METHOD FOR MANUFACTURING A PROPHYLAXIC ITEM

Description

[0001] The invention relates to a method for producing a prophylactic article, in particular a glove, from a (carboxylated) diene rubber, according to which at least one layer of a (carboxylated) diene latex is applied to a mold, and the (carboxylated) diene latex is crosslinked with a crosslinking agent.

[0002] Furthermore, the invention relates to the use of a multifunctional monomer and / or polymer.

[0003] Prophylactic products, especially surgical and examination gloves, are typically made from an elastomer latex by dipping hand-shaped molds into the mold. A film forms on the molds, from which the finished disposable glove is subsequently created through vulcanization or cross-linking of the latex.

[0004] Prophylactic products made of natural latex have a relatively high allergy potential. For this reason, synthetic latexes are increasingly being used to manufacture these products. However, even these are not completely hypoallergenic, as they may still contain allergens from the manufacturing process, such as powders used to improve donning, or process chemicals such as cross-linking chemicals or cross-linking accelerators.

[0005] To address these problems, processes for producing prophylactic articles with reduced allergy potential have already been proposed in the prior art.

[0006] For example, WO 2011 / 068394 A1 describes a process by which methacrylic acid and ZnO are added to a carboxylated nitrile butadiene. This gives the mixture self-crosslinking properties, eliminating the need for sulfur crosslinkers and accelerators. However, this composition still contains the heavy metal Zn, so a certain residual allergen potential remains.

[0007] Similarly, US 2010 / 0152365 A1 describes the use of a carboxylated nitrile-butadiene copolymer to manufacture a glove using a dipping process. ZnO is again used for ionic crosslinking.

[0008] It is also known to modify the surface of natural rubber gloves to reduce their allergy potential. For example, US 2014 / 0096307 A1, filed by the applicant, describes a process for modifying the surface of an elastomer with unsaturated carbon-carbon bonds, which are at least partially saturated in the surface region with at least one thiol through a photochemical reaction. Solid particles can be used for saturation, which are covalently bonded to the surface of the glove.

[0009] Similarly, US 2014 / 0096308 Al, which also originates from the applicant, describes, among other things, the attachment of zeolite particles to a natural rubber glove via epoxy groups.

[0010] EP1762586A2 describes a process for producing crosslinked elastomer by preparing a mixture of latex and a photoinitiator as a starter component and irradiating it with UV or visible light to initiate crosslinking. EP1209186A1 describes a non-adhesive, carboxylated, dipped latex product in which at least one surface is treated with a carboxyl group blocking agent and aluminate or aluminum hydroxide gel is added internally to the latex.

[0011] WO00 / 11980 describes medical devices that are non-allergenic and suitable for contact with living tissue of humans or animals. Devices consist of a non-allergenic synthetic polymer manufactured from an aqueous polymer dispersion. These polymers possess functional groups that can be crosslinked by reactants that can react with these functional groups.

[0012] Brown (Rubber Chemistry and Technology (1963) 36 (4): 931-962) discloses that carboxyl groups in elastomer molecules contribute to crosslinking through various mechanisms, including hydrogen bonding, salt formation, reactions with epoxides, amines, carbodiimides, polyimines, and polyisocyanates. These reactions can be used alone or in combination with other crosslinking processes such as sulfur or peroxide vulcanization, particularly in conjunction with zinc oxide in sulfur vulcanizations. Carboxyl groups can also be formed during the crosslinking reaction.

[0013] The present invention is based on the object of creating an improved prophylactic article.

[0014] The problem is solved by the method according to claim 1.

[0015] The object of the invention is also achieved by the use of a multifunctional polymer with a number of monomer units between 2 and 50 (a molecular weight between 170 g / mol and 4000 g / mol) for adjusting the modulus of a prophylactic article made of a (carboxylated) diene elastomer, wherein the polymer is selected from a group consisting of multifunctional epoxides, multifunctional silanes, multifunctional siloxanes, multifunctional thiols, and mixtures thereof.

