An animal restraint device for inhalation drug delivery
By designing a highly adaptable animal restraint device, the problems of compliance and drug absorption in large laboratory animals during oral and nasal inhalation drug administration were solved, achieving higher data accuracy and experimental safety.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- MEDICILONMPI PRECLINICAL RES SHANGHAI
- Filing Date
- 2025-01-23
- Publication Date
- 2026-05-26
AI Technical Summary
Existing animal restraints result in low animal compliance during oral and nasal drug administration to large laboratory animals, causing compression of the lungs and abdomen, which affects drug absorption and data accuracy. Furthermore, unabsorbed drug residues pose a safety hazard to the environment.
An animal restraint device was designed, including a support frame, an animal fixation box, a head cover, and a tray. The device allows experimental animals to stand on the tray, and the height and angle of the tray can be adjusted to accommodate different animals, reducing lung and abdominal pressure. Unabsorbed drugs are adsorbed by an adsorption medium inside the head cover.
It improved compliance and data accuracy in large laboratory animals undergoing oral and nasal inhalation drug administration, reduced drug leakage to the environment, and enhanced the safety and reliability of experiments.
Smart Images
Figure CN224269510U_ABST
Abstract
Description
Technical Field
[0001] This utility model belongs to the field of preclinical research experimental instruments in biomedicine, specifically relating to an animal restraint device for inhalation drug delivery. Background Technology
[0002] Food and Drug Administrations in various countries stipulate that new drugs must undergo safety and toxicity assessments in at least two animal species before entering human clinical trials, at least one of which must be a non-rodent large animal, such as a monkey, dog, or pig.
[0003] With the increasing efforts in drug research and development both domestically and internationally, nebulized inhalation therapy is being explored and developed more and more. Inhaled formulations are no longer limited to treating traditional respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD), but can also be used to treat cardiovascular diseases (coronary heart disease, angina pectoris, etc.), cerebrovascular diseases (stroke, cerebral infarction, migraine, etc.), endocrine diseases (diabetes, etc.), analgesia, and neurological diseases. As an alternative route of administration besides oral and intravenous administration, inhaled drug delivery is more targeted and efficient. Inhaled formulations are portable and have better patient compliance. Furthermore, they can not only utilize their physical targeting and local application to treat lung diseases, but also leverage the large absorption surface area and rich vascular network of the lungs for systemic delivery of large biological molecules and poorly soluble drugs.
[0004] When administering such inhaled formulations via nasal or oral in large animals such as pigs or dogs, the animals need to be restrained. Commonly used restraints include slotted restraints and V-shaped surgical restraints, suitable for restraining animals such as pigs or dogs during anesthesia or surgery. Additionally, there is the Nagai-type restraint, which confines large animals in a cage with their forelimbs extended, allowing for injection / nasal / oral administration, blood collection, and other procedures. However, using these restraints presents certain problems when administering drugs via nasal or oral inhalation to experimental animals. Firstly, animal compliance during restraint is low, causing difficulties for nasal or oral administration and data collection. Secondly, the lungs or abdomen of the animal are compressed during restraint, especially during inhalation administration, severely interfering with the absorption of the test substance (experimental drug) and thus affecting the conduct of non-clinical research.
[0005] Existing immobilizers of this type do not result in high animal compliance during either dry powder inhalation or liquid nebulization inhalation experiments. The direct reason is that when animals are immobilized, their lungs and abdomen are directly compressed by the immobilizer. For drug delivery methods that enter the lungs through inhalation via the mouth and nose, the actual amount deposited in the lungs does not meet the design requirements. Ultimately, this leads to the exposure of the test product into the lungs and bloodstream not reaching the experimental target value, resulting in significant data deviation and hindering the objective evaluation of the test product in preclinical trials.
