Visible component detecting and accommodating device and detecting device

Abstract

The visible component detection accommodating device and the detection device comprise a detection part A and a detection part E; the detection part A comprises a cavity A, the cavity A is used for accommodating a sample A, the cavity A is used for shooting a microscopic magnification image of the microscopic examination sample, and the microscopic magnification image is used for visible component analysis; the detection part E comprises a cavity E; the cavity E is used for accommodating a sample E for static layering; the hierarchical information of the sample E is used to calculate the volume of the component in the visible component. The detecting device is matched with the visible component detecting and accommodating device; comprising a microscopic amplification digital imaging assembly and a layered detection assembly, the microscopic magnification digital imaging assembly is used for shooting a microscopic magnification image of the microscopic examination sample; obtaining an image of the sample in the cavity A for visible component analysis; the layering detection assembly is used for obtaining layering information of the sample E.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of medical equipment, and particularly relates to a formed component detection container and a detection device. BACKGROUND

[0002] Medical detection analysis devices include various instruments, which can be classified in various ways according to functions or detection principles, such as:

[0003] Type A: detection devices based on optical reaction characteristics of samples, such as flow cytometers, biochemical analysis instruments, etc. These devices detect light energy based on the transmission, scattering or absorption characteristics of different substances in the sample, thereby obtaining information such as the composition or content of the corresponding components.

[0004] Type B: detection devices for quantifying and qualitatively detecting trace amounts of immune markers. These devices have complex principles, including enzyme-linked immunosorbent assays, radioimmunoassays, immunoturbidimetric assays, immunofluorescence assays, and chemiluminescence immunoassays. Most of these devices use optical characteristics for detection.

[0005] When patients enter a hospital, they need to undergo various tests using different instruments, which is time-consuming and costly.

[0006] With the development of the pet economy, pet hospitals require more and more high-end instruments, but pet hospitals are sensitive to the cost of instrument investment, and the area of pet hospitals is limited, making it difficult to place more instruments and equipment.

[0007] The applicant has proposed a series of Chinese patents, such as

[0008] 1. CN2020112669290, "Cell analysis method and system and quantitative method and system";

[0009] 2. CN2022104799126, "Microscopic image acquisition device rapid focusing method and microscopic image detection method";

[0010] 3. CN2023100423151, "Blood imaging analysis system and method".

[0011] A new technical solution is used to measure the content of formed components in a blood sample with the help of artificial intelligence. In the use process, traditional detection items such as blood pressure and blood immunity detection still need other instruments for detection. How to integrate blood pressure or immune detection items in the formed component detection device is a technical problem that needs to be solved by the present application.

[0012] The applicant has also proposed a series of Chinese patents, such as

[0013] 4. CN2020226212835, "Integrated kit";

[0014] 5. CN2020226244056 "Integrated kit";

[0015] 6. CN2020112692418 "Integrated kit".

[0016] These patents propose to integrate the detection site and the reagent containing cavity together, so that the reagent running preservation device and the detection device are fused into one device. However, these devices require high requirements in the process of adding formed components, and the present application further proposes a convenient detection and sampling device. SUMMARY

[0017] The present application proposes a formed component detection and containing device, which includes at least two cavities, cavity A for formed component analysis, and cavity E for containing sample E static stratification, so as to obtain the volume or volume ratio of the corresponding component based on the static stratification.

[0018] The solution of the present application to solve the above technical problems is a formed component detection and containing device, which includes a detection part A and a detection part E; the detection part A includes a cavity A, and the cavity A is used for containing a sample A and is used for shooting a microscopic magnified image of the microscopic sample, and the above-mentioned microscopic magnified image is used for formed component analysis; the detection part E includes a cavity E; the cavity E is used for containing a sample E static stratification; and the stratification information of the sample E is used for calculating the volume of the component in the formed component.

[0019] The detection part E can further include a sampling port E; the cavity E is in communication with the sampling port E; the detection part A further includes a sampling port A; and the cavity A is in communication with the sampling port A.

