A cleaning device for preparing a liquid phase

Abstract

The utility model discloses a kind of cleaning devices for preparing liquid phase, which aims to solve the technical problem that flushing cannot be effectively carried out on local pipeline or specified pipeline under prior art, thereby reducing the cleaning effect. It includes support and box, the support top end is fixedly connected with top plate, the top plate top surface is installed with liquid chromatograph main body, the box is installed on top plate top surface, the box inner wall is fixedly connected with vertical partition, the box inner wall is fixedly connected with horizontal partition between vertical partition right side wall, the horizontal partition lower side is clean water cavity, the vertical partition left side wall is fixedly connected with mounting plate between box inner wall, the mounting plate lower side is sewage cavity;The horizontal partition upper side is storage cavity, the utility model can avoid residual sample, mobile phase impurity or salt deposition to block pipeline by cleaning pipeline.

Description

Technical Field

[0001] This invention belongs to the field of liquid phase preparation technology, specifically relating to a cleaning device for preparing liquid phases. Background Technology

[0002] Cleaning the tubing for preparative liquid chromatography is a critical operation for maintaining instrument performance. The mobile phase must be filtered with a 0.22μm or 0.45μm filter membrane (hydrophilic membrane for aqueous phase and hydrophobic membrane for organic phase) and degassed (ultrasonic degassed for 10-15 minutes or online degassed) before use to avoid particle or bubble deposition that may clog the tubing.

[0003] After the experiment, flush the tubing with methanol-water (80:20) or acetonitrile-water (80:20) at a flow rate of 1-2 mL / min for 30-60 minutes to remove residual sample impurities and salts. If a buffered salt mobile phase is used, flush with water-methanol (90:10) for 20-30 minutes first, and then flush with the organic phase to prevent salt crystallization.

[0004] When using existing cleaning devices, it is generally necessary to insert the inlet pipe into the cleaning fluid bottle and extract the cleaning fluid to clean the pipeline. However, this method cannot effectively flush local or designated pipelines, thus reducing the cleaning effect.

[0005] Therefore, a cleaning device for preparing liquid phases is designed to overcome the above-mentioned technical defects. Utility Model Content

[0006] (1) Technical problems to be solved

[0007] In view of the shortcomings of the prior art, the purpose of this utility model is to provide a cleaning device for preparing liquid phases. This cleaning device aims to solve the technical problem that the prior art cannot effectively flush local pipelines or designated pipelines, thereby reducing the cleaning effect.

[0008] (2) Technical solution

[0009] To solve the above-mentioned technical problems, this utility model provides a cleaning device for preparing liquid chromatography, including a support and a housing. A top plate is fixedly connected to the top of the support, and the main body of the liquid chromatograph is installed on the top surface of the top plate. The housing is installed on the top surface of the top plate. A vertical partition is fixedly connected to the inner wall of the housing. A horizontal partition is fixedly connected between the inner wall of the housing and the right side wall of the vertical partition. The lower side of the horizontal partition is a clear water chamber. An mounting plate is fixedly connected between the left side wall of the vertical partition and the inner wall of the housing. The lower side of the mounting plate is a wastewater chamber.

[0010] The upper side of the partition plate is a storage cavity, and a flexible tube is installed inside the storage cavity. One end of the flexible tube extends to the outside of the box and is fixedly connected to a first connector. A winding and unwinding assembly is installed inside the storage cavity.

[0011] Furthermore, the winding and unwinding assembly includes a grooved wheel rotatably connected between the vertical partition and the housing. Both ends of the grooved wheel are fixedly connected to a rotating shaft, and the other end of the rotating shaft is rotatably connected to the vertical partition and the housing respectively. The rotating shaft on the left side is a hollow structure. The flexible hose is wound and connected to the grooved wheel. The other end of the flexible hose communicates with the inner cavity of the rotating shaft. An elastic element is provided on the side wall of the rotating shaft on the right side. A flow guiding assembly is provided on the top surface of the mounting plate.

