Bioanalysis experiment oscillation type water bath device

Abstract

This utility model discloses a shaking water bath device for bioanalytical experiments, including a housing with an internal partition. Guide rods are respectively positioned between the left side of the partition and the left inner wall of the housing. A sliding frame is slidably connected between the two guide rods. The device also includes a fixing mechanism. The fixing mechanism includes a fixing frame, adjusting rods, fixing holes, vertical grooves, movable blocks, and fixing columns. The sliding frame contains a fixing frame, with adjusting rods slidably connected inside the fixing frame. Fixing holes are formed on the upper and lower inner walls of the fixing frame. Vertical grooves are formed at the front and rear ends of the left and right inner walls of the adjusting rods. Movable blocks are slidably connected between two adjacent vertical grooves located on the same side within the same adjusting rod. This utility model effectively meets the fixing requirements of containers of different sizes in bioanalytical experiments, ensuring the reliability of the shaking water bath process.

Description

Technical Field

[0001] This utility model relates to the field of pharmacokinetic research technology, specifically to a oscillating water bath device for bioanalytical experiments. Background Technology

[0002] Bioanalytical experiments are a core means of elucidating the laws governing life activities and exploring the mechanisms of biomolecular action. They provide quantitative and qualitative evidence for disease diagnosis, drug development, and environmental monitoring. For example, detecting the concentration of specific proteins in blood can indicate disease progression, or analyzing the microbial content in environmental samples can assess ecological risks. Their role is to transform complex biological systems into measurable data, propelling life sciences from phenomenological observation to mechanistic explanation. The oscillating water bath is a key piece of equipment in this experiment. It maintains the activity of biological samples through precise temperature control, while oscillation ensures thorough contact between the sample and reagents, significantly improving reaction efficiency and uniformity, avoiding errors caused by manual shaking. It is particularly suitable for batch sample processing and is an important tool for ensuring the accuracy and repeatability of experimental results.

[0003] The existing bioanalytical oscillating water bath device first installs the fixing plate corresponding to the carrier container onto the internal oscillating frame with bolts. Then, the containers are placed into the corresponding fixing holes in sequence. After all are fixed, liquid is added into the chamber. Then, the motor is controlled to rotate, which pulls the oscillating frame back and forth on the slide rod through the connecting rod.

[0004] Existing oscillating water bath devices for this type of bioanalysis experiment have poor adaptability. When frequently switching container specifications in multiple experiments, they will significantly consume experimental time, reduce work efficiency, affect the stability of the reaction environment of biological samples, and thus interfere with the accuracy of experimental results. Utility Model Content

[0005] The technical problem to be solved by this utility model is to overcome the existing defects and provide a shaking water bath device for biological analysis experiments, which can effectively meet the fixing requirements of containers of different specifications in biological analysis experiments, ensure the reliability of the shaking water bath process, and effectively solve the problems in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a biological analysis experimental oscillating water bath device, comprising a box body, wherein a partition is provided inside the box body, and guide rods are respectively provided between the left side of the partition and the left inner wall of the box body, and a sliding frame is slidably connected between the two guide rods, and a microcontroller is provided on the front side of the box body, wherein the input terminal of the microcontroller is electrically connected to an external power supply.

[0007] It also includes a fixing mechanism; the fixing mechanism includes a fixing frame, an adjusting rod, fixing holes, vertical slots, movable blocks, and fixing columns. The sliding frame is provided inside, and the adjusting rod is slidably connected inside the fixing frame. Fixing holes are opened on the upper and lower inner walls of the fixing frame. Vertical slots are opened at the front and rear ends of the left and right inner walls of the adjusting rod. Movable blocks are slidably connected between two adjacent vertical slots located inside the same adjusting rod. Fixing columns are provided on the side of the movable block away from the center of the fixing frame. The fixing columns are installed by fixing holes that are vertically adjacent on the same side. Evenly distributed arc-shaped slots are opened on the left and right inner walls of the fixing frame and the left and right sides of the adjusting rod.