[0006] In addition, during the oral and nasal inhalation of atomized substances, any test substances that are not absorbed by the experimental animals may remain in the room and be directly discharged into the surrounding environment, posing a safety hazard to experimental personnel and the laboratory environment. Utility Model Content
[0007] In view of the shortcomings of the prior art described above, the purpose of this utility model is to provide an animal restraint device for inhalation drug administration, thereby solving the problem that the existing animal restraints exert great pressure on the lungs and abdomen of the animals, making it difficult for the animals to inhale the drug during inhalation drug administration experiments and resulting in low compliance of the experimental animals during the experiments.
[0008] To achieve the above objectives, the present invention adopts the following technical solution:
[0009] An animal restraint device for inhalation administration, comprising:
[0010] A support frame, the support frame including a plurality of support legs and a support plate disposed at the top of the plurality of support legs;
[0011] An animal restraint box, which is mounted on the support plate, is used to house and restrain laboratory animals;
[0012] A head cover, which is closably connected to a side opening on one side of the animal holding box along its length; and
[0013] A tray, movably mounted on the support leg and located below the animal holding box, has sliding through holes corresponding to the support leg, and is slidably connected to the support leg through these holes. The side of the tray has a support hole communicating with the sliding through hole and a fixing member disposed within the support hole.
[0014] A predetermined gap exists between the sliding through-hole of the tray and the support leg, so that the horizontal angle of the tray can be adjusted by adjusting the height of only one side of the tray.
[0015] As one embodiment of this utility model, the animal holding box includes: a lower box body, which is installed on the support plate of the support frame; and an upper cover body, which is closably connected to the lower box body.
[0016] In one embodiment of this utility model, the upper cover is hinged or pushed-pull connected to the lower box.
[0017] In one embodiment of this utility model, the lower housing has a ring frame along its length on the same side of the headgear, the ring frame forming the side opening, and the headgear is closably connected to the ring frame.
[0018] In one embodiment of this utility model, the bottom surface of the animal restraint box is provided with multiple restraint holes, which are used for inserting the limbs of the experimental animal to restrain the experimental animal, so that the experimental animal can stand on the tray after inserting its limbs into the restraint holes.
[0019] In one embodiment of this utility model, the bottom surface of the animal restraint box is provided with a canvas for restraining the experimental animal, and the canvas is provided with the plurality of restraint holes.
[0020] In one embodiment of this utility model, the bottom surface of the animal holding box is an arc surface, and the top of the support frame is provided with an arc-shaped mounting surface that fits into the arc surface. The animal holding box is mounted on the arc-shaped mounting surface of the support frame through the arc surface fitting into the arc surface.
[0021] In one embodiment of this utility model, the head cover is provided with a vent, which is used for the inhalation of medication by the experimental animal while ensuring the animal's respiration.
[0022] In one embodiment of this utility model, the headgear is provided with an adsorption medium, which is used to adsorb experimental drugs that are not absorbed by the experimental animals during inhalation administration.
[0023] In one embodiment of this utility model, there are two vents, which are respectively located on the front end and the lower end of the head cover.
[0024] In one embodiment of this utility model, the fixing member is an adjusting bolt that passes through the support hole and extends to the support leg.
[0025] In one embodiment of this utility model, the support leg is provided with a T-shaped guide groove extending along the height direction and a fastening nut slidably disposed in the T-shaped guide groove. The adjusting bolt is threadedly connected to the fastening nut, and there is a specified gap between the fastening nut and the bottom of the T-shaped guide groove to achieve adjustment of the horizontal angle of the tray.
[0026] In one embodiment of this utility model, the support leg is provided with a limiting groove extending along the height direction and adjacent to the T-shaped guide groove, and a sliding block protruding from the sliding through hole is slidably connected to the limiting groove.
[0027] In one embodiment of this utility model, there are two limiting grooves, which are respectively provided on the opposite sides of the supporting leg.
[0028] In one embodiment of this utility model, the bottom end of the support frame is equipped with multiple casters.
[0029] Compared with the prior art, the beneficial effects of this utility model are as follows:
[0030] 1. The animal restraint device of this utility model improves the comfort of large animals in oral and nasal inhalation fixation by a reasonable restraint method (i.e., by enabling the experimental animal to stand on the tray), reduces pressure on the lungs and abdomen of large animals, and ultimately improves the accuracy and stability of drug administration data of large animals via oral and nasal inhalation.
