Fixing table suitable for animal functional ultrasonic imaging

Abstract

The utility model discloses a fixing table suitable for animal function ultrasonic imaging, which comprises a bottom plate, a plurality of fixing plates and a plurality of fixing plates, and the bottom plate extends along the length direction of an animal to be detected; the transverse positioning assembly is movably arranged on the bottom plate, and a limiting space is formed by the transverse positioning assembly; the longitudinal positioning assemblies are perpendicular to the transverse positioning assemblies, the longitudinal positioning assemblies are movably arranged on the two sides of the bottom plate, and positioning spaces are formed by the longitudinal positioning assemblies and used for positioning the neck and the tail of the animal to be detected respectively. The abdomen of an animal to be detected is limited through the transverse positioning assembly, the head and the tail of the animal to be detected are limited through the longitudinal positioning assembly, and a plurality of animals to be detected in the same batch use the same limiting space, so that standardized body position placement is realized, and the influence of body position change on a B-ultrasonic detection image is reduced.

Description

Technical Field

[0001] This utility model relates to a stationary stage suitable for functional ultrasound imaging of animals. Background Technology

[0002] In vivo imaging of mice is an important experimental technique in basic research. In vivo imaging not only displays the functional state of experimental animals in real time and reflects their timely response to stimuli, but also allows for repeated observation of the same individual to record the progression of disease or the effects of drug treatment.

[0003] Functional ultrasound imaging (fUSI) is a relatively new technology that includes ultrasound localization microscopy and ultrafast ultrasound. It features high spatiotemporal resolution, high sensitivity, and dynamic monitoring, enabling the detection of target organ function under non-invasive or minimally invasive conditions. However, a suitable mouse immobilization device is currently lacking for this technology. While this technology was introduced relatively early in neurological research, and related patents exist for immobilization devices applied to the mouse head, a suitable immobilization device is still lacking for imaging of thoracic and abdominal organs. This patent designs a immobilization device for functional ultrasound imaging of abdominal organs in mice, optimizing the immobilization of mice of different sizes and positions from multiple angles, as well as addressing the accuracy of repeated imaging localization. Utility Model Content

[0004] The technical problem this invention aims to solve is the inaccurate positioning of the animals being tested due to their struggles or the varying sizes of animals from the same batch.

[0005] The present invention solves the above-mentioned technical problems through the following technical solution:

[0006] A stage suitable for functional ultrasound imaging in animals, the stage comprising:

[0007] A base plate that extends along the length of the animal to be tested;

[0008] A lateral positioning component is movably disposed on the base plate, and the lateral positioning component forms a limiting space.

[0009] A longitudinal positioning component is provided, which is perpendicular to the transverse positioning component. The longitudinal positioning component is movably disposed on both sides of the base plate, forming a positioning space to locate the neck and tail of the animal to be tested.

[0010] In this technical solution, the lateral positioning component restricts the abdomen of the animal to be tested, and the longitudinal positioning component restricts the head and tail of the animal to be tested. Multiple animals to be tested in the same batch use the same limiting space, thereby achieving standardized body positioning and reducing the impact of body position changes on ultrasound images.

[0011] Preferably, the lateral positioning component includes:

[0012] An adjustable slide table, wherein the base plate is provided with a mounting groove, and the adjustable slide table is disposed in the mounting groove;

[0013] A positioning plate is connected to the movable part of the adjustable slide, and the positioning plate extends in a direction away from the base plate.

[0014] Preferably, the lateral positioning component includes:

[0015] An abutment plate is disposed on the base plate, and the abutment plate is disposed opposite to the positioning plate, forming the limiting space between the abutment plate and the positioning plate.

[0016] Preferably, the adjustable slide and the positioning plate include multiple components, wherein at least two of the positioning plates are arranged opposite to each other, and the limiting space is formed between the two oppositely arranged positioning plates.

[0017] Preferably, the two positioning plates that are positioned opposite each other are at the same horizontal height.

[0018] Preferably, the lateral positioning component includes:

[0019] A front fixing plate is detachably connected to the base plate, the front fixing plate extends in a direction away from the base plate, and a limiting groove is formed between the front fixing plate and the base plate;

[0020] The rear positioning assembly includes a rear fixed plate and an adjustable slide. The base plate is provided with a fixing groove, the adjustable slide is disposed in the fixing groove, the rear fixed plate is connected to the movable part of the adjustable slide, and the rear fixed plate is provided with a through hole.

