Long tube atomizing applicator

Abstract

The application provides a long-tube atomization administration device, which comprises an atomization administration hose with a length greater than 200 mm, the atomization administration hose comprises an airflow cavity and a drug liquid cavity, the area of a jet hole at the head end of the airflow cavity is not greater than 0.3 times the cross section of the airflow cavity; a drug outlet hole at the head end of the drug liquid cavity is arranged at the edge of the jet hole, the drug outlet hole and the central axis of the jet hole form an included angle of 45-90 degrees; a gas supply device is communicatively arranged at the tail end of the airflow cavity, and a drug administration device is communicatively arranged at the tail end of the drug liquid cavity; the pressurized airflow of the gas supply device is sprayed out through the narrow jet hole, a negative pressure is generated at the jet hole, the drug liquid discharged from the drug administration device through the drug outlet hole is sucked into the airflow and scattered into a mist, the long-tube atomization administration device is used for atomization administration of a deep body cavity through a medical endoscope operation channel or direct placement into a human body cavity, or is used for realizing oral and nasal atomization inhalation treatment of a patient in a lying position, and the long-tube atomization administration device has the advantages of simple structure, low cost, accurate administration, uniformity, high speed, safety and reliability.

Description

Technical Field

[0001] This invention relates to the field of medical devices, and more particularly to long-tube nebulizers for drug delivery. Background Technology

[0002] During endoscopic examinations, it is often necessary to administer medication (porphyrin drugs or fluorescein) locally into body cavities (digestive tract, airway) to perform fluorescence endoscopy. This facilitates the early detection of small tumors and precancerous lesions that cannot be diagnosed by conventional endoscopy, guides accurate biopsies, helps in the differential diagnosis of certain conditions, precisely locates the boundaries of tumors, and determines the extent of resection and the tumor killing effect.

[0003] Currently, most endoscopic fluorescent agents are administered via injection or spray, resulting in uneven distribution and large dosages. This not only affects clinical efficacy but also poses health risks. If a nebulizer is connected to the end of the endoscopic cavity, the atomized medication often forms condensation droplets on the inner wall as it passes through the narrow endoscopic passage, leading to extremely poor efficacy.

[0004] To enable fluoroscopic examination, fluorescent agent is often nebulized before the examination, which takes about half an hour. The dosage of fluorescent agent is large, and all respiratory tracts and alveoli are exposed to the fluorescent agent, which is harmful to patients and causes inconvenience to clinicians.

[0005] There is an urgent clinical need for a device that can be inserted through an endoscopic examination channel, and after exiting the endoscopic examination channel, can locally atomize and uniformly administer drugs on the inner wall of the body cavity to be examined, reducing the dosage of fluorescent agents and facilitating temporary implementation.

[0006] Meanwhile, respiratory or pulmonary diseases frequently occur in intubated patients in anesthesiology departments or ICUs, requiring nebulized drug delivery. During nebulized drug delivery, the nebulizer is located at the connection point between the endotracheal tube and the breathing tubing. The nebulized medication enters the respiratory system through the endotracheal tube. Due to the influence of the patient's respiratory airflow, a large amount of nebulized medication adheres to the inner wall of the endotracheal tube and the large airways, making it difficult to penetrate deep into the lungs, resulting in drug waste and poor efficacy. Clinically, there is an urgent need for a device that can directly deliver medication deep into the airways via nebulization, increasing the dosage of medication reaching the small airways and alveoli, reducing drug waste caused by respiration, and improving treatment effectiveness.

[0007] Currently, whether using medical or home nebulizers, nebulizers require the medication container at the inhalation end to be upright for non-intubated, conscious patients. Patients must be standing or sitting to receive nebulization, making it impossible to administer while supine. This is extremely inconvenient for critically ill elderly patients, comatose patients, and uncooperative young children, causing them burden and discomfort. There is an urgent clinical need for a device that does not restrict patient position, allowing for easy nebulization even when the patient is supine, facilitating nebulization for the elderly, comatose patients, and sleeping children. Summary of the Invention

[0008] To address the aforementioned deficiencies in the prior art, the present invention provides a long-tube nebulizer, comprising a nebulizer tube with a length greater than 200 mm. The nebulizer tube includes an airflow chamber and a drug liquid chamber. An air jet hole is provided at the head end of the airflow chamber, and the area of ​​the air jet hole is not greater than 0.3 times the cross-sectional area of ​​the airflow chamber.

[0009] The drug outlet is provided at the head end of the liquid cavity and is located at the edge of the air jet hole; the drug outlet forms an angle of 45-90° with the central axis of the air jet hole.

[0010] The air supply device is connected to the airflow chamber at the end of the nebulized drug delivery hose, and the drug liquid chamber is connected to the drug delivery device.

[0011] The pressurized airflow from the air supply device is ejected through the airflow chamber into a narrow jet hole, creating a negative pressure that draws the liquid medicine discharged from the medicine outlet through the medicine chamber into the airflow and disperses it into a mist.

[0012] Furthermore, the nebulizing drug delivery hose has a single-tube dual-lumen structure, with the main lumen being an airflow chamber and the secondary lumen being a drug liquid chamber; the head end of the nebulizing drug delivery hose is closed to form a blind end, and an air jet hole is provided in the drug liquid chamber that penetrates the side wall of the nebulizing drug delivery hose adjacent to the blind end, and the opening of the drug liquid chamber penetrated by the air jet hole forms a drug outlet; a 120-180° bend is provided at a distance of 5-15mm from the tail side of the air jet hole.

[0013] Furthermore, the nebulized drug delivery tubing has a dual-tube structure, with the main tube being an airflow chamber and the secondary tube being a drug liquid chamber.

[0014] The airflow chamber is sealed at the head end and a spray nozzle is provided, with a jet hole formed at the head side port of the spray nozzle; a drug outlet is provided at the edge of the jet hole in the connected drug liquid chamber.

