Solution pipe structure of a sampling and detecting integrated device

Abstract

This utility model belongs to the technical field of sampling and testing equipment, specifically relating to a solution tube structure of an integrated sampling and detection device, including: a tube body, a base plate, and a scraping structure; the base plate is disposed at the bottom of the tube body, and cooperates with the tube body to form a dissolution space with a top opening, the dissolution space being filled with solution, and the scraping structure is disposed in the lower half of the tube body, such that the scraping structure is immersed in the solution; for the collection of samples with small sample volumes, this application provides a solution that is easy to operate and can improve sample dissolution efficiency and increase sample concentration.

Description

Technical Field

[0001] This utility model belongs to the field of sampling and testing equipment technology, specifically relating to a solution tube structure of an integrated sampling and testing device. Background Technology

[0002] In existing integrated sampling and testing devices, swabs are typically used to collect samples (such as feces, nasopharyngeal secretions, etc.). The swabs are then inserted into a solution tube containing buffer solution to dissolve the sample in the buffer solution for subsequent testing. However, controlling the amount of sample dissolved in the solution remains a challenge for different samples.

[0003] To address this, Chinese invention patent application CN117007372A discloses an integrated sampling and detection device, comprising a lid 4 and a main container 3. A sampling rod 2 is connected to the lid 4. The main container 3 includes a sample inlet chamber 22 on one side and a test chamber 21 on the other side. The bottom of the storage chamber 25 has a closed-loop groove 9 around the outlet hole 12. This design uses a partition layer 23 in the middle of the sample inlet chamber 22, with a sample inlet hole 24 at its center. This allows for the removal of excess sample from the surface of the sampling rod 2 and the sealing of the sample inlet hole 24 by the sampling rod 2, preventing sample solution overflow. However, the above solution is not suitable for collecting samples with small sample volumes. Specifically, this solution has at least the following shortcomings:

[0004] 1. The sample is dissolved solely through simple contact between the swab and the solution. For trace samples such as viruses and nucleic acids, the dissolution efficiency is low, which may lead to insufficient detection sensitivity and false negative results.

[0005] 2. The lack of an effective mixing mechanism may result in uneven distribution of the dissolved sample in the solution, leading to increased sampling errors during detection and affecting the stability of the test results.

[0006] Therefore, there is an urgent need for a new type of integrated sampling and detection device that can improve sample dissolution efficiency and detection accuracy while ensuring ease of operation. Utility Model Content

[0007] The purpose of this invention is to provide a solution tube structure for an integrated sampling and detection device, so as to partially alleviate or solve the above-mentioned problems and improve the sample dissolution efficiency.

[0008] To solve the aforementioned technical problems, the present invention specifically adopts the following technical solution:

[0009] A solution tube structure for an integrated sampling and detection device includes: a tube body, a base plate, and a sample scraping structure;

[0010] The base plate is disposed at the bottom of the tube body and cooperates with the tube body to form a dissolution space with a top opening, and the dissolution space is filled with solution;

[0011] The scraping structure is located in the lower half of the tube body, so that the scraping structure is immersed in the solution. The scraping structure includes a collection area and a scraping area arranged sequentially from top to bottom. The inner diameter of the collection area gradually decreases from top to bottom. The inner diameter of the scraping area is the same along the height direction of the solution tube, so that the scraping structure is funnel-shaped. The scraping area is provided with at least two scraping protrusions, and a scraping groove is formed between two adjacent scraping protrusions.

[0012] When the sampled swab is inserted into the solution tube, the swab enters the scraping area under the guidance of the collection area, and the sample on the swab is fully dissolved in the solution around the scraping protrusion under the action of the scraping protrusion.

[0013] As an improvement, at least one exchange hole is provided at the top of the collection zone to form a solution exchange zone at the top of the collection zone;

[0014] When the swab is inserted into the sampling area, the solution can be exchanged through the exchange hole under the stirring action of the swab.

[0015] As an improvement, the tube body and the base plate are integrally formed.

[0016] As an improvement, the scraping structure is fixedly installed inside the tube body.

[0017] As an improvement, the scraping structure also includes a support portion, the inner diameter of which increases sequentially from top to bottom, the top of which is connected to the bottom of the scraping area, and the bottom of which abuts against the inner wall of the tube.

[0018] As an improvement, the support portion is provided with at least one through hole, which communicates with the exchange hole.

[0019] As an improvement, the outer diameter of the scraping structure is the same from top to bottom, and the outer wall of the scraping structure is tightly connected to the inner wall of the tube. At least one exchange channel is provided inside the scraping structure, and the exchange hole and the through hole are connected through the exchange channel.

[0020] As an improvement, the bottom of the solution tube is provided with a puncture groove provided on the base plate, and the thickness of the puncture groove is less than the thickness of the base plate;

[0021] When a force is applied to the puncture groove, the puncture groove is torn to form a crack in the base plate, allowing the solution to flow out from the solution tube.

[0022] As an improvement, the integrated sampling and detection device further includes a detection tube and a base. Both ends of the detection tube are provided with openings, and the diameter of the detection tube gradually increases from the top to the bottom. At least a portion of the solution tube is fitted inside the detection tube, and the base is engaged with the opening at the bottom of the detection tube.