[0031] 2. This invention exhibits high compliance when restraining large animals such as pigs and dogs, reduces the pressure on the abdomen of experimental animals during inhalation administration, and improves the accuracy and stability of dosage data testing for drugs inhaled into the lungs via the mouth and nose, which is beneficial for the objective evaluation of preclinical test substances.
[0032] 3. This invention, by setting up a head cover, can avoid interference from the external environment to the experimental animals during the experiment. At the same time, the adsorption medium can be used to inhale the residual drug after atomization, reducing the amount of test substance directly exposed to the environment during atomization drug administration. Attached Figure Description
[0033] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0034] Figure 1 This is a schematic diagram of the structure of an animal restraint device for inhalation drug delivery according to a specific embodiment of the present invention;
[0035] Figure 2 yes Figure 1 A magnified view of a portion of the image;
[0036] Figure 3 This is a cross-sectional view showing the connection structure of the support legs and tray of the animal restraint device.
[0037] Figure label:
[0038] 10-Laboratory animals;
[0039] 100-Support frame, 110-Support leg, 111-Guide groove, 112-Limiting groove, 120-Support plate;
[0040] 200-Animal restraint box, 210-Lower box body, 211-Ring frame, 212-Restraint hole, 213-Side opening, 220-Upper cover;
[0041] 300-Headgear;
[0042] 400 - Tray, 410 - Sliding through hole, 420 - Support hole, 430 - Adjusting bolt, 440 - Fastening nut;
[0043] 500-Swivel casters. Detailed Implementation
[0044] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application. In addition, it should be understood that the specific embodiments described herein are only for illustration and explanation of this application and are not intended to limit this application. In this application, unless otherwise stated, directional terms such as "up," "down," "left," "right," "front," and "back" generally refer to up, down, left, and right in the actual use or working state of the device, specifically the drawing directions in the accompanying drawings.
[0045] It should be noted that the order of description of the following embodiments is not intended to limit the preferred order of the embodiments of this application. Furthermore, the descriptions of each embodiment in the following embodiments have their own emphasis; for parts not described in detail in a certain embodiment, please refer to the relevant descriptions in other embodiments.
[0046] like Figure 1 The illustration shows an animal restraint device for inhalation drug delivery according to a specific embodiment of the present invention. This animal restraint device is used to restrain experimental animals 10 during animal experiments involving the inhalation of formulation drugs, facilitating oral and nasal administration of the drug. While the experimental animal 10 depicted in the figure is a dog (shown by dashed lines), it can also be other types of animals such as pigs or monkeys. The animal restraint device of this invention can be used to restrain various types of large experimental animals.
[0047] Continue to refer to Figure 1In one specific embodiment, the animal restraint device comprises: a support frame 100, an animal fixation box 200, a head cover 300, and a tray 400. The animal fixation box 200 is mounted on top of the support frame 100 and is used to house and restrain the experimental animal 10. The head cover 300 is closable and mounted on a side opening 213 along the length of the animal fixation box 200, allowing the head of the experimental animal to extend into the head cover 300 through the side opening 213. The head cover 300 has a vent (not shown) through which the experimenter can administer medication to the experimental animal 10 in the animal fixation box 200, while also ensuring the animal's breathing. The tray 400 is vertically movable and mounted on the support frame 100, located below the animal fixation box 200 and opposite its bottom surface. The bottom surface of the animal fixation box 200 has multiple restraint holes 212 into which the limbs of the experimental animal 10 can be inserted, thereby restraining the experimental animal 10. The experimental animal 10 has its limbs inserted into the restraint holes 212 and stands on the tray 400 after its feet reach the tray. Standing the animal on the tray ensures that its abdomen or lungs are not compressed by the bottom of the animal cage, allowing for smooth drug inhalation and improving the success rate of inhalation drug delivery experiments. Furthermore, the tray can move up and down within the support frame to adjust the distance from the animal cage, thus accommodating experimental animals of different heights and leg lengths.