[0021] Preferably, there are multiple front fixing plates, and the multiple limiting grooves have different sizes.

[0022] Preferably, the rear fixing plate includes a horizontal portion and a vertical portion, the horizontal portion being connected to the sliding portion of the slide table, and the vertical portion having the through hole.

[0023] Preferably, the front fixing plate is L-shaped, the limiting groove is provided on the vertical plate of the front fixing plate, the positioning hole is provided on the bottom surface of the horizontal part of the front fixing plate, and the mounting hole is provided on the bottom plate, the positioning hole and the mounting hole cooperate with each other.

[0024] Preferably, the adjustable slide is provided with a scale.

[0025] The positive and progressive effects of this utility model are as follows:

[0026] The abdomen of the animal to be tested is restricted by a lateral positioning component, and the head and tail of the animal to be tested are also restricted by a lateral positioning component. Multiple animals to be tested in the same batch use the same restricted space, thereby achieving standardized body positioning and reducing the impact of body position changes on ultrasound images. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the structure of a fixed stage for animal functional ultrasound imaging according to an embodiment of the present invention.

[0028] Figure 2 for Figure 1 The diagram shows a structural schematic of a fixation stage suitable for functional ultrasound imaging of animals at other angles.

[0029] Figure 3 An exploded view of the fixation stage for animal functional ultrasound imaging shown in Figure 1.

[0030] Figure 4 Figure 1 shows a schematic diagram of the rear fixation plate structure of a fixation stage suitable for animal functional ultrasound imaging.

[0031] Figure 5 This is a schematic diagram of the fixture for animal functional ultrasound imaging, shown in Figure 1, from another angle.

[0032] Explanation of reference numerals in the attached figures

[0033] Base plate 1

[0034] Adjustable slide 2

[0035] Mounting slot 3

[0036] Positioning plate 4

[0037] Front fixing plate 5

[0038] Limiting groove 6

[0039] Rear fixing plate 7, horizontal part 71, vertical part 72

[0040] Fixed slot 8

[0041] Through hole 9

[0042] Positioning hole 10

[0043] Mounting hole 11 Detailed Implementation

[0044] The present invention will be further illustrated by way of embodiments below, but the present invention is not limited to the scope of the embodiments described herein.

[0045] like Figure 1 and Figure 2 As shown, this utility model discloses a fixed stage suitable for animal functional ultrasound imaging. The fixed stage includes a base plate 1, a lateral positioning component, and a longitudinal positioning component. The base plate 1 extends along the length of the animal to be examined. The lateral positioning component is movably mounted on the base plate 1, forming a limiting space for restricting the abdomen of the animal to be examined. The longitudinal positioning component is perpendicular to the lateral positioning component and movably mounted on both sides of the base plate 1, forming a positioning space for positioning the neck and tail of the animal to be examined, respectively. By restricting the abdomen of the animal to be examined by the lateral positioning component and restricting the head and tail by the longitudinal positioning component, multiple animals in the same batch can use the same limiting space, thereby achieving standardized body positioning and reducing the impact of body position changes on the ultrasound images.

[0046] The tops of both the lateral and longitudinal positioning components contain gas anesthesia platforms for easy maintenance of anesthesia in the animal being tested. The bottoms of both components have animal tail platforms for convenient injection of microbubble contrast agents via the tail vein.

[0047] like Figure 1 and Figure 3 As shown, in this embodiment, the lateral positioning component includes an adjustable slide 2 and a positioning plate 4. A mounting groove 3 is provided on the left side of the base plate 1, and the adjustable slide 2 is fixedly installed in the mounting groove 3 on the left side of the base plate 1. The positioning plate 4 includes a left positioning plate and a right positioning plate. The left positioning plate is installed on the left side of the base plate 1, and the movable part of the left positioning plate is connected to the adjustable slide 2. By adjusting the adjustable slide 2, the position of the left positioning plate can be adjusted laterally. The inner side and upper surface of the left positioning plate are flat and perpendicular to each other. The right positioning plate is similar to the left positioning plate, installed on the right side of the base plate 1, and its movement is controlled by the adjustable slide 2 on the right side.

