Fluorescence signal enhancement device, fluorescence signal detection device, and liquid droplet observation device

By first generating a pre-magnetized magnetic field in the droplet to agglomerate the magnetic particles, and then pulling them into a linear shape in the first magnetic field, the problem of insignificant fluorescence signal in the droplet is solved, and the accuracy of cell recognition is improved.

CN223272420UActive Publication Date: 2025-08-26GUANGZHOU NAT LAB
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Patent Information

Application Number
CN202421635217.5
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Priority Date
2023-12-07
Filing Date
2024-07-10
Publication Date
2025-08-26
Estimated Expiration
2034-07-10

AI Technical Summary

Technical Problem

The magnetic particles in the droplets are irregularly distributed in the magnetic field, resulting in less obvious peaks in fluorescence signal characteristics, affecting cell recognition accuracy.

Method used

The pre-magnetization assembly is used to generate a pre-magnetization magnetic field, so that the magnetic particles are agglomerated in the liquid droplets, and then a first magnetic field is formed through the magnet assembly, so that the agglomerated magnetic particles are pulled into a linear shape in the first magnetic field, enhancing the fluorescence signal.

Benefits of technology

By combining pre-magnetization and the first magnetic field, the identification accuracy of the droplets is improved, making the characteristic peaks of the fluorescence signal more obvious and reducing misjudgment.

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Abstract

The utility model relates to the technical field of cell sorting, and discloses a fluorescence signal enhancement device which comprises a pre-magnetization assembly and a magnet assembly, the pre-magnetization assembly is used for generating a pre-magnetization magnetic field, and magnetic particles in liquid drops are magnetized and agglomerated in the pre-magnetization magnetic field; the magnet assembly is used for generating a first magnetic field, and the magnetic particles agglomerated in the liquid drops are pulled into a linear shape in the first magnetic field. The utility model further discloses a fluorescence signal detection device and a liquid drop observation device.
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