[0023] As an improvement, the base is provided with a puncture part, which corresponds to the puncture groove;

[0024] When the solution tube is pressed down, the puncture part contacts the puncture groove and punctures the puncture groove.

[0025] The principle and beneficial technical effects of this utility model are as follows:

[0026] For the collection of samples with small sample sizes, such as viruses, this application provides a simple operating method that can improve sample dissolution efficiency and increase sample concentration.

[0027] First, the sampled swab is guided into the scraping area by the funnel-shaped collection area. By pulling the swab up and down or rotating it to rub it against the scraping protrusions, this process is always completed while the sample is immersed in the solution. This allows the sample to fully dissolve in the solution surrounding the scraping structure. During this process, the solution above and below the scraping structure is exchanged through the exchange holes and the gaps between the swab and the inner wall of the scraping area as the swab moves, resulting in a more uniform distribution of the sample in the solution.

[0028] Furthermore, the support section and the scraper structure with a relatively large thickness can, on the one hand, increase the contact area between the scraper structure and the solution tube, thereby improving the connection strength; on the other hand, it can fill the internal space of the solution tube, thereby reducing the amount of solution to be filled, saving production costs, and making the sample concentration in the solution higher. Attached Figure Description

[0029] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. The elements or parts in the drawings are not necessarily drawn to scale. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without any creative effort.

[0030] Figure 1 This is a perspective view of the integrated sampling and detection device in its initial state in an embodiment of this utility model;

[0031] Figure 2 This is a perspective view of the integrated sampling and detection device in the detection state in an embodiment of this utility model;

[0032] Figure 3 This is an exploded view of the integrated sampling and detection device in this embodiment of the present invention;

[0033] Figure 4 This is a cross-sectional view of the integrated sampling and detection device in its initial state in an embodiment of this utility model;

[0034] Figure 5 This is an enlarged schematic diagram of part B of the integrated sampling and detection device in this embodiment of the present invention;

[0035] Figure 6 This is a cross-sectional view from another angle of the integrated sampling and detection device in the initial state of this utility model embodiment;

[0036] Figure 7 This is a cross-sectional view of the integrated sampling and detection device in this embodiment of the present invention during sampling.

[0037] Figure 8 This is a cross-sectional view of the integrated sampling and detection device in this embodiment of the present invention after sampling, with the sampler inserted back into the solution tube;

[0038] Figure 9 This is a cross-sectional view of the integrated sampling and detection device in this embodiment of the present invention after the limiting component has been removed;

[0039] Figure 10 This is a cross-sectional view of the integrated sampling and detection device in this embodiment of the invention during the detection process after the solution tube and sampler are pressed down;

[0040] Figure 11 This is a perspective view of the base in an embodiment of the present utility model;

[0041] Figure 12 This is a front view of the sampler in an embodiment of this utility model;

[0042] Figure 13 This is a side view of the sampler in an embodiment of the present invention;

[0043] Figure 14 This is a perspective view of the sampler in an embodiment of the present invention;

[0044] Figure 15 for Figure 12 An enlarged schematic diagram of part A in the middle;

[0045] Figure 16 This is an example of the sampler size in an embodiment of the present invention;

[0046] Figure 17 This is an example of the sampler size in an embodiment of the present invention;

[0047] Figure 18 This is a perspective view of the solution tube in an embodiment of this utility model;

[0048] Figure 19 This is a top view of the partition in an embodiment of the present invention;

[0049] Figure 20 This is a schematic diagram of the detection tube in an embodiment of the present invention;

[0050] Figure 21 This is a schematic diagram of the sampling rod in Embodiment 4 of this utility model;

[0051] Figure 22 This is a schematic diagram of the upper cover in Embodiment 4 of this utility model;

[0052] Figure 23 This is a schematic diagram of the scraping structure in Embodiment 5 of this utility model;

[0053] Figure 24 This is a cross-sectional view of the integrated sampling and detection device in the initial state in Embodiment 5 of this utility model;

[0054] Figure 25 This is a cross-sectional view of the integrated sampling and detection device in Embodiment 5 of this utility model during sampling.

[0055] Figure 26 This is a cross-sectional view of the scraping structure in Embodiment 5 of this utility model when it is located above the liquid surface;

[0056] Figure 27 This is a schematic diagram of another form of the scraping structure in Embodiment 5 of this utility model.

[0057] In the diagram, the following are the markings: 1. Sampler; 11. Grip; 111. Anti-slip groove; 12. Joint; 13. Sampling rod; 131. First groove; 132. Second groove; 14. Collection section; 141. Pointed structure; 142. Guide area; 143. Transition area; 144. Partition; 401. Anti-slip protrusion; 402. Receiving area; 145. Receiving cavity; 2. Solution tube; 21. Base plate; 211. Puncture groove; 22. Tube body; 23. Guide section; 24. Anti-slip strip; 25. Storage tank; 26. Solution; 3. Detection tube; 31. Detection space; 32. Opening; 33. Test strip mounting slot; 34. Limiting step; 4. Base; 41. Bottom cover; 42. Enclosure; 421. First baffle; 422. Second baffle; 423. Third baffle; 424. Cavity; 425. Slot; 43. Puncture section; 44. Transition slope; 45. Slot; 46. Enclosure space; 47. Limiting protrusion; 5. Limiting component; 6. Test strip; 7. Fixing component; 71. Display hole; 8. Protective plate; 9. Sealing ring; 10. Top cover; 20. Scraping structure; 201. Solution exchange area; 202. Collection area; 203. Scraping area; 204. Scraping protrusion; 205. Scraping groove; 206. Exchange hole; 207. Support; 208. Through hole. Detailed Implementation

[0058] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without creative effort are within the scope of protection of this utility model.