[0020] The detection part B can further include a cavity B and a sampling port B, and the cavity B is in communication with the sampling port B; the cavity B is used for containing a sample B, and the cavity B is used for optical detection analysis of the sample, and the above-mentioned optical detection analysis is used for biochemical detection analysis or immune detection analysis of the sample B.

[0021] The cavity A can be used for formed component analysis; and the above-mentioned formed component analysis includes any one or more of morphological analysis, biochemical analysis and immune detection analysis.

[0022] The cross section of the sampling port E can be larger than the cross section of the cavity E.

[0023] The sample can be blood, and the stratification information can be used for detecting the hematocrit of the blood.

[0024] The detection part A can further include a sample adding cavity A, a sample adding port A, an exhaust cavity A, and an exhaust port A. The bottom of the sample adding cavity A is communicated with the cavity A, and the sample adding port A is communicated with the sample adding cavity A. The bottom of the exhaust cavity A is communicated with the cavity A, and the exhaust port A is communicated with the exhaust cavity A. The center position of the sample adding cavity A is higher than the center position of the cavity A. The center position of the exhaust cavity A is higher than the center position of the cavity A.

[0025] The detection part C can further include at least one cavity C and a sample adding port C. The cavity C is used for containing a detection reagent. The sample adding port C is upwardly opened, and liquid is added to or taken out from the cavity C through the sample adding port C. The cavity C is used for containing any one of a staining reagent, a biochemical detection reagent, or an immunological detection reagent.

[0026] The cavity heights of the cavities B, C, and E can be consistent.

[0027] The scheme for solving the above technical problem can also be a detection device used in cooperation with a formed component detection and containing device. The detection device includes a microscopic magnification digital imaging assembly and a layered detection assembly. The microscopic magnification digital imaging assembly is used for shooting a microscopic magnification image of a microscope sample. An image of a sample in the cavity A is obtained, and is used for formed component analysis. The layered detection assembly is used for obtaining layered information of the sample E.

[0028] The layered detection assembly can include a camera device. The camera device obtains a photo of the sample E, and obtains the layered information of the sample E through the photo.

[0029] The light in the optical detection assembly irradiates a sample in the cavity B of the external multifunctional detection device. Biochemical detection analysis or immunological detection analysis of the sample is performed according to optical reaction characteristics of the sample. The optical detection assembly includes a light source and a light detection assembly. The light source irradiates the cavity B. The light detection assembly obtains light passing through the cavity B, and obtains optical reaction characteristic information of the sample.

[0030] The technical effect of the above technical scheme is that the cavity A is used for formed component analysis, and the cavity E is used for containing a sample E in a static layered state, thereby providing a basis for more accurate volume ratio calculation.

[0031] The technical effect of the above technical scheme is that the cavity E and the cavity A each have their own sample adding port, which facilitates adding samples in different states or different samples. In some cases, samples with different dilution ratios can be added, thereby facilitating corresponding detection.

[0032] The technical effect of the above technical scheme is that the cavity A is used for formed component analysis, including morphological analysis, biochemical analysis, and immunological detection analysis, and can perform analysis of multiple items, thereby being good in adaptability.

[0033] The technical effects of the above technical solutions are: the cross section of the sample adding port E is larger than the cross section of the cavity E; the sample is conveniently added, the liquid in the cavity E is conveniently collected and layered, and the calculation accuracy is improved.

[0034] The technical effects of the above technical solutions are: the sample is blood, the layering information is used for detecting the hematocrit of the blood, the formed element detection container can be used for microscopic magnified image analysis of the formed elements, and the hematocrit can be accurately calculated.

[0035] The technical effects of the above technical solutions are: the center position of the sample adding cavity A is higher than the center position of the cavity A; the center position of the exhaust cavity A is higher than the center position of the cavity A, which facilitates the flow and paving of the sample in the cavity A.

