Cornea preservation device

Abstract

The utility model provides a cornea preservation device which comprises the following components: a main box body which comprises a first liquid storage cavity and a bracket, the bracket is provided with an arc-shaped groove, the arc-shaped groove is provided with a communicating hole, and the outer side surface of a cornea in the arc-shaped groove is in contact with liquid in the first liquid storage cavity through the communicating hole; the upper box body comprises a second liquid storage cavity with a bottom opening and an elastic film surrounding the bottom opening, the bottom of the elastic film is matched with the shape of the edge of the inner side surface of the cornea to be stored, and the upper box body is arranged above the bracket in the mode that the elastic film is attached to the edge of the inner side surface of the cornea to be stored in the arc-shaped groove; and the inner side surface of the cornea to be preserved in the arc-shaped groove is in contact with the liquid in the second liquid storage cavity through the bottom opening. According to the utility model, the inner side surface and the outer side surface of the cornea can be respectively contacted with different liquids, so that the time for keeping the activity of in-vitro corneal endothelial cells is prolonged.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical instrument field more specifically, relate to a cornea storage device. BACKGROUND

[0002] Corneal transplantation is to replace the diseased cornea with normal cornea, so that the eye can see or control the corneal disease, and the vision can be improved or some corneal diseases can be treated. In order to make the endothelial cells of the graft have good activity, the cornea peeled off must be preserved.

[0003] The existing cornea storage device usually soaks the cornea in liquid. However, since the inner side and the outer side of the human eye cornea are respectively in contact with two different liquids, soaking the cornea in a liquid in vitro will make it difficult to maintain the activity of the corneal endothelial cells for a long time. UTILITY MODEL CONTENT

[0004] The technical problem to be solved by the utility model is to provide a new cornea storage device to solve the problem that the above-mentioned cornea storage device cannot maintain the activity of the cornea in vitro for a long time.

[0005] The technical solution for solving the above-mentioned technical problem is to provide a cornea storage device, which comprises:

[0006] The main box body comprises a first liquid storage cavity with a top opening and a bracket located in the first liquid storage cavity. The bracket has an arc-shaped groove matched with the outer surface of the cornea to be preserved. The arc-shaped groove has a communication aperture. The outer surface of the cornea to be preserved in the arc-shaped groove is in contact with the liquid in the first liquid storage cavity through the communication aperture.

[0007] The upper box body comprises a second liquid storage cavity with a bottom opening and an elastic film surrounding the bottom opening. The bottom of the elastic film is matched with the shape of the edge of the inner surface of the cornea to be preserved. The upper box body is arranged above the bracket in the main box body with the elastic film attached to the edge of the inner surface of the cornea to be preserved in the arc-shaped groove. The inner surface of the cornea to be preserved in the arc-shaped groove is in contact with the liquid in the second liquid storage cavity through the bottom opening.

[0008] As a further improvement of the utility model, the cornea storage device comprises a main cover for covering the top opening of the first liquid storage cavity. The main cover has a through hole, and when the main cover is arranged in the main box body, the through hole is located directly above the arc-shaped groove of the bracket. The upper box body is arranged on the main cover with the bottom passing through the through hole.

[0009] As a further improvement of the utility model, the upper box body includes a clamping section and a columnar section made of hard material, the second liquid storage cavity extends from the clamping section to the columnar section, and the bottom opening of the second liquid storage cavity is located at the bottom of the columnar section; the clamping section, the columnar section and the elastic film are connected axially in sequence, the radial dimension of the clamping section is greater than the through hole, the radial dimensions of the columnar section and the elastic film are both smaller than the through hole, and when the upper box body is installed on the main cover body, the clamping section is located above the main cover body, and the columnar section and the elastic film pass through the through hole to reach the first liquid storage cavity of the main box body.

[0010] As a further improvement of the utility model, the through hole is circular, the radial cross section of the clamping section, the columnar section and the radial cross section of the elastic film are all annular, and the outer diameter of the columnar section is matched with the diameter of the through hole.

[0011] As a further improvement of the utility model, the main cover body is provided with a first convex ring surrounding the through hole, the inner wall of the first convex ring is provided with a circumferential groove, and a sealing ring is installed in the circumferential groove; when the columnar section is inserted into the through hole, the columnar section is sealingly connected with the inner wall of the first convex ring through the sealing ring.

[0012] As a further improvement of the utility model, the lower surface of the main cover body is provided with a second convex ring surrounding the through hole, and when the main cover body is installed on the main box body, the free end of the second convex ring abuts against the bracket and surrounds the arc-shaped groove.

