A high-throughput rapid filtration device for laboratory use that requires no disassembly or cleaning.

Abstract

This utility model discloses a high-throughput rapid filtration device for laboratory use that requires no disassembly or cleaning. It includes a movable support, a glass frit funnel mounted on the support from top to bottom, and a filtrate buffer bottle. It also includes a peristaltic pump, the output of which is connected to the glass frit funnel, and the input of which is connected to a stock solution container and an ultrapure water container. The lower end of the glass frit funnel is connected to the filtrate buffer bottle. The peristaltic pump draws the stock solution from the stock solution container into the glass frit funnel for filtration, and then into the filtrate buffer bottle for storage. This allows for large-scale, rapid filtration in the laboratory, and once assembled, it does not require repeated disassembly, making it convenient for cleaning and use.

Description

Technical Field

[0001] This utility model relates to the field of filtration equipment technology, specifically a high-throughput rapid vacuum filtration device for laboratory use that does not require disassembly and cleaning. Background Technology

[0002] In the laboratory, high-throughput rapid filtration devices are mainly used to process multiple samples at once, significantly improving the purification efficiency of biological samples such as nucleic acids and proteins, and are especially suitable for 96-well or 384-well plate systems.

[0003] For example, application number CN201620683393.5, entitled "Utility Model Patent for a Laboratory Vacuum Filtration Device," discloses a technical solution including a funnel, a filtration flask, a flow control valve, a micro pump, a container bottle, a vacuum pump, and a level gauge. The funnel is connected to the mouth of the filtration flask, and the upper outlet of the filtration flask is connected to the vacuum pump via a conduit. A feed inlet is provided at the edge of the funnel's opening, and the feed inlet is connected to the container bottle via a pipe. A flow control valve and a micro pump are sequentially arranged between the feed inlet and the container bottle. The level gauge is located at the feed inlet of the funnel. The micro pump, flow control valve, vacuum pump, and level gauge are all connected to a computer.

[0004] For example, patent application number CN201821371485.5, entitled "A Laboratory Vacuum Filtration Safety Component and a Laboratory Vacuum Filtration Device," discloses a technical solution including a safety bottle and a buffer stopper. The safety bottle has an air inlet connected to its opening, which is used to connect with the filtration port of a collection bottle. The buffer stopper is located at the opening of the safety bottle and is sealed to it. The buffer stopper has an air outlet connected to the suction end of a vacuum pump. The buffer stopper prevents water vapor and corrosive gases from entering the vacuum pump. When water vapor and corrosive gases rise from the safety bottle to the buffer stopper, the buffer stopper's buffering effect reduces the amount of water vapor and corrosive gases entering the vacuum pump, thus preventing contamination and corrosion of the pump oil and extending the pump's lifespan, thereby reducing experimental costs.

[0005] However, the above-mentioned methods require manual assembly for each operation, and disassembly for cleaning and storage after each operation, making them extremely inconvenient to use. Therefore, we need a filtration device that can rapidly filter large quantities of liquid and is easy to operate and clean. Utility Model Content

[0006] The purpose of this invention is to solve the above problems and provide a high-throughput rapid filtration device for laboratory use that does not require disassembly and cleaning. It can realize the rapid completion of the filtration process on a large scale in the laboratory, and does not need to be disassembled repeatedly after one assembly, making it convenient for cleaning and use.

[0007] The technical solution adopted by this utility model to solve its technical problem is:

[0008] A high-throughput rapid filtration device for laboratory use that does not require disassembly and cleaning includes a movable support, a glass frit funnel and a filtrate buffer bottle arranged from top to bottom on the support, and a peristaltic pump. The output end of the peristaltic pump is connected to the glass frit funnel, and the input end of the peristaltic pump is connected to a stock solution container and an ultrapure water container, respectively. The lower end of the glass frit funnel is connected to the filtrate buffer bottle.

[0009] Furthermore, the glass core funnel is provided in three parts, and the output end of the peristaltic pump is connected to the three glass core funnels respectively through silicone hoses.

