Experimental device for sweet water preference of rats and mice

Abstract

The utility model discloses a rat and mouse sweet water preference experiment device, which belongs to the field of experiment equipment, and comprises an aluminum alloy frame and an acrylic feeding box, an installation platform is arranged above the aluminum alloy frame, a back plate is arranged on one side of the installation platform, the acrylic feeding box is arranged above the installation platform and is attached to the back plate, and the acrylic feeding box is arranged above the installation platform. A water guiding groove and a feeding groove are formed behind the back plate, the water guiding groove is symmetrically formed in the two sides of the feeding groove, the water guiding groove and the feeding groove both penetrate through the back plate and the acrylic feeding box, a first weighing mechanism and a second weighing mechanism are arranged above the water guiding groove and the feeding groove respectively, a water drinking bottle is inserted into the lower portion of the first weighing mechanism, and a water guiding head of the water drinking bottle stretches into the water guiding groove; a limiting baffle is arranged on the outer side of the water guiding groove, a feeding box is inserted into the lower portion of the second weighing mechanism, the feeding box stretches into the feeding groove, the feeding box abuts against a limiting block, and the limiting block is arranged on the second weighing mechanism. The system can count data in real time, and is high in automation degree and higher in accuracy.

Description

Technical Field

[0001] The utility model belongs to the field of experimental equipment, and in particular relates to a device for experimental testing the preference of mice for sugar water. Background Art

[0002] The Sucrose Preference Test (SPT) is a behavioral test widely used to assess the emotional state of laboratory animals (such as mice and rats). It is mainly used to detect the happiness level and depressive symptoms of animals. This test is based on an observation that healthy animals usually prefer sweet food and drinks, while melancholic or depressed animals may have a reduced preference for sweet substances. Therefore, the SPT can be used as an effective tool to assess the depressive symptoms of laboratory animals.

[0003] A Chinese utility model patent with authorization announcement number CN208144143U discloses a device for a sugar water preference experiment in rats. A rotatable stopcock is provided to prevent water leakage when weighing the water bottle. However, the experimental device has a low degree of automation and cannot monitor the drinking and eating conditions of mice and rats in real time. Deviations may still exist during manual weighing, and the accuracy of the experimental data is low.

[0004] Therefore, it is necessary to propose a sugar water preference experimental device for rats and mice that can perform real-time statistics, automation and high accuracy, so as to reduce data bias and errors caused by manual operations. Summary of the invention

[0005] The main purpose of the utility model is to provide a sugar water preference experimental device for mice and rats. The utility model can monitor the dietary data of mice and rats in real time and automatically collect the data by arranging a first weighing mechanism and a second weighing mechanism, and the data accuracy is higher.

[0006] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0007] A sugar water preference experimental device for mice and rats comprises an aluminum alloy frame and an acrylic breeding box, wherein a mounting platform is arranged above the aluminum alloy frame, a back plate is arranged on one side of the mounting platform, the acrylic breeding box is arranged above the mounting platform, the acrylic breeding box is fitted with the back plate, a water diversion trough and a feeding trough are arranged behind the back plate, the water diversion troughs are symmetrically arranged on both sides of the feeding trough, the water diversion trough and the feeding trough both penetrate the back plate and the acrylic breeding box, and a first weighing mechanism and a second weighing mechanism are arranged above them respectively, a drinking bottle is inserted below the first weighing mechanism, the water diversion head of the drinking bottle protrudes into the water diversion trough, a limiting baffle is arranged on the outer side of the water diversion trough for limiting the drinking bottle, a feeding box is inserted below the second weighing mechanism, the feeding box protrudes into the feeding trough, the feeding box abuts against a limiting block, and the limiting block is arranged on the second weighing mechanism.

[0008] Furthermore, the first weighing mechanism includes a first positioning block, a first weighing sensor and an end fixing ring, the first positioning block is fixed on the back plate above the water diversion trough, the first weighing sensor is arranged on the first positioning block, the detection end of the weighing sensor is connected to the end fixing ring, and the water bottle is mounted on the end fixing ring.

[0009] Furthermore, the second weighing mechanism includes a second positioning block, a fixing plate and a second weighing sensor, the second positioning block is fixed on the back plate above the feeding trough, the second weighing sensor is arranged on the second positioning block, the fixing plate is arranged below the second positioning block, a through hole is arranged on the fixing plate, the detection end of the second weighing sensor passes through the through hole and is connected to the feeding box, the limit block is arranged on the outer side of the fixing plate by bolts, and an oblique baffle is arranged inside the limit block for limiting the feeding box and feeding.

[0010] Furthermore, a top plate is provided on the top of the acrylic breeding box, the top plate is hinged to the breeding box, the top plate is provided with hollow air holes, and an infrared thermal sensor is provided in the middle of the top plate.