[0013] As a further improvement of the utility model, the cornea preservation device includes an upper cover body, the top of the clamping section is provided with a liquid adding port connected with the second liquid storage cavity, and the upper cover body is installed on the top of the clamping section and covers the liquid adding port.

[0014] As a further improvement of the utility model, the elastic film is in the shape of a cylinder with the bottom inwardly contracted, and the size of the bottom of the elastic film in contact with the edge of the cornea to be preserved is less than one fifth of the radial dimension of the cornea.

[0015] As a further improvement of the utility model, the bracket includes a plurality of shelf plates, the plurality of shelf plates are perpendicularly connected in a radial manner at the bottom of the first liquid storage cavity, the top of each of the plurality of shelf plates gradually increases in height from the inside to the outside and forms the arc-shaped groove, and the communication aperture is formed by the gaps between the shelf plates.

[0016] As a further improvement of the utility model, the proportion of the communication aperture in the bottom surface of the arc-shaped groove is greater than 70%, and the main box body includes a heat preservation cavity surrounding the first liquid storage cavity.

[0017] The utility model discloses have the following beneficial effects: through setting first liquid storage cavity in main box body, setting second liquid storage cavity in upper box body, and through the elastic film of upper box body separation first liquid storage cavity and second liquid storage cavity, make the inner side surface and the outer side surface of the cornea to be preserved contact different liquid respectively, thereby prolonging the time of keeping the activity of isolated corneal endothelial cell. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is the schematic diagram of cornea preservation device provided by the utility model embodiment.

[0019] Figure 2 It is the exploded structural schematic diagram of cornea preservation device provided by the utility model embodiment.

[0020] Figure 3 It is the cross section structural schematic diagram of cornea preservation device provided by the utility model embodiment.

[0021] Figure 4 It is the exploded structural schematic diagram of upper box body in cornea preservation device provided by the utility model embodiment. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical scheme and advantage of the utility model more clearly, the following is in conjunction with the drawing and embodiment, and the utility model is further detailedly explained.It should be understood that the specific embodiment described here is only used to explain the utility model, and is not used to limit the utility model.

[0023] As Figures 1-4 Shown, it is the structural schematic diagram of cornea preservation device provided by the utility model embodiment, and the cornea preservation device can be used to preserve isolated cornea, and makes isolated cornea keep active for a long time.The cornea preservation device of this embodiment includes main box body 10 and upper box body 20, and the main body part of the main box body 10 and the upper box body 20 can be made of medical grade plastic, and the upper box body 20 can be installed to the upper of main casing 10.

[0024] The main box body 10 includes first liquid storage cavity 11 and bracket 12, wherein the opening of first liquid storage cavity 11 is located at the top of main box body 10, that is, first liquid storage cavity 11 has top opening, and bracket 12 is located in first liquid storage cavity 11.Especially, for the convenience of production and manufacture, the first bracket 12 can be integrated with the body of main box body 10.The arc-shaped groove is formed on the bracket 12, and the bottom surface of the arc-shaped groove is in contact with the outer side surface of the cornea 50 to be preserved (such as Figure 2 、 Figure 3The arc-shaped groove is adapted to the shape of the lower surface of the cornea 50 (as shown in the figure), and has a communication aperture on the arc-shaped groove. The outer surface of the cornea 50 to be preserved is in contact with the liquid in the first liquid storage cavity 11 through the communication aperture. In addition, in order to improve the preservation effect, the main box 10 can further have a heat preservation cavity 13 surrounding the first liquid storage cavity 11 (except for the top opening of the first liquid storage cavity 11). The heat preservation cavity 13 can be vacuum or near-vacuum, thereby reducing the heat loss of the liquid in the first liquid storage cavity 11.

[0025] The upper box 20 includes a second liquid storage cavity 21 and an elastic film 22. The second liquid storage cavity 21 has a bottom opening, and the elastic film 22 is arranged around the bottom opening. The elastic film 22 can be made of medical silica gel material with certain elasticity, and the bottom of the elastic film 22 is adapted to the shape of the edge of the inner surface of the cornea to be preserved. For example, the bottom of the elastic film 22 is a convex arc surface, and the inner surface of the cornea to be preserved is a concave arc surface. The upper box 20 is arranged above the bracket 12 of the main box 10 with the lower surface of the elastic film 22 adhered to the edge of the inner surface of the cornea 50 to be preserved in the arc-shaped groove, and the first liquid storage cavity 11 and the second liquid storage cavity 21 are isolated by the side wall of the second liquid storage cavity 21, the elastic film 22 and the cornea 50 to be preserved. The inner surface of the cornea 50 to be preserved in the arc-shaped groove is in contact with the liquid in the second liquid storage cavity 21 through the bottom opening of the second liquid storage cavity 21 (i.e. the opening of the bottom of the elastic film 22). It is understood by those skilled in the art that the elastic film 22 needs to have a certain thickness and be relatively soft, so as to isolate the first liquid storage cavity 11 and the second liquid storage cavity 21 while avoiding damaging the cornea 50 to be preserved.