[0015] Furthermore, the liquid medicine chamber is equipped with a control switch; the control switch is linked to the airflow chamber; when the airflow chamber is pressurized and supplied with air, the control switch is opened, and the liquid medicine chamber is connected; when the airflow chamber stops supplying air, the control switch is closed, and the liquid medicine chamber is blocked.

[0016] Furthermore, the control switch includes a bladder cavity communicating with the airflow cavity, a control rod adjacent to and penetrating the drug liquid cavity, a drug passage hole corresponding to the drug liquid cavity on the control rod, and an elastic body sleeve on the control rod.

[0017] When the pressure in the airflow chamber increases, the cyst expands, pushing the control rod to shift, and the drug passage and drug solution chamber are aligned. When the pressure in the airflow chamber decreases, the cyst returns to its original position, the elastic body elastically resets, pushing the control rod to reset, and the drug passage and drug solution chamber are misaligned and blocked.

[0018] Furthermore, the length of the nebulized drug delivery tube is 400-1000 mm, and the outer diameter is set to 1.5-1.8 mm or 2.5-2.8 mm.

[0019] The gas supply device and the drug delivery device are integrated into a dual-chamber syringe. The dual-chamber syringe includes an air injection chamber and a drug injection chamber, and the cross-sectional ratio of the air injection chamber and the drug injection chamber is greater than 5. The push rod pistons of the air injection chamber and the drug injection chamber are linked together.

[0020] Furthermore, the length of the nebulized drug delivery tube is 800-3000 mm, and the outer diameter is set to 15-40 mm.

[0021] The gas supply device includes an air pump and a medical oxygen source; the drug delivery device is configured as an automatic drug delivery device, including an elastic drug capsule, a drug injection micropump, and a suspended drug bag;

[0022] A perforated mask or mouthpiece is connected to the tip of the nebulizer tube.

[0023] Furthermore, the nebulizer tube has a length of 300-500 mm and an outer diameter of 1.5-4 mm.

[0024] The nebulizer tubing is equipped with a tee connector at the tail end, which connects the catheter interface, the circuit interface, and the nebulizer inlet. The catheter interface is compatible with the endotracheal tube breathing interface; the circuit interface is compatible with the threaded tube interface; and the nebulizer inlet is sealed to the outer diameter of the nebulizer tubing.

[0025] The gas supply device includes an air pump and a medical oxygen source; the drug delivery device is configured as an automatic drug delivery device, including an elastic drug capsule, a drug injection micropump, and a suspended drug bag.

[0026] Furthermore, the air pump is electrically connected to a chip for precise control of its power; a gas filter is installed at the air pump inlet.

[0027] Furthermore, the spray nozzle is provided with several three-way tubular adjustment accessories; the adjustment accessories are provided with secondary air jet holes through the long axis, and secondary discharge holes are provided through the side wall of one side of the adjustment accessories and connected to the secondary air jet holes.

[0028] Adjust the shape of the accessory to match the air jet hole of the spray nozzle, with the secondary air jet hole smaller than the air jet hole and the secondary discharge hole smaller than the discharge hole;

[0029] The adjusting accessory is fitted with a sealing assembly inside the jet hole, and the auxiliary jet hole is sealed and connected to the jet hole. At the same time, the auxiliary discharge hole is sealed and connected to the discharge hole.

[0030] The beneficial effects of this invention are:

[0031] 1. Through the unique structure of the nebulizer hose, the liquid medicine container is separated from the nebulizer liquid medicine outlet, thereby making the outer diameter of the entire nebulizer tube smaller, realizing drug delivery at the tail end of the nebulizer hose and nebulization at the head end of the nebulizer hose, enabling nebulizer drug delivery in any body position of the patient, avoiding condensation of the nebulized liquid medicine when it is transported through a long tube, and realizing nebulized drug delivery to deep body cavities.

[0032] 2. The small outer diameter of the drug delivery tube allows for convenient local nebulization drug delivery through endoscopic examination cavities; the drug delivery is uniform, the drug delivery site is precise, the drug dosage is small, and it facilitates fluorescence microscopy examination, improving examination results and reducing drug dosage;

[0033] 3. Facilitates deep airway drug administration for intubated patients, improves the accuracy of drug administration sites, reduces drug waste, and enhances the therapeutic effect of nebulized inhalation.

[0034] 4. Convenient for comatose patients to receive nebulized inhalation medication in any position (supine or semi-sitting); and for uncooperative young children to receive nebulized inhalation therapy while asleep;

[0035] 5. The jet nozzle creates negative pressure, which can draw out and atomize all the liquid medicine, avoiding waste of liquid medicine residue;

[0036] 6. Simple structure, low cost, disposable piping to avoid cross-infection, and easy to promote. Attached Figure Description

[0037] Figure 1 This is a schematic diagram of the structure of the first embodiment of the present invention;

[0038] Figure 2 This is a schematic diagram of the structure of the second embodiment of the present invention;

[0039] Figure 3 This is a schematic diagram of the structure of the third embodiment of the present invention;

[0040] Figure 4 This is a schematic diagram of the structure of the fourth embodiment of the present invention;

[0041] Figure 5 This is a schematic diagram of the structure of the fifth embodiment of the present invention;

[0042] Figure 6 A schematic diagram of a structure for providing a control switch for the liquid medicine chamber of the present invention;

[0043] Figure 7 This is a schematic diagram of one structure of the adjusting accessory of the present invention;

[0044] In the picture,

[0045] 1. Nebulizer tube; 11. Airflow chamber; 12. Medication chamber; 13. Air jet port; 14. Drug outlet port; 15. Spray nozzle; 16. Capsule cavity; 17. Control rod; 18. Drug inlet port; 19. Elastomer; 2. Air supply device; 3. Drug delivery device; 31. Dual-chamber syringe; 32. Air injection chamber; 33. Drug injection chamber; 34. Push rod piston; 4. Connecting tee; 41. Catheter interface; 42. Circuit interface; 43. Nebulizer inlet; 5. Adjustment accessory; 51. Secondary air jet port; 52. Secondary drug outlet port. Detailed Implementation

[0046] To enable those skilled in the art to better understand the technical solutions of the present invention and to make the above-mentioned features, objectives, and advantages of the present invention clearer and easier to understand, the present invention will be further described below with reference to embodiments. These embodiments are for illustrative purposes only and are not intended to limit the scope of the present invention.