[0011] Furthermore, a plurality of installation grooves are longitudinally arranged on both sides of the acrylic breeding box, and infrared radiation gratings are arranged in the installation grooves.

[0012] Furthermore, the aluminum alloy frame is provided with a first slot and a second slot in sequence at the lower end of the acrylic plate, the movable plate is inserted into the first slot, and the excrement filter plate is inserted into the second slot.

[0013] Furthermore, a liquid collecting funnel is provided below the second slot for collecting urine.

[0014] Compared with the prior art, the utility model has the following beneficial effects:

[0015] The utility model proposes a sugar water preference experimental device for mice and rats that can collect real-time statistical data. Through the setting of weighing sensors, the water intake and eating conditions of mice and rats can be monitored in real time, and there is no need to remove the drinking bottle for weighing. The degree of automation is high. The setting of infrared thermal sensors can monitor the amount of exercise of mice and rats. The infrared ray grating can accurately record the number of times the mice and rats raise their heads. The setting of excrement filter plates and liquid collecting funnels can separate the feces and urine of mice and rats, prevent urine evaporation and feces contamination, keep the experimental environment (temperature and humidity) stable, and can collect and weigh urine. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0017] Figure 1 The main structure of the utility model is shown in FIG. Figure 1 ;

[0018] Figure 2 This is a schematic diagram of the internal structure of the acrylic breeding box of the utility model;

[0019] Figure 3 This is a schematic diagram of the installation of the first weighing mechanism and the second weighing mechanism of the utility model;

[0020] Figure 4 It is a schematic diagram of the structure of the first weighing mechanism and the second weighing mechanism of the utility model;

[0021] Figure 5 It is a cross-sectional view of the second weighing mechanism of the utility model.

[0022] Among them, 1-aluminum alloy frame, 2-acrylic breeding box, 3-back plate, 4-water trough, 5-feeding trough, 6-first positioning block, 7-first weighing sensor, 8-end fixing ring, 9-drinking bottle, 10-water head, 11-limit baffle; 12-feeding box; 13-limit block; 14-second positioning block; 15-fixing plate; 16-second weighing sensor; 17-adjusting slot; 18-through hole; 19-oblique baffle; 20-top plate; 21-infrared thermal sensor; 22-installation slot; 23-infrared counter-radiation grating; 24-first slot; 25-second slot; 26-liquid collecting funnel; 27-movable plate; 28-excrement filter plate. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0024] like Figure 1-5As shown, the utility model provides a sugar water preference experimental device for mice and rats, comprising an aluminum alloy frame 1 and an acrylic breeding box 2. The acrylic breeding box 2 in this embodiment is a transparent box, a mounting platform is arranged above the aluminum alloy frame 1, a back plate 3 is arranged on one side of the mounting platform, the acrylic breeding box 2 is arranged above the mounting platform, the acrylic breeding box 2 is fitted with the back plate 3, and two water diversion troughs 4 and a feeding trough 5 are arranged behind the back plate 3.

[0025] The water trough 4 is symmetrically arranged on both sides of the feeding trough 5. The water trough 4 and the feeding trough 5 both penetrate the back plate 3 and the acrylic breeding box 2. A first weighing mechanism is installed above the water trough 4, and a second weighing mechanism is installed above the feeding trough 5.

[0026] Specifically, the first weighing mechanism includes a first positioning block 6, a first weighing sensor 7 and an end fixing ring 8. The first positioning block 6 is fixed on the back plate 3 above the water diversion trough 4. The first weighing sensor 7 is arranged on the first positioning block 6. The weighing end of the first weighing sensor 7 is connected to the end fixing ring 8. The drinking bottle 9 is mounted on the end fixing ring 8. The water diversion head 10 of the drinking bottle 9 is inserted into the water diversion trough 4. A limiting baffle 11 is arranged on the outer side of the water diversion trough 4 for limiting the drinking bottle 9.

[0027] In this embodiment, the drinking bottle A contains pure water, and the drinking bottle B contains a solution containing glucose. By placing the drinking bottle A and the drinking bottle B on both sides of the feeding trough 5 respectively, rats and mice can freely choose.

[0028] As a preferred embodiment of the utility model, a ball bearing can be installed on the surface of the limit baffle 11 that contacts the water bottle 9 to facilitate the placement of the water bottle 9.

[0029] A feeding box 12 is inserted below the second weighing mechanism. The feeding box 12 is inserted into the feeding groove 5. The feeding box 12 abuts against a limiting block 13. The limiting block 13 is arranged on the second weighing mechanism.