[0012] Furthermore, the elastic element includes a circular shell fixedly connected to the inner wall of the box, the rotating shaft passes through the circular shell and is rotatably connected to it, and a spiral spring is provided in the inner cavity of the circular shell, with both ends of the spiral spring fixedly connected to the rotating shaft and the inner wall of the circular shell, respectively.

[0013] Furthermore, the flow guiding assembly includes a water pump fixed on the top surface of the mounting plate, with an inlet pipe fixedly connected to the water pump inlet end, the other end of the inlet pipe extending into the clear water chamber, and the water pump outlet end rotatably connected to the left rotating shaft, and the water pump outlet end communicating with the left rotating shaft.

[0014] Furthermore, a sewage pipe is fixedly connected to the side wall of the box, one end of the sewage pipe extends into the sewage chamber, and the other end of the sewage pipe is fixedly connected to a second connector.

[0015] Furthermore, a filling pipe is fixedly connected to the right side wall of the box, one end of the filling pipe is connected to the clean water chamber, and a sealing cap is threaded to the top of the filling pipe.

[0016] Furthermore, an elongated hole is provided on the top surface of the housing, through which the flexible tube passes.

[0017] (3) Beneficial effects

[0018] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0019] This invention, through the design of a support, housing, hose, and flow guiding assembly, cleans the pipeline to prevent residual samples, mobile phase impurities, or salt deposits from clogging the pipes. This prevents unstable flow rates and decreased column efficiency due to changes in pipeline resistance, ensuring the separation of target substances and the accuracy of detection results. In addition, removing particulate impurities, microorganisms, or chemical contaminants from the pipeline reduces wear and corrosion on precision components such as the chromatographic column and detector flow cell, lowering the risk of instrument malfunction. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the structure of this utility model;

[0021] Figure 2 This is a side view of the present invention;

[0022] Figure 3 This is a perspective view of the housing of this utility model;

[0023] Figure 4 This is a cross-sectional structural diagram of the box body of this utility model.

[0024] The labels in the attached diagram are as follows: 1. Support; 2. Top plate; 3. Liquid chromatograph body; 4. Box; 5. Horizontal partition; 6. Vertical partition; 7. Hoses; 8. First connector; 9. Grooved wheel; 10. Round shell; 11. Scroll spring; 12. Mounting plate; 13. Water pump; 14. Water inlet pipe; 15. Sewage pipe; 16. Second connector; 17. Filling pipe; 18. Elongated hole. Detailed Implementation

[0025] This specific embodiment is a cleaning device for preparing liquid phases, and its structural schematic diagram is shown below. Figures 1-4 As shown, it includes a support 1 and a housing 4. A top plate 2 is fixedly connected to the top of the support 1. The main body of the liquid chromatograph 3 is installed on the top surface of the top plate 2. The housing 4 is installed on the top surface of the top plate 2. A vertical partition 6 is fixedly connected to the inner wall of the housing 4. A horizontal partition 5 is fixedly connected between the inner wall of the housing 4 and the right side wall of the vertical partition 6. The lower side of the horizontal partition 5 is a clear water chamber. An installation plate 12 is fixedly connected between the left side wall of the vertical partition 6 and the inner wall of the housing 4. The lower side of the installation plate 12 is a wastewater chamber.

[0026] The upper side of the partition 5 is a storage cavity, and a flexible hose 7 is installed inside the storage cavity. One end of the flexible hose 7 extends to the outside of the box 4 and is fixedly connected to the first connector 8. A winding and unwinding assembly is installed inside the storage cavity.

[0027] When connecting the pipelines on the main body 3 of the liquid chromatograph, a three-way pipe or a four-way pipe can be used. Both the three-way pipe and the four-way pipe are equipped with valves to control the connection status. A port is reserved that can be connected to the first connector 8 or the second connector 16 to facilitate flushing and cleaning of multiple pipelines or designated pipelines.