[0047] Currently, all clinical nebulizers have their drug dispensing port and nebulizer solution bottle placed adjacent to each other, which has the following drawbacks:

[0048] The nebulizer bottle must be placed adjacent to the patient's mouth and nose, so that the nebulizer outlet is close to the patient's mouth and nose, to avoid excessive condensation of the nebulized medicine on the inner wall of the inhalation tubing, which would affect the nebulization treatment effect.

[0049] The nebulizer bottle must be kept upright, otherwise the medication will spill, which means that the patient must remain standing or sitting. When nebulization treatment must be performed on patients in a supine position, a transition tube must be set up before the nebulizer outlet. In this case, it is unavoidable that the nebulized medication will condense on the inner wall of the tube.

[0050] The nebulizer outlet is adjacent to the nebulizer liquid bottle, and its overall shape is large, making it impossible to enter narrow body cavities. Nebulized inhalation therapy can only be performed outside the mouth and nose. When local nebulized drug delivery to body cavities is required, the drug can only be delivered to the entire respiratory system, which wastes drugs and affects the treatment effect.

[0051] This invention employs a flexible, long tube tip-jet atomization technology. Both the liquid medication and the airflow are supplied from the tail end of the long tube, and drug delivery is atomized at the tip. Different tube diameters allow for application in various scenarios. The principle is based on Bernoulli's principle: when the airflow passes through the long tube and exits through a narrow nozzle, a negative pressure is created locally at the nozzle, drawing the supplied liquid medication into the jet of airflow and causing it to collide and disperse into aerosol particles. The size of the aerosol particles is related to the gas flow rate, the size of the narrow nozzle, and the liquid medication flow rate; the aerosol particle size can be controlled within 0.5-10 micrometers.

[0052] like Figure 1-5 As shown, the long tube nebulizer of the present invention includes a nebulizing drug delivery tube 1 with a length greater than 200 mm. The nebulizing drug delivery tube 1 includes an airflow chamber 11 and a drug liquid chamber 12. An air jet hole 13 is provided at the head end of the airflow chamber 11. The area of ​​the air jet hole 13 is not greater than 0.3 times the cross-section of the airflow chamber 11.

[0053] The drug chamber 12 is provided with a drug outlet 14 at its head end, and the drug outlet 14 is located at the edge of the air jet hole 13; the drug outlet 14 forms an angle of 45-90° with the central axis of the air jet hole 13.

[0054] The air supply device 2 is connected to the airflow chamber 11 at the end of the nebulized drug delivery hose 1, and the drug liquid chamber 12 is connected to the drug delivery device 3.

[0055] The pressurized airflow from the air supply device 2 is ejected through the airflow chamber 11 into the narrow jet hole 13, generating negative pressure in the jet hole 13. This draws the liquid medicine discharged from the drug dispensing device 3 through the drug liquid chamber 12 and the drug outlet 14 into the airflow and disperses it into a mist.

[0056] A nebulized drug delivery tube 1, with a length greater than 200 mm, serves as the flow channel for airflow and drug solution. Airflow passes through a relatively large-diameter airflow chamber 11, while the drug solution flows through a relatively narrow drug solution chamber 12. After flowing through the airflow chamber 11, the airflow exits through a jet nozzle 13 located at the head of the airflow chamber 11. The area of ​​the jet nozzle 13 is no greater than 0.3 times the cross-sectional area of ​​the airflow chamber 11. The airflow velocity increases by more than 3 times at the jet nozzle 13, creating a negative pressure on the sidewall of the jet nozzle 13. Simultaneously, after flowing through the drug solution chamber 12, the nebulized drug solution exits through a drug outlet 14 located at the edge of the jet nozzle 13 at a lower flow rate. Under the negative pressure generated by the high-speed airflow passing through the jet nozzle 13, the drug solution exiting through the drug outlet 14 is drawn into the jet airflow and dispersed into a mist by the collision of the high-speed airflow, thus achieving the atomization effect of the airflow on the drug solution. The central axis of the drug outlet 14 and the jet nozzle 13 forms an angle of 45-90°. This angle refers to the minimum angle between the perpendicular lines of the planes of the drug outlet 14 and the jet nozzle 13, and the maximum angle will not exceed 90°. In practice, the larger the angle between the planes of the drug outlet 14 and the jet nozzle 13, the better, with 90° being optimal. This facilitates the atomization of the liquid drug after it is discharged from the drug outlet 14 and drawn into the airflow by the negative pressure of the high-speed airflow inside the jet nozzle 13.

[0057] During atomization, the gas supply device 2 provides gas at a certain velocity and pressure to the airflow chamber 11. This can be a manual or electric gas supply device, and the airflow velocity can range from 2-15 L / min depending on the diameter of the airflow chamber 11. In this invention, the drug liquid chamber 12 has a long pipeline and a narrow inner cavity. The negative pressure generated solely by the high-speed airflow through the jet orifice 13 is insufficient to meet the drug liquid discharge requirements. The drug delivery device 3 should provide a certain power for the drug liquid flow, which can be done manually, mechanically, or electrically controlled. The discharge speed is much lower than the airflow velocity. The gas velocity supplied by the gas supply device, the drug liquid velocity supplied by the drug delivery device 3, and the ratio of the flow area of ​​the jet orifice 13 to the airflow chamber 11 all jointly determine the size of the aerosol particles after drug liquid atomization. The higher the gas velocity supplied by the gas supply device, the lower the drug liquid velocity supplied by the drug delivery device 3, and the smaller the ratio of the flow area of ​​the jet orifice 13 to the airflow chamber 11, the smaller the atomized drug liquid aerosol particles and the more uniform the atomized particles.