[0016] In addition, the object of the invention is achieved by the use of a multifunctional organic compound as a crosslinking agent for producing a prophylactic article, wherein the multifunctional organic compound has a molecular weight between 170 g / mol and 4000 g / mol and at least two functional groups, and which forms hydroxyl groups under basic catalysis, wherein the crosslinking agent is selected from a group consisting of multifunctional epoxides, multifunctional silanes, multifunctional siloxanes, multifunctional polymeric thiols, and mixtures thereof.

[0017] The advantage here is that the chemical reaction of the crosslinking agent with the elastomer molecules allows the crosslinking agent to be better incorporated into the crosslinked elastomer. As a result, the crosslinking agent is difficult or impossible to extract from the elastomer, or it does not migrate and only migrates very slowly. "Very slowly" means that the migration time is much longer than the application time of the prophylactic device. This prevents the crosslinking agent from coming into contact with human skin, significantly reducing the allergy potential of the prophylactic device. Migration of the crosslinking agent from the prophylactic device can also be prevented or significantly reduced during storage. Furthermore, leaching processes for removing unbound process chemicals can be shortened or even eliminated.The crosslinking agent can be a multifunctional monomer and / or polymer, or mixtures thereof. The process can be used to produce a prophylactic article with very good mechanical properties and high aging and gamma resistance. Furthermore, no influence on film formation during the manufacturing process, particularly during the dipping process, could be detected, so no further measures are required. A further advantage of the process is that no pre-crosslinking of the (carboxylated) diene latex is required, allowing continuous mixing processes to be used and accelerated processes. The process enables energy-efficient, sustainable, and production-efficient production of hypoallergenic prophylactic articles, particularly surgical and examination gloves.Due to the water solubility of the crosslinking agent, no or even absolutely no emulsifier is required when incorporating it into the latex mixture. Multifunctional monomers and / or polymers offer the advantage of easier handling, as the soluble monomer and / or polymer can be mixed into the latex without prior dispersion or emulsion. However, mixing in the form of an emulsion is possible, especially in the case of oil-soluble monomers and / or oil-soluble polymers. Furthermore, the modulus of the prophylactic article can be better adjusted.

[0018] According to a preferred embodiment of the process, it can be provided that exclusively the multifunctional monomer and / or polymer is used as the crosslinking agent. This allows the aforementioned effects to be further improved, while additionally achieving the allergy potential by eliminating heavy metal ions, such as Zn 2+< from ZnO (zinc can be extracted from the elastomer using carboxylic acids, such as acetic acid). Furthermore, no influence on another crosslinking system can occur, as is sometimes reported in the prior art.

[0019] The crosslinking of the (carboxylated) diene latex molecules can be carried out thermally. Thus, the crosslinking of the latex molecules can already take place during the drying of the latex film dipped onto the dipping mold, thereby increasing the efficiency of the process.

[0020] It is also possible to crosslink the (carboxylated) diene latex molecules photochemically using UV light. This can improve the aging resistance of the elastomer. The elastomer products also exhibit improved stability with respect to high-energy radiation. This is particularly important with regard to the sterilization of medical devices with gamma radiation. Furthermore, this process also makes it easier to avoid the use of Type IV allergens.

[0021] The pH of the (carboxylated) diene latex is adjusted to a value greater than or equal to 9. A significant improvement in reaction kinetics was observed at pH values ​​of 9 and above, allowing the crosslinking of the molecules to occur more rapidly. The crosslinking agent is selected from a group consisting of polyfunctional epoxides, polyfunctional silanes, polyfunctional siloxanes, and polyfunctional polymeric thiols. It is advantageous if these (i) have more than one epoxy function for crosslinking the rubber chains. Preferably, the polyfunctional epoxides have a structure such that the hydrolysis product exhibits "conditioning" properties, such as diglycidyl-terminated polyethylene glycol derivatives, epoxy-sorbitol derivatives, or sugar alcohol derivatives. Furthermore, mono- and polysaccharides with epoxy functionalities can be used.