[0059] In this document, suffixes such as "module," "component," or "unit" used to denote elements are used solely for the purpose of illustrative purposes and have no specific meaning in themselves. Therefore, "module," "component," or "unit" can be used interchangeably. In this document, terms such as "upper," "lower," "inner," "outer," "front," "rear," "one end," and "the other end," indicating orientation or positional relationships, are based on the orientation or positional relationships shown in the accompanying drawings and are used only for the convenience of describing this utility model and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0060] In this document, unless otherwise explicitly specified and limited, the terms "installed," "equipped with," and "connected," etc., should be interpreted broadly. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, a direct connection, or an indirect connection through an intermediate medium; it can also refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances. In this document, "multiple" means two or more, that is, it includes two, three, four, five, etc.

[0061] Example 1

[0062] This embodiment is basically as shown in the appendix. Figures 12-17 and Figure 19 As shown:

[0063] This embodiment provides a sampler, see [link to sampler documentation] Figure 12 and Figure 13 It includes a gripping part 11, a connecting part 12, a sampling rod 13 and a collecting part 14 connected from top to bottom.

[0064] See Figure 15 The collecting part has an internal hollowed-out installation space. At least one partition 144 is provided in the installation space along the width direction of the collecting part, and the at least one partition 144 divides the installation space into at least two receiving cavities 145. A pointed structure 141 is provided at the first end of the collecting part. The pointed structure 141 includes a first surface, a second surface, a third surface and a fourth surface connected in sequence. The first surface, the second surface, the third surface and the fourth surface are arranged circumferentially along the pointed structure 141. The first surface and the third surface are respectively recessed inward to form a guide area 142 with a first inclination.

[0065] In some embodiments, the first surface and the third surface are disposed opposite to each other, and the second surface and the fourth surface are disposed opposite to each other. That is, the two sides of the pointed structure form a cut bevel shape (i.e., guide area 142), so that the width of the pointed structure increases from bottom to top and then smoothly transitions with the installation space, thereby enabling the sample to enter the receiving cavity along the guide area when the sampler is inserted into the sample.

[0066] In some embodiments, the middle portion of the cross-section of the installation space is rectangular, and the two width sides of the rectangle extend to both ends to form an arc shape.

[0067] In some embodiments, the pointed tip of the pointed structure is a blunt end.

[0068] See Figure 19The partition is provided with multiple anti-slip protrusions 401 and / or multiple recesses. Adjacent anti-slip protrusions 401 cooperate with the partition to form a restrictive structure, thereby dividing the receiving cavity into multiple receiving areas 402. By cooperating with the surface of the partition, when a sample enters the receiving area, adjacent anti-slip protrusions cooperate to limit the sample in the width direction (radial direction), and two adjacent partitions limit the sample in the height direction, so that the sample can be stably stored inside the receiving area.

[0069] In some embodiments, multiple partitions are provided, and the multiple partitions are evenly arranged within the installation space, such that the multiple receiving cavities have the same height.

[0070] In other embodiments, multiple partitions are provided, and the multiple partitions are not uniformly arranged in the installation space to form multiple receiving cavities of different heights.

[0071] In some embodiments, the partition is a circular partition, the sampling rod is cylindrical, and the diameter of the partition is less than or equal to the diameter of the sampling rod.

[0072] In some embodiments, the second end of the mounting groove extends toward the second end of the collecting portion to form a transition zone with a second inclination.

[0073] In some embodiments, two guide areas and two transition areas are provided, and they are symmetrical about the central axis of the sampling rod.

[0074] In some embodiments, see Figure 14 The sampling rod is provided with a first groove 131 and a second groove 132 in the circumferential direction, and a sealing ring is provided in both the first groove 131 and the second groove 132.

[0075] In some embodiments, see Figure 14 The gripping part is spherical, and the inner diameter of the gripping part gradually increases and then decreases from the first end to the second end. The gripping part is provided with a plurality of anti-slip grooves 111 arranged circumferentially.

[0076] In some specific embodiments, the anti-slip groove is a plurality of grooves formed by the inward indentation of the surface of the spherical grip portion along the width direction.

[0077] In some embodiments, a plurality of the grooves are evenly distributed on the spherical grip portion.

[0078] By designing a spherical grip, users can easily apply force when pressing the grip and pulling the sampler out of the self-testing device. In addition, the grip adopts a hollow structure (anti-slip groove), which saves production costs and reduces the weight of the grip, preventing the sampler from becoming top-heavy and tipping over when it is used with the self-testing device.

[0079] In some embodiments, the volume of the installation space is 50 mm. 3 -200mm 3 (73mm is preferred) 3 ).

[0080] For example, see Figure 16 and Figure 17 The figure shows an example of a sampler. Specifically, the sampler has a total length of 90.1 mm, a joint width of 15 mm, a grip and joint height of 37.7 mm, a collection height of 18.3 mm, an installation space height of 11.8 mm, and six accommodating cavities, five of which have a height of 1.1 mm and the other has a height of 2.25 mm. The sampling rod has a width of 3.9 mm, and the collection section has a width of 3.7 mm.