[0058] Furthermore, such as Figure 1As shown, the nebulizing drug delivery hose 1 has a single-tube double-lumen structure, with the main lumen being the airflow chamber 11 and the secondary lumen being the drug liquid chamber 12. The head end of the nebulizing drug delivery hose 1 is closed to form a blind end, and an air jet hole 13 is provided in the drug liquid chamber 2 that penetrates the side wall of the nebulizing drug delivery hose 1 adjacent to the blind end. The drug liquid chamber 2 is opened by the air jet hole 13 to form a drug outlet hole 14. A 120-180° bend is provided at a distance of 5-15mm from the tail side of the air jet hole 13.

[0059] The nebulizer tubing 1 is designed with a single-tube, dual-lumen structure, manufactured using an extrusion molding process. This allows for the integral molding of the main airflow chamber 11 and the secondary drug solution chamber 12. The diameter and length of the nebulizer tubing 1 can be arbitrarily controlled according to clinical needs, meeting various clinical scenarios. If necessary, the outer diameter of the nebulizer tubing 1 can be reduced by 1-3 mm to meet the needs of localized nebulization within confined cavities. The tip of the nebulizer tubing 1 is closed, forming a blind end. An air jet 13 is located adjacent to the blind end, penetrating the side wall of the drug solution chamber 2. The air jet 13 penetrates the side wall of the tubing 1 and simultaneously penetrates and connects to the corresponding localized main airflow chamber 11, forming a unique airflow outlet for the main airflow chamber 11. The area of ​​the air jet 13 should be less than 0.3 times that of the main airflow chamber 11, ideally 0.05-0.1 times. When the airflow in the main airflow chamber 11 passes through the air jet 13, the gas velocity increases by more than 3 times, ideally 10-20 times, creating negative pressure at the edge of the air jet 13. The head-side opening of the liquid medicine chamber 2, penetrated by the jet nozzle 13, forms the drug outlet 14. The drug outlet 14 is located at the tail edge of the jet nozzle 13. After the liquid medicine in the liquid medicine chamber 2 is discharged from the jet nozzle 13, it is drawn into the airflow by the high-speed airflow under negative pressure and atomized. It should be noted that in this embodiment, the cross-section of the liquid medicine chamber 2 determines the size of the drug outlet 14, and the two are of equal size. In order to control the airflow velocity and the liquid discharge ratio, the cross-section of the liquid medicine chamber 2 should be less than 0.3 times that of the main airflow chamber 11, and the optimal value is 0.05-0.1 times.

[0060] The biggest advantage of the single-tube, dual-lumen nebulizer tubing 1 is its suitability for endoscopic insertion into endoscopic operating channels (3mm or 2mm inner diameter channels), extending beyond the endoscope tip. This allows for localized nebulization of medication onto the inner wall of body cavities under endoscopic visualization. Applications include gastrointestinal fluoroscopy, and bronchoscopic examination of the airway walls during bronchoscopy. This facilitates uniform contact of the nebulized fluorescent agent with the localized inner wall of the body cavity, improving the accuracy of fluoroscopic examinations. Simultaneously, it reduces the amount of fluorescent agent used, avoiding its adverse effects.

[0061] The current method for temporary nebulization of fluorescent agents in fluorescence endoscopy is as follows: the end of a suitable flexible tube is sealed and several micro-holes are punctured. After being inserted into and extended out of the endoscope's operating channel, a syringe is connected to the end of the flexible tube to directly push and squeeze out the drug solution, similar to a shower head. The nebulization effect is extremely poor, the fluorescent agent on the inner wall of the body cavity is extremely uneven, the amount of fluorescent agent used is large, and it seriously affects the effect of fluorescence endoscopy.

[0062] A 120-180° bend is set at a distance of 5-15mm from the tail side of the jet hole 13 in the nebulizing drug delivery tube 1, specifically the angle between the long axes of the two sides of the bend. By setting the bend at a distance of 5-15mm from the tail side of the jet hole 13, the jet hole 13, which was originally located on the side of the head end of the nebulizing drug delivery tube 1, returns to its natural state after exiting the endoscope operating port, so that the jet hole 13 is facing the center of the body cavity, which facilitates rapid and uniform nebulization drug delivery to the annular inner wall of the body cavity under endoscopic visualization.

[0063] Furthermore, such as Figure 2-5 As shown, the nebulized drug delivery hose 1 has a dual-tube structure, with the main tube being an airflow chamber 11 and the secondary tube being a drug liquid chamber 12. The cross-sectional area of ​​the main tube is larger than that of the secondary tube, at least three times the cross-sectional area of ​​the secondary tube. The secondary tube can be located inside the main tube, such as... Figure 2-4 It can also be placed inside or outside the main cavity, such as... Figure 5 Depending on clinical needs, it is preferably placed inside the main lumen.

[0064] The airflow chamber 11 is sealed at one end with a spray nozzle 15. The spray nozzle 15 has a tubular structure, and its tail end is adapted to the opening on the head side of the airflow chamber 11, allowing for a sealed connection. The inner cavity of the spray nozzle 15 is tubular, and the airflow outlet on the head side is less than 0.3 times the cross-section of the airflow chamber 11. An air jet hole 13 is formed at the head side port of the spray nozzle 15. A drug outlet hole 14 is provided at the edge of the air jet hole 13 in the connected drug liquid chamber 12. Specifically, the drug outlet hole 14 is provided on the inner wall of the air jet hole 13 on the head side of the spray nozzle 15. The drug outlet hole 14 penetrates the side wall or tail end of the spray nozzle 15. A connection port is provided on the side wall or tail end of the spray nozzle 15 and is sealed to the drug liquid chamber 12. The drug liquid in the drug liquid chamber 12 is discharged through the drug outlet hole 14 on the inner edge of the air jet hole 13. The advantage of the spray nozzle 15 is that the discharge port 14 is directly set at the head end of the airflow chamber 11, and the position is upright; the disadvantage is that it is necessary to add the airflow chamber 11 pipeline and the liquid chamber 12 pipeline, which is difficult to implement for pipelines smaller than 3mm.