[0008] Furthermore, the fixing mechanism also includes longitudinal grooves, extrusion blocks, studs, U-shaped frames, and bellows. Longitudinal grooves are respectively formed at the front and rear ends of the left and right inner walls of the adjusting rod. Extrusion blocks are slidably connected between two adjacent longitudinal grooves located inside the same adjusting rod. U-shaped frames are respectively provided on the side of the extrusion blocks away from the center of the adjusting rod. Studs are rotatably connected to the front and rear ends of the adjusting rod. Each stud is threadedly connected to an adjacent U-shaped frame located on the same side of the same adjusting rod. A limiting piece is fixedly connected to the end of the stud closest to the center of the adjusting rod. Bellows are provided between the limiting piece and the adjacent U-shaped frame located on the same side of the same adjusting rod, and between the U-shaped frame and the adjacent front and rear inner walls of the adjusting rod. The studs are all located inside the adjacent bellows on the same side. The extrusion blocks are fitted with two adjacent movable blocks located on the same side of the same adjusting rod to achieve insertion of the fixing post into the fixing hole.

[0009] Furthermore, the fixing mechanism also includes springs, which are movably sleeved on the outside of the fixing column. The front and rear ends of the upper and lower surfaces of the adjusting rod are respectively bolted with sealing plates. The middle of the sealing plates is provided with round holes corresponding to the fixing column. The springs are located between the side of the movable block away from the center of the adjusting rod and the inner wall of the sealing plate, so as to realize the rebound of the fixing column.

[0010] Furthermore, a support plate is provided between the right side of the partition and the right inner wall of the box. A turntable is rotatably connected to the upper surface of the support plate via a rotating column. A cylinder is provided at the edge of the upper surface of the turntable and the right end of the upper surface of the sliding frame. A connecting rod is rotatably connected between the two cylinders. A clearance groove corresponding to the connecting rod is opened in the middle of the partition to achieve stable oscillation.

[0011] Furthermore, a motor is provided on the lower surface of the support plate. The top end of the motor's output shaft is fixedly connected to the bottom end of the rotating column, and the input end of the motor is electrically connected to the output end of the microcontroller to provide oscillation drive.

[0012] Furthermore, a support base is provided on the rear side of the box, and a cover plate is rotatably connected inside the support base. A handle is provided on the front side of the upper surface of the cover plate to facilitate the protection of the internal solution.

[0013] Compared with the prior art, the beneficial effects of this utility model are:

[0014] By turning the stud, the stud pushes the extrusion block to move along the longitudinal groove toward the center of the adjusting rod. During the movement of the extrusion block, it squeezes two adjacent movable blocks on the same side, causing the movable blocks to slide along the vertical groove away from the center of the adjusting rod. The movable blocks drive the fixed post to insert into the fixing holes on the upper and lower inner walls of the fixed frame, thereby fixing the adjusting rod and the fixed frame relative to each other, achieving clamping and fixing of the container. It can adapt to containers of different sizes, improves compatibility with various experimental instruments, is easy to operate, and is flexible in adjustment without complicated operations, making it easy to quickly change or put away containers. Attached Figure Description

[0015] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0016] Figure 2 This is a schematic diagram of the opening and closing structure of the cover plate of this utility model;

[0017] Figure 3 This is a cross-sectional structural diagram of the present invention;

[0018] Figure 4 This is an enlarged structural schematic diagram of point A of this utility model;

[0019] Figure 5 This is a schematic diagram of the structure of the sliding frame of this utility model;

[0020] Figure 6 This is a schematic diagram of the structure of the fixing mechanism of this utility model in an exploded cross section;

[0021] Figure 7 This is an enlarged structural schematic diagram of section B of this utility model.