[0081] In summary, this application, by setting multiple "semi-enclosed" receiving cavities in the collection section and setting guide structures on both sides of the collection section, can collect and stably store samples of different shapes, and to a certain extent prevent samples from falling off the sampler.

[0082] First, the receiving cavity in this application is formed by the inner wall of the installation space (i.e., the side wall of the collection part) and the partition. In use, the two side walls of the collection part can limit the sample in the width direction in the receiving cavity, and the two adjacent partitions, or one partition and the bottom or top wall of the installation space, limit the sample in the height direction in the receiving cavity, so that the sample is in a "semi-enclosed" space. The sampler remains upright after sampling and during the insertion of the self-testing device. In this way, by limiting the sample in the width and height directions simultaneously through the above structure, the sample can be effectively prevented from falling out of the receiving cavity.

[0083] Furthermore, "guide structures" are provided on both sides of the collection section, which enables the sampler to collect as many samples as possible during the insertion and removal of the sample. Specifically, a guide area is provided on the pointed structure at the first end of the collection section. During the insertion of the sampler into the sample, the sample can enter the receiving cavity along the guide area. At the same time, during the removal of the sampler from the sample, due to the resistance of the sample, the sample located above the receiving cavity can enter the receiving cavity along the transition area.

[0084] Furthermore, for different samples, uniformly or non-uniformly arranged partitions can be selected. For example, for watery feces, uniformly arranged partitions can be used, which allows the sample to enter the receiving cavity evenly. In addition, the density of the partitions can be increased, that is, the spacing between the partitions can be reduced, making the height of the receiving cavity lower and easier to store the sample. For solid feces, non-uniformly arranged partitions can be used, so that the receiving space of different heights can collect solid feces with different particle sizes separately, and samples of different particle sizes can be stuck in different receiving spaces.

[0085] Example 2

[0086] This embodiment provides a self-testing device, see [link / reference] Figure 1 and Figure 20 It includes solution tube 2, detection tube 3 and base 4.

[0087] Both ends of the detection tube are provided with openings, and the diameter of the detection tube gradually increases from the top to the bottom, that is, the cross-sectional shape of the detection tube is trapezoidal. At least a part of the solution tube is fitted inside the detection tube, and the base is matched with the opening at the bottom of the detection tube.

[0088] In some embodiments, the diameter of the portion of the solution tube extending into the detection tube is smaller than the inner diameter of the opening at the top of the detection tube, so that the solution tube can extend into the detection tube from the top of the solution tube, while the base is mounted to the bottom of the detection tube from the opening at the bottom of the detection tube.

[0089] In some embodiments, see Figure 5 The bottom of the base is provided with a limiting protrusion 47, and the bottom of the detection tube is provided with a limiting step 34. When the base is installed in the detection tube, the limiting protrusion 47 abuts against the limiting step 34, thereby limiting the base and further ensuring the sealing between the two to prevent the solution from leaking out from the connection between them.

[0090] See Figure 4 , Figure 5 and Figure 11 The base includes a bottom cover 41, and a surface disposed on the bottom cover.

[0091] The enclosure 42 and the puncture part 43 are provided. The outer wall of the enclosure 42 is attached to the inner wall of the detection tube, that is, the base is also a trapezoidal structure. The puncture part 43 is located in the enclosure space 46 formed by the enclosure 42. The inner diameter of the top of the enclosure 42 decreases from top to bottom, so that the top of the enclosure 42 forms a transition slope 44. A slot 45 is provided on one side of the enclosure. The detection tube is provided with a detection space 31 for accommodating the test strip. The bottom of the detection space 31 is provided with an opening 32 that communicates with the slot 45, so that the first end of the test strip can extend out from the opening 32 and pass through the slot 45 into the enclosure space 46.

[0092] In some embodiments, the height of the enclosure is less than the height of the detection tube, and the top of the enclosure is located in the lower half of the detection tube.

[0093] Compared with the straight tube structure in the prior art and the "layer-by-layer nesting" installation method from top to bottom, this application provides a self-testing device to prevent tipping by setting a frustum-shaped detection tube and using a "semi-enclosed" cooperation method between the detection tube and the base from bottom to top.

[0094] Specifically, the base engages with the detection tube through the opening at the bottom of the detection tube, using a bottom-up installation method. This ensures that the installed base is located in the lower half of the detection tube. On one hand, this concentrates the center of gravity of the self-testing device at the bottom of the device, and together with the frustum-shaped detection tube, it can prevent tipping to some extent. On the other hand, the test strips located in the detection tube can be directly introduced into the enclosed space during installation, which is convenient and quick, and does not require the installation of an additional test strip holding structure.

[0095] Furthermore, a transition slope is provided at the top of the enclosure. Even if it tilts, the solution is unlikely to leak out of the detection tube because the enclosure is close to the inner wall of the detection tube. After the self-testing device is uprighted, the solution above the enclosure can flow back into the enclosure space through the transition slope, further preventing leakage.