[0048] Furthermore, administering medication to the experimental animal 10 via the vent on the head cover 300 can be done using existing methods of placing a mask over the animal's head or mouth and nose. Specifically, first, the head cover 300 is opened and the mask (not shown) is placed over the animal's mouth and nose. Second, the medication delivery tube (not shown) connected to the mask is passed through the vent on the head cover 300 and connected to an external medication delivery device (not shown). Finally, the medication is administered to the experimental animal through the medication delivery device. Of course, other types of medication delivery methods can also be used, and this invention is not limited to these.
[0049] Continue to refer to Figure 1In one specific embodiment, the support frame 100 consists of four support legs 110 and two support plates 120 mounted on the tops of the four support legs. One support plate 120 connects two support legs 110 on one side of the length direction, and the other support plate 120 connects two support legs 110 on the other side of the length direction, thereby forming a pair of support frames arranged opposite each other in the length direction (i.e., the support frame 100 is composed of this pair of support frames). The animal holding box 200 is mounted on top of this pair of support frames (specifically, mounted on the two support plates 120). Furthermore, there may be three or four or more support legs, and the support plates may be not two but a single plate connecting multiple support legs. This invention does not limit the specific structure of the support frame, as long as it can accommodate the aforementioned animal holding box 200 and tray 400.
[0050] Continue to refer to Figure 1 In one specific embodiment, the animal restraint box 200 includes a lower box body 210 at the bottom and an upper cover body 220 at the top. The lower box body is mounted on top of the support frame 100 (specifically, on two support plates 120), and the upper cover body 220 is closably connected to the lower box body 210. Opening the upper cover body 220 allows the experimental animal to be placed and restrained in the lower box body 210; closing the upper cover body 220 seals the animal restraint box 200, allowing for the next step of drug administration. The upper cover body 220 and the lower cover body 210 may be hinged. Preferably, the upper cover body 220 and the lower cover body 210 are hinged on one side in the width direction, and the other side in the width direction is connected by a snap-fit connection, facilitating the fixing and unfixing of the upper cover body 220 and the lower cover body 210. Alternatively, the upper cover 220 and the lower cover 210 can adopt a push-pull opening and closing structure. Specifically, the lower cover 210 has sliding grooves on both sides in the width direction, and the upper cover 220 has sliding rods slidably connected to the sliding grooves on both sides in the width direction. The upper cover 220 and the lower cover 210 are connected by the sliding rods and sliding grooves in a push-pull manner. Thus, by setting the animal restraint box 200 as a lower box body and an upper cover body that can be opened and closed, it is convenient to fix and release the experimental animal 10. However, the animal restraint box may not be set as an upper and lower cover structure, or the head cover may be set as an openable and closable structure, thereby placing the experimental animal through the aforementioned side opening 213; or a cover for opening and closing may be set on the other side of the length direction of the animal restraint box. This utility model does not limit the specific opening and closing method of the animal restraint box, as long as it is a structure that can open and close the animal restraint box.
[0051] In one specific embodiment, the upper cover 220 or the lower cover 210 may be made of materials such as stainless steel, acrylic sheet, or plastic.
[0052] In a preferred embodiment, the bottom surface of the animal restraint box 200 is provided with a canvas for restraining the experimental animal 10, and a plurality of restraint holes 212 are provided on the canvas. Specifically, the bottom surface of the animal restraint box 200 has a canvas mounting opening, and the canvas is installed over the canvas mounting opening. Using a flexible canvas to restrain animals can accommodate animals of different sizes, and the canvas can completely cover the animal, improving the animal's compliance. Preferably, the number of restraint holes 212 is four. More preferably, the restraint holes 212 are arranged in pairs along the length direction, with four or more holes. Thus, different restraint holes can be selectively inserted according to the animal's body length to accommodate experimental animals of different lengths.
