A device for a rat spinal cord injury model

Abstract

The utility model relates to the field of medical animal model, especially a rat spinal cord injury model device, including fixed base, fixed base top sliding connection has the moving support. Through the switch of different buckle seat to adjust the number of spring, to obtain different elastic potential energy in the same buckle seat rise same height, and then elastic potential energy and gravity potential energy more convenient and accurate to promote air flow to produce impact force, immediately with air kinetic energy as moulding to the spinal cord impact, and can be in the completion spinal cord injury air is dispersed in the surrounding, avoid the continuous compression effect can cause secondary secondary ischemic injury, because air density is small, the deformation amount is bigger, under the same energy strike, to the spinal cord tissue under the instantaneous impact can produce the influence of over-retraction less, laser orientation range and air kinetic energy strike, avoid the space interference of residual lamina and surrounding soft tissue, and impact angle offset and energy transmission uneven when carrying out the strike.

Description

Technical Field

[0001] This utility model relates to the field of medical animal models, and in particular to a device for a rat spinal cord injury model. Background Technology

[0002] Spinal cord injury (SCI) is a serious neurological disease with high rates of disability and mortality. Its clinical features are mainly manifested as motor dysfunction below the level of injury, sensory loss, and autonomic dysfunction. Because SCI involves complex pathophysiological mechanisms, establishing standardized animal models has become an important foundation for studying its pathogenesis, assessing pathological changes, quantifying the degree of injury, and developing treatment methods.

[0003] Currently used animal models of spinal cord injury (such as the heavy object drop impact model) still have the following technical limitations in practical applications: First, during the mechanical impact, when the potential energy of the falling object is converted into impact energy and acts on the spinal cord tissue, its damage effect is closely related to biomechanical parameters such as spinal cord diameter, tissue elastic modulus, force-bearing area, and deformation displacement. Existing research shows that when the density and weight of the impacting object exceed the critical value, the spinal cord tissue can produce excessive recoil under instantaneous impact (the safe threshold for compression displacement is 22 mm), which can easily lead to irreversible damage such as complete spinal cord transection. However, most current models use high-density impact devices such as metal, which cannot avoid such excessive damage risks when achieving controllable contusion.

[0004] Secondly, existing modeling techniques involve complex invasive procedures, including surgical steps such as hair removal in the surgical area, layer-by-layer incision of skin and muscle tissue, and laminectomy. To ensure the postoperative survival rate of experimental animals, the surgical field exposure range is often limited. However, smaller animals (such as rats) are prone to spatial interference from the residual lamina and surrounding soft tissues when impacted due to the narrow vertebral canal anatomy, resulting in impact angle deviation and uneven energy transfer, which ultimately affects the reproducibility of the model.

[0005] Finally, the dynamic control of traditional heavy object drop models has defects; if the heavy object is not removed in time after the initial impact, its continuous compression can cause secondary ischemic injury. This mixed mechanical compression effect will cause the pathological changes to deviate from the target set by the simple contusion model. Therefore, developing an impact device with precise energy regulation and instant withdrawal mechanism is a key technical direction for optimizing animal models of spinal cord injury. Utility Model Content

[0006] The purpose of this invention is to provide a rat spinal cord injury model device in order to solve the above-mentioned problems.

[0007] This utility model achieves the above objectives through the following technical solutions:

[0008] A rat spinal cord injury model device includes a fixed base, a movable support slidably connected to the top of the fixed base, a fixed plate fixed to the upper end of the movable support, a firing mechanism, and an impact mechanism.

[0009] The impact mechanism includes an adjustment frame that is slidably connected to the front side of the fixed plate. An impact cylinder is fixed in the middle of the adjustment frame. An impact tube is detachably connected to the lower end of the impact cylinder. A piston is provided inside the impact cylinder. A piston rod is fixed to the top of the piston. A T-shaped through groove is opened at the end of the piston rod that extends out of the impact cylinder. A horizontal plate is fixed to the outer side of the upper end of the impact tube. Multiple laser auxiliary heads for displaying the air impact range are fixed on the horizontal plate. The multiple laser auxiliary heads are arranged in a ring around the impact tube.