[0010] Furthermore, the peristaltic pump input end is connected to a peristaltic tube, and there are two peristaltic tubes, which are respectively connected to the stock solution container and the ultrapure water container.

[0011] Furthermore, the lower end of the glass core funnel is provided with an adjustable valve.

[0012] Furthermore, the glass core funnel is divided into upper and lower parts, which are connected by threads, and the top of the lower part is provided with a microporous filter membrane.

[0013] Furthermore, the filtrate buffer bottle is provided with an inlet at the upper end, and a rubber stopper is provided inside the inlet, with a four-way pipe inside the rubber stopper.

[0014] Furthermore, the output end of the four-way pipe includes an outer pipe and an inner pipe with an umbrella-shaped bottom. The upper end of the inner pipe is provided with a sealing plate, and the sealing plate is symmetrically provided with through holes. The lower end of the through holes communicates with the gap between the outer pipe and the inner pipe. The four-way pipe is provided with a rotating shaft, and the rotating shaft is provided with a first sealing head that cooperates with the upper end of the inner pipe. The rotating shaft is symmetrically provided with a second sealing head about the axis of the first sealing head. The axis of the first sealing head is perpendicular to the axis of the second sealing head, and the second sealing head corresponds to the through hole.

[0015] Furthermore, a vacuum pump is connected to the right side of the filtrate buffer bottle.

[0016] Furthermore, a filtrate switch valve is provided at the lower end of the filtrate buffer bottle.

[0017] Furthermore, the lower end of the bracket is equipped with casters.

[0018] The beneficial effects of this utility model are:

[0019] 1. This utility model includes a movable support, a glass frit funnel and a filtrate buffer bottle arranged from top to bottom on the support, and a peristaltic pump. The output end of the peristaltic pump is connected to the glass frit funnel, and the input end of the peristaltic pump is connected to a stock solution container and an ultrapure water container, respectively. The lower end of the glass frit funnel is connected to the filtrate buffer bottle. The peristaltic pump draws the stock solution from the stock solution container into the glass frit funnel for filtration, and then into the filtrate buffer bottle for storage. This allows for large-scale and rapid completion of the filtration process in the laboratory, and once assembled, it does not require repeated disassembly, making it convenient for cleaning and use. Attached Figure Description

[0020] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, for those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0021] Figure 1 This is a schematic diagram of the present invention;

[0022] Figure 2 This is a cross-sectional view of the four-way pipe of this utility model;

[0023] Figure 3 This is a cross-sectional view of the glass sand core funnel of this utility model.

[0024] In the diagram: 1. Support frame; 2. Glass frit funnel; 3. Filtrate buffer bottle; 4. Peristaltic pump; 5. Silicone tubing; 6. Peristaltic tube; 7. Adjustable valve; 8. Microporous filter membrane; 9. Rubber stopper; 10. Outer tube; 11. Inner tube; 12. Sealing plate; 13. Through hole; 14. Rotating shaft; 15. First sealing head; 16. Second sealing head; 17. Vacuum pump; 18. Filtrate switch valve; 19. Caster wheel. Detailed Implementation

[0025] To enable those skilled in the art to better understand the technical solutions of this utility model, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort should fall within the protection scope of this utility model.

[0026] like Figure 1As shown, a high-throughput rapid filtration device for laboratory use that requires no disassembly or cleaning includes a movable support 1, a glass frit funnel 2 and a filtrate buffer bottle 3 mounted on the support 1 from top to bottom, and a peristaltic pump 4. The output end of the peristaltic pump 4 is connected to the glass frit funnel 2, and the input ends of the peristaltic pump 4 are connected to a stock solution container and an ultrapure water container, respectively. The lower end of the glass frit funnel 2 is connected to the filtrate buffer bottle 3. The peristaltic pump 4 draws the stock solution from the stock solution container into the glass frit funnel 2 for filtration, and then into the filtrate buffer bottle 3 for storage. This device enables large-scale, rapid filtration in the laboratory, and once assembled, it does not require repeated disassembly, making it convenient for cleaning and use.