[0022] In the case of carboxylated diene latices, crosslinking with epoxides offers the advantage that covalent network sites are formed via the carboxyl groups, resulting in very high tensile strengths - covalent crosslinking via the C=C double bonds of the butadiene units, on the other hand, hardly brings any improvement in strength.

[0023] Another advantage of epoxides is their high reactivity with carboxyl groups (no additional accelerator or initiator is required), which leads to efficient crosslinking during the drying step.

[0024] The advantages of multifunctional polymeric thiols are that they (i) have a high molecular weight (molar mass between 200 g / mol and 4000 g / mol); (ii) have a high mercaptoequivalent number (at least 20%, especially at least 50%, of the monomer units should bear SH groups); and (iii) are accessible via simple synthetic strategies. Due to the high molecular weight, odor problems can also be better managed.

[0025] An advantage of multifunctional silanes and siloxanes is that they (i) carry more than one reactive group (e.g., CoatOSil MP200 leads to higher tensile strengths than 3-glycidoxypropyltrimethoxysilane). Another advantage is that they remain liquid even at high molecular weights (e.g., up to 4000 g / mol) and can therefore be more easily incorporated into the latex mixture. Furthermore, the flexible backbone of siloxanes prevents excessive increases in modulus.

[0026] To better adjust the modulus of the prophylactic device, an organic monomer and / or polymer with a molecular weight between 170 g / mol and 4000 g / mol can be used. This can result in greater comfort for the user of the prophylactic device.

[0027] As already mentioned, it is also possible to add the crosslinking agent to the (carboxylated) diene latex as an emulsion. The fine distribution of the crosslinking agent in the emulsion makes it easier to achieve a more homogeneous prophylactic article.

[0028] The crosslinking agent is added to the (carboxylated) diene latex in a proportion of 1 phr to 10 phr, based on the total composition of the (carboxylated) diene latex. This makes it easier to prevent the 50% modulus from becoming too high, which would impair the wearability of the prophylactic article. At the same time, however, a crosslinking agent concentration in this range maintains other good mechanical properties of the elastomer, such as tear strength or maximum extensibility. Preferably, at least one photoinitiator is also added in a proportion of 0.5 phr to 5 phr. In particular, α-hydroxyalkylphenones, α-aminoalkylphenones, acylphosphine oxides, benzoin ethers, benzil ketals, and α-dialkoxyacetophenones can be used as photoinitiators.

[0029] For a better understanding of the invention, it is explained in more detail using the following figures.

[0030] They show: Fig. 1 shows the degree of swelling of cross-linked XNBR latex films over the cross-linking time at different DEPEG-500 concentrations; Fig. 2 shows the degree of swelling of cross-linked XNBR latex films over the cross-linking time at different GE-100 concentrations; Fig. 3 shows the degree of swelling of cross-linked XNBR latex films over the cross-linking time at different SPE concentrations; Fig. 4 shows the moduli (50% elongation) of cross-linked XNBR latex films at different DEPEG-500 concentrations; Fig. 5 shows the moduli (50% elongation) of cross-linked XNBR latex films (non-sterile / non-aged) for DEPEG types with different molecular weights. Fig. 6: The moduli (50% elongation) of cross-linked XNBR latex films (non-sterile / aged at 70°C for 7 days) for DEPEG grades with different molecular weights; Fig. 7: The tear strengths of UV-cross-linked NR latex films (non-sterile, non-aged) at different poly(mercaptopropylmethyl)siloxane concentrations (synthesis time: 3, 6, and 9 h); Fig.Fig. 8 shows the elongation at break of UV-crosslinked NR latex films (non-sterile, non-aged) at different poly(mercaptopropylmethyl)siloxane concentrations (synthesis time: 3, 6, and 9 h); Fig. 9 shows the moduli (50% elongation) of UV-crosslinked NR latex films (non-sterile, non-aged) at different poly(mercaptopropylmethyl)siloxane concentrations (synthesis time: 3, 6, and 9 h); Fig. 10 shows the tear strengths of UV-crosslinked NR latex films (non-sterile, non-aged) at different poly(mercaptopropylmethyl)siloxane concentrations (monomer concentration: 9 and 18% (w / v)); Fig. 11: The elongations at break of UV-crosslinked NR latex films (non-sterile, non-aged) at different poly(mercaptopropylmethyl)siloxane concentrations (monomer concentration: 9 and 18% (w / v)); Fig. 12: The moduli (50% elongation) of UV-crosslinked NR latex films (non-sterile, non-aged) at different poly(mercaptopropylmethyl)siloxane concentrations (monomer concentration: 9 and 18% (w / v)).