[0026] In use, the first liquid (same as or similar to the composition of the tear fluid outside the human eyeball) is first added to the first liquid storage cavity 11 of the main box body 10, and the upper surface of the first liquid needs to reach or be above the top surface of the arc-shaped groove; then the elastic film 22 of the upper box body 20 is attached to the edge of the inner side surface of the cornea 50 to be preserved, and the cornea 50 to be preserved is pushed into the arc-shaped groove from above the arc-shaped groove, at which time the cornea 50 to be preserved and the elastic film 22 will displace the first liquid until the outer side surface of the cornea 50 to be preserved is in contact with the bottom surface of the arc-shaped groove, at which time the first liquid storage cavity 11 and the second liquid storage cavity 21 can still be isolated from each other under the action of the buoyancy of the first liquid; then the second liquid (same as or similar to the composition of the body fluid inside the human eyeball) is injected into the second liquid storage cavity 21, i.e., the cornea 22 to be preserved is placed on the upper surface of the first liquid (above the arc-shaped groove). In particular, the density of the above-mentioned second liquid can be greater than the density of the first liquid, so that the second liquid can press the elastic film 22 against the edge of the cornea 50 to be preserved (since the contact surface between the elastic film 22 and the cornea 50 to be preserved is a concave arc surface, the pressure of the second liquid can be applied to the elastic film 22 from the axial and radial directions, so that the elastic film 22 is attached to the edge of the cornea 50 to be preserved), avoiding the rapid diffusion of the second liquid in the second liquid storage cavity 21 into the first liquid storage cavity 11, i.e., even if complete isolation of the first liquid and the second liquid cannot be maintained, the inner side surface and the outer side surface of the cornea 50 to be preserved can still be in contact with two different liquids within a certain period of time.

[0027] In actual application, after the first liquid is injected into the first liquid storage cavity, the cornea 50 to be preserved can also be placed on the surface of the first liquid (under the action of the buoyancy and surface tension of the first liquid, the cornea 50 to be preserved will not sink), then the elastic film 22 of the upper box body 20 is attached to the edge of the cornea 50 to be preserved, and the cornea 50 is pushed into the first liquid until the outer side surface of the cornea 50 to be preserved is in contact with the bottom surface of the arc-shaped groove, and finally the second liquid is injected into the second liquid storage cavity 21 of the upper box body 20.

[0028] The above-mentioned cornea preservation device, by providing the first liquid storage cavity 11 in the main box body 10, providing the second liquid storage cavity 21 in the upper box body 20, and separating the first liquid storage cavity 11 and the second liquid storage cavity 21 by the elastic film 22 of the upper box body 20 (in contact with the cornea 50 to be preserved and the side wall of the second liquid storage cavity 21), so that the inner side surface and the outer side surface of the cornea 50 to be preserved are respectively in contact with different liquids within a certain period of time, thereby prolonging the time for which the corneal endothelial cells of the ex vivo cornea remain active.

[0029] In an embodiment of the present application, the cornea storage device further comprises a main cover 30, which can be assembled to the top of the main box 10 (for example by threaded connection, clamping, etc.) and used to cover the top opening of the first liquid storage cavity 11. The main cover 30 has a through hole 31, and when the main cover 30 is assembled to the main box 10, the through hole 31 is located directly above the arc-shaped groove of the bracket 12. The upper box 20 is assembled on the main cover 30 in a manner that the bottom passes through the through hole 31. Through the above-mentioned manner, the assembly of the upper box 20 can be realized.

[0030] Specifically, the arc-shaped groove at the top of the bracket 12 can be located in the center of the main box 10, and correspondingly, the through hole 31 of the main cover 30 can also be located in the center of the main cover 30, so that the cornea 50 to be stored is stored in the center of the main box 10, facilitating the taking and placing of the cornea 50 to be stored.