[0048] In other embodiments, there are multiple adjustable slides 2 and positioning plates 4, with at least two positioning plates 4 arranged opposite each other, forming a limiting space between the two oppositely arranged positioning plates 4. The horizontal heights of the two oppositely arranged positioning plates 4 are the same.

[0049] In other embodiments, the lateral positioning component includes one of a left positioning plate and a right positioning plate, as well as an abutment plate. The abutment plate is disposed on the base plate 1, and is disposed opposite to the left or right positioning plate, forming a limiting space between the abutment plate and the left or right positioning plate.

[0050] The limiting space formed in various embodiments not only assists in fixing the animal to be tested, but also limits the application height of the ultrasound coupling agent, ensuring the stability and repeatability of imaging.

[0051] During the examination, the ultrasound probe slides against the upper surface of the positioning plate 4. The upper surface is flat, which makes it easy to control the vertical distance between the ultrasound probe and the abdomen of the animal being examined.

[0052] In this embodiment, the left positioning plate and the right positioning plate respectively define the lateral positions of the left and right sides of the animal to be tested. The left positioning plate and the right positioning plate together form a limiting space, which limits the left and right movement of the animal to be tested, thereby facilitating the standardized positioning of ultrasound detection.

[0053] In this embodiment, the adjustable slide 2 is equipped with a scale, which records the adjusted distance. Both the lateral and longitudinal positioning components have coordinate values, making the fixed position below the neck of the animal under test essentially repeatable. Simultaneously, the four corners of the lateral and longitudinal positioning components have holes, allowing them to be relatively fixed to the stage and the stepper holding the ultrasound probe on the stage. Therefore, for two-dimensional imaging ultrasound technology, relatively stable tracking of the abdominal imaging plane of the same mouse can be achieved.

[0054] like Figure 1 and Figure 4 As shown, the left and right positioning plates are at the same height and lie in the same plane. This plane is higher than the height of the animal's torso. The ultrasound probe rests against the upper surface of the positioning plate 4, allowing the distance between the ultrasound probe and the mouse's abdomen to remain constant. Simultaneously, the ultrasound probe can slide freely on the upper surface of the positioning plate 4, thus detecting different target areas.

[0055] like Figure 1 and Figure 2 As shown, the longitudinal positioning assembly includes a front fixing plate 5, a rear fixing plate 7, and an adjustable slide 2. The front fixing plate 5 extends away from the base plate 1. The front fixing plate 5 is L-shaped, and a limiting groove 6 is provided on the vertical plate of the L-shape. The limiting groove 6 is U-shaped and is used to fix the neck of the animal to be tested. The horizontal portion 71 of the L-shaped plate abuts against the base plate 1 and is detachably connected to the base plate 1. The bottom surface of the horizontal portion 71 is provided with a positioning hole 10, which can cooperate with the mounting hole 11 on the base plate 1, so that the horizontal portion 71 of the L-shaped plate is connected to the base plate 1. In this embodiment, the positioning hole 10 on the bottom surface of the horizontal portion 71 is magnetically connected to the base plate 1.

[0056] In this embodiment, as Figure 1 and Figure 2 As shown, there are multiple anterior fixation plates 5, each with a different upper limit groove 6 size. Different anterior fixation plates 5 can be selected according to the neck size of the animal to be tested. The designed dimensions allow for multiple body positions of the animal to be tested, including supine, lateral, and prone positions. Furthermore, by moving the tail slide, it is possible to fix animals of different ages and body lengths to be tested.

[0057] In this embodiment, as Figure 1 and Figure 2 As shown, the rear positioning assembly includes a rear fixing plate 7 and an adjustable slide 2. The adjustable slide 2 is fixedly installed in the fixing groove 8 of the base plate 1. The rear fixing plate 7 includes a horizontal part and a vertical part. The horizontal part is connected to the sliding part of the adjustable slide 2 and can be adjusted back and forth with the adjustable slide 2. A through hole 9 is provided on the vertical part for the tail of the animal to be tested to pass through, which facilitates the injection of microbubble contrast agent through the tail vein.

