Control circuit for eliminating interference signals and pulse ablation system
By introducing a delay control circuit into the pulse ablation system, the problem of interference signals during temperature acquisition was solved, enabling accurate monitoring and safety assurance of the temperature of the ablated tissue, and avoiding the risks of equipment failure and electric arc sparks.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- JIANGXI INSTANT MEDICAL TECHNOLOGY CO LTD
- Filing Date
- 2024-12-23
- Publication Date
- 2026-05-19
AI Technical Summary
Existing pulse ablation systems are severely affected by interference signals during temperature acquisition, leading to inaccurate temperature acquisition of ablated tissues and posing a risk of thermal damage to normal tissues.
Design a control circuit for eliminating interference signals, including a pulse generation module, an interface module, a control module, a switch module, and a delay module. The delay module controls the working time of the switch module and the pulse generation module to ensure that the pulse lead group is disconnected or short-circuited to ground, thereby eliminating the influence of interference signals.
This improves the accuracy of real-time acquisition of tissue temperature during pulse ablation treatment, reduces the risk of equipment failure, avoids the generation of electric arc sparks, and ensures the safety of the treatment process.
Smart Images
Figure CN224251476U_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of medical device technology, specifically to a control circuit for eliminating interference signals, a temperature acquisition circuit based thereon, and a pulse ablation system. Background Technology
[0002] Pulsed electric field ablation is a new technology that has begun to be used clinically in China in recent years and has developed rapidly. It achieves a treatment mode that improves the physiological and pathological state of tissues without thermal damage, and then adopts a surgical treatment method that destroys tissues, eliminates lesions, and restores tissue and body health.
[0003] Pulsed electric field ablation uses high-voltage, high-frequency pulse signals to pulse discharge onto the lesion tissue, causing irreversible electroporation of the lesion tissue cells, resulting in cell apoptosis and death, thereby destroying the tissue, eliminating the lesion, and restoring the tissue and the body's health.
[0004] During pulsed electric field ablation discharge, some heat is generated. To prevent thermal damage to normal tissue at the ablation site due to excessive temperature, the temperature of the ablation site needs to be monitored during discharge. Discharge should be suspended when the tissue temperature rises above 5°C and the discharge treatment should continue after the temperature drops to the normal range. This ensures that there is no thermal damage to normal tissue.
[0005] like Figure 1 As shown, the pulse ablation catheter includes a catheter housing, a pulse electrode ring assembly (including multiple pulse electrode rings), a pulse lead assembly (including multiple enameled wires), a temperature electrode ring, a thermocouple wire, a connector (i.e., a terminal block), and an interface module. One end of the multiple enameled wires is connected to the pulse electrode ring, and the other end is connected to the connector. One end of the thermocouple wire is connected to the temperature electrode ring, and the other end is connected to the connector. The connector is connected to the interface module on the pulse ablation host via a plug-in method.
[0006] The pulse ablation host transmits pulse energy signals (such as high-frequency energy signals) sequentially through a connector and pulse lead assembly to a pulse electrode ring assembly via an interface module. This enables discharge ablation of the tissue to be ablated, and the temperature electrode ring and thermocouple wires are used to collect the temperature of the tissue in real time. Figure 2 , Figure 3As shown, in a conventional pulse ablation system, during the power-on phase (t1-t2), the main unit is powered on, but the pulse generation module has not yet started charging; at this time, the temperature signal is smooth and free of interference. During the charging phase (t2-t3), the pulse generation module is performing voltage doubling charging, and interference begins to appear in the temperature signal. As the charging time increases, the radiation and interference on the pulse conductor become stronger, with the interference amplitude on the pulse conductor far exceeding the maximum temperature signal limit (maximum temperature change limit 75mV). During the discharge phase (t3-t4), the pulse signal output phase, the interference amplitude on the pulse conductor remains high, and the radiation and interference on the pulse conductor continuously affect the accuracy of temperature signal acquisition. During the pause phase (t4-t5), the pulse signal output stops, awaiting the next pulse discharge; at this time, the radiation on the pulse conductor still interferes with the temperature signal. Therefore, it is evident that the temperature signal acquisition in a conventional pulse ablation system is severely affected by interference.
[0007] The reason for this interference is that the pulse energy signal has rich pulse frequency components and high amplitude. The thermocouple wires and pulse lead groups are inserted inside the conduit shell. Inevitably, due to the short spacing (less than 15mm) between the thermocouple wires and pulse lead groups inside the conduit shell and the overall length of the conduit shell (up to 4m), their coupling length is long and the coupling distance is short. Therefore, in such an environment, the pulse lead group can easily couple the pulse energy signal to the thermocouple wires through the air conduction inside the conduit shell and its interior. At the same time, the spatial radiation of the pulse energy signal is also coupled to the thermocouple wires. This can easily interfere with the temperature signal acquisition results of the thermocouple wires, resulting in inaccurate temperature acquisition of the ablated tissue, and thus leading to the risk of thermal damage to normal tissue. Summary of the Invention
[0008] In order to overcome the defects existing in the prior art, the purpose of this invention is to provide a control circuit for eliminating interference signals, a temperature acquisition circuit based thereon, and a pulse ablation system, which can eliminate interference signals generated during the discharge of the pulse ablation system, and is particularly suitable for accurate monitoring of the temperature of lesion tissue during pulse ablation discharge.
[0009] To achieve the above-mentioned objectives of the present invention, the present invention provides a control circuit for eliminating interference signals, comprising:
[0010] The pulse generation module is used to generate and output pulse signals;
[0011] An interface module, electrically connected to the pulse generator module, is used to receive the pulse signal;
[0012] The control module is electrically connected to the pulse generation module and is used to send a first control signal to the pulse generation module to generate a pulse signal and a second control signal to stop outputting the pulse signal.
