NMR tube sample detection fluid configuration device

Abstract

The utility model discloses a kind of nuclear magnetic tube sample detection liquid preparation device, relate to nuclear magnetic resonance detection field.A kind of nuclear magnetic tube sample detection liquid preparation device, including mounting frame, further include: multiple liquid storage tanks, sequentially installed in the upper end of the mounting frame, tank cover is installed at the upper end tank mouth of the liquid storage tank;High-precision metering pump, fixedly connected at the bottom of the liquid storage tank;The utility model replaces artificial quantity with high-precision metering pump to take reagent, avoids artificial operation error, accurately controls each reagent dosage, guarantees detection liquid concentration accuracy, simultaneously automatic reagent extraction and conveying process, without artificial repeated quantity, especially when a large number of different kinds of detection liquid is configured, configuration time is greatly shortened, reduce manpower input, improve overall work efficiency.

Description

Technical Field

[0001] This utility model belongs to the field of nuclear magnetic resonance detection technology, specifically, it relates to a device for preparing nuclear magnetic resonance tube sample detection solution. Background Technology

[0002] In nuclear magnetic resonance (NMR) detection experiments, the quality of the NMR tube sample detection solution preparation plays a decisive role in the reliability of the final detection results. Currently, the preparation process of the detection solution mostly relies on manual operation. Operators need to frequently use basic tools such as graduated cylinders and pipettes to measure different types of reagents according to strict experimental requirements.

[0003] However, this traditional manual preparation method is easily affected by the individual operating habits of the operator, visual errors, and environmental factors (such as temperature and light). Even experienced experimentalists cannot guarantee absolute accuracy in each measurement during repeated operations. Small errors, when combined with multiple reagents, can cause the concentration of the final prepared detection solution to deviate from the standard value, which in turn negatively affects the accuracy of nuclear magnetic resonance detection, causing deviations in the detection data and failing to truly reflect the characteristics of the sample. In severe cases, it can even lead to erroneous conclusions, affecting scientific research results or production quality control.

[0004] In terms of efficiency, when faced with the task of configuring a large number and variety of test solutions, operators have to perform a lot of repetitive work, which not only consumes a lot of time but also requires a lot of manpower. Especially in high-throughput testing scenarios, the speed of manual preparation of test solutions is far from meeting the testing needs, becoming a bottleneck in the entire testing process, greatly limiting the improvement of testing efficiency, and delaying the progress of scientific research projects or product quality testing cycles. In view of this, this utility model is proposed. Utility Model Content

[0005] The technical problem to be solved by this utility model is to overcome the shortcomings of the prior art and provide a nuclear magnetic resonance tube sample detection solution preparation device that can overcome the above problems or at least partially solve the above problems.

[0006] To solve the above-mentioned technical problems, the basic concept of the technical solution adopted by this utility model is as follows: a nuclear magnetic resonance tube sample detection solution preparation device, including an installation frame, and further including: multiple liquid storage tanks, which are sequentially installed on the upper end of the installation frame, and a tank cover is installed at the upper end of the liquid storage tank; a high-precision metering pump, which is fixedly connected to the bottom of the liquid storage tank, and the inlet of the high-precision metering pump is connected to the outlet of the bottom of the liquid storage tank through a connecting rigid pipe, and an outlet rigid pipe is fixedly connected to the outlet of the high-precision metering pump; and a sample preparation cup, which is placed on the installation frame.

[0007] To further simplify the configuration process by reducing the need to move the sample preparation cup, the liquid storage tank is installed circumferentially on the mounting frame, the sample preparation cup is placed in the middle of the mounting frame, and the multiple liquid outlet tubes are tilted downwards towards the sample preparation cup.

[0008] To facilitate lowering the height of the liquid outlet tube and allow the reagent to enter the sample preparation cup more smoothly and accurately, the liquid storage tank is further slidably connected to the mounting frame. A fixing ring is fixedly connected to the liquid storage tank, and multiple tension springs are fixedly connected to the lower end of the fixing ring at equal intervals around the circumference. The lower ends of the tension springs are fixedly connected to the mounting frame.

[0009] Furthermore, two support plates are symmetrically fixedly connected to the mounting frame near the liquid storage tank, and a rotating shaft is rotatably connected between the two support plates. A motor is fixedly connected to one of the support plates, and the output end of the motor is fixedly connected to the end of the rotating shaft. A lever is fixedly connected to the rotating shaft, and a fixing plate that cooperates with the lever is fixedly connected to the bottom of the liquid storage tank.