[0096] In some embodiments, see Figure 4 The enclosure includes a first baffle 421 and a second baffle 422 arranged sequentially from the outside to the inside. The height of the second baffle 422 is lower than the height of the first baffle 421. The first end of the first baffle 421 and the first end of the second baffle 422 are connected by a third baffle 423, and a transition slope is formed on the first surface of the third baffle 423. The outer wall of the first baffle 421 is in contact with the inner wall of the detection tube 3. The first baffle 421, the second baffle 422, the third baffle 423 and the bottom cover enclose a cavity 424.

[0097] In some embodiments, see Figure 11 The enclosure 42 is recessed downward along its height direction on the side near the opening to form the slot 45. The portions of the enclosure 42 located on both sides of the slot are recessed inward to form slots 425 that communicate with the enclosure space. The slots 45 are set along the height direction of the enclosure 42.

[0098] When the first end of the test strip extends out of the opening and is inserted into the enclosure space along the slot, the two sides of the first end of the test strip are locked into the slot; wherein, the first end of the test strip refers to the end of the test strip that is in contact with the liquid.

[0099] By fixing the first end of the test strip with a slot, it is possible to prevent the test strip from curling up after being bent through the opening and slot structure, thus ensuring that the end of the test strip is always located at the bottom of the enclosed space to absorb liquid.

[0100] In some embodiments, see Figure 5 The solution tube includes an integrally formed base plate 21 and a tube body. The base plate is disposed at the bottom of the tube body, and the top of the solution tube is provided with an opening.

[0101] In some embodiments, the base plate 21 is provided with a puncture groove 211 that mates with the tip of the puncture portion, and the thickness of the puncture groove 211 is less than the thickness of the base plate 21.

[0102] In some embodiments, the solution tube is made of plastic.

[0103] Compared to existing technologies that use open-top and bottom solution tubes with an aluminum film at the bottom for sealing, this application uses an integrated solution tube with a puncture groove. This simplifies the manufacturing process, reduces costs, and does not increase the difficulty of puncture. During puncture, the bottom of the solution tube breaks along the puncture groove. This means the solution enters the enclosure space through the crack formed by the puncture groove, preventing larger particles in the solution from directly contacting the test strip and causing inaccurate measurement results.

[0104] In some embodiments, the limiting member is detachably disposed outside the solution tube. In some specific embodiments, the limiting member includes an elastic retaining ring with one open end and a pull ring located on the opposite side of the opening. In use, the retaining ring is engaged with the solution tube to limit the height of the solution tube, preventing the bottom plate of the solution tube from contacting and being punctured by the puncture site. When the pull ring is pulled to remove the retaining ring from the solution tube, pressing the solution tube downwards allows the bottom plate to contact and be punctured by the puncture site.

[0105] In some embodiments, see Figure 3The detection tube is provided with a display area, and a test strip mounting groove 33 is provided in the display area along the height direction of the detection tube. The test strip mounting groove 33 is connected to the opening. The test strip is fixed in the test strip mounting groove by a fixing member 7. The fixing member is provided with a display hole 71, and a transparent protective plate 8 is also provided on the outside of the fixing member.

[0106] In some embodiments, see Figure 18 The solution tube has a guide portion 23 on its outer wall. The outer diameter of the guide portion 23 gradually increases from its first end to its second end, and the first end of the guide portion 23 smoothly transitions into the solution tube. The first end is the end of the guide portion near the bottom plate of the solution tube, and the second end is the end of the guide portion near the opening of the solution tube. By providing the guide portion, it is easier to press the solution tube downwards, preventing jamming.

[0107] In some embodiments, the second end of the guide extends along the height direction of the solution tube to form a plurality of anti-slip strips 24.

[0108] In some embodiments, the top of the solution tube extends upward to form a storage tank 25, the cross-sectional shape of which is an inverted trapezoid. By providing the inverted trapezoidal storage tank, it serves two purposes: firstly, it guides the sampler when it is inserted into the solution tube; secondly, this structure can collect excess sample. Specifically, during user operation, the user typically holds the detection tube with one hand and the grip with the other to insert the sampler back into the detection tube. During this process, the sample may drip from the sampler, and the storage tank can collect the dripping sample, preventing it from dripping onto the user's hand.

[0109] In some embodiments, the storage tank and the solution tube are integrally formed; in some specific embodiments, the storage tank is made of plastic.

[0110] In summary, this embodiment provides a self-testing device to prevent tipping by setting a frustum-shaped detection tube and using a "semi-enclosed" cooperation method between the detection tube and the base.

[0111] Example 3

[0112] This embodiment is basically as shown in the appendix. Figures 1-20 As shown:

[0113] This embodiment provides an integrated sampling and detection device, including a sampler 1 and a self-testing device. The self-testing device includes a solution tube 2, a detection tube 3, and a base 4. The sampler 1 can refer to the structure of the sampler 1 in Embodiment 1, and the self-testing device can adopt the structure of the self-testing device in Embodiment 2.

[0114] In some embodiments, the integrated sampling and detection device includes: a sampler 1, a solution tube 2, a detection tube 3, and a base 4; both ends of the detection tube 3 are provided with openings, and the diameter of the detection tube 3 gradually increases from the top to the bottom; at least a portion of the solution tube 2 is fitted inside the detection tube 3; at least a portion of the sampler 1 is fitted inside the solution tube 2; and the base 4 is engaged with the opening at the bottom of the detection tube 3.