[0030] Specifically, the second weighing mechanism includes a second positioning block 14, a fixing plate 15 and a second weighing sensor 16. The second positioning block 14 is fixed on the back plate 3 above the feeding trough 5. The second weighing sensor 16 is arranged on the second positioning block 14. The fixing plate 15 is arranged below the second positioning block 14. A through hole 18 is arranged on the fixing plate 15. The weighing end of the second weighing sensor 16 passes through the through hole 18 and is connected to the feeding box 12. An adjusting groove 17 is arranged on the limit block 13. The limit block 13 is sleeved on the outer side of the fixing plate 15 through bolts and the adjusting groove 17. An oblique baffle 19 is arranged inside the limit block 13 for limiting and feeding the feeding box 12. The setting of the adjusting groove 17 facilitates the position adjustment of the limit block 13.

[0031] As a preferred embodiment of the utility model, a top plate 20 is provided on the top of the acrylic breeding box 2, and the top plate 20 is hinged to the breeding box. The top plate 20 is provided with hollow air holes to facilitate the ventilation of the breeding box. An infrared thermal sensor 21 is provided in the middle of the top plate 20 for monitoring the amount of exercise of mice and rats. A number of mounting grooves 22 are longitudinally provided on both sides of the acrylic breeding box 2, and infrared gratings 23 are provided in the mounting grooves 22 to monitor the number of times the mice and rats stand up.

[0032] As a preferred embodiment of the utility model, the aluminum alloy frame 1 is sequentially provided with a first slot 24 and a second slot 25 at the lower end of the acrylic board, a movable plate 27 is inserted in the first slot 24 for stepping on by mice and rats, an excrement filter plate 28 is inserted in the second slot 25 for filtering feces, and a liquid collecting funnel 26 is provided below the second slot 25 for collecting urine.

[0033] The utility model is connected with a collection module and a computer information collection system, and can be used for automatically collecting experimental data of sugar water consumption, food consumption, movement trajectory and standing monitoring of mice and rats, so as to evaluate the depressive-like behavior of animals and the effect of antidepressant drugs through sugar water preference experiments.

[0034] In this specification, each embodiment is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part.

[0035] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A sugar water preference experimental device for rats and mice, characterized in that: It includes an aluminum alloy frame and an acrylic breeding box, wherein a mounting platform is arranged above the aluminum alloy frame, a back plate is arranged on one side of the mounting platform, the acrylic breeding box is arranged above the mounting platform, the acrylic breeding box is fitted with the back plate, a water trough and a feeding trough are arranged behind the back plate, the water troughs are symmetrically arranged on both sides of the feeding trough, the water troughs and the feeding trough both penetrate the back plate and the acrylic breeding box, and a first weighing mechanism and a second weighing mechanism are arranged above them respectively, a drinking water bottle is inserted below the first weighing mechanism, the water head of the drinking water bottle protrudes into the water trough, a limiting baffle is arranged on the outer side of the water trough for limiting the drinking water bottle, a feeding box is inserted below the second weighing mechanism, the feeding box protrudes into the feeding trough, the feeding box abuts against a limiting block, and the limiting block is arranged on the second weighing mechanism.

2. The sugar water preference experimental device for rats and mice according to claim 1, characterized in that: The first weighing mechanism includes a first positioning block, a first weighing sensor and an end fixing ring. The first positioning block is fixed on the back plate above the water diversion trough. The first weighing sensor is arranged on the first positioning block. The detection end of the first weighing sensor is connected to the end fixing ring. The drinking bottle is mounted on the end fixing ring.

3. The sugar water preference experimental device for rats and mice according to claim 1, characterized in that: The second weighing mechanism includes a second positioning block, a fixing plate and a second weighing sensor. The second positioning block is fixed on the back plate above the feeding trough. The second weighing sensor is arranged on the second positioning block. The fixing plate is arranged below the second positioning block. A through hole is arranged on the fixing plate. The detection end of the second weighing sensor passes through the through hole and is connected to the feeding box. The limit block is arranged on the outer side of the fixing plate by bolts. An oblique baffle is arranged inside the limit block for limiting the feeding box and feeding.

4. The sugar water preference experimental device for rats and mice according to claim 1, characterized in that: A top plate is arranged on the top of the acrylic breeding box, the top plate is hinged to the breeding box, the top plate is provided with hollow air holes, and an infrared thermal sensor is arranged in the middle of the top plate.

5. The sugar water preference experimental device for rats and mice according to claim 1, characterized in that: A plurality of installation grooves are longitudinally arranged on both sides of the acrylic breeding box, and infrared ray counter-radiation gratings are arranged in the installation grooves.

6. The sugar water preference experimental device for rats and mice according to claim 1, characterized in that: The aluminum alloy frame is provided with a first slot and a second slot in sequence at the lower end of the acrylic board, the first slot is plugged with a movable plate, and the second slot is plugged with an excrement filter plate.

7. The sugar water preference experimental device for rats and mice according to claim 6, characterized in that: A liquid collecting funnel is arranged below the second slot for collecting urine.

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