[0027] like Figure 1 As shown, there are three glass core funnels 2, and the output end of the peristaltic pump 4 is connected to the three glass core funnels 2 respectively through silicone hoses 5.

[0028] like Figure 1 As shown, the peristaltic pump 4 has a peristaltic tube 6 connected to its input end. Two peristaltic tubes 6 are provided, one connected to the stock solution container and the other to the ultrapure water container. In this embodiment, the peristaltic tube at the left end of the peristaltic pump 4 is connected to the stock solution container before filtration. The type of container is not limited; the peristaltic tube is directly inserted into the stock solution container. The liquid flow rate can be adjusted by the peristaltic pump. Multiple silicone tubing is connected to the front end of the peristaltic pump. The peristaltic tube at the right end of the peristaltic pump is connected to laboratory ultrapure water for easy cleaning during the filtration process.

[0029] like Figure 1 As shown, the lower end of the glass core funnel 2 is equipped with an adjustable valve 7, which can be opened when needed and closed when not in use.

[0030] like Figure 2 As shown, the glass frit funnel 2 is divided into upper and lower parts, which are connected by threads. The top of the lower part is equipped with a microporous filter membrane 8 and a glass frit core sealing layer. The microporous filter membrane 8 is placed on the glass frit core sealing layer. An adjustable valve is connected to the bottom of the lower part. The upper and lower parts can be unscrewed by threads. The microporous filter membrane can be placed in the middle. Compared with the traditional method of fixing with clips, it is more convenient to replace the filter membrane, and the sealing performance is stronger, which is more conducive to maintaining the vacuum level during use.

[0031] like Figure 1 As shown, the filtrate buffer bottle 3 has an inlet at its upper end, and a rubber stopper 9 is installed inside the inlet. A four-way pipe is located inside the rubber stopper 9. The input end of the four-way pipe consists of three pipes at the upper end, each connected to a corresponding glass frit funnel 2. The output end of the four-way pipe passes through the rubber stopper 9 and extends into the filtrate buffer bottle 3. A valve is connected to the four-way pipe, allowing the filtrate buffer bottle to be filled. The bottle opening is sealed with a rubber stopper.

[0032] like Figure 2As shown, the output end of the four-way pipe includes an outer tube 10 with an umbrella-shaped bottom and an inner tube 11. A sealing plate 12 is provided at the upper end of the inner tube 11, and the sealing plate 12 is fixed inside the four-way pipe. Symmetrically arranged through holes 13 are provided on the sealing plate 12, and the lower end of the through holes 13 communicates with the gap between the outer tube 10 and the inner tube 11. A rotating shaft 14 is provided inside the four-way pipe. A first sealing head 15, which mates with the upper end of the inner tube 11, is provided on the rotating shaft 14. A second sealing head 16 is symmetrically arranged on the rotating shaft 14 with the axis of the first sealing head 15 as the center. The axis of the first sealing head 15 is perpendicular to the axis of the second sealing head 16, and the second sealing head 16 corresponds to the through hole 13. The lower end of the four-way pipe has a double-layer pipe structure: the inner pipe is the filtrate flow pipe, and the outer pipe is the washing liquid flow pipe. During cleaning, the inner pipe is blocked, and the liquid can flow down the filtrate bottle wall through the umbrella-shaped port at the lower end of the outer pipe, which facilitates a cleaner cleaning of the filtrate buffer bottle. When the shaft 14 rotates, the first sealing head 15 is in a vertical position, sealing the upper end of the inner tube 11. At this time, the second sealing head 16 is in a horizontal position, the through hole 13 is open, and the washing liquid enters the gap between the outer tube 10 and the inner tube 11 through the through hole 13. The liquid can be controlled to flow down the wall of the filter bottle through the umbrella-shaped port at the lower end of the outer tube. After cleaning, the shaft is rotated, and the second sealing head 16 is in a vertical position, sealing the through hole 13. At this time, the second sealing head 16 is in a vertical position, the through hole 13 is closed, and the original liquid enters the filter buffer bottle 3 through the inner tube 11.