[0115] The base 4 includes a bottom cover 41, and a barrier and a puncture part 43 disposed on the bottom cover 41. The outer wall of the barrier is fitted with the inner wall of the detection tube 3. The puncture part 43 is located within the barrier space 46 formed by the barrier. The inner diameter of the top of the barrier decreases from top to bottom, so that the top of the barrier forms a transition slope 44. A slot 45 is provided on one side of the barrier. A detection space 31 for accommodating the test strip is provided on the detection tube 3. An opening 32 communicating with the slot 45 is provided at the bottom of the detection space 31, so that the first end of the test strip can extend out from the opening 32 and pass through the slot 45 into the barrier space 46.

[0116] In some embodiments, the enclosure includes a first baffle 421 and a second baffle 422 arranged sequentially from the outside to the inside. The height of the second baffle 422 is lower than the height of the first baffle 421. The first end of the first baffle 421 and the first end of the second baffle 422 are connected by a third baffle 423, and the transition slope 44 is formed on the first surface of the third baffle 423. The outer wall of the first baffle 421 is in contact with the inner wall of the detection tube 3. The first baffle 421, the second baffle 422, the third baffle 423 and the bottom cover 41 enclose a cavity 424.

[0117] In some embodiments, the enclosure is recessed downward along its height direction on the side near the opening 32 to form the groove 45, and the portions of the enclosure on both sides of the groove 45 are recessed inward to form slots 425 communicating with the enclosure space 46. The slots 425 are arranged along the height direction of the enclosure. When the first end of the test strip extends out of the opening 32 and the first end of the test strip is inserted into the enclosure space 46 along the slots 425, the two sides of the first end of the test strip are locked into the slots 425 and fixed.

[0118] In some embodiments, the solution tube 2 includes an integrally formed base plate 21 and a tube body 22, the base plate 21 being disposed at the bottom of the tube body 22, and the top of the solution tube 2 being provided with an opening that cooperates with the sampler 1.

[0119] In some embodiments, the solution tube is provided with a mounting portion having a first inner diameter and a solution cavity having a second inner diameter from top to bottom. When the sampler is inserted into the solution cavity, the connecting portion of the sampler is located inside the mounting portion, and the collecting portion is located inside the solution cavity.

[0120] In some embodiments, the base plate 21 is provided with a puncture groove 211 that engages with the tip of the puncture part 43, and the thickness of the puncture groove 211 is less than the thickness of the base plate 21.

[0121] For specific usage of this device, please refer to [link / reference]. Figures 6-10 , Figure 6 This diagram shows the device in its initial state. To use it, first grasp the grip, pull the sampler out of the solution tube, and then insert the collection part of the sampler into the sample to collect it (see [link]). Figure 7 Then, the sampler is reinserted into the solution tube, so that the sample in the collection section comes into contact with the solution in the solution tube (see [link]). Figure 8 Then remove the limiting device located on the solution tube (see...). Figure 9 Press down on the grip, causing it to move the solution tube downwards, thus bringing the bottom plate of the solution tube into contact with and puncturing the tip of the puncture site (see...). Figure 10 The liquid containing the sample in the solution tube flows through the gap formed by the puncture groove in the base plate and into the enclosed space to contact the first end of the test strip, thus achieving the test strip's run. The test result is then displayed in the display area outside the solution tube. During this process, the liquid level inside the enclosure is always below the groove. In other words, under normal upright conditions, the solution will not enter the test tube, thereby preventing solution leakage.

[0122] The integrated fecal sampling and testing device with the above structure provides a self-testing device that prevents tipping by setting a frustum-shaped detection tube with a "semi-enclosed" fit between the detection tube and the base, and setting a "semi-hollowed" grip.

[0123] Specifically, the base engages with the detection tube through the opening at the bottom of the detection tube, using a bottom-up installation method. This ensures that the installed base is located in the lower half of the detection tube. On one hand, this concentrates the center of gravity of the self-testing device at the bottom of the device, and together with the frustum-shaped detection tube, it can prevent tipping to some extent. On the other hand, the test strips located in the detection tube can be directly introduced into the enclosed space during installation, which is convenient and quick, and does not require the installation of an additional test strip holding structure.

[0124] Furthermore, a transition slope is provided at the top of the enclosure. Even if it tilts, the solution is unlikely to leak out of the detection tube because the enclosure is close to the inner wall of the detection tube. After the self-testing device is uprighted, the solution above the enclosure can flow back into the enclosure space through the transition slope, further preventing leakage.

[0125] Furthermore, by setting a spherical grip, users can easily apply force when pressing the grip and pulling the sampler out of the self-testing device. In addition, the grip adopts a hollow structure (anti-slip groove), which can save production costs and reduce the weight of the grip, preventing the sampler from becoming "top-heavy" and tipping over when it is used with the self-testing device.

[0126] Example 4

[0127] Unlike Example 3, see [link to Example 3] Figure 21 In this embodiment, sampler 1 is an independent sampling structure, such as a swab; see [link to previous document]. Figure 22 The self-testing device also includes an independent upper cover 10, which is detachably disposed in the opening at the top of the solution tube. The upper cover 10 is used to cooperate with the solution tube to seal the solution inside the solution tube.