[0053] Continue to refer to Figure 1 In one specific embodiment, the bottom surface of the animal restraint box 200 is an arc surface, and the top of the support frame 100 is provided with an arc-shaped mounting surface that fits into the arc surface (for example, the upper surface of the support plate 120 is the arc-shaped mounting surface). The animal restraint box 200 is mounted to the arc-shaped mounting surface through the arc surface. By setting the bottom surface of the animal restraint box 200 to an arc surface, it can adapt to the body shape of the experimental animal and improve the compliance of the restrained experimental animal. Preferably, the animal restraint box 200 is a cylindrical box, and the arc surface is the arc surface of the cylindrical box. More preferably, the animal restraint box 200 is divided into an upper cover 220 and a lower box 210 along the radial direction of the cylindrical box. Setting it to a cylindrical box facilitates the molding and manufacturing of the animal restraint box.
[0054] In a preferred embodiment, the connection between the upper cover 220 and the lower box 210 is positioned to prevent the upper cover 220 from pinching the experimental animal during opening and closing. Preferably, it is parallel to or higher than the back of the experimental animal. For example, the connection between the upper cover 220 and the lower box 210 can be located on the lower side of the middle of the animal restraint box.
[0055] Continue to refer to Figure 1In one specific embodiment, a ring frame 211 is provided on one side of the lower housing 210 along its length, and the ring frame 211 forms the aforementioned side opening 213. A head cover 300 is closably mounted on one side of the ring frame 211 along its length. Here, mounting the head cover 300 on the housing via the ring frame 211 prevents the head cover 300 from interfering with the opening and closing of the upper cover 220 and the lower housing. Furthermore, the head cover 300 is designed to be closable, not only for opening the side opening to cover the experimental animal, but also for allowing researchers to easily open the head cover and observe the animal's condition through the side opening. The upper side of the head cover 300 is hinged to the ring frame 211. Of course, other types of opening and closing structures are also possible, and this invention does not limit the specific opening and closing methods of the head cover and ring frame. In the closed state, the head cover 300 is sealed to one side of the ring frame 211. Preferably, a sealing strip can be provided between the edge of the head cover and the edge of the ring frame to achieve a sealed connection in the closed state. Furthermore, when closed, the upper cover 220 is sealed to the other side of the lower housing 210 and the ring frame 211. Preferably, sealing strips can be provided at the edges of the upper cover, the lower cover, and the ring frame to achieve a sealed connection in the closed state. This prevents leakage of experimental drugs from the joints of the components.
[0056] In a preferred embodiment, the hood is made of a transparent material, which allows for real-time monitoring of the experimental animal's condition even when the hood is closed.
[0057] In one specific embodiment, the head cover 300 has two vents, located at the front and lower ends of the head cover 300, respectively. By providing two vents, the breathing sufficiency of the experimental animals is improved, further enhancing their compliance during the experiment, and consequently improving the accuracy and stability of the experimental data.
[0058] The headgear 300 contains an adsorption medium for adsorbing atomized residues of experimental drugs excreted or unabsorbed by the experimental animals. The adsorption medium can be, for example, activated carbon. By providing an adsorption medium, the direct release of test drug residues into the surrounding environment is prevented, thus avoiding safety hazards to laboratory personnel and the laboratory environment. Preferably, the headgear 300 includes a accommodating space (not shown) where the activated carbon is stored. More preferably, the accommodating space is located at the upper part of the headgear 300. This location at the upper part keeps the head away from the animal's head, preventing contact between the animal and the adsorption medium and thus avoiding stress reactions.
[0059] Reference Figures 1 to 3 In one specific embodiment, the tray 400 employs the following structure to achieve adjustment of its angle and height relative to the animal holding box 200. The tray 400 is located below the lower box 210 and is movably connected to the support frame 100, and its height and horizontal angle are adjustable.