[0013] A switch module, one end of which is disposed in the path between the pulse generating module and the interface module, and the other end of which is grounded. When the switch module is closed, both the pulse generating module and the interface module are grounded.
[0014] The delay module has its input terminal electrically connected to the control module, its first output terminal electrically connected to the control terminal of the switch module, and its second output terminal electrically connected to the pulse generation module.
[0015] Specifically, the time when the delay module receives the first control signal and controls the pulse generation module to generate and output a pulse signal based on the first control signal is delayed compared to the time when the switch module is controlled to open; the time when the delay module receives the second control signal and controls the switch module to close based on the second control signal is delayed compared to the time when the pulse generation module is controlled to stop outputting the pulse signal.
[0016] This control circuit for eliminating interference signals can eliminate interference signals generated during the discharge of the pulse ablation system, improve the accuracy of real-time temperature acquisition of the ablated tissue throughout the entire pulse ablation treatment phase, and can also be used to improve the accuracy of other signal acquisitions.
[0017] Optionally, the delay module receives the first control signal and delays it for a first duration before inputting it to the switch module, and delays it for a second duration before inputting it to the pulse generation module, wherein the first duration is less than the second duration;
[0018] The delay module receives the second control signal and delays it for the first duration before inputting it to the pulse generation module, and then delays it for the second duration before inputting it to the switch module.
[0019] Optionally, the delay module includes:
[0020] The first delay submodule has its input terminal electrically connected to the control signal output terminal of the control module, and its output terminal electrically connected to the control terminal of the switch module. The first delay submodule receives the first control signal and delays for the first duration or receives the second control signal and delays for the second duration.
[0021] The second delay submodule has its input terminal electrically connected to the control signal output terminal of the control module. The second delay submodule receives the first control signal and delays for the second duration, or receives the second control signal and delays for the first duration.
[0022] This optional solution allows the switching module to close after the first control signal output by the control module and to open after the second control signal output by the control module. At the same time, the timing of the pulse signal output by the control pulse generation module is later than the opening time of the switching module, and the timing of the control pulse generation module stopping the output of the pulse signal is earlier than the opening time of the switching module. This ensures that there is no risk of the pulse generation module outputting a pulse signal when the pulse wire is grounded.
[0023] Optionally, the delay module includes:
[0024] The first delay submodule has its input terminal electrically connected to the control signal output terminal of the control module, and its output terminal electrically connected to the control terminal of the switch module. The first delay submodule receives the first control signal and delays for the first duration or receives the second control signal and delays for the second duration.
[0025] The second delay submodule is electrically connected between the control signal output terminal of the control module and the input terminal of the pulse generation module;
[0026] The first switch submodule is electrically connected between the control signal output terminal of the control module and the input terminal of the second delay submodule;
[0027] The second switch submodule is electrically connected between the first delay submodule and the second delay submodule;
[0028] When the control module outputs a first control signal, the first switch submodule is opened, the second switch submodule is closed, and the second delay submodule delays the first control signal after a first delay for a third delay; when the control module outputs a second control signal, the first switch submodule is closed, the second switch submodule is opened, and the second delay submodule receives the second control signal and delays it for the first delay.
[0029] The third duration is the difference between the second duration and the first duration.
[0030] This optional solution allows the switching module to close after the first control signal output by the control module and to open after the second control signal output by the control module. At the same time, the timing of the pulse signal output by the control pulse generation module is later than the opening time of the switching module, and the timing of the control pulse generation module stopping the output of the pulse signal is earlier than the opening time of the switching module. This ensures that there is no risk of the pulse generation module outputting a pulse signal when the pulse wire is grounded.
[0031] Optionally, the delay module includes:
[0032] The first delay submodule has its input terminal electrically connected to the control signal output terminal of the control module, and its output terminal electrically connected to the control terminal of the switch module. The first delay submodule receives the first control signal and delays for a first duration or receives the second control signal and delays for a second duration, wherein the first duration is less than the second duration.
[0033] The second delay submodule has its input terminal electrically connected to the control signal output terminal of the control module. The second delay submodule receives the first control signal and delays for the second duration, or receives the second control signal and delays for the first duration; or, the input terminal of the second delay submodule is electrically connected to the output terminal of the first delay submodule. The second delay submodule receives the first control signal or the second control signal after the delay by the first delay submodule, and then delays again.
[0034] An AND gate is configured such that its inputs are electrically connected to the control signal output of the control module and the output of the second delay submodule, and its output is electrically connected to the input of the pulse generation module. After receiving the first control signal output by the control module and the first control signal output by the second delay submodule, the AND gate outputs the first control signal to the pulse generation module. After receiving the second control signal output by the control module, the AND gate outputs the second control signal to the pulse generation module.
[0035] This optional solution allows the switching module to close after the first control signal output by the control module and open after the second control signal output by the control module. Simultaneously, the timing of the pulse signal output by the control pulse generator module is later than the opening time of the switching module, and the timing of the control pulse generator module stopping outputting the pulse signal is earlier than the opening time of the switching module. This ensures that there is no risk of the pulse generator module outputting a pulse signal when the pulse wire is grounded. Furthermore, it ensures that the timing of the pulse generator module receiving the stop pulse output signal is consistent with the timing of the second control signal output by the control module, allowing for further control of the pulse generator module stopping outputting the pulse signal earlier than the opening time of the switching module.
[0036] Optionally, the delay module further includes:
[0037] The first NOT gate has its input terminal connected to the signal output terminal of the first delay submodule, and performs inversion processing on the signal output by the first delay submodule. The signal output terminal of the first NOT gate is connected to the control terminal of the switch module.
[0038] The second NOT gate has its input connected to the signal output of the first NOT gate, and inverts the output signal of the first NOT gate. The signal output of the second NOT gate is connected to the signal input of the AND gate.