[0033] like Figure 1 As shown, the filtrate buffer bottle 3 is connected to a vacuum pump 17 on the right side, which can provide sufficient power to maintain the vacuum level during operation.

[0034] like Figure 1 As shown, the filtrate buffer bottle 3 is equipped with a filtrate switch valve 18 at the lower end, which can realize timely discharge when the filtrate collection is gradually full. Compared with the traditional vacuum filtration device, which requires the filtrate bottle to be disassembled from the whole device to discharge the filtrate, it is more convenient and faster.

[0035] like Figure 1 As shown, the lower end of the bracket 1 is equipped with casters 19, and the entire filtration device is equipped with casters and wheel brakes, which can be easily moved in the laboratory.

[0036] In the description of this utility model, it should be noted that the terms "left", "right", "up", "down", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0037] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

Claims

1. A doffing-free cleaning high-throughput rapid suction filtration device for laboratory use, characterized in that, It includes a movable support (1), a glass frit funnel (2) and a filtrate buffer bottle (3) arranged from top to bottom on the support (1), and also includes a peristaltic pump (4). The output end of the peristaltic pump (4) is connected to the glass frit funnel (2), and the input end of the peristaltic pump (4) is connected to the original liquid container and the ultrapure water container respectively. The lower end of the glass frit funnel (2) is connected to the filtrate buffer bottle (3).

2. The laboratory high-throughput rapid filtration device that requires no disassembly and cleaning as described in claim 1, characterized in that, The glass core funnel (2) is provided in three parts, and the output end of the peristaltic pump (4) is connected to the three glass core funnels (2) respectively through silicone hoses (5).

3. The laboratory high-throughput rapid filtration device that requires no disassembly and cleaning as described in claim 1, characterized in that, The peristaltic pump (4) has a peristaltic tube (6) connected to its input end. There are two peristaltic tubes (6), which are respectively connected to the original liquid container and the ultrapure water container.

4. The laboratory high-throughput rapid filtration device that requires no disassembly and cleaning as described in claim 1, characterized in that, An adjustable valve (7) is provided at the lower end of the glass core funnel (2).

5. A laboratory high-throughput rapid filtration device that requires no disassembly and cleaning, as described in claim 1, characterized in that... The glass core funnel (2) is divided into upper and lower parts, which are connected by threads. The top of the lower part is provided with a microporous filter membrane (8).

6. The laboratory high-throughput rapid filtration device that requires no disassembly and cleaning as described in claim 1, characterized in that, The filtrate buffer bottle (3) is provided with an inlet at the upper end, and a rubber stopper (9) is provided inside the inlet. The rubber stopper (9) contains a four-way pipe.

7. A laboratory high-throughput rapid filtration device that requires no disassembly and cleaning, as described in claim 6, is characterized in that... The output end of the four-way pipe includes an outer pipe (10) with an umbrella-shaped bottom and an inner pipe (11). The upper end of the inner pipe (11) is provided with a sealing plate (12). The sealing plate (12) is symmetrically provided with through holes (13). The lower end of the through hole (13) is connected to the gap between the outer pipe (10) and the inner pipe (11). The four-way pipe is provided with a rotating shaft (14). The rotating shaft (14) is provided with a first sealing head (15) that cooperates with the upper end of the inner pipe (11). The rotating shaft (14) is symmetrically provided with a second sealing head (16) with the axis of the first sealing head (15) as the center. The axis of the first sealing head (15) is perpendicular to the axis of the second sealing head (16). The second sealing head (16) corresponds to the through hole (13).

8. A laboratory high-throughput rapid filtration device that requires no disassembly and cleaning, as described in claim 1, characterized in that... The filtrate buffer bottle (3) is connected to a vacuum pump (17) on the right side.

9. A laboratory high-throughput rapid filtration device that requires no disassembly and cleaning, as described in claim 1, characterized in that... The filtrate buffer bottle (3) is equipped with a filtrate switch valve (18) at the lower end.

10. A laboratory high-throughput rapid filtration device that requires no disassembly and cleaning, as described in claim 1, characterized in that... The bracket (1) is equipped with casters (19) at its lower end.

Images