[0031] All standards cited in the description refer to the version valid at the time of filing the patent application in question, unless otherwise stated.

[0032] The invention relates to a method for producing a prophylactic article.

[0033] The prophylactic article is preferably a glove, in particular a surgical glove (operating glove) or an examination glove. However, the prophylactic article can also be, for example, a finger cot, a catheter, a condom, a (medical) balloon, a suction device, etc. In general, the prophylactic article is preferably a dipped article, i.e., a product manufactured using a dipping process.

[0034] The following will only address the design of the prophylactic article as a glove. However, the explanations can also be applied to other elastomer articles, especially dipped articles manufactured using a dipping process.

[0035] The glove comprises or consists of a diene elastomer (diene rubber), in particular a carboxylated diene elastomer.

[0036] The elastomer of the elastomer layer can be based on either a natural or a synthetic latex. These can be selected from a group comprising or consisting of natural rubber (NR), polyisoprene latex (IR), nitrile-butadiene rubber latex (NBR), carboxylated nitrile-butadiene rubber latex (XNBR), carboxylated butadiene latex (XBR), chloroprene latex (CR), styrene-butadiene latex (SBR), carboxylated latices made from polymer blends, and mixtures thereof.

[0037] In particular, a carboxylated nitrile-butadiene rubber latex, a polyisoprene latex, or a natural rubber is used to produce the elastomer layer. The nitrile-butadiene rubber latex preferably has an acrylonitrile content of between 15 wt.% and 40 wt.%, in particular between 20 wt.% and 35 wt.%.

[0038] The prophylactic article or elastomer glove is preferably manufactured using a dipping process. Such dipping processes are generally known from the prior art, so for details, please refer to the relevant prior art.

[0039] Essentially, this process involves immersing a mold (usually several molds are used in serial production) into a dipping bath. The mold has the shape of the finished product, for example, the shape of a hand.

[0040] The respective elastomer latex is placed in the dipping bath and is to be applied to the dipping mold.

[0041] In principle, however, any other suitable mold can be used in the processes described in this description, especially if the elastomer layer is not produced using a dipping process. The elastomer layer can also be produced, for example, by brushing or spraying the elastomer latex onto a mold. Other suitable methods for applying the latex to a mold are also applicable.

[0042] The term "elastomer latex" is used in this description in accordance with common technical usage. Accordingly, an elastomer latex is a dispersion of uncrosslinked, pre-crosslinked, or crosslinkable polymer molecules for producing an elastomer. Pre-crosslinked elastomer latices can therefore also be processed within the scope of the invention, with the pre-crosslinking being carried out in particular using the crosslinking agent mentioned in this description, which is a polyfunctional monomer and / or polymer added to the (carboxylated) diene latex and dissolved, emulsified, or dispersed therein.

[0043] However, it is still possible that the elastomer latex is only cross-linked after it has been applied to the mold, i.e. the applied elastomer latex.

[0044] A typical process route of a coagulation immersion process can, for example, include the following process steps: Washing the dipping mold and degreasing it with an organic solvent; preheating the dipping mold; dipping the dipping mold into a first dipping bath containing a coagulant; drying the first surfaced layer; dipping the dipping mold into another dipping bath to form the elastomer layer; drying / vulcanizing (crosslinking); removing the dipped article from the mold.