[0039] Optionally, the switching module includes:
[0040] A physical switch module, one end of which is connected to the path between the pulse generation module and the interface module, the other end of which is grounded, and its control terminal is connected to the first output terminal of the delay module;
[0041] The physical switch monitoring module is electrically connected between the AND gate module and the physical switch module;
[0042] The physical switch monitoring module monitors the closed and open states of the physical switch module and sends the monitoring results to the AND gate module, so that when the physical switch module is closed, the signal generating module does not output a pulse signal.
[0043] This optional solution reduces the risk of the pulse generation module outputting a pulse signal when the pulse wire is grounded by setting up a physical switch monitoring module.
[0044] Optionally, a temperature acquisition module is also included. The signal input terminal of the control module is electrically connected to the signal output terminal of the temperature acquisition module through the interface module to receive the temperature signal acquired by the temperature acquisition module.
[0045] This application also proposes a pulse ablation system, including a pulse ablation host and a pulse ablation catheter electrically connected to the pulse ablation host, wherein the pulse ablation host is provided with a control circuit as described above for eliminating interference signals.
[0046] The signal input terminal of the control module is electrically connected to the wiring terminal located on the pulse ablation catheter through the interface module.
[0047] This pulse ablation system possesses all the advantages of the control circuits described above used to eliminate interference signals.
[0048] Optionally, the pulse ablation catheter is equipped with a temperature sensor, and the wiring terminal includes a thermocouple wire welded to the temperature sensor; the thermocouple wire is electrically connected to the signal input terminal of the control module through the interface module.
[0049] The beneficial effects of this invention include:
[0050] This application uses a delay module to delay the working time of the switching module and the pulse generation module. Specifically, during the pulse discharge phase, the switching module opens earlier than the pulse generation module outputs the pulse signal, ensuring the pulse width. Simultaneously, it ensures that when the pulse signal is emitted, the pulse lead group is disconnected from ground, preventing short circuits in the pulse generation module and thus avoiding equipment malfunctions. When discharging stops, the switching module closes after the pulse generation module stops outputting the pulse signal, and the pulse lead group is short-circuited to ground after the pulse generation module stops outputting the pulse signal. This allows interference signals on the pulse lead to be discharged through grounding after each pulse discharge, eliminating the influence of interference signals on the temperature signal. This improves the accuracy of continuous real-time temperature acquisition of the ablated tissue throughout the treatment phase and can also be used to improve the accuracy of other signal acquisitions. Furthermore, it avoids the risk of arcing when a high-pulse voltage circuit is suddenly disconnected, enhancing circuit safety.
[0051] Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description
[0052] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:
[0053] Figure 1 This is a schematic diagram showing the connection between the main unit of an existing pulse ablation device and the pulse ablation catheter;
[0054] Figure 2 This is a waveform diagram of the discharge pulse within one cycle of a conventional pulse ablation device;
[0055] Figure 3 This is a waveform diagram of pulse interference encountered during temperature signal acquisition in a conventional pulse ablation device;
[0056] Figure 4 This is a schematic diagram of the principle of this application;
[0057] Figure 5 The signal timing of the delay module in Embodiment 1 Figure 1 ;
[0058] Figure 6a This is a principle block diagram of Embodiment 1;
[0059] Figure 6b This is a block diagram of the principle in Embodiment 3;
[0060] Figure 7a This is a principle block diagram of Embodiment 2;
[0061] Figure 7b This is another principle block diagram of Embodiment 3;
[0062] Figure 7c This is a principle block diagram of Embodiment 4;
[0063] Figure 8a This is a principle block diagram of Embodiment 2;
[0064] Figure 8b This is another principle block diagram of Embodiment 3;
[0065] Figure 8c This is another principle block diagram of Embodiment 4;
[0066] Figure 9 The signal timing of the delay module in Embodiment 2 Figure 2 ;
[0067] Figure 10 This is a set of pulse discharge parameter waveforms of the pulse electric field ablation system in Example 2;
[0068] Figure 11a This is a waveform diagram of the discharge pulses within two cycles in Example 2;
[0069] Figure 11b This is a waveform diagram of pulse signal interference encountered during temperature signal acquisition after Example 2;
[0070] Figure 12a This is a principle block diagram of Example 5;
[0071] Figure 12b This is another principle block diagram of Embodiment 5;
[0072] Figure 12c This is another principle block diagram of Embodiment 5;
[0073] Figure 13 This is the signal timing diagram of the delay module in Embodiment 5. Detailed Implementation
[0074] Embodiments of the present invention are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.
[0075] In the description of this invention, unless otherwise specified and limited, it should be noted that the terms "installation", "connection" and "linking" should be interpreted broadly. For example, they can refer to mechanical or electrical connections, or internal connections between two components. They can be direct connections or indirect connections through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms according to the specific circumstances. Example
[0076] This invention provides a control circuit for eliminating interference signals, which is particularly suitable for eliminating interference signals generated during the discharge of a pulse ablation system and can accurately monitor the temperature of lesion tissue during pulse ablation discharge.
[0077] like Figure 4 As shown, the control circuit for eliminating interference signals in this embodiment specifically includes: a pulse generation module, an interface module, a control module, a switch module, and a delay module.
[0078] The system comprises a pulse generation module for generating and outputting pulse signals, an interface module electrically connected to the pulse generation module for receiving the pulse signals output by the pulse generation module, and an interface module for electrical connection to the pulse lead assembly in the pulse ablation catheter. A control module electrically connected to the pulse generation module sends a first control signal to the pulse generation module to generate pulse signals and a second control signal to stop pulse signal output. One end of a switch module is positioned in the path between the pulse generation module and the interface module, and the other end is grounded. When the switch module is closed, both the pulse generation module and the interface module are grounded.
