Blood transfusion apparatus matched with disposable platelet bacteria inactivation device

Abstract

The utility model discloses a blood transfusion apparatus matched with a disposable platelet bacteria inactivation device, comprising: a blind end catheter provided with a plurality of strands which are converged into the same pipeline and can be connected with a platelet bag to be collected through sterile connection; the multiple strands of blind-end catheters are connected to the input end of the collection bag after being converged into the same pipeline, and the collection bag is used for converging platelets; the output end of the collection bag is connected to the input end of the illumination plate through a pipeline, and the platelets flow through the illumination plate and are subjected to bacterium illumination inactivation treatment; the output end of the illumination plate is connected to the input end of the storage bag through a pipeline, and the storage bag is used for storing the platelets subjected to bacteria illumination inactivation treatment and clinical platelets infusion. The platelet bacteria inactivation light treatment device can prevent blood safety from being affected by cross infection of platelets in the treatment process, is matched with a medical platelet bacteria inactivation device for use, and realizes platelet bacteria inactivation light treatment with high efficiency and accurate control of light dose.

Description

TECHNICAL FIELD

[0001] The present application relates to platelet bacterial inactivation equipment, in particular to a blood transfusion equipment matched with a disposable platelet bacterial inactivation device. BACKGROUND

[0002] Platelet transfusion is a very important treatment method in clinic, which can be used for treating platelet reduction caused by various diseases, and for preoperative platelet elevation, coagulation dysfunction and patients with massive blood transfusion. However, the current platelet bacterial contamination situation is not optimistic. There are mainly two methods for preparing platelets. One is to collect platelets by manual mixing method. The manual platelets need to be mixed and collected from multiple people at one time, and the mixed and collected process has a high bacterial contamination rate, which is more likely to cause bacterial contamination. The other method is machine collection of platelets, which is set according to the platelet count of the blood donor before blood donation. The quality is more stable, and the risk of contamination is smaller than that of manual platelets. However, any blood product can be contaminated by bacteria, and platelets are particularly susceptible to bacterial contamination. Because platelets cannot be frozen and stored, in order to maintain physiological function, platelets must be stored in a constant temperature oscillation box at 22±2℃, and the rich nutrition of platelets also benefits the growth of bacteria. Once contaminated, bacteria will quickly reproduce in it. If the patient is transfused with bacteria-contaminated blood, the patient will have chills, fever, hypotension, nausea, vomiting, and even shock within a short period of time, which can cause bacteremia and lead to a high risk of clinical platelet transfusion therapy.

[0003] Platelets are a clinically scarce medical resource. Bacterial culture is currently considered an effective detection method before platelets are used in clinic. However, bacterial culture has true and false positive reactions. In order to reduce platelet bacterial contamination, reduce adverse reactions of blood transfusion, reduce platelet bacterial culture false positives, and reduce unnecessary platelet waste, new platelet bacterial inactivation technology has emerged. Light irradiation is one of the effective bacterial inactivation technologies. Irradiation of blood and blood components with light of a certain wavelength can cause obstacles to the replication of bacterial nucleic acids and protein synthesis, thereby achieving bacterial inactivation.

[0004] In the existing light irradiation treatment technology, a plastic blood bag suitable for light penetration of a certain wavelength is usually used to contain the treated blood and blood components for bacterial light irradiation inactivation. This method has strict requirements for the liquid thickness of the treated blood and the light transmittance of the plastic blood bag, and requires a long light irradiation inactivation time. However, long time irradiation can cause damage to the effective components of blood components and blood products.

[0005] More importantly, using plastic blood bags to contain the blood to be treated, the blood inside the bag can not be irradiated or insufficiently irradiated, affecting the bacteria inactivation effect. Even by shaking, shaking method, cannot guarantee the whole blood loaded controllable, quantitative irradiation, easy to affect the effect of bacteria inactivation. Utility model content

[0006] The utility model discloses a kind of disposable platelet bacteria inactivation device supporting blood transfusion equipment, avoid blood cross infection in the process of treatment to affect blood safety, while realizing the light treatment of high efficiency, light dose accurate control.

[0007] To achieve the above object, the utility model provides the following technical scheme.