[0031] As shown in Figure 4 In an embodiment of the present application, the upper box 20 comprises a clamping section 23 and a columnar section 24 made of hard material, and the clamping section 23, the columnar section 24 and the elastic film 22 are axially connected in sequence, wherein the clamping section 23 and the columnar section 24 can be integrally formed, and the second liquid storage cavity 21 extends from the clamping section 23 to the columnar section 24, and the bottom opening 25 of the second liquid storage cavity 21 is located at the bottom of the columnar section 24. The radial dimension of the clamping section 23 is greater than that of the through hole 31 on the main cover 30, the radial dimensions of the columnar section 24 and the elastic film 22 are both less than that of the through hole 31, and when the upper box 20 is assembled to the main cover 30, the clamping section 23 is located above the main cover 30, and the columnar section 24 and the elastic film 22 pass through the through hole to reach the first liquid storage cavity 11 of the main box 10. Those skilled in the art can understand that the axial dimension of the columnar section 24 is adapted to the distance between the through hole 31 and the arc-shaped groove of the bracket 12. Through the above-mentioned structure, the assembly of the upper box 20 can be limited, avoiding the damage to the cornea 50 to be stored caused by excessive insertion of the upper box 20 into the through hole.

[0032] In an embodiment of the present application, the through hole of the main cover 30 is circular, and correspondingly, the radial cross section of the clamping section 23 of the upper box 20, the radial cross section of the columnar section 24 and the radial cross section of the elastic film 22 are all circular ring-shaped, and the outer diameter of the columnar section 24 is adapted to the diameter of the through hole 31 (for example, the outer diameter of the columnar section 24 is equal to or slightly smaller than the diameter of the through hole 31). Through the above-mentioned structure, not only the upper box 20 can be easily assembled to the main cover 30, but also the upper box 20 can be kept stable after assembly, reducing the probability of the second liquid in the second liquid storage cavity 21 flowing into the first liquid storage cavity 11.

[0033] In particular, the elastic film 22 can be in a cylindrical shape with a bottom inwardly contracted, and the size of the bottom of the elastic film 22 in contact with the edge of the cornea 50 to be preserved is less than one fifth of the radial size of the cornea 50 to be preserved. Through the above structure, the inner side surface of the cornea 50 to be preserved can be in contact with the second liquid in the second liquid storage cavity 21 as much as possible while better isolating the first liquid storage cavity 11 and the second liquid storage cavity 21, so that the inner side surface of the cornea 50 to be preserved is kept active.

[0034] In an embodiment of the present application, the main cover body 30 has a first convex ring 32 surrounding the through hole 31, for example, the first convex ring 32 can protrude above the through hole 31 and the inner diameter of the first convex ring 32 is the same as the diameter of the through hole 31. The inner wall of the first convex ring 32 has a circumferential groove 34, and a sealing ring is arranged in the circumferential groove 34; when the cylindrical section 24 of the upper box body 20 is inserted into the through hole 31, the cylindrical section 24 and the inner wall of the first convex ring 32 are sealingly connected through the sealing ring. Through the structure, the risk of the first liquid in the first liquid storage cavity 11 flowing out of the through hole 31 can be avoided.

[0035] In an embodiment of the present application, the lower surface of the main cover body 30 has a second convex ring 33, which also surrounds the through hole 31, and the inner diameter of the second convex ring 33 is adapted to the diameter of the arc-shaped groove on the top of the bracket 12 in the main box body 10. When the main cover body 30 is arranged on the main box body 10, the free end of the second convex ring 33 (i.e. the bottom end of the second convex ring 33) abuts against the bracket 12 and surrounds the arc-shaped groove. Through the structure, the cornea 50 to be preserved in the arc-shaped groove can be limited, and the cornea 50 to be preserved is prevented from falling out of the arc-shaped groove to other positions of the first liquid storage cavity 11 when the cornea preservation device moves. Figure 3

[0036] In an embodiment of the present application, the cornea preservation device can further include an upper cover body 40, and correspondingly, the top of the clamping section 23 has a liquid inlet opening communicating with the second liquid storage cavity 21, and the upper cover body 40 is arranged on the top of the clamping section 23 (for example, by clamping or threaded connection, etc.) and covers the liquid inlet opening. The above-mentioned upper cover body 40 can prevent contaminants (such as dust or other debris) from falling into the second liquid storage cavity 21, and can also prevent the second liquid in the second liquid storage cavity 21 from overflowing when the cornea preservation device moves.

[0037] In an embodiment of the present application, the bracket 12 includes a plurality of shelf plates, which are perpendicularly connected to the bottom of the first liquid storage cavity 11 in a radial manner, and the top of the plurality of shelf plates gradually increases in height from the inside to the outside and forms an arc-shaped groove, and correspondingly, the communication gap is formed by the gap between the shelf plates. Through the above structure, the cornea 50 to be preserved can be well supported.