[0022] In the diagram: 1. Box body, 2. Partition, 3. Guide rod, 4. Sliding frame, 5. Microcontroller, 6. Fixing mechanism, 601. Fixing frame, 602. Adjusting rod, 603. Fixing hole, 604. Vertical groove, 605. Movable block, 606. Fixing column, 607. Longitudinal groove, 608. Extrusion block, 609. Stud, 610. Spring, 611. U-shaped frame, 612. Corrugated pipe, 7. Support plate, 8. Turntable, 9. Column, 10. Connecting rod, 11. Motor, 12. Cover plate. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] Please see Figure 1-7 This embodiment provides a technical solution: a bioanalytical oscillating water bath device, including a housing 1, with a partition 2 inside the housing 1. Guide rods 3 are respectively provided between the left side of the partition 2 and the left inner wall of the housing 1, and a sliding frame 4 is slidably connected between the two guide rods 3. A microcontroller 5 is provided on the front side of the housing 1, and the input terminal of the microcontroller 5 is electrically connected to an external power source. A support plate 7 is provided between the right side of the partition 2 and the right inner wall of the housing 1. A turntable 8 is rotatably connected to the upper surface of the support plate 7 via a rotating column. A cylinder 9 is provided at the edge of the upper surface of the turntable 8 and the right end of the upper surface of the sliding frame 4, and a rotatable connection is provided between the two cylinders 9. The connecting rod 10 and the partition plate 2 have a relief groove in the middle corresponding to the connecting rod 10 (a rubber sealing gasket is provided inside the relief groove, and the middle part of the rubber sealing gasket is fixedly connected to the outside of the connecting rod 10. The rubber sealing gasket itself is plastic and can expand and contract with the connecting rod 10 when it slides in the relief groove, preventing the solution from entering the transmission component on the right side of the box 1); a motor 11 is provided on the lower surface of the support plate 7, the top end of the output shaft of the motor 11 is fixedly connected to the bottom end of the rotating column, and the input end of the motor 11 is electrically connected to the output end of the microcontroller 5; a support base is provided on the rear side of the box, and a cover plate 12 is rotatably connected inside the support base. A handle is provided on the front side of the upper surface of the cover plate 12.

[0025] It also includes a fixing mechanism 6; the fixing mechanism 6 includes a fixing frame 601, an adjusting rod 602, fixing holes 603, vertical grooves 604, movable blocks 605, and fixing posts 606. The sliding frame 4 has a fixing frame 601 inside, and the adjusting rod 602 is slidably connected inside the fixing frame 601. Fixing holes 603 are opened on the upper and lower inner walls of the fixing frame 601, and vertical grooves 604 are opened at the front and rear ends of the left and right inner walls of the adjusting rod 602. Movable blocks 605 are slidably connected between two vertical grooves 604 located inside the same adjusting rod 602 and adjacent on the same side. Fixing posts 606 are provided on the side of the movable block 605 away from the center of the fixing frame 601. The fixing posts 606 are all vertically adjacent on the same side with fixing holes 606. 03. For installation, the left and right inner walls of the fixing frame 601 and the left and right sides of the adjusting rod 602 are respectively provided with evenly distributed arc-shaped grooves; the fixing mechanism 6 also includes longitudinal grooves 607, extrusion blocks 608, studs 609, U-shaped frames 611 and bellows 612. The front and rear ends of the left and right inner walls of the adjusting rod 602 are respectively provided with longitudinal grooves 607. Extrusion blocks 608 are slidably connected between two longitudinal grooves 607 located inside the same adjusting rod 602 and adjacent on the same side. U-shaped frames 611 are respectively provided on the side of the extrusion blocks 608 away from the center of the adjusting rod 602. Studs 609 are rotatably connected to the front and rear ends of the adjusting rod 602. The studs 609 are all connected to the U-shaped frames 611 located on the same side of the same adjusting rod 602. The threaded connection includes a limiting plate fixedly connected to one end of the stud 609 near the center of the adjusting rod 602. A bellows 612 is provided between the limiting plate and the adjacent U-shaped frame 611 on the same side of the adjusting rod 602, and between the U-shaped frame 611 and the adjacent inner walls of the front and rear of the adjusting rod 602. (The bellows 612 expands and contracts with the movement of the U-shaped frame 611 according to its own plasticity, always keeping the stud 609 inside the bellows 612 to prevent dust and other impurities from affecting its precision transmission.) The studs 609 are all located inside the adjacent bellows 612 on the same side. The pressing blocks 608 are all installed in conjunction with two adjacent movable blocks 605 located on the same side of the adjusting rod 602 (because the pressing block 608 is close to the center of the fixed frame 601). All sides are tapered inclined surfaces, and the side of the movable block 605 closest to the center of the fixed frame 601 is also inclined. The fixing mechanism 6 also includes springs 610, which are movably sleeved on the outside of the fixed column 606. The front and rear ends of the upper and lower surfaces of the adjusting rod 602 are respectively bolted with sealing plates. The middle of the sealing plates is provided with round holes corresponding to the fixed column 606. The springs 610 are located between the side of the movable block 605 away from the center of the adjusting rod 602 and the inner wall of the sealing plate. (When the spring 610 ages and its rebound performance is poor after long-term use and needs to be replaced, loosen the bolts to open the sealing plates on the upper and lower sides of the adjusting rod 602, and pull the movable block 605 out of the interior of the vertical groove 604 to replace the spring 610.)

