Magnetic type frozen section embedding device
The magnetic frozen section embedding device, which uses liquid nitrogen cooling base and permanent magnet layer for magnetic fixation, solves the problems of low efficiency and poor stability of traditional devices, and realizes rapid and stable tissue freezing and multi-sample processing, which is suitable for high-frequency pathology laboratories.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- THE STOMATOLOGIAL HOSPITAL OF ZHEJIANG UNIV SCHOOL OF MEDICINE
- Filing Date
- 2025-06-03
- Publication Date
- 2026-06-19
AI Technical Summary
Traditional frozen section embedding devices are inefficient and unstable, making it difficult to fix multiple samples, and their cooling efficiency is low.
The design employs a magnetic attraction system, utilizing liquid nitrogen to cool the base and OCT fixture. The extremely low temperature of liquid nitrogen enables rapid cooling, and multiple samples are magnetically secured by the permanent magnet layer and the soft magnetic layer, preventing displacement and uneven temperature distribution.
It enables rapid and stable tissue freezing, reduces ice crystal formation, is suitable for various sample sizes, simplifies the operation process, and meets the needs of high-frequency and high-precision pathology laboratories.
Smart Images
Figure CN224382931U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of biomedical technology, specifically to a magnetically suction-type frozen section embedding device. Background Technology
[0002] Cryo-embedding involves rapidly freezing and solidifying tissue at low temperatures (-20°C to -30°C), replacing the traditional dehydration and wax impregnation process of paraffin embedding. This allows the tissue to reach the appropriate hardness for sectioning in a short time, thus quickly obtaining sections. Commonly used embedding agents include OCT compounds (Optimal Cutting Temperature compounds), a water-soluble gel that protects tissue and reduces ice crystal formation.
[0003] Traditional embedding bases are mostly one-piece designs, which can only fix a single sample at a time, making the operation cumbersome and time-consuming; and planar embedding grooves are difficult to fix cylindrical OCT embedding blocks, which can easily cause sample rotation and displacement during slicing; in addition, traditional aluminum bases rely on the cooling stage for conduction cooling, which has low cooling efficiency and takes 8-10 minutes to cool from room temperature to -20℃. Utility Model Content
[0004] In order to overcome the shortcomings of the existing technology, the purpose of this utility model is to provide a magnetically suction-type frozen section embedding device, which can solve the problems of low efficiency and poor stability of traditional embedding technology.
[0005] The objective of this utility model is achieved through the following technical solution:
[0006] This utility model provides a magnetically attached frozen section embedding device, comprising:
[0007] A liquid nitrogen cooling base has a storage box inside. The upper surface of the liquid nitrogen cooling base has a soft magnetic layer and a mounting position. The mounting position has an injection hole that communicates with the storage box.
[0008] A liquid nitrogen injection device is fixedly installed at the mounting position and corresponds to the position of the injection hole, and is used to inject cool liquid nitrogen into the storage box through the injection hole;
[0009] The OCT fixture has a permanent magnet layer on its lower surface and is magnetically fixed by the permanent magnet layer and the soft magnetic layer of the liquid nitrogen-cooled base.
[0010] In this invention, as an optional embodiment, the liquid nitrogen cooling base includes an antifreeze shell, with the storage box disposed inside the antifreeze shell, and a heat insulation layer provided between the four sides of the storage box and the four inner sides of the antifreeze shell. The heat insulation layer between the storage box and the antifreeze shell effectively blocks external heat transfer, preventing external temperature fluctuations from affecting the interior of the storage box, ensuring temperature uniformity and stability during the freezing process. Simultaneously, because the storage box inside the liquid nitrogen cooling base is extremely cold for the human body, the heat insulation layer prevents users from being frostbitten when they come into contact with the liquid nitrogen cooling base, and also reduces condensation on the outer wall of the storage box due to temperature differences, lowering the risk of short circuits or corrosion. The antifreeze shell, as a physical barrier for the liquid nitrogen cooling base, reduces direct contact between liquid nitrogen and outside air, slows down the evaporation rate of liquid nitrogen, and extends the effective cooling time after a single filling.