[0065] To further control the discharge from the drug delivery device 3 and prevent accidental loss of the medication during non-nebulization operations, a control switch is locally installed corresponding to the medication chamber 12. This control switch is linked to the airflow chamber 11. During nebulization, the air supply device 2 supplies air, pressurizing the airflow chamber 11. Under pressure feedback, the control switch automatically opens, connecting the medication chamber 12, and the medication from the drug delivery device 3 is discharged through the medication chamber 12 and atomized by the airflow. When nebulization stops, the air supply device 2 stops supplying air, the pressure feedback ceases, the airflow chamber 11 stops supplying air, the control switch automatically closes, the medication chamber 12 is blocked, and the medication from the drug delivery device 3 stops flowing into the medication chamber 12, thus stopping nebulization. The control switch can be configured as a pressure-sensitive electric control or a mechanical structure.

[0066] Specifically, such as Figure 6 The diagram shows a mechanical control switch for a drug-filled cavity 12. The control switch includes a pressure cavity 16 communicating with an airflow cavity 11. The pressure cavity 16 is a thin-walled bladder that expands under gas pressure and elastically returns to its original position when the gas pressure is released. A control rod 17 is positioned adjacent to and penetrating the drug-filled cavity 12. A drug passage hole 18 is correspondingly provided on the control rod 17 and the drug-filled cavity 12. An elastic body 19 is sleeved on the control rod. Initially, the elastic body 19 is in an elastically compressed state. Under the elastic action of the elastic body 19, the drug passage hole 18 of the control rod 17 is misaligned with the drug-filled cavity 12, and the control rod 17 penetrates and blocks the drug-filled cavity 12.

[0067] The air supply device 2 supplies air, pressurizing the airflow chamber 11. The increased pressure in the airflow chamber 11 expands the bladder 16, pushing the control rod 17 to move, further compressing the elastic body 19. This causes the drug passage 18 to align with both sides of the drug liquid chamber 12, connecting the two chambers. The drug liquid from the applicator 3 flows into the drug liquid chamber 12 and is discharged through the drug outlet 14. The discharged drug liquid is drawn into the airflow by the negative pressure generated by the high-speed airflow at the tail edge of the jet hole 13 at the head end of the airflow chamber 11 and is atomized and sprayed out. When the gas supply device 2 stops supplying gas, the airflow in the airflow chamber 11 ceases, the pressure in the airflow chamber 11 decreases, and the bladder cavity 16 elastically resets. Under the re-tensioning action of the elastic body 19, the control rod 17 is pushed to shift, and finally the elastic body 19 returns to its initial slightly compressed state. At the same time, the control rod 17 returns to its original position, and the drug passage 18 is misaligned with the two sides of the drug liquid chamber 12, blocking the drug liquid chamber 12. The drug liquid from the drug delivery device 3 no longer flows into the drug liquid chamber 12, and the drug outlet 14 no longer discharges drug liquid, thus stopping nebulization. This achieves the following: when the gas supply device 2 supplies gas, the drug delivery device 3 discharges liquid and performs nebulization; when the gas supply device 2 stops supplying gas, the drug delivery device 3 stops discharging liquid, and nebulization is paused. This ensures that the gas supply device 2's gas supply and the liquid discharge nebulization are linked, avoiding waste of drug liquid.

[0068] Furthermore, such as Figure 1As shown, the length of the nebulizing drug delivery tube 1 is 400-1000mm, and the outer diameter is set to 1.5-1.8mm or 2.5-2.8mm.

[0069] The gas supply device 2 and the drug delivery device 3 are integrated into a dual-chamber injector 31. The dual-chamber injector 31 includes an air injection chamber 32 and a drug injection chamber 33. The cross-sectional ratio of the air injection chamber 32 and the drug injection chamber 33 is greater than 5. The push rod piston 34 of the air injection chamber 32 and the drug injection chamber 33 are linked together.

[0070] This embodiment is mainly used for fluorescent nebulization or rapid intracavitary drug delivery during endoscopic examinations. The operating lumen of the endoscope is 2mm or 3mm. A 1.5-1.8mm nebulization drug delivery tube 1 can be smoothly inserted through the 2mm operating lumen of the endoscope, and a 2.5-2.8mm nebulization drug delivery tube 1 can be smoothly inserted through the 3mm operating lumen of the endoscope. After being inserted into and extended from the operating lumen of the endoscope, it can deliver nebulized drug delivery to the inner wall of the body cavity for fluorescent endoscopic examination or local treatment. The length of the nebulization drug delivery tube 1 is 400-1000mm to meet the needs of endoscopes of different lengths. The optimal length of the nebulization drug delivery tube 1 should be 3-5cm longer than the operating lumen of the endoscope for easy operation.