[0079] The input terminal of the delay module is electrically connected to the control module, its first output terminal is electrically connected to the control terminal of the switch module, and its second output terminal is electrically connected to the pulse generation module.
[0080] The time it takes for the delay module to receive the first control signal and control the pulse generator module to generate and output a pulse signal based on the first control signal is delayed compared to the time it takes to control the switch module to open. The time it takes for the delay module to receive the second control signal and control the switch module to close based on the second control signal is delayed compared to the time it takes to control the pulse generator module to stop outputting the pulse signal. This ensures that during discharge, the switch module opens before the pulse generator module outputs the pulse signal, i.e., the pulse lead group is disconnected from ground before the pulse generator module outputs the pulse signal. When discharging stops, the switch module closes after the pulse generator module stops outputting the pulse signal, i.e., the pulse lead group is short-circuited to ground after the pulse generator module stops outputting the pulse signal. This ensures that the discharge pulse width and pulse signal are not transmitted to the casing, preventing other risks such as short circuits that could damage the equipment.
[0081] In this embodiment, the delay module achieves the above function in the following way:
[0082] The delay module receives the first control signal, delays it for a first duration, and then inputs it to the switch module. After a second delay, it inputs it to the pulse generation module. The first duration is less than the second duration. The delay module receives the second control signal, delays it for a first duration, and then inputs it to the pulse generation module. After a second delay, it inputs it to the switch module.
[0083] like Figure 4 and Figure 5 As shown, the S signal is the control signal output by the control module. When the S signal is the first control signal, it is a high-level S1 signal; when the S signal is the second control signal, it is a low-level S2 signal. The A signal is the signal output by the delay module after processing the S signal to the switch module, and the C signal is the signal output by the delay module after processing the S signal to the pulse generation module. The time for the operator to start discharging the host is b1, and the time for the operator to stop discharging the host is b2. b1 is the time when the S1 high-level signal is emitted, and b2 is the time when the S1 high-level signal stops. b3 is the start time when the switch module receives the A signal, and b4 is the end time when the switch module receives the A signal. b5 is the start time when the pulse generation module receives the C signal, and b6 is the end time when the pulse generation module receives the C signal. When the control module outputs the first control signal, due to the delay processing of the control signal by the delay module—that is, the delay module receives the first control signal and delays it for a first duration before inputting it to the switch module, and then delays it for a second duration before inputting it to the pulse generating module—the first duration is less than the second duration. This causes the switch module to receive the first control signal earlier than the pulse generating module (b3 < b5), meaning the switch module opens before the pulse generating module emits a pulse signal during discharge. When the control module outputs the second control signal, because the delay module delays the second control signal for a first duration before inputting it to the pulse generating module, and then delays it for a second duration before inputting it to the switch module, the switch module receives the second control signal later than the pulse generating module (b4 > b6). This means the switch module closes only after the pulse generating module stops outputting pulse signals when discharging stops. In this embodiment, the delay module also inverts the high-level signal of S1, turning it into a low-level signal. Therefore, the A signal received by the switch module after the delay is a low-level signal.
[0084] In this embodiment, the delay module preferably, but is not limited to, adopts the following structure to implement the above functions.
[0085] like Figure 6a As shown, the delay module includes a first delay submodule and a second delay submodule. Specifically:
[0086] The input terminal of the first delay submodule is electrically connected to the control signal output terminal of the control module, and the output terminal of the first delay submodule is electrically connected to the control terminal of the switch module. The first delay submodule receives a first control signal and delays for a first duration or receives a second control signal and delays for a second duration.
[0087] The second delay submodule has its input terminal electrically connected to the control signal output terminal of the control module. The second delay submodule receives the first control signal and delays for the second duration, or receives the second control signal and delays for the first duration.
[0088] The first delay submodule delays the first control signal for a first duration and the second delay signal for a second duration, which can be achieved by switching between high and low potentials of the signals (for example, two timers can be used, one to generate a high-potential delay and the other to generate a low-potential delay, thus delaying the first control signal for a first duration and the second delay signal for a second duration); similarly, the second delay submodule can also delay the first control signal for a second duration and the second delay signal for a first duration by switching between high and low potentials of the signals.
[0089] Regarding the opening and closing of the switch module, it can be opened by a high level trigger (without a NOT gate) or by a low level trigger (requiring a NOT gate). Example
[0090] This embodiment is largely the same as Embodiment 1, except that an AND gate is added.
[0091] like Figure 7a As shown, the input terminal of the AND gate is electrically connected to the control signal output terminal of the control module and the output terminal of the second delay submodule, respectively, and its output terminal is electrically connected to the input terminal of the pulse generation module. After receiving the first control signal output by the control module and the first control signal output by the second delay submodule, the AND gate outputs the first control signal to the pulse generation module. After receiving the second control signal output by the control module, the AND gate outputs the second control signal to the pulse generation module.
[0092] The control module outputs a high-level first control signal. An AND gate, upon receiving the first control signal delayed by the second delay submodule, performs an AND operation with it and then inputs the result to the pulse generator module. The control module outputs a low-level second control signal. The AND gate directly inputs this received second control signal to the pulse generator module without any delay.
[0093] Since a low-level signal is typically used to control the switch to open and a high-level signal to control the switch to close, therefore, in this embodiment... Figure 8a In this circuit, a first NOT gate is electrically connected to the output of the first delay submodule. The first NOT gate inverts the signal output by the first delay submodule, that is, it processes the low level to a high level or the high level to a low level, thereby controlling the closing or opening of the switch module.
[0094] The delay module can also be equipped with a second NOT gate, whose input is electrically connected to the output of the first NOT gate. The output of the second NOT gate is electrically connected to one input of an AND gate. The signal output from the first NOT gate is then inverted and input into the AND gate. Alternatively, the signal output from the first delay submodule can be directly input into the AND gate.