[0011] In this invention, as an optional embodiment, the insulation layer is a foam insulation layer or an aerogel insulation layer. Foam insulation layers are low-cost and easy to cut; the foam contains a large number of closed air bubbles, which effectively prevent heat conduction. Aerogel insulation layers, on the other hand, have a nanoscale porous network structure with extremely high porosity and extremely low thermal conductivity, which more effectively blocks heat transfer, significantly reduces liquid nitrogen evaporation, extends the service life of a single liquid nitrogen refill, and lowers the cost of liquid nitrogen consumption.
[0012] In this invention, as an optional embodiment, the liquid nitrogen cooling base and the liquid nitrogen injection component are fixed together by welding. Welding is a rigid connection method that enables the liquid nitrogen cooling base and the liquid nitrogen injection component to form a highly integrated structure.
[0013] In this invention, as an optional embodiment, the number of OCT fixation devices is multiple. Multiple OCT fixation devices can simultaneously fix multiple tissue embedding blocks, achieving "one device for multiple uses," supporting flexible combinations of various samples. Different fixation devices can be designed in various sizes (such as diameters of 10mm, 15mm, and 20mm) to adapt to diverse needs from small biopsy specimens (such as endoscopic biopsies) to large tissue blocks (such as tumor resection specimens), avoiding tissue compression or waste of embedding agent due to mismatched fixation device sizes.
[0014] In this invention, as an optional embodiment, the dimensions of the multiple OCT fixation devices are all different, all the same, or at least two of the OCT fixation devices are the same size. By flexibly configuring the size of the OCT fixation devices, the device achieves comprehensive optimization in terms of adaptability, efficiency, cost, and user experience, meeting diverse needs from basic research to clinical translation.
[0015] In this invention, as an optional embodiment, the liquid nitrogen injection component includes a body and a sealing cap. The body includes an injection section and a flow section. The upper end of the injection section has an opening, and the lower end of the injection section has an outlet connected to one end of the flow section. The opening communicates with the outlet. The other end of the flow section is fixed to a position corresponding to the injection hole. The outlet communicates with a storage box through the flow section and the injection hole. The sealing cap is used to cover the opening of the injection section and close it. The sealing cap forms an airtight seal, effectively preventing the evaporation of liquid nitrogen in the non-injected state. The sealing cap closes immediately after injection to prevent liquid nitrogen from being exposed to the environment, reducing the risk of operators coming into contact with cryogenic liquids or gases, and also accelerating cooling.
[0016] In this invention, as an optional embodiment, the injection port is funnel-shaped, and the upper surface of the sealing cap is provided with a protruding block. The combination of the funnel-shaped injection port and the anti-slip sealing cap significantly reduces the difficulty of liquid nitrogen injection. By dispersing the impact force during liquid nitrogen injection, it reduces stress concentration at the welding points of the flow section, extending the equipment's service life. The protruding block serves as a handle for easy lifting of the sealing cap, and by increasing the coefficient of friction on the sealing cap surface, it allows users to easily tighten / loosen the sealing cap even when wearing gloves or with wet hands.
[0017] Compared with the prior art, the beneficial effects of this utility model are as follows:
[0018] This invention provides a magnetically attached frozen section embedding device, comprising a liquid nitrogen cooling base, a liquid nitrogen injection component, and an OCT fixation component. The liquid nitrogen cooling base directly injects liquid nitrogen into the storage box, utilizing the extremely low temperature (-196℃) of liquid nitrogen to achieve rapid cooling. Compared to traditional intermediate refrigerants (such as propane and isopentane), liquid nitrogen has a lower boiling point, enabling more efficient tissue freezing and reducing ice crystal formation. Reduced ice crystals mean less damage to cell structure, resulting in clearer sections, especially suitable for fat-rich tissues (such as breast tissue and lymph nodes). The OCT fixation component is magnetically fixed to the soft magnetic layer of the base via a permanent magnet layer, ensuring stable adhesion of the tissue block during embedding and avoiding uneven temperature or tissue deformation caused by displacement. Furthermore, the magnetic fixation method replaces traditional mechanical fixation methods (such as screws or clips), achieving "automatic adsorption and locking." Users do not need precise alignment or to apply excessive insertion or extraction force, simplifying the operation process. It is particularly suitable for pathology laboratories with high-frequency, high-precision requirements, preventing misoperation and facilitating disassembly. Attached Figure Description
[0019] Figure 1 This is a schematic diagram of the overall structure of the magnetically suction-type frozen section embedding device according to an embodiment of the present invention;
[0020] Figure 2This is a side view of the magnetically suction-type frozen section embedding device according to an embodiment of the present invention.