[0008] The application embodiment discloses a kind of disposable platelet bacteria inactivation device supporting blood transfusion equipment, comprising:

[0009] Blind-end conduit is provided with multiple strands and converges into the same pipeline, is connected to the platelet bag to be converged by sterile connecting pipe machine;

[0010] Converged bag, multiple strands of the blind-end conduit converge into the same pipeline and are connected to the input end of the converged bag, for collecting converged platelets;

[0011] Illumination plate, the output end of the converged bag is connected to the input end of the illumination plate through the pipeline, the illumination plate is the pipeline structure of light-transmitting material, and the platelets flow through the illumination plate to receive bacterial light inactivation treatment;

[0012] Storage bag, the output end of the illumination plate is connected to the input end of the storage bag through the pipeline, and the storage bag is used to store the platelets after bacterial light inactivation and clinical platelet transfusion.

[0013] Preferably, in the above-mentioned disposable platelet bacteria inactivation device supporting blood transfusion equipment, a sample bag is connected to the pipeline between the illumination plate and the storage bag.

[0014] Preferably, in the above-mentioned disposable platelet bacteria inactivation device supporting blood transfusion equipment, the first flow-stopping clamp is arranged on the pipeline into which multiple strands of the blind-end conduit converge.

[0015] Preferably, in the above-mentioned disposable platelet bacteria inactivation device supporting blood transfusion equipment, the second flow-stopping clamp is arranged on the pipeline between the converged bag and the illumination plate.

[0016] Preferably, in the above-mentioned disposable platelet bacteria inactivation device supporting blood transfusion equipment, the third flow-stopping clamp is arranged on the pipeline to the sample bag.

[0017] Preferably, in the blood transfusion device matched with the disposable platelet bacterial inactivation device, the input end and the output end of the collecting bag are arranged at the top end of the collecting bag.

[0018] Preferably, in the blood transfusion device matched with the disposable platelet bacterial inactivation device, the light irradiation plate is a flat plate with a serpentine pipeline structure, the input end of the light irradiation plate is arranged at the top of the light irradiation plate, and the output end is arranged at the bottom of the light irradiation plate.

[0019] Preferably, in the blood transfusion device matched with the disposable platelet bacterial inactivation device, the storage bag is made of special PVC film material, has good air permeability, and meets the storage requirements of the physiological cycle of platelets.

[0020] Compared with the prior art, the utility model discloses a pipeline, light irradiation plate, blood bag (collecting bag, storage bag, sample bag) composition. One of the core parts is the blind end catheter of multiple strands, and each single blind end catheter can be sterilely connected with a portion of platelets to be collected, thereby reducing the risk of cross contamination during collection. The second core part is a light irradiation plate made of special light-transmitting material. Here, the platelets receive the irradiation of short-wave ultraviolet light to kill possible bacteria. The third core part is a storage bag made of special PVC film material, which has good air permeability and meets the storage requirements of the physiological cycle of platelets. Under the specified conditions, the storage performance of the platelets is guaranteed. The complete set of equipment forms a closed path, which prevents bacterial contamination and is matched with medical platelet bacterial inactivation equipment. The accurate light irradiation dose of all platelets to be treated is controlled, and the safe and efficient bacterial inactivation effect is achieved. BRIEF DESCRIPTION OF DRAWINGS

[0021] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed in the embodiment or prior art description will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments described in the present application, and those skilled in the art can also obtain other drawings according to these drawings without creating any creative labor.

[0022] Figure 1 The figure shows the schematic diagram of the blood transfusion device matched with the disposable platelet bacterial inactivation device in the embodiment of the utility model. DETAILED DESCRIPTION

[0023] With reference to the accompanying drawings, the technical solutions in the embodiments of the present application will be described in detail. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without creative efforts fall within the scope of the present application.

[0024] In combination Figure 1 As shown in the drawings, the blood transfusion device 100 matched with the disposable platelet bacterial inactivation device includes:

[0025] The blind-end catheter 101 is provided with multiple strands and is connected to the platelet bag to be collected through a sterile connecting pipe machine.

[0026] The collecting bag 102 is connected to the input end of the collecting bag 102 after the multiple blind-end catheters 101 are merged into the same pipeline, and is used for collecting the merged platelets.

[0027] The light board 103 is connected to the input end of the light board 103 through the pipeline, the light board 103 is a pipeline structure made of a light-transmitting material, and the platelets flow through the light board 103 to receive the bacterial light inactivation treatment.