[0026] The working principle of this utility model is as follows:

[0027] When a vibrating water bath is needed in a bioanalytical laboratory, test tubes or beakers are first placed between the fixed frame 601 and the arc-shaped groove of the adjusting rod 602. The arc-shaped groove can initially limit the position of the test tubes. The position of the adjusting rod 602 within the fixed frame 601 can be adjusted to accommodate containers of different sizes.

[0028] Once the position of the adjusting rod 602 is determined, the stud 609 is turned. The stud 609 pushes the extrusion block 608 along the longitudinal groove 607 towards the center of the adjusting rod 602 through the U-shaped frame 611. During the movement of the extrusion block 608, it extrudes two adjacent movable blocks 605 on the same side, causing the movable blocks 605 to slide away from the center of the adjusting rod 602 along the vertical groove 604. The movable blocks 605 drive the fixing post 606 to insert into the fixing holes 603 on the upper and lower inner walls of the fixing frame 601, thereby fixing the adjusting rod 602 and the fixing frame 601 relative to each other, thus completing the clamping of the container.

[0029] When the stud 609 is loosened, the elastic force of the spring 610 pushes the movable block 605 to reset, the fixed post 606 exits from the fixed hole 603, and the adjusting rod 602 can slide again to adjust its position, making it easier to pick up and put down the container.

[0030] After the container is fixed, a certain amount of water is added into the inside of the box 1, and then the cover plate 12 is closed. Under the control of the microcontroller 5, the motor 11 starts to run, driving the turntable 8 on the support plate 7 to rotate through the rotating column. The cylinder 9 on the upper surface edge of the turntable 8 moves in a circular motion with the turntable 8. Since the two cylinders 9 are located on the turntable 8 and the sliding frame 4 respectively and are connected by the connecting rod 10, the circular motion of the cylinder 9 on the turntable 8 is converted into the sliding frame 4 sliding back and forth along the guide rod 3 through the connecting rod 10, thereby realizing that the sliding frame 4 drives the container containing the biological analysis to oscillate.

[0031] It is worth noting that the microcontroller 5 disclosed in the above embodiments can be a PIC18F4520, the motor 11 can be a YS8024, and the microcontroller 5 controls the operation of the motor 11 using methods commonly used in the prior art.