[0010] The firing mechanism includes a sliding seat, with a limit rod fixed to the lower end of the sliding seat. A top plate and a bottom plate are sleeved on the lower side of the limit rod. The top plate is located above the bottom plate. Six guide frames are fixed between the top plate and the bottom plate in a ring. Each guide frame is slidably connected to a locking seat. Each locking seat has a T-shaped seat fixed at its bottom for engaging with a T-shaped through slot. Each locking seat has a spring fixed on it, and the number of springs on the six locking seats increases by one in each subsequent sequence.

[0011] Preferably, the limiting rod has multiple annular grooves, the top plate has a limiting ring, and the limiting ring has a first screw for inserting into the annular groove.

[0012] Preferably, the top of the movable bracket has a groove, and the sliding seat is slidably connected in the groove of the sliding seat.

[0013] Preferably, a square hole is provided in the middle of the fixed plate to allow the top plate and bottom plate to move, and a locking strip with multiple lock holes is provided on both sides of the square hole.

[0014] Preferred configuration: The two locking bars are provided with guide grooves on opposite sides, and the adjustment bracket is threaded with a second screw on both sides.

[0015] Preferably, the fixed base has limit grooves on both sides of the top, the lower end of the movable bracket is fixed with a slider for sliding in the limit groove, and a third screw is provided on the rear side of the slider for fixing it.

[0016] Preferably, the top of the fixed base is provided with multiple clamping frames for clamping and fixing the rat, and the multiple clamping frames are located on the underside of the movable support.

[0017] Preferably, two parallel adjustment grooves are provided between the two limiting grooves, and the lower end of the clamping frame is slidably connected in the adjustment groove.

[0018] The advantages compared to existing technologies are as follows:

[0019] 1. By switching different buckle seats to adjust the number of springs, different elastic potential energies can be obtained by raising the same height on the same buckle seat. The elastic potential energy and gravitational potential energy can then more easily and accurately drive the airflow to generate impact force. Subsequently, the air kinetic energy is used as a model to impact the spinal cord. After the spinal cord injury is completed, the air is dispersed around to avoid the continuous compression that may cause secondary ischemic injury.

[0020] 2. Due to the low density and large deformation of air, under the same energy impact, the excessive retraction of spinal cord tissue under instantaneous impact is less likely.

[0021] 3. Laser directional range and aerodynamic impact: When carrying out the impact, avoid spatial interference from residual lamina and surrounding soft tissue, as well as impact angle deviation and uneven energy transfer. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This is a schematic diagram of the structure of the rat spinal cord injury model device described in this utility model;

[0024] Figure 2 This is a cross-sectional view of the rat spinal cord injury model device described in this utility model;

[0025] Figure 3 This is a partial drawing of the clamping frame of the rat spinal cord injury model device described in this utility model;

[0026] Figure 4 This is a partial part drawing of the laser-assisted head of the rat spinal cord injury model device described in this utility model;

[0027] Figure 5 This is a partial part drawing of the firing mechanism of the rat spinal cord injury model device described in this utility model;

[0028] Figure 6 This is a partial drawing of the adjustment frame of the rat spinal cord injury model device described in this utility model;

[0029] Figure 7 This is a partial drawing of the piston rod and piston parts of the rat spinal cord injury model device described in this utility model.

[0030] The annotations in the attached figures are explained as follows:

[0031] 1. Firing mechanism; 2. Impact mechanism; 3. Laser-assisted head; 4. Moving bracket; 5. Fixed base; 6. Clamping frame; 7. Fixing plate; 11. Sliding seat; 12. Limiting rod; 13. Top plate; 14. Snap-fit ​​seat; 15. Guide frame; 16. Base plate; 21. Impact cylinder; 22. Piston rod; 23. Impact tube; 24. Adjusting frame; 25. Piston. Detailed Implementation

[0032] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0033] The present invention will be further described below with reference to the accompanying drawings:

[0034] like Figures 1-7 As shown, a rat spinal cord injury model device includes a fixed base 5, a movable support 4 slidably connected to the top of the fixed base 5, a fixed plate 7 fixed to the upper end of the movable support 4, limit grooves on both sides of the top of the fixed base 5, a slider for sliding in the limit groove fixed to the lower end of the movable support 4, and a third screw for fixing the slider to the rear side, a plurality of clamping frames 6 for clamping and fixing the rat on the top of the fixed base 5, the plurality of clamping frames 6 being located under the movable support 4, two parallel adjustment grooves between the two limit grooves, and the lower end of the clamping frame 6 being slidably connected in the adjustment groove, a firing mechanism 1, and an impact mechanism 2.