[0036] The technical effects of the above technical solutions are: the cavity A, that is, the formed element detection cavity, is used for shooting a microscopic magnified image of the microscopic sample, and the cavity B, that is, the optical detection cavity, is used for optical detection and analysis of the sample, so that the detection sample container is suitable for different application scenarios and can also be suitable for comprehensive application scenarios, that is, can be used for microscopic digital imaging analysis of the formed elements and can also be used for biochemical detection and immune detection analysis. The material of the cavity B meets the corresponding optical characteristic requirements and can be glass, sapphire, transparent plastic or other materials with different optical characteristics.

[0037] The technical effects of the above technical solutions are: the detection part C can increase a detection sample containing space like the detection part B.

[0038] The technical effects of the above technical solutions are: the cavity C in the detection part C is used for containing a staining reagent; or the cavity C is used for containing an immune detection reagent or a biochemical detection reagent; and the reagent in the process is provided with a storage space, so that the reagent and the sample container can be integrated.

[0039] The technical effects of the above technical solutions are: the cavity heights of the cavity B, the cavity C and the cavity E are consistent, which facilitates manufacturing and comparison of sample storage volumes between different cavities.

[0040] The technical effects of the above technical solutions are: the detection device can obtain a microscopic magnified image; based on the image, formed element analysis can be performed, and accurate hematocrit calculation can be performed.

[0041] The technical effects of the above technical solutions are: the detection device, while completing formed element analysis and hematocrit calculation, can also perform biochemical detection analysis or immune detection analysis of the sample according to the optical reaction characteristics of the sample. BRIEF DESCRIPTION OF DRAWINGS

[0042] Figure 1 is a schematic block diagram of a detection device;

[0043] Figure 2is a schematic diagram of a detection device;

[0044] Figure 3 is a schematic block diagram of a detection device;

[0045] Figure 4 is a schematic diagram of a detection device;

[0046] Figure 5 is a schematic diagram of a formed component detection containment device;

[0047] Figure 6 is a schematic diagram of a formed component detection containment device;

[0048] Figure 7 is a bottom view schematic diagram of a formed component detection containment device;

[0049] Figure 8 is an exploded view schematic diagram of a formed component detection containment device;

[0050] Figure 9 is a cross-sectional view schematic diagram of a formed component detection containment device;

[0051] Figure 10 is a cross-sectional view schematic diagram of a formed component detection containment device;

[0052] Figure 11 is a cross-sectional view schematic diagram of a formed component detection containment device. DETAILED DESCRIPTION

[0053] The content of the present application will be further described in conjunction with the accompanying drawings.

[0054] It should be noted that the following description is merely exemplary of the application, and is not intended to limit the application since modifications will readily occur to those skilled in the art. Like numbers refer to like elements throughout the drawings and detailed description. Unless otherwise indicated, the drawings and descriptions are not to scale.

[0055] In the description of the present application, it needs to be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, which is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second", and technical features numbered with Arabic numerals 1, 2, 3, etc., and "A" and "B" such numbering, are only for the purpose of description, for the convenience of explanation, and do not represent the chronological or spatial sequence; cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined with "first", "second", and technical features numbered with Arabic numerals 1, 2, 3, etc. can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "several" is two or more, unless otherwise explicitly specified.

[0056] As Figures 1-2 An embodiment of the formed component detection containing device includes a detection part A, a detection part E; the detection part A includes a cavity A, i.e. a formed component detection cavity, the cavity A is used to contain a sample A, the cavity A is used to take a microscopic magnified image for a microscopic sample, and the above-mentioned microscopic magnified image is used for formed component analysis; the detection part E includes a cavity E, i.e. a pressure accumulation detection cavity; the cavity E is used to contain a sample E static stratification; the stratification information of the sample E is used to calculate the volume of the components in the formed component.

[0057] As Figure 5 The detection part E further includes a sample adding port E; the cavity E is communicated with the sample adding port E; the detection part A further includes a sample adding port A; the cavity A is communicated with the sample adding port A. In some embodiments, a scale line is arranged on the pressure accumulation detection cavity, which is used to distinguish the stratification state information.