[0010] To facilitate the efficient discharge of reagents adhering to the outlet tube into the sample preparation cup, a ring-shaped impact plate is further fixedly connected to the lower surface of the storage tank at the top of the mounting frame.

[0011] To facilitate re-inspection of the reagents delivered to the sample preparation cup and further ensure accuracy, a high-precision weighing sensor is further included, on which a weighing pan is fixedly connected, and the sample preparation cup is placed on the weighing pan.

[0012] After adopting the above technical solution, the present invention has the following beneficial effects compared with the prior art: The present invention uses a high-precision metering pump to replace manual measurement of reagents, avoiding human operation errors, accurately controlling the amount of each reagent, ensuring the accuracy of the concentration of the detection solution, and effectively improving the accuracy of nuclear magnetic resonance detection. At the same time, the automated reagent extraction and delivery process eliminates the need for repeated manual measurement. Especially when preparing a large number of different types of detection solutions, it greatly shortens the preparation time, reduces manpower input, and improves the overall work efficiency. The device has a reasonable structural design and a clear operation process. Operators only need to place the sample preparation cup and control the high-precision metering pump to prepare the sample detection solution, reducing the difficulty and complexity of operation.

[0013] The specific embodiments of this utility model will be described in further detail below with reference to the accompanying drawings. Attached Figure Description

[0014] In the attached diagram:

[0015] Figure 1 This is a schematic diagram of the structure of the present invention. Figure 1 ;

[0016] Figure 2 This is a schematic diagram of the structure of the present invention. Figure 2 ;

[0017] Figure 3 This is a cross-sectional structural diagram of the present invention.

[0018] In the diagram: 1. Mounting frame; 101. High-precision weighing sensor; 102. Weighing pan; 103. Sample preparation cup; 2. Storage tank; 201. Tank lid; 202. Fixing ring; 203. Tension spring; 204. Annular impact plate; 205. Fixing plate; 3. High-precision metering pump; 301. Connecting rigid pipe; 302. Discharge rigid pipe; 4. Support plate; 401. Rotating shaft; 402. Motor; 403. Pulley. Detailed Implementation

[0019] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions in the embodiments will be clearly and completely described below with reference to the accompanying drawings. The following embodiments are used to illustrate this utility model, but are not intended to limit the scope of this utility model.

[0020] Example 1:

[0021] Reference Figures 1-3 A sample preparation device for nuclear magnetic resonance tubes includes a mounting frame 1 and further includes: multiple storage tanks 2, which are sequentially installed on the upper end of the mounting frame 1, with a tank cover 201 installed at the upper end of each storage tank 2; a high-precision metering pump 3, which is fixedly connected to the bottom of the storage tank 2, with the inlet of the high-precision metering pump 3 connected to the outlet at the bottom of the storage tank 2 via a connecting rigid pipe 301, and an outlet rigid pipe 302 fixedly connected to the outlet of the high-precision metering pump 3; and a sample preparation cup 103, which is placed on the mounting frame 1.

[0022] In existing technologies, the preparation of sample detection solutions largely relies on manual labor, using tools such as graduated cylinders and pipettes to measure reagents. Manual operation is prone to errors, resulting in inaccurate concentrations of the detection solutions, which affects the accuracy of nuclear magnetic resonance detection. Furthermore, it is inefficient, requiring significant time and labor costs when preparing large quantities of different types of detection solutions.

[0023] When using this NMR tube sample preparation device, first open the canister lid 201 and load different types of reagents into multiple storage tanks 2. Then, the operator places the sample preparation cup 103 on the mounting frame 1, below a certain storage tank 2 and directly below the outlet of the corresponding outlet tube 302. Then, the high-precision metering pump 3 is controlled by the controller to extract the reagent from the storage tank 2 according to the required volume of the reagent in the formula. The reagent enters the high-precision metering pump 3 through the connecting tube 301 and is then delivered to the sample preparation cup 103 through the outlet tube 302. In the same way, the required reagents from other storage tanks 2 are delivered to the sample preparation cup 103 in the specified dosage. Finally, the operator gently shakes the sample preparation cup 103 to mix the various reagents, thus completing the sample preparation. After that, it is delivered into the NMR tube for subsequent NMR detection.