[0021] Figure 3 This is a schematic diagram of the structure of the liquid nitrogen cooling base according to an embodiment of the present invention;
[0022] Figure 4 This is a schematic diagram of the liquid nitrogen injection component according to an embodiment of the present invention.
[0023] In the diagram: 1. Liquid nitrogen cooling base; 11. Antifreeze shell; 12. Storage box; 13. Heat insulation layer; 14. Soft magnetic layer; 2. Liquid nitrogen injection component; 21. Body; 211. Injection section; 212. Flow section; 22. Sealing cap; 221. Protrusion block; 3. OCT fixing component. Detailed Implementation
[0024] The present invention will now be further described in conjunction with the accompanying drawings and specific embodiments. It should be noted that, without conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments. Unless otherwise specified, the materials and equipment used in this embodiment are all commercially available. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this application, and should not be construed as limiting this application.
[0025] In the description of this application, it should be understood that the terms "upper," "lower," "front," "rear," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on this application. In the description of this application, "a plurality of" means two or more, unless otherwise precisely specified.
[0026] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "connected," "linked," and "connected" should be interpreted broadly. For example, they can refer to a fixed connection, a connection through an intermediary, or a connection within two elements or an interaction between two elements. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.
[0027] The terms "first," "second," etc., in the specification, claims, and accompanying drawings of this application are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion; for example, a process, method, system, product, or apparatus that comprises a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units not explicitly listed or inherent to such process, method, product, or apparatus.
[0028] This application provides a magnetically attached frozen section embedding device. The liquid nitrogen cooling base directly injects liquid nitrogen into the storage box, utilizing the extremely low temperature (-196°C) of liquid nitrogen for rapid cooling. Compared to traditional intermediate refrigerants (such as propane and isopentane), liquid nitrogen has a lower boiling point, enabling more efficient tissue freezing and reducing ice crystal formation. Reduced ice crystals mean less damage to cell structure, resulting in clearer sections, especially suitable for fat-rich tissues (such as breast tissue and lymph nodes). The OCT fixation element is magnetically secured to the soft magnetic layer of the base via a permanent magnet layer, ensuring stable adhesion of the tissue block during embedding and preventing temperature unevenness or tissue deformation caused by displacement. Furthermore, the magnetic fixation method replaces traditional mechanical fixation methods (such as screws or clips), achieving "automatic adsorption and locking." Users do not need precise alignment or excessive insertion / extraction force, simplifying the operation process. This is particularly suitable for pathology laboratories with high-frequency, high-precision requirements, preventing misoperation and facilitating disassembly.
[0029] Please refer to Figure 1-2 As shown, this embodiment provides a magnetically attached frozen section embedding device, comprising: a liquid nitrogen cooling base 1, which has a storage box 12 inside. The upper surface of the liquid nitrogen cooling base 1 is provided with a soft magnetic layer 14 and a mounting position. The mounting position has an injection hole communicating with the storage box 12; a liquid nitrogen injection component 2, which is fixedly installed on the mounting position and corresponds to the position of the injection hole, for injecting cooling liquid nitrogen into the storage box 12 through the injection hole; and an OCT fixing component 3, which has a permanent magnet layer on its lower surface and is magnetically fixed by the permanent magnet layer and the soft magnetic layer 14 of the liquid nitrogen cooling base 1.
[0030] Furthermore, in combination Figure 3As shown, the liquid nitrogen cooling base 1 includes an antifreeze shell 11, and a storage box 12 is disposed inside the antifreeze shell 11. A heat insulation layer 13 is provided between the four sides of the storage box 12 and the four inner sides of the antifreeze shell 11. The heat insulation layer 13 between the storage box 12 and the antifreeze shell 11 effectively blocks external heat transfer, preventing external temperature fluctuations from affecting the interior of the storage box 12, ensuring temperature uniformity and stability during the freezing process. Simultaneously, since the storage box 12 inside the liquid nitrogen cooling base 1 is extremely cold for the human body, the heat insulation layer 13 prevents users from being frostbitten when they come into contact with the liquid nitrogen cooling base 1, and also reduces condensation on the outer wall of the storage box 12 due to temperature differences, reducing the risk of corrosion. The antifreeze shell 11, as a physical barrier for the liquid nitrogen cooling base 1, reduces direct contact between liquid nitrogen and outside air, slows down the evaporation rate of liquid nitrogen, and extends the effective cooling time after a single filling.