[0058] As Figures 3-4 And Figure 5 An embodiment of the formed component detection containing device further includes a detection part B, the detection part B includes a cavity B and a sample adding port B, the cavity B is communicated with the sample adding port B; the cavity B is used to contain a sample B, and the cavity B is used for optical detection analysis of the sample, and the above-mentioned optical detection analysis is used for biochemical detection analysis or immune detection analysis of the sample B. The cavity A is used for formed component analysis; the above-mentioned formed component analysis includes any one or more of morphological analysis, biochemical analysis and immune detection analysis.

[0059] As Figures 6-9An embodiment of a formed element detection and containment device, wherein the cross-section of the sample inlet E is larger than the cross-section TA30 of the cavity E; the sample is blood; and the layering information is used to detect the blood hematoma.

[0060] like Figures 5-6 An embodiment of a formed element detection and containment device includes a detection unit A further comprising a sample addition chamber A, a sample addition port A, an exhaust chamber A, and an exhaust port A. The bottom of the sample addition chamber A is connected to the cavity A, and the sample addition port A is connected to the sample addition chamber A. The bottom of the exhaust chamber A is connected to the cavity A, and the exhaust port A is connected to the exhaust chamber A. The center position of the sample addition chamber A is higher than the center position of the cavity A. The center position of the exhaust chamber A is higher than the center position of the cavity A.

[0061] like Figure 7 A schematic diagram of the bottom of the formed element detection and containment device; G1 in the figure is the bottom of the sample addition chamber A, and G2 in the figure is the bottom of the exhaust chamber A.

[0062] like Figure 8 A schematic diagram of the disassembled state of the formed element detection and containment device; a sealing membrane covers the upper part of the above-mentioned multiple sample addition chambers, and external devices can pass through the sealing membrane.

[0063] Figure 9 yes Figure 8 A schematic cross-sectional view of section E; as shown. Figure 9 The sample application port E has a cross-section larger than the cross-section TA30 of the cavity E. The sample is blood, and the stratification information is used to detect the blood hematocrit. The width of cross-section E1 is greater than the width of cross-section E2; the cavity E is wider at the top and narrower at the bottom. In some embodiments, the sample application cavity A or cavity A is connected to cavity E. In other embodiments, cavity B is connected to cavity E. In still other embodiments, cavity B can also function as cavity E.

[0064] Figure 10 yes Figure 8 Schematic sectional view of mid-section A1; Figure 11 yes Figure 8 A cross-sectional view of section A2; the inner diameter of the sample feeding chamber A is larger than the inner diameter of the exhaust chamber.

[0065] In some embodiments, the cavity E is provided with scale lines to mark the layering positions.

[0066] like Figures 5-6 An embodiment of a formed element detection and containment device further includes a detection unit C, which includes at least one set of cavities C and a sample dispensing port C. The cavities C are used to contain detection reagents, and the sample dispensing port C is open upward. Liquid is added to or removed from the cavities C through the sample dispensing port C. The cavities C are respectively used to contain any one of staining reagents, biochemical detection reagents, or immunoassay reagents.

[0067] As Figures 5-6 One embodiment of the structured component detection and holding device, the cavity height of cavity B, cavity C, cavity E is consistent.

[0068] As Figure 1 And Figure 2 A detection device for cooperating with the structured component detection and holding device; comprising a microscopic magnification digital imaging assembly, a layered detection assembly; the microscopic magnification digital imaging assembly is used for taking microscopic magnification images of the microscopic sample; obtaining the image of the sample in cavity A for structured component analysis; the layered detection assembly is used for obtaining the layered information of sample E. The layered detection assembly comprises a camera device, the camera device obtains the photo of sample E, and the layered information of sample E is obtained through the photo.