[0035] In this embodiment: the impact mechanism 2 includes an adjustment frame 24, which is slidably connected to the front side of the fixed plate 7. An impact cylinder 21 is fixed in the middle of the adjustment frame 24. An impact tube 23 is inserted into the lower end of the impact cylinder 21. A piston 25 is provided inside the impact cylinder 21. A piston rod 22 is fixed on the top of the piston 25. A T-shaped through groove is opened at the end of the piston rod 22 that extends out of the impact cylinder 21. A horizontal plate is fixed on the outer side of the upper end of the impact tube 23. Multiple laser auxiliary heads 3 for displaying the air impact range are fixed on the horizontal plate. The multiple laser auxiliary heads 3 are arranged in a ring around the impact tube 23. The piston rod 22 pushes the piston 25 to move downward quickly, thereby spraying the air inside the impact cylinder 21 through the impact tube 23 into a certain segment of the rat's spinal cord. The sprayed air impacts the rat's spinal cord to create an injury model.

[0036] In this embodiment: the firing mechanism 1 includes a sliding seat 11, with a limiting rod 12 fixed at the lower end of the sliding seat 11. A top plate 13 and a bottom plate 16 are sleeved on the lower side of the limiting rod 12. The top plate 13 is located above the bottom plate 16. Six guide frames 15 arranged in a ring are fixed between the top plate 13 and the bottom plate 16. A fastening seat 14 is slidably connected to each guide frame 15. A T-shaped seat for engaging with a T-shaped through slot is fixed at the bottom of each fastening seat 14. A spring is fixed on each fastening seat 14. The number of springs on the six fastening seats 14 increases by one in succession. Multiple annular grooves are opened on the limiting rod 12. The top plate... The top of plate 13 is provided with a limiting ring, and the limiting ring is provided with a first screw for inserting into the annular groove. The top of the movable bracket 4 is provided with a sliding groove, and the sliding seat 11 is slidably connected in the sliding groove of the sliding seat 11. The position of the top plate 13 and the bottom plate 16 on the limiting rod 12 is adjusted by removing the first screw. Rotating the top plate 13 causes the bottom plate 16 to rotate around the axis of the limiting rod 12 through the six guide frames 15. By rotating the guide frames 15 around the limiting rod 12, the locking seats 14 of different numbers of springs are selected to cooperate with the piston rod 22, thereby achieving different impact forces to damage the rat spinal cord.

[0037] In this embodiment: a square hole is provided in the middle of the fixing plate 7 for the top plate 13 and the bottom plate 16 to move. Locking strips with multiple locking holes are provided on both sides of the square hole. Guide grooves are provided on the side of the two locking strips that are far apart from each other. The two sides of the adjusting frame 24 are threaded with second screws. By removing the second screws, the position of the adjusting frame 24 is adjusted by following the movement of the fastening seat 14, and then the height of the lower end of the impact tube 23 to the rat spinal cord is adjusted.

[0038] Working principle: When using the device, first place it on the test bench, then place the rat that needs to establish the injury model in the middle of the fixed base 5, and then clamp and fix the rat with the clamp 6 on the fixed base 5; at the same time, remove the third screw and move the moving bracket 4 back and forth, and move the sliding seat 11 to both sides of the moving bracket 4 so that the lower end of the impact tube 23 is above a certain segment of the spinal cord of the rat that needs to be impacted and injured; then tighten the third screw again to fix the slider at the lower end of the moving bracket 4.

[0039] Then remove the first and second screws, and adjust the positions of the top plate 13 and the bottom plate 16 up and down along the limiting rod 12. At the same time, the adjusting bracket 24 follows the bottom plate 16 to adjust the position of the impact cylinder 21 up and down along the guide groove, so that the T-shaped through groove at the upper end of the piston rod 22 can always cooperate with the T-shaped seat of the fastening seat 14. When the lower end of the impact tube 23 is close to the spinal cord of the rat that needs to be impacted, tighten the second screw and the first screw, so that the top plate 13 is fixed in the corresponding annular groove of the limiting rod 12, and the adjusting bracket 24 is also fixed in the corresponding lock hole of the locking bar.