[0045] As explained in more detail below, instead of thermally crosslinking the elastomer molecules, photochemical crosslinking using UV light can also be performed, optionally after adding a photoinitiator. The photoinitiator can be a commercially available photoinitiator and added in conventional concentrations. Reference is made to the aforementioned US 2014 / 0096307 A1 and US 2014 / 0096308 A1, which are part of the subject description in terms of the photoinitiators and their concentrations in the latex.

[0046] If the elastomer glove is designed with multiple layers, additional layers made of the first elastomer latex or another elastomer latex or another polymer can be dipped or generally applied. For example, a polymer layer can be dipped as the final layer, which, after the glove is removed from the dipping mold, is transferred to the inside of the glove by turning it inside out. Such polymer layers can be designed, for example, as sliding layers to improve the donning of the elastomer glove.

[0047] The elastomer glove can therefore be single- or multi-layered, with the individual layers being made of different materials or the same materials. It is also possible for two or more layers of the elastomer glove to be made of the same material and one or more layers to be made of a different material.

[0048] Since all this is known in itself, it will not be discussed further.

[0049] In this description, materials are understood to mean elastomers and polymers, although the elastomer glove has at least one layer made of an elastomer.

[0050] The terms vulcanization and crosslinking are used synonymously in this description.

[0051] To crosslink the (carboxylated) diene elastomer latex, a crosslinking agent is added to it, i.e., in particular to the dipping bath used to produce the at least one layer of the (carboxylated) diene elastomer. In addition, the diene elastomer latex or the dipping bath may contain at least one further additive, such as at least one emulsifier, at least one anti-aging agent, at least one dye, or at least one antiozonate, as are known per se for the production of dipping articles. The total proportion of these additives may be between 0.1 phr and 10 phr, based on the total composition of the diene elastomer latex or the dipping bath.

[0052] A monomer- and / or polymer-based crosslinking agent is added to the (carboxylated) diene elastomer latex and dissolved in the (carboxylated) diene elastomer latex. The concentration of crosslinking agent is between 1 phr and 10 phr, in particular between 1 phr and 7.5 phr.

[0053] In the preferred embodiment of the process, no additional crosslinking agents are used, meaning that only the monomer and / or polymer soluble in the (carboxylated) diene elastomer latex is used as the crosslinking agent. However, as already explained above, at least one photoinitiator may be added.

[0054] The term "polymer" as used in this description generally encompasses molecules with two or more monomer units, i.e., molecules with dimers. The multifunctional monomers and / or polymers are preferably selected from a group comprising or consisting of multifunctional epoxides, multifunctional silanes, multifunctional siloxanes, multifunctional thiols, and mixtures thereof.

[0055] Examples are short-chain: sorbitol polyglycidyl ether, glycerol glycidyl ether, 1,6-hexanediol diglycidyl ether, resorcinol diglycidyl ether, 1,4-cyclohexanedimethanol diglycidyl ether, diglycidyl 1,2-cyclohexanedicarboxylate, long-chain: diepoxy-terminated polyethylene glycol, diepoxy-terminated polypropylene glycol, polyglycidyl methacrylate (homopolymers and copolymers with ethylene glycol units, ethylene units, etc.), polyglycerol polyglycidyl ether, polyglycidoxypropyltrimethoxysilane.

[0056] Short-chain compounds are monomeric, polyfunctional compounds, especially those with a molecular weight of at least 170 g / mol. Long-chain compounds have at least two or more repeating units (dimers and larger).

[0057] In general, the term "polymer" also includes oligomers in the context of the invention.

[0058] According to another embodiment of the process, a mercaptofunctional siloxane homopolymer or a copolymer of the mercaptofunctional siloxane homopolymer with an acrylosilane is used as the mercaptofunctional siloxane polymer. In particular, a mercaptofunctional siloxane homopolymer with the structural formula wherein R1 represents a first unit selected from a first group consisting of -CH 3 , -OH, -C 2 H 5 , -C 3 H 7 , aromatic groups, R2 represents a second unit selected from a second group consisting of -CH 2 , C 2 H 4 , C 3 H 6 ; -(CH 2 ) 11 -, aromatic groups, -CH 2 -aromatic, and / or an acrylsiloxane having the structural formula wherein R1 represents a first unit selected from a first group consisting of -OH, -CH 3 , -C 2 H 5 , -C 3 H 7 , aromatic groups, R2 represents a second unit selected from a second group consisting of -CH 2 , C 2 H 4 , C 3 H 6 ; aromatic groups.

