 16 transmits a signal to the temperature control system, and the temperature control system sends cold water or hot water into the heat pipe 2 to cool or heat the tank body 1 to maintain the reaction environment of the material. After the product reacts in the tank body 1, the discharge port is opened to discharge the material from the discharge port. In the final stage of discharge, the second motor 12 drives the second driving gear 13 to rotate, and the rotating second driving gear 13 drives the gear ring 14 to rotate at the bottom of the first mounting ring 8, thereby driving the scraper rod 10 to move. The scraper rod 10 makes a circular motion between the first mounting ring 8 and the second mounting ring 9. During the movement of the scraper rod 10, the outer side of the scraper rod 10 acts on the inner wall of the tank body 1 to scrape off the residue on the inner wall of the tank body 1.

[0030] Finally, it should be noted that the above description is only a preferred embodiment of the utility model and is not intended to limit the utility model. Although the utility model is described in detail with reference to the above embodiments, those skilled in the art can still modify the technical solutions recorded in the above embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A synthesis reactor for amlodipine besylate, comprising a tank (1), characterized in that: The tank body (1) is rotatably connected to a mounting shaft (6), and a plurality of stirring arms (11) are fixedly connected to the outside of the mounting shaft (6). The tank body (1) is fixedly connected to a first mounting ring (8) and a second mounting ring (9), and the first mounting ring (8) is arranged above the second mounting ring (9). A scraper rod (10) is arranged inside the tank body (1), and the upper and lower ends of the scraper rod (10) are respectively slidably connected to the inside of the first mounting ring (8) and the second mounting ring (9). The side surface of the scraper rod (10) is in contact with the inner wall of the tank body (1), and a driving assembly is arranged on the top of the scraper rod (10).

2. A synthesis reactor for levamlodipine besylate according to claim 1, characterized in that: The driving assembly comprises a second motor (12), and the second motor (12) is fixedly connected to the inside of the tank body (1), the output end of the second motor (12) is fixedly connected to a second driving gear (13), the side of the second driving gear (13) is meshingly connected to a toothed ring (14), and the side of the toothed ring (14) is fixedly connected to the scraper rod (10), and the toothed ring (14) is rotatably connected to the bottom of the first mounting ring (8).

3. A synthesis reactor for levamlodipine besylate according to claim 1, characterized in that: The bottom end of the installation shaft (6) is fixedly connected to a temperature detector (16), the outer side of the tank body (1) is fixedly connected to a heat pipe (2), and both ends of the heat pipe (2) are connected to a temperature control system, and the top end of the temperature detector (16) is fixedly connected to a wire (7), and the wire (7) passes through the installation shaft (6) and is electrically connected to the temperature control system.

4. A synthesis reactor for levamlodipine besylate according to claim 1, characterized in that: The top end of the tank body (1) is fixedly connected to a first motor (3), the output end of the first motor (3) is fixedly connected to a first driving gear (4), the side of the first driving gear (4) is meshingly connected to a driven gear (5), and the driven gear (5) is fixedly connected to the top of the mounting shaft (6).

5. A synthesis reactor for levamlodipine besylate according to claim 3, characterized in that: The bottom end of the installation shaft (6) is fixedly connected to a connecting ring (15), the outer side of the connecting ring (15) is rotatably connected to a protective cover (17), and the temperature detector (16) is arranged inside the protective cover (17).

6. A synthesis reactor for levamlodipine besylate according to claim 5, characterized in that: A plurality of side plates (18) are fixedly connected to the side surface of the protection cover (17), and the plurality of side plates (18) are arranged in a circle.

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