[0060] Specifically, refer to Figure 2 and Figure 3 The tray 400 has four sliding through holes 410 at its four corners, through which it is slidably connected to the support leg 110. This allows the tray 400 to slide up and down along the support leg 110 via the sliding through holes 410 to achieve height adjustment. Furthermore, the side of the tray 400 has a support hole 420 perpendicular to and communicating with the sliding through hole 410, and an adjusting bolt 430 located within the support hole 420. The support leg 110 has a T-shaped guide groove 111 extending along the height direction and opposite to the support hole. The bottom dimension of the guide groove 111 is larger than the opening dimension, and a slidable fastening nut 440 is located within the bottom of the guide groove 111. The adjusting bolt 430 passes through the opening of the guide groove 111 and is threadedly connected to the fastening nut 440 at the bottom. The tray 400 is fixed to the guide groove 111 of the support leg 110 by tightening the adjusting bolt 430 and the fastening nut 440, thereby fixing the tray 400 in its current position. When the tray height needs to be adjusted, loosen the adjusting bolt 430 and the fastening nut 440, adjust the height of the tray 400, and then tighten the adjusting bolt 430 again to complete the height adjustment. Alternatively, the T-shaped guide groove 111 and the fastening nut 440 can be omitted. In this case, the support hole 420 can be a threaded hole, and the adjusting bolt 430 is threaded into the support hole 420. Tightening the adjusting bolt 430 so that it abuts against the support leg 110 will fix the tray 400 in its current position. When the tray height needs to be adjusted, loosen the adjusting bolt 430, adjust the height of the tray 400, and then tighten the adjusting bolt 430 so that it abuts against the support leg 110 to complete the height adjustment. Other fasteners, such as elastic elements or snap-fit elements, can also be used instead of the adjusting bolt 430 in the support hole 420. This utility model is not limited to this, as long as the position of the tray can be fixed and adjusted through the support hole 420.
[0061] Furthermore, there is a certain gap between the sliding through hole 410 of the tray 400 and the support leg 110, and there is also a certain gap between the fastening nut 440 and the bottom of the guide groove 111. Therefore, the horizontal angle can be adjusted by adjusting the height of only one side of the tray 400. For example, by pushing one side of the tray 400 upwards while keeping the other side stationary, the sliding through hole 410 on one side of the tray 400 moves upwards and tilts relative to the support leg 110, while the fastening nut 440 in the guide groove 111 moves upwards and tilts relative to the guide groove 111 (the aforementioned gaps can serve as the tilting space for the sliding through hole 410 relative to the support leg 110 and the tilting space for the fastening nut 440 relative to the guide groove 111). Thus, one side of the tray 400 is higher than the other, causing the tray 400 to tilt, thereby adjusting the horizontal angle.
[0062] In one specific embodiment, each of the four support legs 110 is provided with at least one limiting groove 112 extending along the height direction; a sliding block corresponding to the limiting groove 112 is protruding inside the sliding through hole 410, and the sliding block is slidably connected to the limiting groove 112. The guide groove 111 of this invention is provided on the side of the support leg 110 perpendicular to the length direction of the animal fixing box, and the limiting groove 112 is provided on the side of the support leg 110 perpendicular to the width direction of the animal fixing box, that is, the limiting groove 112 and the guide groove 111 are adjacent. Therefore, when adjusting the height of the tray 400, the adjustment process of the tray is limited by the sliding block and the limiting groove 112, preventing the adjustment height of one corner of the tray 400 from being higher than other corners, thus preventing jamming. Figure 1 and Figure 2 As shown, for example, there are two limiting grooves 112, which are respectively provided on opposite sides of the animal fixing box of the support leg 110 in the width direction.
[0063] Therefore, by setting the tray 400 to be height-adjustable, it can be adapted to animals of different heights and sizes, thereby improving the comfort of different animals; by setting the tray 400 to be angle-adjustable, the excrement of experimental animals can slide down the inclined tray, making it easier to clean the excrement.
[0064] In one specific embodiment, the bottom ends of the plurality of support legs 110 are respectively equipped with casters 500, which facilitates the movement of the animal restraint device.
[0065] The solution of this application has been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of this application. The description of the above embodiments is only for the purpose of helping to understand the method and core ideas of this application. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the ideas of this application. Therefore, the content of this specification should not be construed as a limitation of this application.