[0059] The following dimer can also be used as a mercaptofunctional siloxane.

[0060] According to a particularly preferred embodiment of the process, the mercapto-functional siloxane homopolymer is selected from a group consisting of poly(mercaptomethylpropyl)siloxane, poly(mercaptomethylpropyl)siloxane, poly(mercaptomethylmethyl)siloxane, poly(mercaptoethylmethyl)siloxane, poly(mercaptomethylethyl)siloxane, poly(mercaptopropylmethyl)siloxane, poly(mercaptomethylbenzyl)siloxane, poly(mercaptopropylbenzyl)siloxane, poly(mercaptoethylbenzyl)siloxane and / or the copolymer of the mercapto-functional siloxane homopolymer with an acrylsiloxane is selected from a group consisting of poly(mercaptomethylpropyl-co-acryloxymethylpropyl)siloxane, poly(mercaptomethylmethyl-co-acryloxymethylpropyl)siloxane, poly(mercaptomethylmethyl-co-acryloxypropylmethyl)siloxane, Poly(mercaptomethylmethyl-co-acryloxypropylethyl)siloxane, Poly(mercaptomethylmethyl-co-acryloxyethylpropyl)siloxane, Poly(mercaptomethylmethyl-co-acryloxymethylmethyl)siloxane,Poly(mercaptomethylmethyl-co-acryloxypropyl)siloxane, Poly(mercaptomethylmethyl-co-acryloxyethyl)siloxane, Poly(mercaptomethylmethyl-co-acryloxymethyl)siloxane, Poly(mercaptopropylmethyl-co-acryloxymethylpropyl)siloxane.,

[0061] The proportion of the mercapto-functional siloxane polymer in the copolymer of the mercapto-functional siloxane polymer with an acrylsiloxane can be selected from a range of 20 wt.% to 99 wt.%, in particular from a range of 20 wt.% to 80 wt.%.

[0062] The thickness of the elastomer layer can be between 30 µm and 500 µm.

[0063] In general, the (carboxylated) diene elastomer latex can have a solid content of (carboxylated) diene elastomer between 10 drc (dry rubber content) and 60 drc.

[0064] The pH of the (carboxylated) diene elastomer latex is adjusted to a value greater than or equal to 9. For this purpose, an aqueous KOH solution (1 wt.% to 5 wt.%) can be used, for example. Generally, suitable basic substances, such as alkalis, can be used.

[0065] In a preferred embodiment of the process, the crosslinking of the (carboxylated) diene elastomer molecules occurs thermally, particularly during the drying of the (surfaced) layer of the (carboxylated) diene elastomer latex. The temperature can be between 90 °C and 140 °C. Crosslinking can take place over a period of between 5 and 20 minutes.

[0066] A crosslinking agent with a molecular weight between 170 g / mol and 4000 g / mol, especially between 170 g / mol and 1700 g / mol (polymeric, water-soluble compounds according to DIN 55672-3:2007-08 (GPC)) or above the viscosity of liquid polymers according to DIN 51 562-1) can be used. For example, ethylene glycol diglycidyl ether (molecular weight 170 g / mol) or diethylene glycol diglycidyl ether (molecular weight 218 g / mol) can be used. This also makes it possible to adjust the (50%) modulus of the elastomer glove to a desired value. The modulus of the elastomer glove can be adjusted via the chain length of the crosslinking agent.

[0067] The method can be used to produce a prophylactic article, in particular a glove, comprising a layer of a (carboxylated) diene elastomer, wherein the (carboxylated) diene elastomer molecular chains of the (carboxylated) diene elastomer are covalently crosslinked via organic molecules.