[0069] As Figure 3 And Figure 4 A detection device, the light in the optical detection assembly irradiates the sample in the cavity B of the external multifunctional detection device, and the biochemical detection analysis or immunoassay of the sample is carried out according to the optical reaction characteristics of the sample; the optical detection assembly comprises a light source and a light detection assembly; the light source irradiates the cavity B, and the light detection assembly obtains the light passing through the cavity B to obtain the optical reaction characteristic information of the sample.

[0070] Although the present application is described and illustrated according to the preferred embodiments and several alternatives, the application will not be limited by the specific description in the specification. Other additional alternatives or equivalent components can also be used to practice the present application.

Claims

1. A device for detecting and containing a formed element, comprising: a detection portion A; and a detection portion E; wherein the detection portion A comprises a cavity A for containing a sample A, the cavity A being configured to capture a microscopic image of the sample A for formed element analysis; and the detection portion E comprises a cavity E for containing a sample E in a static layer; and the sample E has layer information for calculating a volume of a component in the formed element.

2. The device of claim 1, wherein: the detection portion E further comprises a sample inlet E, the cavity E being in communication with the sample inlet E; and the detection portion A further comprises a sample inlet A, the cavity A being in communication with the sample inlet A.

3. The device of claim 1, further comprising: a detection portion B, the detection portion B comprising a cavity B and a sample inlet B, the cavity B being in communication with the sample inlet B; wherein the cavity B is configured to contain a sample B, the cavity B being configured for optical detection analysis of the sample B, the optical detection analysis being configured for biochemical detection analysis or immunoassay analysis of the sample B.

4. The device of claim 2, wherein: any one of the following technical features is included: TA 10: the cavity A is configured for formed element analysis, the formed element analysis comprising any one or more of morphological analysis, biochemical analysis, and immunoassay analysis; TA 20: the sample inlet E has a cross-sectional area that is larger than a cross-sectional area of the cavity E; and TA 30: the sample is blood, the layer information being configured to detect a hematocrit of the blood.

5. The device of claim 1, wherein: the detection portion A further comprises a sample cavity A, a sample inlet A, a vent cavity A, and a vent inlet A; the sample cavity A is in communication with the cavity A at a bottom of the sample cavity A, the sample inlet A being in communication with the sample cavity A; the vent cavity A is in communication with the cavity A at a bottom of the vent cavity A, the vent inlet A being in communication with the vent cavity A; the sample cavity A has a center that is higher than a center of the cavity A; and the vent cavity A has a center that is higher than the center of the cavity A.

6. The device of claim 1, further comprising: a detection portion C, the detection portion C comprising at least one cavity C and a sample inlet C, the cavity C being configured to contain a detection reagent, the sample inlet C being configured to allow liquid to be added to or removed from the cavity C; and the cavity C being configured to contain any one of a staining reagent, a biochemical detection reagent, or an immunoassay reagent.

7. The device of claim 1, wherein: the cavity B, the cavity C, and the cavity E have equal cavity heights.

8. A detection device, comprising: a microscopic digital imaging assembly; and a layer detection assembly; wherein the detection device is configured to cooperate with any one of the devices of claims 1-7; and wherein the microscopic digital imaging assembly is configured to capture a microscopic image of a sample in the cavity A for formed element analysis; and the layer detection assembly is configured to obtain layer information of a sample in the cavity E; and the layer detection assembly comprises a camera configured to capture a photograph of the sample in the cavity E, the layer information of the sample being obtained from the photograph; and the detection device further comprises an optical detection assembly. ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ 9. The detection device of claim 8, wherein, ​ 10. The detection device of claim 8, wherein, ​ The optical detection assembly irradiates the sample in the cavity B of the external multifunctional detection device with light, and performs biochemical detection analysis or immunoassay analysis on the sample according to the optical reaction characteristics of the sample; The optical detection assembly comprises a light source and a light detection assembly; the light source irradiates the cavity B, and the light detection assembly obtains the light passing through the cavity B to obtain the optical reaction characteristic information of the sample.

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