[0024] This device replaces manual reagent measurement with a high-precision metering pump 3, avoiding human error, precisely controlling the amount of each reagent, ensuring the accuracy of the detection solution concentration, and effectively improving the accuracy of nuclear magnetic resonance detection. At the same time, the automated reagent extraction and delivery process eliminates the need for repeated manual measurement. Especially when preparing a large number of different types of detection solutions, it significantly shortens the preparation time, reduces manpower input, and improves overall work efficiency. The device has a reasonable structural design and a clear operation process. Operators only need to place the sample preparation cup 103 and control the high-precision metering pump 3 to prepare the sample detection solution, reducing the difficulty and complexity of operation.

[0025] Example 2:

[0026] Reference Figures 1-3 A sample detection solution preparation device for nuclear magnetic resonance tubes is basically the same as that in Example 1, but further: the storage tank 2 is installed on the mounting frame 1 in a circular and equidistant manner, the sample preparation cup 103 is placed in the middle position of the mounting frame 1, and multiple liquid outlet hard tubes 302 are all tilted downwards towards the sample preparation cup 103.

[0027] The storage tank 2 is installed circumferentially on the mounting frame 1, and the sample preparation cup 103 is placed in the middle of the mounting frame 1. Multiple outlet tubes 302 are tilted downwards towards the sample preparation cup 103. Because the storage tank 2 is circumferentially distributed around the sample preparation cup 103, each outlet tube 302 can be directly aligned with the sample preparation cup 103. During the preparation of the test solution, the operator does not need to move the sample preparation cup 103 multiple times, avoiding the risk of operational errors caused by frequent movement, such as reagent spillage or tipping of the sample preparation cup 103. This effectively ensures the safety and stability of the preparation process. Furthermore, reducing the operation of moving the sample preparation cup 103 significantly simplifies the preparation process. The operator only needs to control the high-precision metering pump 3 to deliver reagents sequentially, without repeatedly adjusting the position of the sample preparation cup 103 when measuring different reagents, thus saving a significant amount of time and significantly improving the efficiency of test solution preparation. This makes the entire preparation process smoother and more efficient, especially when multiple different test solutions need to be prepared.

[0028] Example 3:

[0029] Reference Figures 1-3 A sample detection solution preparation device for nuclear magnetic resonance tubes is basically the same as that in Example 2, but further: the storage tank 2 is slidably connected to the mounting frame 1, and a fixing ring 202 is fixedly connected to the storage tank 2. Multiple tension springs 203 are fixedly connected to the lower end of the fixing ring 202 at equal intervals around the circumference, and the lower end of the tension springs 203 is fixedly connected to the mounting frame 1.

[0030] Two support plates 4 are symmetrically fixedly connected to the mounting frame 1 near the liquid storage tank 2. A rotating shaft 401 is rotatably connected between the two support plates 4. A motor 402 is fixedly connected to one of the support plates 4. The output end of the motor 402 is fixedly connected to the end of the rotating shaft 401. A lever 403 is fixedly connected to the rotating shaft 401. A fixing plate 205 that works with the lever 403 is fixedly connected to the bottom of the liquid storage tank 2.

[0031] When delivering reagents into the sample preparation cup 103 through the outlet tube 302, the motor 402 can drive the rotating shaft 401 to rotate, causing the dial plate 403 to move the fixed plate 205, which in turn causes the storage tank 2 to slide downwards against the elastic force of the tension spring 203. This controls the outlet of the outlet tube 302 to descend a certain height, thereby shortening the distance between the outlet of the outlet tube 302 and the sample preparation cup 103. This allows the reagents to enter the sample preparation cup 103 more smoothly and accurately, reducing splashing and spillage during the transfer process and improving reagent utilization. At the same time, the tension spring 203 can automatically reset the storage tank 2 when the dial plate 403 no longer acts on the fixed plate 205, facilitating the next operation.