[0068] The elastomer gloves produced using this process exhibit good skin compatibility. Tests conducted have shown no skin irritation or sensitization potential.

[0069] In the course of testing the cross-linking process, the following experiments were conducted, among others. These are only selected examples, as reproducing all of them would exceed the scope of this description.

[0070] The following are the experimental results for the process using multifunctional monomers and / or polymers as crosslinking agents. Table 1 summarizes the reactants used for this purpose. Table 1: Materials used name function Description Nipol LX556 latex ZEON Corporation (JPN) BST8502N XNBR PolyLac 582N Dry rubber content: 45.2% pH value: 8 to 8.8 SPE, epoxy sorbitol Polymeric crosslinking agent CVC Thermo-set Specialties Sorbitol polyglycidyl ether (ERISYS GE 60) GE100 Polymeric crosslinking agent Quick Glycerol glycidyl ether DEPEG Polymeric crosslinking agent Sigma-Aldrich (USA) PolyScience (USA) Diepoxy-terminated polyethylene glycol DEPEG-200 Mn=200 DEPEG-500 Mn=500 DEPEG-1000 Mn=1000 Production of latex mixtures, dipping and crosslinking

[0071] The water-soluble crosslinking agent was added to the latex mixture (pH = 10, ~25 drc.) at varying concentrations (0.5 to 1.5 phr). An anti-aging agent (0.5 phr to 2 phr Ralox) was then added to the mixture and stirred for approximately 15 minutes at room temperature. The films were then prepared using the coagulation dip method described above and dried at 100°C for 15 minutes. No pre-crosslinking or latex aging was required. Crosslinking occurred during drying of the films at 100°C.

[0072] The latex mixture can be easily stirred during the dipping process using a magnetic stirrer. This generally applies to the process described in this specification.

[0073] Subsequent reactions are based on thermal crosslinking with monomers and / or polymeric epoxy crosslinkers. It is advantageous to adjust the pH of the latex mixture beforehand, for example, with 1 wt.% KOH to pH 10, since the reaction is catalyzed at higher pH values.

[0074] Reaction of a carboxylated elastomer with an epoxy

[0075] Acid and base catalyzed ring opening of epoxides.

[0076] The successful crosslinking of XNBR latex upon addition of selected water-soluble polymeric crosslinking agents was demonstrated by equilibrium swelling in chloroform (determined according to: (1) Macromolecules 2008, 41, 4717-4729, (2) J. Appl. Polym. Sci. 129(5), 2735-2743 and (3) Zaborski, M.; Kosmalska, A.; Gulinski, J. Kautsch. Gummi Kunstst. 2005, 58, 354). The results are presented in the Fig. 1 to 3The crosslinking time in minutes is shown on the abscissas, and the degree of swelling is shown on the ordinates. The crosslinking density increases with increasing crosslinking time and crosslinking agent concentration, with the reactivity of the crosslinking agents increasing from DEPEG-500 < SPE < GE100.

[0077] In addition to equilibrium swelling, the crosslinking of XNBR latex was also demonstrated by tensile testing upon addition of selected water-soluble polymeric crosslinking agents.

[0078] When using DEPEG-500, mechanical strengths in the range of 22 ± 2 MPa can be observed starting at a concentration of 5 phr. At lower concentrations (0.5 to 3 phr), a low crosslink density is achieved, and tensile strengths are below 10 MPa. Increasing the crosslinker concentration to 7.5 phr results in a further increase in strength up to 35 ± 2 MPa. Therefore, a concentration of 5 phr to 7.5 phr is preferred.

[0079] Very good mechanical strengths and aging or gamma resistance were also observed with DEPEG-200 in a concentration range between 3 phr and 7.5 phr (non-sterile / non-aged: 26 MPa - 40 MPa; non-sterile / aged: 37 MPa - 26 MPa; sterile / non-aged: 28 MPa - 24 MPa; sterile / aged: 25 MPa - 35 MPa).