[0066] Throughout this specification, the terms "an embodiment," "embodiment," or "specific embodiment" refer to a particular feature, structure, or characteristic described in connection with an embodiment that is included in at least one embodiment of this application, but not necessarily in all embodiments. Therefore, the various representations of the phrases "in one embodiment," "in an embodiment," or "in a specific embodiment" in different places throughout this specification do not necessarily refer to the same embodiment. Furthermore, a particular feature, structure, or characteristic of any specific embodiment of this application may be combined with one or more other embodiments in any suitable manner. It should be understood that other variations and modifications of the embodiments described and illustrated herein may be based on the teachings herein and will be considered part of the spirit and scope of this application.
[0067] It should also be understood that one or more of the elements shown in the figures may be implemented in a more separate or more integrated manner, or may even be removed because they are inoperable in certain circumstances or provided because they may be useful for a particular application.
[0068] Furthermore, unless otherwise expressly stated, any arrows in the accompanying drawings should be considered illustrative only and not limiting. Additionally, unless otherwise stated, the term "or" as used herein is generally intended to mean "and / or". Where a term is anticipated to provide a separation or combination capability that is unclear, a combination of components or steps will also be considered as indicated.
Claims
1. An animal restraint device for inhalation administration, characterized in that, have: A support frame, the support frame including a plurality of support legs and a support plate disposed at the top of the plurality of support legs; An animal restraint box, which is mounted on the support plate, is used to house and restrain laboratory animals; A head cover, which is closably connected to a side opening on one side of the animal holding box along its length; and A tray, movably mounted on the support leg and located below the animal holding box, has sliding through holes corresponding to the support leg, and is slidably connected to the support leg through these holes. The side of the tray has a support hole communicating with the sliding through hole and a fixing member disposed within the support hole. A predetermined gap exists between the sliding through-hole of the tray and the support leg, so that the horizontal angle of the tray can be adjusted by adjusting the height of only one side of the tray.
2. The animal restraint device for inhalation administration according to claim 1, characterized in that, The animal holding cage includes: The lower housing, which is mounted on the support plate of the support frame; and The upper cover is closable and connectable to the lower housing.
3. The animal restraint device for inhalation administration according to claim 2, characterized in that, The lower housing has a ring frame along its length on the same side of the headgear, the ring frame forming the side opening, and the headgear is closably connected to the ring frame.
4. The animal restraint device for inhalation administration according to claim 1 or 2, characterized in that, The bottom surface of the animal holding box is provided with multiple restraint holes, which are used for inserting and restraining the limbs of the experimental animal, so that the experimental animal can stand on the tray after inserting its limbs into the restraint holes.
5. The animal restraint device for inhalation administration according to claim 4, characterized in that, The bottom of the animal restraint box is provided with a canvas for restraining the experimental animal, and the canvas has the plurality of restraint holes.
6. The animal restraint device for inhalation administration according to claim 1 or 2, characterized in that, The headgear is equipped with a vent for inhaling medication into the experimental animal while ensuring the animal's respiration.
7. The animal restraint device for inhalation administration according to claim 1 or 2, characterized in that, The fastener is an adjusting bolt that passes through the support hole and extends to the support leg.
8. The animal restraint device for inhalation administration according to claim 7, characterized in that, The support leg is provided with a T-shaped guide groove extending along the height direction and a fastening nut slidably disposed in the T-shaped guide groove. The adjusting bolt is threadedly connected to the fastening nut. There is a specified gap between the fastening nut and the bottom of the T-shaped guide groove to achieve adjustment of the horizontal angle of the tray.
9. The animal restraint device for inhalation administration according to claim 8, characterized in that, The support leg is provided with a limiting groove extending along the height direction and adjacent to the T-shaped guide groove, and a sliding block protruding from the sliding through hole is slidably connected to the limiting groove.
10. The animal restraint device for inhalation administration according to claim 9, characterized in that, The limiting grooves are two in number and are respectively located on the opposite sides of the supporting legs.