[0038] ​In particular, the proportion of the communicating holes on the bottom surface of the arc-shaped groove is greater than 70%. Through the structure, the outside surface of the cornea 50 to be preserved in the arc-shaped groove can be in contact with the liquid in the first liquid storage cavity 11 as much as possible while effectively supporting the cornea 50 to be preserved, so that the outside surface of the cornea 50 to be preserved remains active.

[0039] The above merely describes a preferred specific embodiment of the present application, but the protection scope of the present application is not limited to this. Any person skilled in the art can easily think of changes or replacements within the technical range disclosed by the present application, which should be covered in the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A corneal preservation device, characterized by, The application relates to a cornea storage device, which comprises a main box body, an upper box body, a main cover body and an upper cover body. The main box body comprises a first liquid storage cavity with a top opening and a bracket in the first liquid storage cavity, wherein the bracket is provided with an arc-shaped groove matched with the outer surface of a cornea to be stored, and the arc-shaped groove is provided with a communication aperture; the outer surface of the cornea to be stored in the arc-shaped groove is in contact with liquid in the first liquid storage cavity through the communication aperture. The upper box body comprises a second liquid storage cavity with a bottom opening and an elastic film surrounding the bottom opening, wherein the bottom of the elastic film is matched with the shape of the edge of the inner surface of the cornea to be stored, and the upper box body is arranged above the bracket in the main box body with the elastic film attached to the edge of the inner surface of the cornea to be stored in the arc-shaped groove; the inner surface of the cornea to be stored in the arc-shaped groove is in contact with liquid in the second liquid storage cavity through the bottom opening.

2. The corneal preservation device of claim 1, wherein, The cornea storage device comprises a main cover body for covering the top opening of the first liquid storage cavity, wherein the main cover body is provided with a through hole, and the through hole is located directly above the arc-shaped groove of the bracket when the main cover body is arranged in the main box body; the upper box body is arranged in the main cover body with the bottom penetrating through the through hole.

3. The corneal preservation device of claim 2, wherein, The upper box body comprises a clamping section and a columnar section made of hard material, the second liquid storage cavity extends from the clamping section to the columnar section, and the bottom opening of the second liquid storage cavity is located at the bottom of the columnar section; the clamping section, the columnar section and the elastic film are connected axially in sequence, the radial dimension of the clamping section is larger than that of the through hole, the radial dimensions of the columnar section and the elastic film are both smaller than that of the through hole, and when the upper box body is arranged in the main cover body, the clamping section is located above the main cover body, and the columnar section and the elastic film penetrate through the through hole into the first liquid storage cavity of the main box body.

4. The corneal preservation device of claim 3, wherein, The through hole is circular, the radial cross sections of the clamping section, the columnar section and the elastic film are all circular rings, and the outer diameter of the columnar section is matched with the diameter of the through hole.

5. The corneal preservation device of claim 4, wherein, The main cover body is provided with a first convex ring surrounding the through hole, the inner wall of the first convex ring is provided with a circumferential groove, and a sealing ring is arranged in the circumferential groove; when the columnar section is inserted into the through hole, the columnar section and the inner wall of the first convex ring are sealingly connected through the sealing ring.

6. The corneal preservation device of claim 4, wherein, The lower surface of the main cover body is provided with a second convex ring surrounding the through hole, and when the main cover body is arranged in the main box body, the free end of the second convex ring abuts against the bracket and surrounds the arc-shaped groove.

7. The corneal preservation device of claim 3, wherein, The cornea storage device comprises an upper cover body, the top of the clamping section is provided with a liquid adding opening connected with the second liquid storage cavity, and the upper cover body is arranged on the top of the clamping section and covers the liquid adding opening.

8. The corneal preservation device of claim 1, wherein, The elastic film is in the shape of a cylinder with the bottom inwardly contracted, and the size of the bottom of the elastic film in contact with the edge of the cornea to be stored is less than one fifth of the radial dimension of the cornea.

9. The corneal preservation device of claim 1, wherein, The bracket comprises a plurality of shelf plates, the plurality of shelf plates are perpendicularly connected to the bottom of the first liquid storage cavity in a radial manner, the top of each of the plurality of shelf plates gradually increases in height from the inner side to the outer side and forms the arc-shaped groove, and the communication aperture is formed by the gap between the shelf plates.

10. The corneal preservation device of claim 9, wherein, The ratio of the communicating holes on the bottom surface of the arc-shaped groove is greater than 70%; and the main box body comprises a heat preservation cavity arranged around the first liquid storage cavity.

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