[0032] Example 4:

[0033] Reference Figures 1-3 A device for preparing NMR tube sample detection solution is basically the same as in Example 3, but with a further improvement: a ring-shaped impact plate 204 is fixedly connected to the lower surface of the top of the mounting frame 1, where the storage tank 2 is located. After the storage tank 2 completes the reagent delivery task, it resets upward under the action of the tension spring 203. At this time, the ring-shaped impact plate 204 will collide with the lower surface of the top of the mounting frame 1. The vibration force generated by this collision will be transmitted to the outlet hard tube 302 connected to the storage tank 2, causing a small amount of reagent originally attached to the inner wall of the outlet hard tube 302 to fall off due to vibration and enter the sample preparation cup 103 more fully. In the process of preparing NMR tube sample detection solution, since the amount of sample detection solution prepared is small, the precise amount of each drop of reagent is related to the accuracy of the detection results. This design avoids the dosage deviation caused by reagent residue, effectively reduces the preparation error caused by reagent adhesion, further improves the preparation accuracy of sample detection solution, and ensures that the concentration of the final prepared detection solution is closer to the theoretical value, providing a more reliable sample basis for subsequent NMR detection.

[0034] It also includes a high-precision weighing sensor 101, to which a weighing pan 102 is fixedly connected, and a sample preparation cup 103 is placed on the weighing pan 102.

[0035] After the reagent is added, the high-precision weighing sensor 101 can weigh the reagent in the sample preparation cup 103 in real time and accurately, and obtain the actual weight data of the reagent. The operator can compare this data with the theoretical preparation amount. If there is a deviation, the problem can be detected and analyzed in time, so as to make targeted adjustments and re-inspections. Compared with the single control of relying solely on the high-precision metering pump 3 to deliver the reagent, this dual guarantee mechanism of preparation-weighing-re-inspection further ensures the accuracy of the sample detection solution preparation. By accurately measuring the weight of the detection solution, it can not only make up for the dosage error caused by uncontrollable factors such as reagent evaporation and pipeline residue, but also effectively eliminate the impact of the slight precision deviation that may occur in the metering pump during long-term use. It ensures the accuracy of the final prepared sample detection solution in terms of dosage from multiple dimensions, providing a more reliable and accurate sample for subsequent nuclear magnetic resonance detection, and improving the scientificity and credibility of the entire detection process.

[0036] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model in any way. Although the present utility model has been disclosed above with reference to a preferred embodiment, it is not intended to limit the present utility model.

Claims

1. A device for preparing NMR tube sample detection solution, characterized in that, Including the mounting frame (1), it also includes: Multiple liquid storage tanks (2) are sequentially installed on the upper end of the mounting frame (1), and a tank cover (201) is installed at the upper end of the liquid storage tank (2); A high-precision metering pump (3) is fixedly connected to the bottom of the storage tank (2). The inlet of the high-precision metering pump (3) is connected to the outlet of the bottom of the storage tank (2) through a connecting hard pipe (301). An outlet hard pipe (302) is fixedly connected to the outlet of the high-precision metering pump (3). The sample preparation cup (103) is placed on the mounting frame (1).

2. The NMR tube sample detection solution preparation device according to claim 1, characterized in that, The storage tank (2) is installed circumferentially on the mounting frame (1), the sample preparation cup (103) is placed in the middle of the mounting frame (1), and the multiple liquid outlet tubes (302) are all tilted downwards towards the sample preparation cup (103).

3. The NMR tube sample detection solution preparation device according to claim 2, characterized in that, The liquid storage tank (2) is slidably connected to the mounting frame (1). A fixed ring (202) is fixedly connected to the liquid storage tank (2). Multiple tension springs (203) are fixedly connected to the lower end of the fixed ring (202) at equal intervals around the circumference. The lower end of the tension springs (203) is fixedly connected to the mounting frame (1).

4. The NMR tube sample detection solution preparation device according to claim 3, characterized in that, Two support plates (4) are symmetrically fixedly connected to the mounting frame (1) near the liquid storage tank (2). A rotating shaft (401) is rotatably connected between the two support plates (4). A motor (402) is fixedly connected to one of the support plates (4). The output end of the motor (402) is fixedly connected to the end of the rotating shaft (401). A lever (403) is fixedly connected to the rotating shaft (401). A fixing plate (205) that works with the lever (403) is fixedly connected to the bottom of the liquid storage tank (2).

5. The NMR tube sample detection solution preparation device according to claim 4, characterized in that, The liquid storage tank (2) is fixedly connected to a ring-shaped impact plate (204) on the lower surface of the top of the mounting frame (1).

6. The NMR tube sample detection solution preparation device according to claim 1, characterized in that, It also includes a high-precision weighing sensor (101), on which a weighing pan (102) is fixedly connected, and the sample preparation cup (103) is placed on the weighing pan (102).

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