[0028] The storage bag 104 is connected to the input end of the storage bag 104 through the pipeline, the storage bag 104 is made of a special PVC film material, has good air permeability, meets the storage requirements of the physiological cycle of platelets, and is used for storing the platelets after the bacterial light inactivation and clinical platelet transfusion.

[0029] The pipeline between the light board 103 and the storage bag 104 is connected with the sample bag 105.

[0030] The first flow-stopping clamp 106 is arranged on the pipeline into which the multiple blind-end catheters 101 are merged. The second flow-stopping clamp 107 is arranged on the pipeline between the collecting bag 102 and the light board 103. The third flow-stopping clamp 108 is arranged on the pipeline branched to the sample bag 105. The input end and the output end of the collecting bag 102 are both arranged at the top end thereof. The light board 103 is a flat plate with a serpentine pipeline structure, the input end of the light board 103 is located at the top thereof, and the output end is located at the bottom thereof.

[0031] In the embodiment, the present application is applied to the collection and bacterial inactivation of manual platelets, and the following steps are used for processing in the specific implementation.

[0032] Preparation before use:

[0033] (1) The platelets to be collected are taken from a blood bank.

[0034] (2) Before using the product, please check the package bag for any damage, whether it is within the shelf life, and whether the package bag has been opened. If any of the above conditions are not met, the product should not be used.

[0035] (3) Open the package bag.

[0036] Manual platelet pooling:

[0037] (1) Close all the flow stoppers on the equipment, and connect the blind end catheter with the platelet bag to be pooled using a sterile connection machine.

[0038] (2) Place the platelet bag to be pooled at a high position to form a pressure difference with the pooling bag, and open the first flow stopper.

[0039] (3) Pool the platelets into the pooling bag.

[0040] Irradiation process:

[0041] (1) Close the first flow stopper or heat seal the waste multi-blind end catheter part, hang the pooling bag to be treated on the top hook of the matching "medical platelet bacterial inactivation cabinet"; the pipeline of the input end of the irradiation plate is clamped into the flow rate control socket corresponding to the top hook number; the irradiation plate is inserted into the irradiation position corresponding to the top hook number; the pipeline of the output end of the irradiation plate naturally droops, and the storage bag and the sample bag are placed flat on the bottom of the inactivation cabinet in the corresponding oscillation frame.

[0042] (2) Open the second flow stopper, and start the "medical platelet bacterial inactivation cabinet" to perform irradiation inactivation according to the set program.

[0043] (3) After the irradiation inactivation is completed, the platelets flow into the storage bag.

[0044] (4) Take out all the kits, heat seal the pipeline of the output end of the irradiation plate, discard the pooling bag and the irradiation plate, and place the storage bag and the sample bag in the platelet special storage box for storage according to the relevant requirements.

[0045] (5) When sampling and detection are needed, the third flow stopper can be opened to collect the detection sample from the storage bag to the sample bag, and the input end catheter of the storage bag is heat sealed after sampling is completed.

[0046] (6) The storage bag loaded with bacterial inactivated platelets can be directly transfused in clinic.

[0047] In example two, the present application is applied to the bacterial inactivation of machine-collected platelets, and the specific processing steps are as follows,

[0048] Preparation before use:

[0049] (1) Collect machine-collected platelets from the blood bank.

[0050] (2) Before using the product, please check the package for any damage, whether it is within the shelf life, and whether the package has been opened. If any of the above conditions are not met, the product should not be used.

[0051] (3) Open the package.

[0052] Specific use:

[0053] Close all flow clamps on the equipment, and connect the input conduit of the illumination plate to the platelet collection bag using a sterile connection machine. Discard the blind end conduit and the collection bag.

[0054] Illumination process:

[0055] (1) Hang the platelet collection bag to be treated on the top hook of the "medical platelet bacterial inactivation cabinet" used in conjunction. The input conduit of the illumination plate is inserted into the flow rate control socket corresponding to the top hook number. The illumination plate is inserted into the illumination position corresponding to the top hook number. The output conduit of the illumination plate naturally droops, and the storage bag and the sample bag are placed flat on the bottom of the inactivation cabinet.

[0056] (2) Open the second flow clamp and start the "medical platelet bacterial inactivation cabinet" according to the set program for illumination and inactivation.