[0031] Preferably, the insulation layer 13 is a foam insulation layer or an aerogel insulation layer. Foam materials such as polyurethane foam and polystyrene foam are relatively low in cost and have mature production processes, which can reduce the overall manufacturing cost of the liquid nitrogen cooling base, making the equipment more price-competitive and suitable for cost-sensitive large-scale production or budget-constrained applications. The foam contains a large number of closed air bubbles, which can effectively prevent heat conduction, reduce heat exchange between the liquid nitrogen storage box and the outside environment to a certain extent, maintain the low temperature environment inside the storage box, and meet the basic temperature requirements for general cryo-section embedding operations. Foam materials are easy to cut, shape, and install, and can be customized according to the spatial shape between the storage box 12 and the antifreeze shell 11 to ensure that the insulation layer 13 fits tightly with the equipment structure and improves the insulation effect. Aerogel has a nanoscale porous network structure with extremely high porosity and extremely low thermal conductivity, and is one of the lightest solid materials known to date. Using an aerogel insulation layer in the liquid nitrogen cooling base 1 can more effectively block heat transfer, significantly reduce the evaporation of liquid nitrogen, extend the service life of a single liquid nitrogen refill, and reduce the consumption cost of liquid nitrogen. Even at extremely low temperatures (-196℃) in liquid nitrogen, aerogel maintains stable physical and chemical properties, unlike some ordinary foam materials that exhibit performance degradation, shrinkage, or embrittlement. This ensures the insulation layer maintains its excellent thermal insulation performance throughout long-term use. Aerogel insulation layers can be made very thin and light, minimizing the space occupied by the equipment while ensuring insulation effectiveness. This facilitates miniaturization and lightweight design. Furthermore, its good flexibility allows it to adapt to different shapes of storage boxes 12 and antifreeze shells 11, achieving better fit and sealing. Finally, aerogel materials possess excellent fire-retardant properties, effectively preventing the spread of fire in case of accidents during equipment use, thus improving equipment safety.
[0032] As a preferred technical solution, the liquid nitrogen cooling base 1 and the liquid nitrogen injection component 2 are fixed together by welding. Welding is a rigid connection method that enables the liquid nitrogen cooling base 1 and the liquid nitrogen injection component 2 to form a highly integrated structure. Compared with detachable connection methods such as threaded connections and snap-fit connections, welding eliminates connection gaps, avoids the risk of liquid nitrogen leakage due to loose connections or aging seals, ensures the airtightness of the cooling system, and guarantees the safety of the experimental environment. During equipment use, it may be subjected to external forces such as vibration and impact. The welded fixed structure has higher strength and rigidity, which can effectively resist these external forces, prevent the liquid nitrogen injection component 2 from shifting or falling off the liquid nitrogen cooling base 1, and ensure the stable operation of the equipment. The welded connection enables direct metal-to-metal contact between the liquid nitrogen cooling base 1 and the liquid nitrogen injection component 2, greatly reducing the thermal resistance of the contact surface. This means that the liquid nitrogen injection component 2 can transfer liquid nitrogen to the storage box more efficiently, allowing the cooling effect of liquid nitrogen to be fully utilized, improving cooling efficiency, helping to freeze tissues to the required temperature more quickly, and shortening slide preparation time. The rigid connection of the weld helps maintain the precise alignment between the liquid nitrogen injection component 2 and the storage box 12, ensuring that the liquid nitrogen can be injected into the storage box 12 accurately and evenly. This avoids the injection position shift caused by loosening of the connector, ensuring the uniformity and stability of the freezing process and facilitating the acquisition of high-quality slices.