[0040] Subsequently, lasers emitted by multiple laser-assisted heads 3 are projected onto the impact position of the rat to form a ring of light, thereby marking the impact range. Then, the top plate 13 or bottom plate 16 is rotated around the axis of the limiting rod 12. Through the rotation of the multiple guide frames 15 between the top plate 13 and the bottom plate 16 and their corresponding fastening seats 14 around the limiting rod 12, the fastening seats 14 with different numbers of springs can be selected to cooperate with the piston rod 22, thereby causing the piston rod 22 to exert different impact forces downward.

[0041] Then, the fastening seat 14 is lifted upwards and moved upwards along the guide frame 15. During the upward movement of the fastening seat 14, the piston rod 22 and piston 25 move synchronously. When the top of the fastening seat 14 coincides with the top of the top plate 13, the fastening seat 14 is released. At this time, the spring pulls the fastening seat 14 downwards along the guide frame 15. At the same time, the fastening seat 14 drives the piston rod 22 and piston 25 to move downwards synchronously. During this process, the elastic potential energy of the spring and the gravitational potential energy of the fastening seat 14, piston rod 22 and piston 25 send the air inside the impact cylinder 21 into the impact tube 23. Then, the high-speed airflow is blown out from the lower end of the impact tube 23 and impacts the spinal cord, thus completing the entire rat drumming injury model.

[0042] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model.

Claims

1. A rat spinal cord injury model device, comprising a fixed base (5), wherein a movable support (4) is slidably connected to the top of the fixed base (5), and a fixed plate (7) is fixed to the upper end of the movable support (4), characterized in that: Firing mechanism (1) and impact mechanism (2); The impact mechanism (2) includes an adjustment frame (24), which is slidably connected to the front side of the fixed plate (7). An impact cylinder (21) is fixed in the middle of the adjustment frame (24). An impact tube (23) is detachably connected to the lower end of the impact cylinder (21). A piston (25) is provided inside the impact cylinder (21). A piston rod (22) is fixed to the top of the piston (25). A T-shaped through groove is opened at one end of the piston rod (22) that extends out of the impact cylinder (21). A horizontal plate is fixed to the outer side of the upper end of the impact tube (23). Multiple laser auxiliary heads (3) for displaying the air impact range are fixed on the horizontal plate. The multiple laser auxiliary heads (3) are arranged in a ring around the impact tube (23). The firing mechanism (1) includes a sliding seat (11), with a limit rod (12) fixed at the lower end of the sliding seat (11). A top plate (13) and a bottom plate (16) are sleeved on the lower side of the limit rod (12). The top plate (13) is located above the bottom plate (16). Six guide frames (15) arranged in a ring are fixed between the top plate (13) and the bottom plate (16). Each guide frame (15) is slidably connected to a fastening seat (14). Each fastening seat (14) has a T-shaped seat fixed at its bottom for engaging with a T-shaped through slot. Each fastening seat (14) is fixed with a spring. The number of springs on the six fastening seats (14) increases by one each time.

2. The rat spinal cord injury model device according to claim 1, characterized in that: The limiting rod (12) has multiple annular grooves, and the top plate (13) has a limiting ring at the top, and the limiting ring has a first screw for inserting into the annular groove.

3. The rat spinal cord injury model device according to claim 1, characterized in that: The top of the movable bracket (4) is provided with a sliding groove, and the sliding seat (11) is slidably connected in the sliding groove of the sliding seat (11).

4. The rat spinal cord injury model device according to claim 1, characterized in that: The fixing plate (7) has a square hole in the middle for moving the top plate (13) and the bottom plate (16), and a locking strip with multiple lock holes is provided on both sides of the square hole.

5. The rat spinal cord injury model device according to claim 4, characterized in that: The two locking bars are provided with guide grooves on opposite sides, and the adjustment bracket (24) is threaded with second screws on both sides.

6. The rat spinal cord injury model device according to claim 1, characterized in that: Limiting grooves are provided on both sides of the top of the fixed base (5), and a slider for sliding in the limiting groove is fixed at the lower end of the movable bracket (4), and a third screw for fixing it is provided on the rear side of the slider.

7. The rat spinal cord injury model device according to claim 6, characterized in that: The top of the fixed base (5) is provided with a plurality of clamping frames (6) for clamping and fixing rats, and the plurality of clamping frames (6) are located on the underside of the movable support (4).

8. The rat spinal cord injury model device according to claim 7, characterized in that: Two parallel adjustment grooves are provided between the two limiting grooves, and the lower end of the clamping frame (6) is slidably connected in the adjustment groove.

Images