[0095] like Figure 8a , Figure 9 As shown, c1 is the time when the S1 high-level signal is emitted, c2 is the time when the S1 high-level signal stops, and since the two signals are switched at the same time, c2 is also the time when the S2 low-level signal is emitted; c3 is the start time when the switch module receives the A signal, c4 is the end time when the switch module receives the A signal; c5 is the start time when the AND gate module receives the B signal, c6 is the end time when the AND gate module receives the B signal; c7 is the start time when the pulse generation module receives the C signal, c8 is the end time when the pulse generation module receives the C signal; thus, after the first sub-delay module, the second sub-delay module, the AND gate module, and the first NOT gate and the second NOT gate operate on the S signal, c7=c5>c3>c1, c8=c2, and (c8-c7) is equal to the pulse train width.
[0096] In this scheme, the pulse generation module will send out a pulse signal after receiving a high-level signal, and the discharge will begin; the pulse generation module will stop sending out pulse signals after receiving a low-level signal, and the discharge will stop.
[0097] Because the delay module is configured such that the delay time of the first delay submodule is shorter than that of the second delay submodule, and because the AND gate, the first NOT gate, and the second NOT gate do not have a delay in signal processing, therefore, in Figure 8a In the process, when the control module sends an S signal as a high-level S1 signal, the S signal is split into three paths and received by the first delay submodule, the second delay submodule, and an AND gate, respectively. After the S1 high-level signal is delayed by the first and second delay submodules, at time c3, the high-level signal output by the first delay submodule is inverted by the first NOT gate and becomes a low-level signal, which is received by the switch module. The switch module is then disconnected, and the pulse lead group is disconnected from ground. In addition, at time c3, the low-level signal inverted by the first NOT gate is also received by the second NOT gate and inverted by the second NOT gate to become a high-level signal, which is received by the AND gate. At time c5, the high-level signal output by the second delay submodule is received by the AND gate. Since c5 > c3, at time c5, all three input terminals of the AND gate are high-level, and the output terminal of the AND gate outputs a high-level signal (according to the property of the AND gate, when all input terminals are high-level signals, the circuit outputs a high-level signal). The pulse generation module receives the high-level signal, sends out a pulse signal, and the pulse ablation catheter begins to discharge. In summary, when the control module sends out the S signal as a high-level S1 signal, since the delay time of the first delay submodule is shorter than that of the second delay submodule, the switching module receives the first control signal earlier than the pulse generation module (c3 < c5). That is, during discharge, the switching module opens before the pulse generation module sends out the pulse signal.
[0098] When the control module sends an S signal that is a low-level S2 signal, the S signal is split into three paths and received by the first delay submodule, the second delay submodule, and the AND gate, respectively. According to the properties of the AND gate—that is, when all inputs are high-level signals, the circuit outputs a high-level signal, otherwise it outputs a low-level signal—when the control module sends an S signal that is a low-level S2 signal, the low-level S2 signal is input to the AND gate module through the input terminal electrically connected to the AND gate, and simultaneously output to the pulse generation module via the AND gate. That is, at time point c8, the AND gate outputs a low-level signal, and the pulse generation module also receives a low-level signal at time point c8, stopping the pulse signal output, and the ablation catheter suspends discharge. For the switching module, the low-level S2 signal needs to be processed by the first delay submodule before being accepted by the switching module. That is, at time point c4, the first delay submodule outputs a low-level signal, which is inverted by the first NOT gate to become a high-level signal and received by the switching module. The switching module closes, the pulse lead group is connected to the chassis, and the pulse lead group is short-circuited to ground, achieving ground discharge of the remaining pulse radiation interference and eliminating the interference. In summary, when the control module sends out the S signal as a low-level S2 signal, due to the processing of the first delay submodule, the second delay submodule, and the AND gate, the switching module receives the first control signal later than the pulse generation module (c8=c2<c4). That is, when the pulse discharge is paused, the switching module closes after the pulse generation module stops discharging.
[0099] Therefore, through the above circuit operation mode, it is achieved that during pulse discharge, the switching module disconnects earlier than the pulse generating module discharges; and during pulse pause discharge, the pulse generating module stops discharging slightly earlier than the switching module conducts, thus avoiding the danger of high voltage pulses flowing to the casing, while simultaneously achieving ground discharge of pulse interference signals to eliminate interference.
[0100] To further verify the effectiveness of this embodiment, a set of pulse discharge parameter waveforms of the pulsed electric field ablation system were selected as follows: Figure 10 As shown, the parameters selected for testing were a pulse voltage of 3000V, a pulse width of 100µs, and a discharge frequency of 1Hz. The current pulse ablation system is set to discharge 1-2 times per second, with each discharge pulse width less than 1ms. Achieving a nanometer-level pulse width results in better therapeutic effects.
[0101] The first pulse train discharge phase: a1~a2, pulse amplitude 3000V, pulse width 100us (the parameters are designed for the effect verification test of this embodiment, and the pulse width will be smaller in actual treatment).
[0102] The first pulse train pauses the discharge phase: a2~a3, pulse amplitude 0V, pulse width 999900us.
[0103] The second pulse train discharge stage: a3~a4, pulse amplitude 3000V, pulse width 100us.
[0104] The implementation effect of this embodiment in the pulsed electric field ablation system is as follows: Figure 11a , Figure 11b As shown:
[0105] Power-on phase: T1~T2, the host is powered on and the pulse generation module has not started charging. At this time, the temperature signal is smooth and there is no interference signal.
[0106] Charging phase: T2~T3, the pulse generation module performs voltage doubling charging. At this time, the temperature signal begins to interfere. As the charging time increases, the radiation and interference on the pulse wire become stronger. The interference amplitude on the pulse wire is much greater than the maximum limit of the temperature signal (maximum temperature change limit 75mV).