[0128] In some embodiments, the upper cover 10 includes a gripping portion 11 and a connecting portion 12 connected sequentially from top to bottom.

[0129] In some embodiments, see Figure 14 The gripping part is spherical, and the inner diameter of the gripping part gradually increases and then decreases from the first end to the second end. The gripping part is provided with a plurality of anti-slip grooves 111 arranged circumferentially.

[0130] In some specific embodiments, the anti-slip groove is a plurality of grooves formed by the inward indentation of the surface of the spherical grip portion along the width direction.

[0131] In some embodiments, a plurality of the grooves are evenly distributed on the spherical grip portion.

[0132] In some embodiments, a sealing ring 9 is provided on the joint portion 12.

[0133] By designing a spherical grip, users can easily apply force when pressing the grip and pulling the sampler out of the self-testing device. In addition, the grip adopts a hollow structure (anti-slip groove), which saves production costs and reduces the weight of the grip, preventing the sampler from becoming top-heavy and tipping over when it is used with the self-testing device.

[0134] The integrated sampling and detection device with the above structure is used as follows:

[0135] See Figure 24 The figure shows a schematic diagram of the device in its initial state. In use, first, a sample is taken using the independent sampling structure (preferably a swab). Then, hold the grip and remove the top cap from the solution tube. Immediately afterwards, insert the swab into the solution tube for dissolution (see...). Figure 25 Then, the swab is removed from the solution tube, and the top cap is put back on the solution tube. The limiting piece on the solution tube is then removed, and the grip is pressed down, causing the grip to move the solution tube downwards. This causes the bottom plate of the solution tube to contact and be punctured by the tip of the puncture part. The liquid containing the sample in the solution tube flows into the enclosed space and contacts the first end of the test strip, thus completing the test strip test. The test result is then displayed in the display area outside the solution tube.

[0136] Example 5

[0137] Unlike Examples 1 to 4, see [link to example]. Figure 23 The solution tube is internally provided with a scraping structure 20. The scraping structure 20 includes a collection area 202 and a scraping area 203 arranged sequentially from top to bottom. The scraping area 203 is provided with at least two scraping protrusions 204, and a scraping groove 205 is formed between adjacent scraping protrusions 204. In some embodiments, the inner diameters of the exchange area and the collection area 202 gradually decrease from top to bottom, and the inner diameter of the scraping area 203 is the same along the height direction of the solution tube, making the scraping structure 20 funnel-shaped.

[0138] In some embodiments, the scraping structure 20 may be fixedly disposed inside the solution tube. In other embodiments, the scraping structure 20 may also be movably disposed inside the solution tube, similar to a piston structure.

[0139] It should be noted that the scraping structure is tightly connected to the solution tube. Even if the scraping structure is movable inside the solution tube, the sampling structure (sampler or swab) will not move when it passes by the scraping structure.

[0140] For larger samples, such as feces (especially solid feces), the scraping structure 20 can be placed in the upper part of the solution tube, that is, above the liquid surface inside the solution tube. When the sampler (see Embodiment 1 for the specific structure) is inserted into the solution tube, the larger particles of the sampler (such as solid feces) fall off the sampler under the action of the scraping structure 20 and are collected in the collection area 202. This prevents the sample from dissolving too much into the solution in the solution tube and prevents large particles of the sample from entering the enclosure space and directly contacting the test strip, which could lead to inaccurate measurement results.

[0141] In other words, this application effectively prevents large particle samples from entering the "open" enclosure space and directly contacting the test strips embedded within it, thus avoiding inaccurate measurement results, by implementing dual confinement (firstly, confining them to the collection area, and secondly, even if large particles accidentally fall below the scraping structure, they are still confined above the smaller gap in the base plate after tearing). "Open" here refers to the enclosure space being unobstructed above and connected to the internal space of the detection tube.

[0142] In some embodiments, at least one exchange hole 206 is provided on the top of the collection area 202 to form a solution exchange area 201 on the top of the collection area.

[0143] In some embodiments, multiple exchange holes 206 are provided circumferentially along the solution exchange zone 201, and all of the multiple exchange holes 206 are located at the top of the solution exchange zone 201, that is, on the side where the solution exchange zone 201 is connected to the solution tube.

[0144] For samples with small quantity and / or volume, such as viruses, the scraping structure 20 can be placed in the lower half of the solution tube, immersing it in the solution inside the tube. When a swab is inserted into the solution tube, the sample is fully dissolved in the solution by scraping the scraping protrusion 204. During the scraping process, the solution on the upper and lower sides of the scraping structure 20 can also be exchanged through the exchange hole 206 under the stirring action of the swab, as well as through the gap between the sampler and the scraping structure 20, to flush the sample on the scraping structure, making the sample distribution in the solution more uniform. Even if the sample or swab completely blocks the scraping area 203, the exchange hole 206 can still meet the solution exchange requirements, thereby preventing the generation of negative pressure that would make it difficult to remove the sampler.

[0145] In some embodiments, see Figure 27 The scraping structure also includes a support portion 207, the inner diameter of which increases sequentially from top to bottom. The top of the support portion 207 is connected to the bottom of the scraping area, and the bottom of the support portion 207 abuts against the inner wall of the tube. That is, both ends of the scraping structure are flared.