[0033] As an optional embodiment, the number of OCT fixation pieces 3 is multiple. Multiple OCT fixation pieces 3 can simultaneously fix multiple tissue embedding blocks, achieving "one machine for multiple uses" and supporting flexible combinations of various samples. Different OCT fixation pieces 3 can be designed in various sizes (e.g., diameters of 10mm, 15mm, 20mm) to adapt to diverse needs ranging from small biopsy specimens (e.g., endoscopic biopsies) to large tissue samples (e.g., tumor resection specimens), avoiding tissue compression or embedding agent waste due to mismatched fixation piece sizes. Through magnetic quick-change of fixation pieces, users can operate continuously on a single liquid nitrogen cooling base 1, reducing equipment downtime. For example, while freezing the first sample, the embedding of the second sample can be prepared in advance, achieving a "seamless" workflow. By configuring multiple OCT fixation pieces 3, the equipment achieves comprehensive improvements in efficiency, flexibility, user experience, and cost-effectiveness, making it particularly suitable for pathological diagnosis and research scenarios involving high-frequency, diverse sample processing, providing laboratories with a more efficient and economical solution.
[0034] Furthermore, in this embodiment, the dimensions of the multiple OCT fixation pieces 3 are either all different or all the same, or at least two of the OCT fixation pieces 3 are the same size. The at least two OCT fixation pieces 3 being the same size includes several scenarios. Taking a total of six OCT fixation pieces 3 as an example, they can be divided into three groups, with each group consisting of two OCT fixation pieces 3. Each group of OCT fixation pieces 3 has the same size. In another example, two of the six OCT fixation pieces 3 are the same size, while the other four are different in size from these two OCT fixation pieces 3, and the dimensions of these four OCT fixation pieces 3 are also different from each other. Small-sized fixation pieces (e.g., 10mm in diameter) are specifically used for endoscopic biopsies, puncture specimens, and other small tissues, reducing the amount of embedding agent (OCT) used and avoiding material waste. Large-sized fixation pieces (e.g., 25mm in diameter) can accommodate tumor resection specimens, organ tissues, etc., preventing tissue compression and deformation and ensuring the integrity of the slides. Fixation pieces of different sizes can be mixed and arranged on the liquid nitrogen cooling base 1 to fully utilize the base space, reduce ineffective cooling areas, and improve the processing capacity per unit area.
[0035] Furthermore, in combination Figure 4 As shown, the liquid nitrogen injection device 2 in this embodiment includes a body 21 and a sealing cap 22. The body 21 includes an injection section 211 and a flow section 212. The upper end of the injection section 211 has an opening, and the lower end of the injection section 211 has an outlet connected to one end of the flow section 212. The opening communicates with the outlet. The other end of the flow section 212 is fixed to a position corresponding to the injection hole. The outlet communicates with the storage box 12 through the flow section 212 and the injection hole. The sealing cap 22 is used to cover the opening of the injection section 211 and close the opening. The sealing cap 22 can be tightly fitted with the opening of the injection section through a threaded or snap-fit structure to form an airtight seal, effectively preventing the evaporation of liquid nitrogen in the non-injected state. The sealing cap 22 is closed immediately after injection to prevent liquid nitrogen from being exposed to the environment, reduce the risk of operators coming into contact with cryogenic liquids or gases, and also accelerate cooling. In this embodiment, the flow section 212 can adopt a conical or spiral flow channel structure to accelerate the flow of liquid nitrogen using the Venturi effect, while reducing the generation of bubbles and ensuring that the liquid nitrogen enters the storage box in a laminar flow state. The straight-through connection (without bends or narrow sections) between the injection section 211 and the flow section 212 reduces the liquid nitrogen injection resistance by more than 40%, achieving an "instant injection" function. The time from injection to the storage box temperature dropping to -60°C is shortened to within 15 seconds, meeting the needs of rapid freezing during surgery.
[0036] Furthermore, in this embodiment, the injection port 211 is funnel-shaped, and the upper surface of the sealing cap 22 is provided with a protrusion 221. The protrusion 221 serves as a handle for easy lifting of the sealing cap 22 by the user. Simultaneously, by increasing the coefficient of friction on the surface of the sealing cap 22, the protrusion 221 allows the user to easily tighten / loosen the sealing cap 22 even when wearing gloves or with wet hands. The combination of the funnel-shaped injection port and the non-slip sealing cap significantly reduces the difficulty of liquid nitrogen injection, and by dispersing the impact force during liquid nitrogen injection, reduces stress concentration at the welding points of the flow section 212, thus extending the equipment's service life.