[0107] The first pulse train discharge stage: T3~T4, the first pulse signal output stage of the pulse generation module. The interference amplitude on the pulse conductor remains high, and the radiation and interference on the pulse conductor continue to affect the accuracy of temperature signal acquisition.
[0108] Pause discharge phase: Pulse conductor grounding phase (i.e., the pause phase in the middle of two pulse train discharge phases): T4~T5, the first pulse signal output of the pulse generation module stops, waiting for the next pulse discharge. During the pause discharge phase, the pulse generation module of this utility model is short-circuited (grounded) with the main unit casing. The radiated interference on the pulse conductor is discharged to the ground through the grounding line. At this time, the radiated interference is eliminated, the reference voltage of the temperature signal returns to smoothness, and the acquired temperature signal is accurate.
[0109] The second pulse train discharge stage: T5~T6, the second pulse signal output stage of the pulse generation module. The interference amplitude on the pulse conductor remains high, and the radiation and interference on the pulse conductor continue to affect the accuracy of temperature signal acquisition.
[0110] Although pulse interference still exists during the charging and discharging phases, no treatment is performed during the charging phase, so there is no need to detect the temperature of the ablation area at this time. Therefore, the pulse interference during this period does not affect the accuracy of temperature detection during treatment. During the pulse train discharge phase, although pulse interference exists, there are spike pulses during pulse discharge. The spike pulses and discharge pulses have the same width, both being narrow pulses on the nanosecond level. The conventional filtering function of the pulse ablation instrument host system software can eliminate the influence on temperature signal acquisition. Therefore, in this scheme, even if the lead group is not grounded during the discharge phase, the temperature signal detected during the discharge phase that is interfered with will be filtered out, thus making the temperature signal collected throughout the treatment phase relatively accurate. Example
[0111] like Figure 6b As shown, this embodiment is similar to Embodiment 1, except for the structural configuration of the delay module.
[0112] The delay module includes: a first delay submodule, a second delay submodule, and a second switch module. The second switch module includes the first switch submodule and the second switch submodule.
[0113] The input terminal of the first delay submodule is electrically connected to the control signal output terminal of the control module. The output terminal of the first delay submodule is electrically connected to the control terminal of the switch module. The first delay submodule receives the first control signal and delays for the first duration, or receives the second control signal and delays for the second duration, wherein the first duration is less than the second duration. The second delay submodule is electrically connected between the control signal output terminal of the control module and the input terminal of the pulse generation module. The first switch submodule is electrically connected between the control signal output terminal of the control module and the input terminal of the second delay submodule. The second switch submodule is electrically connected between the first delay submodule and the second delay submodule.
[0114] When the control module outputs the first control signal, the first delay submodule receives the first control signal and delays it for a first duration; the first switch submodule is opened, the second switch submodule is closed, and the second delay submodule delays the first control signal after the first duration by a third duration, the third duration being the difference between the second duration and the first duration. Thus, the first control signal output by the second delay submodule is delayed for a total of a second duration; when the control module outputs the second control signal, the first switch submodule is closed, the second switch submodule is opened, and the second delay submodule receives the second control signal and delays it for a first duration.
[0115] Based on the above structure, the switching module can be opened before the pulse generator module outputs a pulse signal during discharge, and closed after the pulse generator module stops outputting a pulse signal when the discharge stops.
[0116] This embodiment can also be similar to Embodiment 2, by adding an AND gate, a first NOT gate, and a second NOT gate, as shown below. Figure 7b , Figure 8b As shown, the specific principle can be referred to in Example 2, and will not be repeated here.
[0117] In Embodiments 1, 2, and 3, the switching module may include multiple physical switches. When any physical switch is grounded, the switching module is grounded. The physical switches can be relays or switching elements such as MOSFETs. When the physical switch is a relay, one end of the relay contact is connected to the path between the pulse generation module and the interface module, and the other end is grounded. The relay coil power supply terminal is connected to the first output terminal of the delay module. When the physical switch is a MOSFET, the drain (D) of the MOSFET is connected to the path between the pulse generation module and the interface module, its source (S) is grounded, and its gate (G) is connected to the first output terminal of the delay module. The first and second delay submodules are not limited to resistor-capacitor (RC) circuits or delay devices. The first and second NOT gates are not limited to comparators, inverters, phase inverters, NOT gates, or other logic devices or circuit modules with the same function. The AND gate is not limited to combinations of digital logic chips or other circuits with the same function. The interface module is an electronic socket or a wiring socket, etc. Example
[0118] This embodiment is similar to Embodiment 1, except for the structural configuration of the delay module in this embodiment.
[0119] In this embodiment, the delay module includes: a first delay submodule, a second delay submodule, and an AND gate. For example... Figure 7c As shown, the input terminal of the first delay submodule is electrically connected to the control signal output terminal of the control module, and the output terminal of the first delay submodule is electrically connected to the control terminal of the switch module. The first delay submodule receives a first control signal and delays for a first duration, or receives a second control signal and delays for a second duration, where the first duration is less than the second duration. The input terminal of the second delay submodule is electrically connected to the output terminal of the first delay submodule. The second delay submodule receives the first or second control signal after the first delay submodule has been delayed, and then delays it again. The delay duration can be the first duration, the second duration, or any other duration. The input terminals of an AND gate are electrically connected to the control signal output terminal of the control module and the output terminal of the second delay submodule, respectively, and its output terminal is electrically connected to the input terminal of the pulse generation module. After receiving the first control signal output by both the control module and the second delay submodule, the AND gate outputs the first control signal to the pulse generation module. After receiving the second control signal output by the control module, the AND gate simultaneously outputs the second control signal to the pulse generation module.
[0120] The structure of other parts can be referred to in Embodiment 1, and will not be repeated here.