[0071] For fluorescence endoscopy or local drug administration, the drug volume is relatively small, and the size of the atomized particles is not critical. The main requirement is uniform drug administration, which must be completed within 1-5 minutes. To achieve this, the gas supply device 2 and the drug delivery device 3 are preferably integrated into a dual-chamber injector 31. The dual-chamber injector 31 includes an injection chamber 32 and a drug delivery chamber 33. The injection chamber 32 functions as the gas supply device 2, and the drug delivery chamber 33 functions as the drug delivery device 3. The cross-sectional ratio of the injection chamber 32 and the drug delivery chamber 33 is greater than 5, so that the gas volume of the injection chamber 32 is more than 5 times the volume of the drug delivery chamber 33, preferably 20-25 times. The gas injection chamber 32 and the drug injection chamber 33 are of similar length. The push rod piston 34 of both chambers is integrated and linked. When the push rod piston 34 pushes the gas in the gas injection chamber 32 out through the jet port 13, the drug in the drug injection chamber 33 is simultaneously discharged through the drug outlet port 14. The airflow velocity is 20-25 times the drug flow velocity. When the push rod piston 34 is pushed to the bottom of the dual-chamber syringe 31, the gas injection ends, and the drug in the drug injection chamber 33 is also completely discharged, thus achieving rapid and precise local nebulization drug delivery. In clinical practice, a volume of 50ml for the gas injection chamber 32 and 2ml for the drug injection chamber 33 are optimal. The tail ends of the airflow chamber 11 and the drug solution chamber 12 are respectively provided with interfaces for temporary fixation to the head-side injection interfaces of the air injection chamber 32 and the drug injection chamber 33. When multiple nebulization administrations are required, the dual-chamber syringe 31 is detached from the tail end of the nebulization administration tubing 1, and a needle is connected to the head-side injection interface of the drug injection chamber 33 to re-draw the nebulized drug solution while simultaneously adding air to the air injection chamber 32. After the drug drawing and air filling are completed, the needle is removed and reconnected and fixed to the tail interfaces of the airflow chamber 11 and the drug solution chamber 12, so that rapid quantitative nebulization administration can be repeated again.

[0072] Furthermore, such as Figure 2-4 As shown, the length of the nebulized drug delivery tube 1 is 300-500mm, and the outer diameter is set to 1.5-4mm.

[0073] The nebulizing drug delivery hose 1 has a movable ring at the tail end with a connecting tee 4, which connects a catheter interface 41, a circuit interface 42, and a nebulization inlet 43. The catheter interface 41 is adapted to the tracheal tube breathing interface; the circuit interface 42 is adapted to the threaded tube interface; and the nebulization inlet 43 is sealed to the outer diameter of the nebulizing drug delivery hose 1.

[0074] The gas supply device 2 includes an air pump and a medical oxygen source; the drug delivery device 3 is configured as an automatic drug delivery device, including an elastic drug sac, a drug injection micropump, and a suspended drug bag.

[0075] This embodiment is mainly used for deep airway nebulization administration to intubated patients. The nebulized drugs are mainly hormones, antispasmodics, expectorants, and antibiotics. Examples include dexamethasone, debutonol, salbutamol, montelukast, adrenaline, ammonium chloride, ambroxol, bromhexine, and bacterially sensitive antibiotics. Depending on the condition, one to three medications are selected for deep airway nebulization administration, either separately or simultaneously.

[0076] The specific details are as follows: To reduce the number of product models and lower production costs, for pediatric patients whose endotracheal tubes are thinner and shorter, a thinner and shorter nebulizer tube 1 with a length of 400mm and an outer diameter of 1.5mm can be used to meet all needs without causing blockage of the endotracheal tube lumen, thus satisfying the requirements of mechanical ventilation. For adult endotracheal patients whose endotracheal tubes are thicker and longer, a slightly longer and thicker nebulizer tube 1 with a length of 500mm and an outer diameter of 3.5mm can be used to meet their needs. Of course, in adults with tracheal spasm and tracheal narrowing, a pediatric-sized nebulizer tube 1 can be used for nebulized inhalation.

[0077] When intubated patients receive nebulized inhalation, the catheter interface 41 of the three-way connector 4 is sealed and connected to the endotracheal tube breathing interface. The circuit interface 42 is sealed and connected to the threaded end of the ventilator or anesthesia machine. The nebulized drug delivery tubing 1 is then inserted into the patient's airway to an appropriate depth through the nebulization inlet 43. The insertion depth varies depending on the specific condition: for main tracheal diseases, the optimal position is 10-20 mm above the carina; for bronchial diseases, the optimal position is at the corresponding bronchial lesion site. At this time, the three ends of the three-way connector 4 are sealed to their respective tubing, allowing for deep airway nebulized inhalation therapy while mechanically ventilating under ventilator support.

[0078] Because respiratory diseases require a relatively large amount of nebulized medication (5-15ml) and a relatively long treatment time (30-60 minutes per session), the air supply device 2 needs to continuously supply air to the air injection chamber 32. Figure 2-3 You can choose an air pump with a separate battery or external power supply (the air pump inlet should be equipped with a gas filter to ensure gas cleanliness), or such as... Figure 4 A medical oxygen source is used as the gas supply device 2 in a medical setting. The power of the air pump is set according to the specific condition, or the gas supply flow is adjusted through the oxygen cylinder of the oxygen source. At the same time, the drug delivery device 3 needs to continuously discharge liquid medicine into the injection chamber 33, and an elastic drug capsule can be selected. Figure 2 ), drug injection micropump and hanging drug bag ( Figure 3-4 Elastic drug capsules are commonly used in analgesic pumps. The elasticity of the capsule, its wall thickness, and the inner diameter of the dispensing tubing control the dispensing speed and time. Micropumps are also commonly used in medical settings. Medication is drawn into a syringe, placed inside the micropump, and its dispensing speed is precisely controlled by adjusting the pump's infusion rate. (Illustration omitted). In less advanced conditions, hanging drug bags can be used. The drip rate is monitored using a drip chamber, and the dispensing speed is controlled by adjusting the tubing's inner diameter using an infusion regulator. To reduce costs and ensure single-use, in medical settings, the gas supply device 2 is preferably an oxygen source containing an oxygen cylinder, and the drug delivery device 3 is preferably a micropump. This method offers the lowest cost, precise control, and provides oxygen to the patient during nebulization therapy.

[0079] Furthermore, such as Figure 5 As shown, the length of the nebulized drug delivery tube 1 is 800-3000 mm, and the outer diameter is set to 15-40 mm.