[0037] The usage steps of this embodiment are as follows: An appropriate amount of liquid nitrogen is added to the storage box 12 through the liquid nitrogen injection device 2, and the sealing cap 22 is closed to rapidly cool the surface of the device to the solidification temperature of the OCT embedding agent. A suitable fixation device and quantity are selected: Based on the number of samples to be embedded, OCT fixation devices 3 are placed on the soft magnetic layer of the liquid nitrogen cooling base 1, and cooling is allowed. Embedding agent is added to embed the samples: Embedding agent is placed into the OCT fixation device 3, followed by embedding the target sample, and the process is allowed to stand until the embedding agent solidifies. After the tissue-embedding agent has solidified as a whole, the fixation device is removed, the embedding block is ejected, and it is stored in a -80 degree refrigerator. The sealing cap 22 is removed, and excess liquid nitrogen is poured back into the liquid nitrogen tank for future use. One application scenario involves processing six mouse brain tissue samples, configuring a corresponding number of OCT fixation devices (any size larger than the sample diameter can be selected), and embedding mouse brain tissue slices. From pre-cooling to completion of sample embedding, it only takes 2 minutes. Another application scenario involves processing four canine kidney samples, using a large-size embedding fixation device larger than the sample size, successfully achieving rapid and complete embedding without any liquid nitrogen leakage or magnetic failure.
[0038] Although only certain components and embodiments of this application have been illustrated and described, many modifications and changes will be apparent to those skilled in the art without actually departing from the scope and spirit of the claims. These modifications include variations in the size, dimensions, structure, shape, proportions, installation arrangement, material usage, color, and orientation of the various elements. Dynamic selection of the fixture combination based on the sample quantity avoids space waste or frequent equipment replacements caused by single-size fixtures. Uniform-sized fixtures are suitable for large-scale homogeneous samples (such as tumor screening projects), simplifying the operation process and reducing human error. Through flexible configuration of OCT fixture sizes, the equipment achieves comprehensive optimization in terms of adaptability, efficiency, cost, and user experience, meeting diverse needs from basic research to clinical translation.
[0039] The above embodiments are merely preferred embodiments of the present utility model and should not be construed as limiting the scope of protection of the present utility model. Any non-substantial changes and substitutions made by those skilled in the art based on the present utility model shall fall within the scope of protection claimed by the present utility model.
Claims
1. A magnetic freezing section embedding device, characterized by, include: A liquid nitrogen cooling base has a storage box inside. The upper surface of the liquid nitrogen cooling base has a soft magnetic layer and a mounting position. The mounting position has an injection hole that communicates with the storage box. A liquid nitrogen injection device is fixedly installed at the mounting position and corresponds to the position of the injection hole, and is used to inject cool liquid nitrogen into the storage box through the injection hole; The OCT fixture has a permanent magnet layer on its lower surface and is magnetically fixed by the permanent magnet layer and the soft magnetic layer of the liquid nitrogen-cooled base.
2. The magnetic frozen section embedding device of claim 1, wherein, The liquid nitrogen cooling base includes an antifreeze shell, the storage box is disposed inside the antifreeze shell, and a heat insulation layer is provided between the four sides of the storage box and the four inner sides of the antifreeze shell.
3. The magnetic freeze section embedding device according to claim 2, wherein The insulation layer is a foam insulation layer or an aerogel insulation layer.
4. The magnetic frozen section embedding device of claim 1, wherein, The liquid nitrogen cooling base and the liquid nitrogen injection component are fixed together by welding.
5. The magnetic frozen section embedding device of claim 1, wherein, The number of OCT fasteners is multiple.
6. The magnetic freeze-fracture embedding device of claim 5, wherein, The dimensions of the multiple OCT fasteners are all different or all the same, or at least two of the OCT fasteners are the same size.
7. The magnetic freeze section embedding device according to claim 1, wherein The liquid nitrogen injection device includes a body and a sealing cap. The body includes an injection section and a flow section. The upper end of the injection section is provided with an opening, and the lower end of the injection section is provided with an outlet and connected to one end of the flow section. The opening communicates with the outlet. The other end of the flow section is fixed to a position corresponding to the injection hole. The outlet communicates with the storage box through the flow section and the injection hole. The sealing cap is used to cover the opening of the injection section and close the opening.
8. The magnetic freeze section embedding device according to claim 7, wherein, The injection section is funnel-shaped, and the upper surface of the sealing cap is provided with protrusions.