[0121] The control module outputs a high-level first control signal. An AND gate, upon receiving the delayed first control signal from the second delay submodule, performs an AND operation with it and then inputs the result to the pulse generator module. The control module outputs a low-level second control signal, which the AND gate directly inputs to the pulse generator module without delay. This ensures that the pulse generator module outputs a pulse signal after the switch module opens, and stops outputting the pulse signal before the switch module closes.
[0122] like Figure 8c As shown, the output of the first delay submodule can also be electrically connected to the first NOT gate. The first NOT gate inverts the signal output by the first delay submodule, that is, it processes the low level to the high level or the high level to the low level, so as to control the closing or opening of the switch module.
[0123] The delay module can also be equipped with a second NOT gate, whose input is electrically connected to the output of the first NOT gate. The output of the second NOT gate is electrically connected to one input of an AND gate. The signal output from the first NOT gate is then inverted and input into the AND gate. Alternatively, the signal output from the first delay submodule can be directly input into the AND gate. Example
[0124] like Figure 12a , Figure 12b or Figure 12c As shown, based on Embodiments 2, 3, or 4, this application provides Embodiment 5 to further ensure safety. In this embodiment, the switch module includes a physical switch module and a physical switch monitoring module. One end of the physical switch module is connected to the path between the pulse generation module and the interface module, and the other end is grounded. Its control terminal is connected to the first output terminal of the delay module, i.e., the output terminal of the first delay submodule. The physical switch monitoring module is electrically connected between the AND gate module and the physical switch module. The physical switch monitoring module monitors the closed and open states of the physical switch module and sends the monitoring results to the AND gate module, so that when the physical switch module is closed, the signal generation module does not output a signal, thereby reducing the risk of the pulse generation module outputting a pulse signal when the pulse wire is grounded. The physical switch monitoring module is not limited to using isolation circuits such as transformers and optocouplers to collect the status of the physical switch module.
[0125] In this embodiment, a first NOT gate can be electrically connected to the output of the first delay submodule. The signal output by the first NOT gate is then inverted and input to the physical switch module. A second NOT gate is provided, with its input electrically connected to the output of the first NOT gate. The output of the second NOT gate is electrically connected to one input of an AND gate. The signal output by the first NOT gate is then inverted and input to the AND gate. Alternatively, the signal output by the first delay submodule can be directly input to the AND gate.
[0126] like Figure 12a , Figure 13 As shown, signal D is the output signal of the physical switch monitoring module. If one or more physical switches are grounded, signal D is a low-level signal; otherwise, it is a high-level signal. d1 is the time when the high-level signal S1 is emitted, and d2 is the time when the high-level signal S1 stops. d2 is also the time when the low-level signal S2 is emitted. d3 is the start time when the switch module receives signal A, and d4 is the end time when the switch module receives signal A. d5 is the start time when the AND gate module receives signal B, and d6 is the end time when the AND gate module receives signal B. d7 is the start time when the AND gate receives signal D, and d8 is the end time when the AND gate receives signal D. d9 is the start time when the pulse generation module receives signal C, and d10 is the end time when the pulse generation module receives signal C. Thus, after the first delay submodule, the second delay submodule, the AND gate module, the first NOT gate, and the second NOT gate operate on the S signal, and the delay time of the first delay submodule is shorter than the delay time of the second delay submodule, d9 > d5 > d1, d6 > d4 > d10 = d2.
[0127] like Figure 12a and Figure 13 As shown, pulse discharge begins only when the S signal received by the pulse generation module, the B signal output by the second delay submodule, the signal output by the first delay submodule, and the D signal output by the physical switch monitoring module are all simultaneously high-level signals. Alternatively, the pulse generation module will only begin discharging when the S signal received by the pulse generation module, the B signal output by the second delay submodule, the signal output by the second NOT gate, and the D signal output by the physical switch monitoring module are all simultaneously high-level signals. As long as any of the above signals does not meet the requirements, regardless of whether pulse discharge has started, there is no risk of the pulse generation module outputting a pulse signal when the pulse wire is grounded. Example
[0128] This embodiment adds a temperature acquisition module to embodiment one, two, three, four, or five. The signal input terminal of the control module is electrically connected to the signal output terminal of the temperature acquisition module to receive the temperature signal acquired by the temperature acquisition module. When acquiring temperature, the temperature acquisition module eliminates pulse interference signals through embodiment one, two, three, four, or five, thereby improving the accuracy of the acquired signal. Example
[0129] This application also provides a pulse ablation system, including a pulse ablation host and a pulse ablation catheter electrically connected to the pulse ablation host. The pulse ablation host is provided with a control circuit for eliminating interference signals as provided in any one of Embodiments 1 to 5.
[0130] In this pulse ablation system, the signal input terminal of the control module is electrically connected to the wiring terminals on the pulse ablation catheter via an interface module. The pulse ablation catheter includes thermocouple wires and a pulse lead assembly. The control module connects to the thermocouple wires within the pulse ablation catheter. The thermocouple wires are electrically connected to the signal output terminal of a temperature sensor used to acquire the temperature of the ablated tissue. The control module receives the ablated tissue temperature acquired by the temperature sensor through the thermocouple wires. Based on the aforementioned control circuit for eliminating interference signals, when the switch module is open, the pulse lead assembly is disconnected from ground; when closed, the pulse lead assembly within the pulse ablation catheter is connected to ground. This discharges interference signals on the pulse lead through grounding, clearing the interference signals and achieving accurate acquisition of the ablated tissue temperature. In this embodiment, the ground of the pulse ablation system host can be used directly. That is, when the switch module is closed, the pulse lead assembly is short-circuited to the host casing of the pulse ablation system; when the switch module is open, the pulse lead assembly is disconnected from the host casing of the pulse ablation system.
[0131] In the description of this specification, references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.