[0080] The gas supply device 2 includes an air pump and a medical oxygen source; the drug delivery device 3 is configured as an automatic drug delivery device, including an elastic drug capsule, a drug injection micropump, and a suspended drug bag;

[0081] A perforated mask or mouthpiece is connected to the end of the nebulized drug delivery hose 1.

[0082] This embodiment is primarily applicable to nebulized inhalation in non-endotracheal intubated patients, such as those with respiratory infections or mild asthma. The nebulized medication is inhaled through a perforated mask or mouthpiece worn over the patient's mouth and nose. Its advantage lies in the bending and deformation of the nebulized delivery tube 1, which moves the delivery device 3 away from the nebulized medication outlet. This allows weak patients to undergo nebulized inhalation in a side-lying or supine position, and enables young children to undergo nebulized inhalation while sleeping in a supine position, improving the comfort and feasibility of nebulized inhalation.

[0083] In this embodiment, the length of the nebulizer tubing 1 is 800-3000 mm, which facilitates the placement of the air supply device 2 and the drug delivery device 3 on a bedside table far from the patient's head. Therefore, in this scenario, there are no limitations on the tubing's outer diameter, and the nebulization treatment involves a large amount of medication over a long period. Setting its outer diameter to 15-40 mm is most suitable, as it provides a larger airflow, resulting in smaller aerosol particles. When needed, it can provide finer nebulized inhalation therapy within the airways and even alveoli.

[0084] The gas supply device 2 can be an air pump in a home environment, and a medical oxygen source is preferred in a medical setting; the drug delivery device 3 is set as an automatic drug delivery device, and a micro-pump and a hanging drug bag are preferred in medical conditions, with the drug delivery speed precisely adjusted by professionals; in a home environment, an elastic drug bag is preferred, and non-professional family members can correctly perform nebulization therapy.

[0085] Furthermore, the air pump is electrically connected to a chip for precise control of its power; a gas filter is installed at the air pump inlet. In a home environment, the drug delivery rate of the applicator 3 is constant. The particle size of the aerosol during nebulization therapy can be adjusted by precisely controlling the air pump power. The higher the air pump power, the greater the airflow, and the smaller the aerosol particles. Larger aerosol particles are mainly used for treating diseases of the main airways, smaller aerosol particles are used for treating diseases of the finer airways, and even smaller aerosol particles are used for treating diseases of the micro-airways and alveoli.

[0086] Furthermore, such as Figure 7 As shown, the spray nozzle 15 is equipped with several three-way tubular adjustment accessories 5; the adjustment accessories 5 are provided with a secondary air jet hole 51 through the long axis, and a secondary discharge hole 52 is provided through one side wall connected to the secondary air jet hole 51.

[0087] Adjust the shape of accessory 5 to match the air jet hole 13 of the spray nozzle 15, with the secondary air jet hole 51 smaller than the air jet hole 13 and the secondary discharge hole 52 smaller than the discharge hole 14.

[0088] Adjust the fitting and sealing assembly of accessory 5 inside the jet hole 13, and the auxiliary jet hole 51 is sealed and connected to the jet hole 13. At the same time, the auxiliary discharge hole 52 is sealed and connected to the discharge hole 14.

[0089] This is aimed at Figure 5 This is a specific embodiment for use in a home environment. In this case, the air supply device 2 is an air pump with a fixed power (the optimal air flow rate is 10L / min). By selecting different specifications of adjustment accessories 5 and assembling them correctly, the jet nozzle 13 is changed to the auxiliary jet nozzle 51, and the drug outlet 14 is changed to the auxiliary drug outlet 52. Thus, under the premise that the air pump power remains unchanged, different adjustment accessories 5 can be selected for different conditions to change the size of aerosol particles during nebulization therapy, and it can be used to treat different respiratory conditions.

[0090] In practical implementation, only two types of adjustment accessories 5 are required: The spray nozzle 15 with the largest jet hole 13 and drug outlet 14, when not equipped with adjustment accessory 5, controls the aerosol particle size during nebulization to 5-10 μm, used for treating tracheal diseases; one adjustment accessory 5 with a slightly smaller inner diameter auxiliary jet hole 51 and auxiliary drug outlet 52, controls the aerosol particle size during nebulization to 2-5 μm, used for treating bronchial diseases; and the other adjustment accessory 5 with the smallest inner diameter auxiliary jet hole 51 and auxiliary drug outlet 52, controls the aerosol particle size during nebulization to 0.5-1 μm, used for treating alveolar diseases. The specific dimensions of the spray nozzle 13 and drug outlet 14 of the spray nozzle 15, and the specific dimensions of the auxiliary jet hole 51 and auxiliary drug outlet 52 of the two types of adjustment accessories 5, are related to the power of the air pump and are not fixed.

[0091] In summary, this invention, through its unique structural design, removes the limitation on the outer diameter of the nebulization tube, allowing it to be as small as 1.5mm. This changes the current situation where nebulization therapy can only be performed outside the mouth and nose, enabling precise nebulization in deep body cavities for examination or treatment. At the same time, it eliminates the restriction that the medication bottle must be upright, allowing patients to receive nebulization therapy while lying down, increasing the comfort and compliance of nebulization therapy. It is also cost-effective and easy to commercialize and promote.

[0092] The above embodiments are merely illustrative of the principles and effects of this patent application and are not intended to limit this patent application. Any person skilled in the art may modify or alter the above embodiments without departing from the spirit and scope of this patent application. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in this patent application shall still be covered by the claims of this patent application.