[0146] In some embodiments, the support portion 207 is provided with at least one through hole 208, which communicates with the exchange hole 206.

[0147] In some embodiments, the outer diameter of the scraping structure is the same from top to bottom, and the outer wall of the scraping structure is tightly connected to the inner wall of the tube. At least one exchange channel is provided inside the scraping structure, and the exchange hole and the through hole are connected through the exchange channel.

[0148] The scraping structure described above can guide the swab and scrape off the sample from it. Firstly, the solution below and above the scraping structure can exchange through sequentially connected exchange holes, channels, and through-holes, resulting in a more uniform sample distribution within the solution. Furthermore, even if the swab shifts within the solution tube, it can move freely up and down under the guidance of the funnel-shaped support and collection area, preventing the swab from getting stuck or unable to be removed. Additionally, the outer wall of the scraping structure is tightly connected to the inner wall of the tube. This enhances the connection strength between the movable scraping structure and the tube body. Furthermore, the larger volume of the scraping structure allows for greater filling of the solution tube, reducing the amount of solution required, saving production costs, and resulting in a higher sample concentration in the solution.

[0149] In summary, this application provides a solution that enables samples to dissolve quantitatively in the solution for samples of different volumes / quantities. Specifically, by adjusting the height of the scraping structure, excessive sample is excluded from the solution, and smaller sample volumes are dissolved in the solution as much as possible, ensuring a high sample concentration. That is, whether it is a large sample (e.g., feces) or a small sample (e.g., virus), this device can stably collect and detect it, thereby ensuring the reliability of the detection results.

[0150] It should be noted that, in this document, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes that element.

[0151] The embodiments of the present invention have been described above with reference to the accompanying drawings. However, the present invention is not limited to the specific embodiments described above. The specific embodiments described above are merely illustrative and not restrictive. Those skilled in the art can make many other forms under the guidance of the present invention without departing from the spirit and scope of the claims. All of these forms are within the protection scope of the present invention.

Claims

1. A solution tube structure for an integrated sampling and detection device, characterized in that, include: Pipe body (22), base plate (21) and scraping structure (20); The bottom plate (21) is disposed at the bottom of the tube body (22) and cooperates with the tube body (22) to form a dissolution space with a top opening, and the dissolution space is filled with solution (26). The scraping structure (20) is disposed in the lower half of the tube body (22), such that the scraping structure (20) is immersed in the solution (26). The scraping structure (20) includes a collection area (202) and a scraping area (203) arranged sequentially from top to bottom. The inner diameter of the collection area (202) gradually decreases from top to bottom. The inner diameter of the scraping area is the same along the height direction of the solution tube (2), so that the scraping structure (20) is funnel-shaped. The scraping area (203) is provided with at least two scraping protrusions (204), and a scraping groove (205) is formed between two adjacent scraping protrusions (204). When the sampled swab is inserted into the solution tube (2), the swab enters the scraping area (203) under the guidance of the collection area (202), and the sample on the swab can be fully dissolved in the solution (26) around the scraping protrusion (204) under the action of the scraping protrusion (204).

2. The solution tube structure according to claim 1, characterized by At least one exchange hole (206) is provided at the top of the collection area (202) to form a solution exchange area (201) at the top of the collection area (202). When the swab is inserted into the scraping area (203), the solution (26) can be exchanged through the exchange hole (206) under the stirring action of the swab.

3. The solution tube structure according to claim 1, wherein The tube body (22) and the base plate (21) are integrally formed.

4. The solution tube structure according to claim 1, wherein The scraping structure (20) is fixedly installed inside the tube body (22).

5. The solution tube structure according to claim 2, wherein The scraping structure (20) also includes a support (207), the inner diameter of which increases from top to bottom, the top of which is connected to the bottom of the scraping area (203), and the bottom of which abuts against the inner wall of the tube (22).

6. The solution tube structure according to claim 5, characterized in that, The support (207) is provided with at least one through hole (208), which is connected to the exchange hole (206).

7. The solution tube structure according to claim 6, characterized in that, The outer diameter of the scraping structure (20) is the same from top to bottom, and the outer wall of the scraping structure (20) is tightly connected to the inner wall of the tube body (22). At least one exchange channel is provided in the scraping structure (20), and the exchange hole (206) and the through hole (208) are connected through the exchange channel.

8. The solution tube structure according to claim 1, characterized in that, The solution tube (2) is provided with a bottom plate (21) and a puncture groove (211) is provided on it. The thickness of the puncture groove (211) is less than the thickness of the bottom plate (21). When a force is applied to the puncture groove (211), the puncture groove (211) is torn to form a crack in the base plate (21), allowing the solution to flow out from the solution tube (2).

9. The solution tube structure according to claim 8, characterized in that, The integrated sampling and detection device also includes a detection tube (3) and a base (4). Both ends of the detection tube (3) are provided with openings, and the diameter of the detection tube (3) gradually increases from the top to the bottom. At least a part of the solution tube (2) is fitted inside the detection tube (3), and the base (4) is engaged with the opening at the bottom of the detection tube (3).

10. The solution tube structure according to claim 9, characterized in that, The base (4) is provided with a puncture part (43), which corresponds to the puncture groove (211); When the solution tube (2) is pressed down, the puncture part (43) contacts the puncture groove (211) and punctures the puncture groove (211).

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