[0132] Although embodiments of the invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
Claims
1. A control circuit for eliminating interference signals, capable of eliminating interference signals generated during discharge in a pulse ablation system, characterized in that, include: The pulse generation module is used to generate and output pulse signals; An interface module, electrically connected to the pulse generator module, is used to receive the pulse signal; The control module is electrically connected to the pulse generation module and is used to send a first control signal to the pulse generation module to generate a pulse signal and a second control signal to stop outputting the pulse signal. A switch module, one end of which is disposed in the path between the pulse generating module and the interface module, and the other end of which is grounded. When the switch module is closed, both the pulse generating module and the interface module are grounded. The delay module has its input terminal electrically connected to the control module, its first output terminal electrically connected to the control terminal of the switch module, and its second output terminal electrically connected to the pulse generation module. The time when the delay module receives the first control signal and controls the pulse generation module to generate and output a pulse signal based on the first control signal is delayed compared to the time when the switch module is turned on. The time at which the delay module receives the second control signal and controls the switch module to close based on the second control signal is delayed compared to the time at which the pulse generation module stops outputting pulse signals.
2. The control circuit for eliminating interference signals according to claim 1, characterized in that, The delay module receives the first control signal and delays it for a first duration before inputting it to the switch module, and delays it for a second duration before inputting it to the pulse generation module, wherein the first duration is less than the second duration; The delay module receives the second control signal and delays it for the first duration before inputting it to the pulse generation module, and then delays it for the second duration before inputting it to the switch module.
3. The control circuit for eliminating interference signals according to claim 2, characterized in that, The delay module includes: The first delay submodule has its input terminal electrically connected to the control signal output terminal of the control module, and its output terminal electrically connected to the control terminal of the switch module. The first delay submodule receives the first control signal and delays for the first duration or receives the second control signal and delays for the second duration. The second delay submodule has its input terminal electrically connected to the control signal output terminal of the control module. The second delay submodule receives the first control signal and delays for the second duration, or receives the second control signal and delays for the first duration.
4. The control circuit for eliminating interference signals according to claim 2, characterized in that, The delay module includes: The first delay submodule has its input terminal electrically connected to the control signal output terminal of the control module, and its output terminal electrically connected to the control terminal of the switch module. The first delay submodule receives the first control signal and delays for the first duration or receives the second control signal and delays for the second duration. The second delay submodule is electrically connected between the control signal output terminal of the control module and the input terminal of the pulse generation module; The first switch submodule is electrically connected between the control signal output terminal of the control module and the input terminal of the second delay submodule; The second switch submodule is electrically connected between the first delay submodule and the second delay submodule; When the control module outputs a first control signal, the first switch submodule is opened, the second switch submodule is closed, and the second delay submodule delays the first control signal after a first delay for a third delay; when the control module outputs a second control signal, the first switch submodule is closed, the second switch submodule is opened, and the second delay submodule receives the second control signal and delays it for the first delay. The third duration is the difference between the second duration and the first duration.
5. The control circuit for eliminating interference signals according to claim 1, characterized in that, The delay module includes: The first delay submodule has its input terminal electrically connected to the control signal output terminal of the control module, and its output terminal electrically connected to the control terminal of the switch module. The first delay submodule receives the first control signal and delays for a first duration or receives the second control signal and delays for a second duration; the first duration is less than the second duration. The second delay submodule has its input terminal electrically connected to the control signal output terminal of the control module. The second delay submodule receives the first control signal and delays for the second duration, or receives the second control signal and delays for the first duration; or, the input terminal of the second delay submodule is electrically connected to the output terminal of the first delay submodule. The second delay submodule receives the first control signal or the second control signal after the delay by the first delay submodule, and then delays again. An AND gate is configured such that its inputs are electrically connected to the control signal output of the control module and the output of the second delay submodule, and its output is electrically connected to the input of the pulse generation module. After receiving the first control signal output by the control module and the first control signal output by the second delay submodule, the AND gate outputs the first control signal to the pulse generation module. After receiving the second control signal output by the control module, the AND gate outputs the second control signal to the pulse generation module.
6. The control circuit for eliminating interference signals according to claim 5, characterized in that, The delay module also includes: The first NOT gate has its input terminal connected to the signal output terminal of the first delay submodule, and performs inversion processing on the signal output by the first delay submodule. The signal output terminal of the first NOT gate is connected to the control terminal of the switch module. The second NOT gate has its input connected to the signal output of the first NOT gate, and inverts the output signal of the first NOT gate. The signal output of the second NOT gate is connected to the signal input of the AND gate.
7. The control circuit for eliminating interference signals according to claim 5, characterized in that, The switching module includes: A physical switch module, one end of which is connected to the path between the pulse generation module and the interface module, the other end of which is grounded, and its control terminal is connected to the first output terminal of the delay module; The physical switch monitoring module is electrically connected between the AND gate module and the physical switch module; The physical switch monitoring module monitors the closed and open states of the physical switch module and sends the monitoring results to the AND gate module, so that when the physical switch module is closed, the signal generating module does not output a pulse signal.
8. The control circuit for eliminating interference signals according to any one of claims 1-6, characterized in that, It also includes a temperature acquisition module, and the signal input terminal of the control module is electrically connected to the signal output terminal of the temperature acquisition module through the interface module.
9. A pulse ablation system, characterized in that, The device includes a pulse ablation host and a pulse ablation catheter electrically connected to the pulse ablation host, wherein the pulse ablation host is provided with a control circuit for eliminating interference signals as described in any one of claims 1-7; The signal input terminal of the control module is electrically connected to the wiring terminal located on the pulse ablation catheter through the interface module.
10. The pulse ablation system according to claim 9, characterized in that, The pulse ablation catheter is equipped with a temperature sensor, and the wiring terminal includes a thermocouple wire welded to the temperature sensor; the thermocouple wire is electrically connected to the signal input terminal of the control module through the interface module.