[0028] Secondly, the main body of the liquid chromatograph 3 is a mature existing technology and is not the focus of this solution. Therefore, this part will not be described in detail in this solution.

[0029] Furthermore, the cleaning structure in this solution can be applied to the main body 3 of various types of liquid chromatographs, providing high flexibility.

[0030] like Figure 4As shown, the winding and unwinding assembly includes a grooved wheel 9 rotatably connected between the vertical partition 6 and the housing 4. The two ends of the grooved wheel 9 are fixedly connected to a rotating shaft, and the other end of the rotating shaft is rotatably connected to the vertical partition 6 and the housing 4 respectively. The left rotating shaft is a hollow structure, and a flexible hose 7 is wound and connected to the grooved wheel 9. The other end of the flexible hose 7 communicates with the inner cavity of the rotating shaft. An elastic element is provided on the side wall of the right rotating shaft, and a flow guiding assembly is provided on the top surface of the mounting plate 12.

[0031] The connection between the hose 7 and the rotating shaft is existing technology, such as the connection of the water pipe inside a fire hydrant. When the hose 7 is pulled out, it drives the grooved wheel 9 to rotate. The grooved wheel 9 compresses the spiral spring 11 through the rotating shaft. When the hose 7 is released, the spiral spring 11 is used to rewind the hose 7 to adapt to different pipeline locations and achieve the purpose of convenient use.

[0032] like Figure 4 As shown, the elastic element includes a circular shell 10 fixedly connected to the inner wall of the housing 4, a rotating shaft passing through the circular shell 10 and rotatably connected to it, and a spiral spring 11 provided in the inner cavity of the circular shell 10. The two ends of the spiral spring 11 are fixedly connected to the rotating shaft and the inner wall of the circular shell 10, respectively.

[0033] like Figure 4 As shown, the flow guiding assembly includes a water pump 13 fixed on the top surface of the mounting plate 12. The water pump 13 has an inlet pipe 14 fixedly connected to its inlet end. The other end of the inlet pipe 14 extends into the clear water chamber. The water pump 13 has an outlet end rotatably connected to the left rotating shaft. The water pump 13 has an outlet end connected to the left rotating shaft.

[0034] The flow guiding component is used to deliver the cleaning solution through the hose 7 to the pipeline on the main body 3 of the liquid chromatograph to achieve the purpose of rinsing and cleaning. The cleaning solution can be water, disinfectant, alcohol or other liquids.

[0035] like Figure 3 As shown, a drain pipe 15 is fixedly connected to the side wall of the housing 4. One end of the drain pipe 15 extends into the wastewater chamber, and the other end of the drain pipe 15 is fixedly connected to a second connector 16. The drain pipe 15 is used to connect to the end of the pipeline on the main body 3 of the liquid chromatograph. The wastewater chamber can be used as a temporary storage. In actual use, the wastewater is directly discharged and collected during rinsing.

[0036] like Figure 4 As shown, a filling pipe 17 is fixedly connected to the right side wall of the housing 4. One end of the filling pipe 17 is connected to the clean water chamber, and a sealing cap is threaded to the top of the filling pipe 17. The filling pipe 17 is used to replenish the cleaning fluid into the clean water chamber to avoid insufficient cleaning fluid during use.

[0037] like Figure 3 and Figure 4 As shown, an elongated hole 18 is provided on the top surface of the housing 4, through which the flexible hose 7 passes. By providing the elongated hole 18, the range of motion of the flexible hose 7 can be increased, preventing the flexible hose 7 from folding.