Claims

1. A long-tube nebulizer for drug delivery, characterized by: The device includes a nebulizing drug delivery hose (1) with a length greater than 200 mm. The nebulizing drug delivery hose (1) includes an airflow chamber (11) and a drug liquid chamber (12). The head end of the airflow chamber (11) is provided with a jet hole (13). The area of ​​the jet hole (13) is not greater than 0.3 times the cross-section of the airflow chamber (11). The drug chamber (12) is provided with a drug outlet (14) at its head end, and the drug outlet (14) is located at the edge of the jet hole (13); the drug outlet (14) forms an angle of 45-90° with the central axis of the jet hole (13); The air supply device (2) is connected to the airflow chamber (11) at the tail end of the nebulized drug delivery hose (1), and the drug liquid chamber (12) is connected to the drug delivery device (3). The pressurized airflow of the air supply device (2) is ejected through the airflow chamber (11) into the narrow jet hole (13). The negative pressure generated in the jet hole (13) draws the liquid medicine discharged by the drug delivery device (3) through the liquid medicine chamber (12) into the airflow and blows it into a mist.

2. The long-tube nebulizer for drug delivery according to claim 1, characterized in that: The nebulizing drug delivery hose (1) has a single-tube double-lumen structure, with the main lumen being the airflow chamber (11) and the secondary lumen being the drug liquid chamber (12). The head end of the nebulizing drug delivery hose (1) is closed to form a blind end. An air jet hole (13) is provided in the drug liquid chamber (12) that penetrates the side wall of the nebulizing drug delivery hose (1) adjacent to the blind end. The opening of the drug liquid chamber (12) penetrated by the air jet hole (13) forms a drug outlet hole (14). A 120-180° bend is provided at a distance of 5-15 mm from the tail side of the air jet hole (13).

3. The long-tube nebulizer for drug delivery according to claim 1, characterized in that: The nebulized drug delivery hose (1) has a dual-tube structure, with the main tube being the airflow chamber (11) and the secondary tube being the drug liquid chamber (12). The airflow chamber (11) is sealed at the head end and a spray nozzle (15) is provided. The spray nozzle (15) forms a jet hole (13) at the head side port. The liquid medicine chamber (12) is connected to the spray nozzle (13) and a discharge hole (14) is provided at the edge of the jet hole (13).

4. The long-tube nebulizer for drug delivery according to claim 1, characterized in that: The liquid medicine chamber (12) is equipped with a control switch; the control switch is linked with the airflow chamber (11). When the airflow chamber (11) is pressurized and supplied with air, the control switch is opened and the liquid medicine chamber (12) is connected; when the airflow chamber (11) stops supplying air, the control switch is closed and the liquid medicine chamber (12) is blocked.

5. The long-tube nebulizer for drug delivery according to claim 4, characterized in that: The control switch includes a bladder (16) communicating with the airflow cavity (11), a control rod (17) is provided adjacent to the bladder (16) and through the liquid medicine cavity (12), the control rod (17) and the liquid medicine cavity (12) are respectively provided with a medicine passage hole (18), and the control rod is covered with an elastic body (19). When the pressure in the airflow chamber (11) increases, the bladder (16) expands, pushing the control rod (17) to shift, and the drug passage (18) and the drug liquid chamber (12) are properly aligned; when the pressure in the airflow chamber (11) decreases, the bladder (16) returns to its original state, the elastic body (19) elastically resets, pushing the control rod (17) to reset, and the drug passage (18) and the drug liquid chamber (12) are misaligned and blocked.

6. The long-tube nebulizer for drug delivery according to claim 2, characterized in that: The nebulized drug delivery tube (1) has a length of 400-1000 mm and an outer diameter of 1.5-1.8 mm or 2.5-2.8 mm; The gas supply device (2) and the drug delivery device (3) are integrated into a dual-chamber syringe (31). The dual-chamber syringe (31) includes an air injection chamber (32) and a drug injection chamber (33). The cross-sectional ratio of the air injection chamber (32) and the drug injection chamber (33) is greater than 5. The push rod piston (34) of the air injection chamber (32) and the drug injection chamber (33) are linked together.

7. The long-tube nebulizer for drug delivery according to claim 1, characterized in that: The nebulized drug delivery tube (1) has a length of 800-3000 mm and an outer diameter of 15-40 mm; The gas supply device (2) includes an air pump and a medical oxygen source; the drug delivery device (3) is configured as an automatic drug delivery device, including an elastic drug sac, a drug injection micro pump and a hanging drug bag; A perforated mask or mouthpiece is connected to the head end of the nebulized drug delivery tube (1).

8. The long-tube nebulizer for drug delivery according to claim 1, characterized in that: The nebulized drug delivery tube (1) has a length of 300-500 mm and an outer diameter of 1.5-4 mm; The nebulizing drug delivery hose (1) has a movable connecting tee (4) at its tail end. The connecting tee (4) connects the catheter interface (41), the circuit interface (42), and the nebulization inlet (43). The catheter interface (41) is adapted to the tracheal tube breathing interface. The circuit interface (42) is adapted to the threaded tube interface. The nebulization inlet (43) is sealed to the outer diameter of the nebulizing drug delivery hose (1). The gas supply device (2) includes an air pump and a medical oxygen source; the drug delivery device (3) is configured as an automatic drug delivery device, including an elastic drug sac, a drug injection micro pump and a suspended drug bag.

9. The long-tube nebulizer according to claim 7 or 8, characterized in that: The air pump is electrically connected to a chip for precise control of its power; a gas filter is installed at the air pump inlet.

10. The long-tube nebulizer for drug delivery according to claim 3, characterized in that: The spray nozzle (15) is provided with several three-way tubular adjustment accessories (5); the adjustment accessories (5) are provided with a secondary air jet hole (51) through the long axis, and a secondary discharge hole (52) is provided through the secondary air jet hole (51) through one side wall of the adjustment accessories (5). Adjust the shape of the accessory (5) to match the jet hole (13) of the spray nozzle (15), the auxiliary jet hole (51) is smaller than the jet hole (13), and the auxiliary discharge hole (52) is smaller than the discharge hole (14). The adjusting accessory (5) is fitted with a sealing assembly inside the jet hole (13), and the auxiliary jet hole (51) is sealed and connected with the jet hole (13). At the same time, the auxiliary discharge hole (52) is sealed and connected with the discharge hole (14).

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