[0057] (3) After the illumination and inactivation is completed, the platelets flow into the storage bag.

[0058] (4) Remove all the kits, heat seal the output conduit of the illumination plate, discard the platelet collection bag and the illumination plate, and place the storage bag and the sample bag in the platelet storage box for storage according to the relevant requirements.

[0059] (5) When sampling and testing are required, open the third flow clamp to collect the sample from the storage bag to the sample bag. After sampling is completed, heat seal the input conduit of the storage bag.

[0060] (6) The storage bag containing the bacterial inactivated platelets can be used for direct infusion in the clinic.

[0061] The utility model discloses a blood platelet collection device, which is composed of a pipeline, an illumination plate and a blood bag (a collection bag, a storage bag and a sample bag). One of the core parts is a multi-strand blind-end catheter. Each single-strand blind-end catheter can be connected to a portion of blood platelets to be collected in a sterile manner, thereby reducing the risk of cross contamination during collection. The second core part is the illumination plate, which is made of special light-transmitting material. Here, the blood platelets are irradiated by short-wave ultraviolet light to kill possible bacteria. The third core part is the storage bag, which is made of special PVC film material and has good air permeability, thereby meeting the storage requirements of the physiological cycle of blood platelets and ensuring the storage performance of the blood platelets under specified conditions. The complete set of equipment forms a closed path, which prevents bacterial contamination and is used in combination with a medical blood platelet bacterial inactivation device to accurately control the light irradiation dose of all blood platelets to be treated, thereby achieving safe and efficient bacterial inactivation effect.

[0062] It should be noted that the relational terms herein such as first and second and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any such actual relationship or order between such entities or actions. Moreover, the terms "comprises", "comprising", or any other variations thereof, are intended to cover a non-exclusive inclusion such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but can include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element preceded by "comprises... a" does not, without more constraints, foreclose the existence of additional identical elements in the process, method, article, or apparatus that comprises the recited element.

[0063] The above description is only a specific embodiment of the present application. It should be noted that for those skilled in the art, without departing from the principles of the present application, a number of improvements and refinements can be made, which should also be considered as the protection scope of the present application.

Claims

1. A blood platelet bacterial inactivation device disposable blood transfusion set, characterized in that, The application relates to a platelet collection device, which comprises: a blind-end catheter provided with multiple strands and connected to platelet bags to be collected through a sterile connecting machine; a collecting bag connected to the input end of the collecting bag after the multiple strands of the blind-end catheter are merged into the same pipeline and used for collecting the merged platelets; an illumination plate, the output end of the collecting bag is connected to the input end of the illumination plate through a pipeline, the illumination plate is a pipeline structure made of a light-transmitting material, and the platelets flow through the illumination plate to receive bacterial light illumination inactivation treatment; a storage bag, the output end of the illumination plate is connected to the input end of the storage bag through a pipeline, and the storage bag is used for storing the platelets after bacterial light illumination inactivation and clinical platelet transfusion.

2. The blood transfusion apparatus for single use platelet bacterial inactivation device according to claim 1, wherein A sample bag is connected to the pipeline between the illumination plate and the storage bag through a branch pipeline.

3. The blood transfusion apparatus for single use platelet bacterial inactivation device according to claim 1, wherein The first flow-stopping clamp is arranged on the pipeline into which the multiple strands of the blind-end catheter are merged.

4. The blood transfusion apparatus for single use platelet bacterial inactivation device according to claim 1, wherein The second flow-stopping clamp is arranged on the pipeline between the collecting bag and the illumination plate.

5. The blood transfusion apparatus for single use platelet bacterial inactivation device according to claim 2, wherein The third flow-stopping clamp is arranged on the pipeline branched to the sample bag.

6. The blood transfusion apparatus for single use platelet bacterial inactivation device according to claim 1, wherein The input end and the output end of the collecting bag are both arranged on the top end of the collecting bag.

7. The blood transfusion apparatus for single use platelet bacterial inactivation device according to claim 1, wherein The illumination plate is a flat plate with a serpentine pipeline structure, the input end of the illumination plate is located at the top of the flat plate, and the output end is located at the bottom of the flat plate.

8. The blood transfusion apparatus for single use platelet bacterial inactivation device according to claim 1, wherein The storage bag is made of special PVC film material and has good air permeability, which meets the storage requirements of the physiological cycle of platelets.

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