[0038] Working principle: When it is necessary to clean the pipeline on the main body 3 of the liquid chromatograph, connect the first connector 8 to the pipeline on the main body 3 of the liquid chromatograph that needs to be cleaned, and connect the end of the pipeline to the second connector 16. Then start the water pump 13. The water pump 13 draws the cleaning solution in the clear water chamber into the hose 7, and then enters the pipeline on the main body 3 of the liquid chromatograph through the first connector 8. After the cleaning solution flows along the pipeline, it is discharged from the drain pipe 15 into the wastewater chamber, thus cleaning the pipeline and avoiding experimental liquid residue.

[0039] All technical features in this embodiment can be freely combined according to actual needs.

[0040] The above embodiments are preferred implementations of this utility model. In addition, this utility model can also be implemented in other ways. Any obvious substitutions without departing from the concept of this technical solution are within the protection scope of this utility model.

Claims

1. A cleaning device for preparing liquid chromatography, comprising a support (1) and a housing (4), wherein a top plate (2) is fixedly connected to the top of the support (1), and a liquid chromatograph body (3) is mounted on the top surface of the top plate (2), characterized in that: The box (4) is installed on the top surface of the top plate (2). A vertical partition (6) is fixedly connected to the inner wall of the box (4). A horizontal partition (5) is fixedly connected between the inner wall of the box (4) and the right side wall of the vertical partition (6). The lower side of the horizontal partition (5) is a clean water chamber. An installation plate (12) is fixedly connected between the left side wall of the vertical partition (6) and the inner wall of the box (4). The lower side of the installation plate (12) is a sewage chamber. The upper side of the partition plate (5) is a storage cavity, and a flexible tube (7) is provided in the storage cavity. One end of the flexible tube (7) extends to the outside of the box body (4) and is fixedly connected to a first connector (8). A winding and unwinding assembly is provided in the storage cavity.

2. The cleaning device for preparing a liquid phase according to claim 1, characterized in that: The winding and unwinding assembly includes a grooved wheel (9) rotatably connected between the vertical partition (6) and the housing (4). The grooved wheel (9) has a rotating shaft fixedly connected to both ends. The other end of the rotating shaft is rotatably connected to the vertical partition (6) and the housing (4) respectively. The rotating shaft on the left side is a hollow structure. The hose (7) is wound and connected to the grooved wheel (9). The other end of the hose (7) is connected to the inner cavity of the rotating shaft. The rotating shaft on the right side is provided with an elastic element. The top surface of the mounting plate (12) is provided with a flow guiding assembly.

3. The cleaning device for preparing a liquid phase according to claim 2, characterized in that: The elastic element includes a circular shell (10) fixedly connected to the inner wall of the housing (4), the rotating shaft passes through the circular shell (10) and is rotatably connected to it, and a spiral spring (11) is provided in the inner cavity of the circular shell (10). The two ends of the spiral spring (11) are fixedly connected to the rotating shaft and the inner wall of the circular shell (10) respectively.

4. The cleaning device for preparing a liquid phase according to claim 2, characterized in that: The flow guiding assembly includes a water pump (13) fixed on the top surface of the mounting plate (12). The water pump (13) has an inlet pipe (14) fixedly connected to its inlet end. The other end of the inlet pipe (14) extends into the clear water chamber. The water pump (13) is rotatably connected to the left rotating shaft. The water pump (13) is connected to the left rotating shaft.

5. A cleaning device for preparing a liquid phase according to claim 1, characterized in that: A drain pipe (15) is fixedly connected to the side wall of the box (4). One end of the drain pipe (15) extends into the sewage chamber, and the other end of the drain pipe (15) is fixedly connected to a second connector (16).

6. The cleaning apparatus for preparing a liquid phase according to claim 1, characterized in that: A filling pipe (17) is fixedly connected to the right side wall of the box (4). One end of the filling pipe (17) is connected to the clean water chamber, and a sealing cap is threaded to the top of the filling pipe (17).

7. The cleaning apparatus for preparing a liquid phase according to claim 1, characterized in that: The top surface of the box (4) has an elongated hole (18), and the flexible tube (7) passes through the elongated hole (18).

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