[0058] During use, the animal to be tested is first anesthetized. Then, the animal is laid flat or sideways on the base plate 1, with its torso parallel to the length of the base plate 1. The front fixing plate 5 is fixed to the base plate 1 from top to bottom, and the limiting groove 6 secures the animal's neck, thus positioning the animal's head. The left and right adjustable slides 2 are adjusted so that the left and right positioning plates 4 are against the torso of the animal. The rear positioning assembly is adjusted so that the rear fixing plate 7 is against the rump of the animal. After adjusting all the fixing plates, the position scale of each fixing plate is recorded. This state represents a standard limiting and positioning space. Multiple animals in the same batch use the same limiting and positioning space, thus achieving standardized body positioning and reducing the impact of body position changes on ultrasound images.

[0059] In this embodiment, the animal to be tested can be a mouse.

[0060] While specific embodiments of this utility model have been described above, those skilled in the art should understand that these are merely illustrative examples, and the scope of protection of this utility model is defined by the appended claims. Those skilled in the art can make various changes or modifications to these embodiments without departing from the principles and essence of this utility model, but all such changes and modifications fall within the scope of protection of this utility model.

Claims

1. A fixation table suitable for functional ultrasound imaging of an animal, characterized in that, The fixing table suitable for functional ultrasonic imaging of animals comprises: a bottom plate extending along the length direction of the animal to be detected; a transverse positioning assembly movably arranged on the bottom plate, the transverse positioning assembly forming a limiting space; a longitudinal positioning assembly arranged perpendicularly to the transverse positioning assembly, the longitudinal positioning assembly movably arranged on both sides of the bottom plate, the longitudinal positioning assembly forming a positioning space for positioning the neck and tail of the animal to be detected respectively.

2. The fixation table suitable for functional ultrasound imaging of animals according to claim 1, characterized in that, The transverse positioning assembly comprises: an adjustable sliding table, the bottom plate being provided with a mounting groove, the adjustable sliding table being arranged in the mounting groove; a positioning plate connected with the movable part of the adjustable sliding table, the positioning plate extending away from the bottom plate.

3. The fixation table suitable for functional ultrasound imaging of animals according to claim 2, characterized in that, The transverse positioning assembly comprises: an abutting plate arranged on the bottom plate, the abutting plate being arranged opposite to the positioning plate, the limiting space being formed between the abutting plate and the positioning plate.

4. The fixation stand for functional ultrasound imaging of animals according to claim 2, characterized in that The adjustable sliding table and the positioning plate comprise a plurality of positioning plates, at least two of which are arranged opposite to each other, the limiting space being formed between the two opposite positioning plates.

5. The fixation table suitable for functional ultrasound imaging of animals according to claim 4, characterized in that, The two opposite positioning plates have the same horizontal height.

6. The fixation stand for functional ultrasound imaging of animals according to claim 2, characterized in that The longitudinal positioning assembly comprises: a front fixing plate detachably connected to the bottom plate, the front fixing plate extending away from the bottom plate, the limiting groove being formed between the front fixing plate and the bottom plate; a rear positioning assembly comprising a rear fixing plate and an adjustable sliding table, the bottom plate being provided with a fixing groove, the adjustable sliding table being arranged in the fixing groove, the rear fixing plate being connected with the movable part of the adjustable sliding table, the rear fixing plate being provided with a through hole.

7. The fixation table suitable for functional ultrasound imaging of animals according to claim 6, characterized in that, The front fixing plate is a plurality of fixing plates, the limiting grooves of the plurality of fixing plates having different sizes.

8. The fixation table suitable for functional ultrasound imaging of animals according to claim 6, characterized in that, The rear fixing plate comprises a horizontal part and a vertical part, the horizontal part being connected with the sliding part of the sliding table, the through hole being arranged on the vertical part.

9. The fixation table suitable for functional ultrasound imaging of animals according to claim 6, characterized in that, The front fixing plate is L-shaped, the limiting groove being arranged on the vertical plate of the front fixing plate, the positioning hole being arranged on the bottom surface of the horizontal part of the front fixing plate, the mounting hole being arranged on the bottom plate, the positioning hole and the mounting hole being matched with each other.

10. The fixation stand for functional ultrasound imaging of animals according to claim 2, characterized in that The adjustable sliding table is provided with a scale.

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