[0032] The above description is merely an embodiment of this utility model and does not limit the patent scope of this utility model. Any equivalent structural or procedural transformations made based on the content of this utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A biological analysis experimental oscillating water bath device, comprising a box (1), wherein a partition (2) is provided inside the box (1), and guide rods (3) are respectively provided between the left side of the partition (2) and the left inner wall of the box (1), and a sliding frame (4) is slidably connected between the two guide rods (3), and a microcontroller (5) is provided on the front side of the box (1), and the input end of the microcontroller (5) is electrically connected to an external power source; Its features are: It also includes fixed mechanisms (6); The fixing mechanism (6) includes a fixing frame (601), an adjusting rod (602), a fixing hole (603), a vertical groove (604), a movable block (605), and a fixing column (606). The sliding frame (4) is provided with a fixing frame (601) inside. The adjusting rod (602) is slidably connected inside the fixing frame (601). The upper and lower inner walls of the fixing frame (601) are respectively provided with fixing holes (603). The front and rear ends of the left and right inner walls of the adjusting rod (602) are respectively provided with vertical grooves. The groove (604) is located inside the same adjusting rod (602) and is adjacent to the other two vertical grooves (604) on the same side. Movable blocks (605) are slidably connected between them. On the side of the movable block (605) away from the center of the fixed frame (601), there are fixed columns (606). The fixed columns (606) are all installed with fixed holes (603) that are adjacent to each other on the same side. The left and right inner walls of the fixed frame (601) and the left and right sides of the adjusting rod (602) are respectively provided with evenly distributed arc-shaped grooves.

2. The oscillating water bath device for biological analysis experiments according to claim 1, characterized in that: The fixing mechanism (6) further includes a longitudinal groove (607), an extrusion block (608), a stud (609), a U-shaped frame (611), and a bellows (612). The front and rear ends of the left and right inner walls of the adjusting rod (602) are respectively provided with longitudinal grooves (607). Extrusion blocks (608) are slidably connected between two longitudinal grooves (607) located inside the same adjusting rod (602) and adjacent on the same side. A U-shaped frame (611) is provided on the side of the extrusion block (608) away from the center of the adjusting rod (602). The front and rear ends of the adjusting rod (602) are respectively rotatably connected with studs (609). All are threadedly connected to the U-shaped frame (611) located on the same side of the same adjusting rod (602). The end of the stud (609) near the center of the adjusting rod (602) is fixedly connected to the limiting plate. The limiting plate is provided with a bellows (612) between the U-shaped frame (611) located on the same side of the same adjusting rod (602) and between the U-shaped frame (611) and the front and rear adjacent inner walls of the adjusting rod (602). The stud (609) is located inside the bellows (612) on the same side. The pressing block (608) is installed in cooperation with two movable blocks (605) located on the same side of the same adjusting rod (602).

3. The oscillating water bath device for biological analysis experiments according to claim 1, characterized in that: The fixing mechanism (6) also includes springs (610), which are movably sleeved on the outside of the fixing column (606). The front and rear ends of the upper and lower surfaces of the adjusting rod (602) are respectively bolted with sealing plates. The middle of the sealing plate is provided with a round hole corresponding to the fixing column (606). The springs (610) are located between the side of the movable block (605) away from the center of the adjusting rod (602) and the inner wall of the sealing plate.

4. The oscillating water bath device for biological analysis experiments according to claim 1, characterized in that: A support plate (7) is provided between the right side of the partition (2) and the right inner wall of the box (1). A turntable (8) is rotatably connected to the upper surface of the support plate (7) via a rotating column. A cylinder (9) is provided at the edge of the upper surface of the turntable (8) and the right end of the upper surface of the sliding frame (4). A connecting rod (10) is rotatably connected between the two cylinders (9). A clearance groove corresponding to the connecting rod (10) is provided in the middle of the partition (2).

5. The oscillating water bath device for biological analysis experiments according to claim 4, characterized in that: The lower surface of the support plate (7) is provided with a motor (11). The top end of the output shaft of the motor (11) is fixedly connected to the bottom end of the rotating column, and the input end of the motor (11) is electrically connected to the output end of the microcontroller (5).

6. The oscillating water bath device for biological analysis experiments according to claim 1, characterized in that: The rear side of the box is provided with a support base, and a cover plate (12) is rotatably connected inside the support base. A handle is provided on the front side of the upper surface of the cover plate (12).

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