[0080] Since similar results have been achieved with other multifunctional monomers or polymeric crosslinking agents, a concentration of 1 phr to 7.5 phr of multifunctional monomers and / or polymeric crosslinking agents in the latex is generally preferred.

[0081] Furthermore, excellent hot air aging (7 days storage at 70°C) and gamma stability (25 kGy) is observed.

[0082] It should be noted that during testing of the prophylactic device, sterilization can be performed using gamma radiation with a Co-60 source and an irradiation dose of 25 kGy. Aging can generally be achieved by hot air aging at 70°C in a circulating air drying oven for 7 days.

[0083] In addition, the stress value at 50% elongation is in the range of 1.2 to 1.4 MPa, even at high tensile strengths, and is hardly increased, especially when using 5 phr crosslinking agent, even after hot air aging and gamma sterilization. This is particularly advantageous for the production of surgical gloves, since a low stress value at 50% elongation is a criterion for comfortable wear. The results of the 50% elongation measurement are shown in Fig. 4The bars are arranged in groups of five, with each group representing a DEPEG-500 concentration of 0.5 phr, 1.0 phr, 3.0 phr, 5.0 phr, and 7.5 phr, from left to right. The groups of five themselves represent, from left to right, non-sterile and unaged, non-sterile and aged, sterile and unaged, and sterile and aged samples. The 50% moduli are given in MPa on the ordinate.

[0084] Similar to crosslinking with DEPEG-500, very good mechanical properties (even after gamma sterilization) were also demonstrated when using SPE (epoxy sorbitol) at higher concentrations (7.5 phr). At a concentration of 7.5 phr SPE, mechanical property values ​​between 12 MPa and 32 MPa were measured (non-sterile / non-aged: 30 MPa - 32 MPa; non-sterile / aged: 12 MPa - 14 MPa; sterile / non-aged: 30 MPa - 32 MPa; sterile / aged: 13 MPa - 15 MPa). At a DEPEG-500 concentration between 0.5 phr and 1.0 phr, however, only values ​​of a maximum of approximately 5 MPa were measured. DEPEG-500 is therefore preferably used in a concentration of 5 phr to 7.5 phr.

[0085] When using SPE as a water-soluble polymer crosslinking agent, additional

[0086] A pronounced increase in the stress value at 50% elongation was observed, which is detrimental to the comfort of the elastomer glove. At 7.5 phr SPE, values ​​in the range of 1.6 to 1.8 MPa were obtained. SPE is therefore preferably used in a concentration of 0.5 phr to 5 phr.

[0087] When using GE100 as a crosslinking agent, very good mechanical strengths ranging from 20 to 27 MPa are achieved even at low concentrations (1 and 3 phr). With higher crosslinking agent concentrations (7.5 phr), a further increase in tensile strength is observed (37 ± 2 MPa). At a concentration of 5 phr, values ​​between 22 MPa and 40 MPa are obtained (non-sterile / non-aged: 35 MPa - 40 MPa; non-sterile / aged: 32 MPa - 35 MPa; sterile / non-aged: 36 MPa - 38 MPa; sterile / aged: 22 MPa - 23 MPa). The crosslinked XNBR latex films are characterized by very good gamma resistance.

[0088] In summary, the results show that high ultimate tensile strengths (30 ± 2 MPa) and gamma resistances (after gamma sterilization: 30 ± 2 MPa) were achieved with all three crosslinkers tested. Regarding resistance to hot air aging and low modulus at 50% elongation, DEPEG-500 clearly outperforms GE-100 and SPE.

[0089] Based on these results, the modulus value of the cross-linked XNBR latex films was specifically adjusted in further studies by adjusting the molecular weight of the epoxy-terminated polyethylene glycol derivative (DEPEG). With a lower molecular weight, very high strength (up to 40 MPa) is achieved while the modulus increases. This is particularly interesting for the production of examination gloves, where high strength is paramount and the modulus (due to the layer thickness) plays only a minor role. XNBR films cross-linked with DEPEG-500 (medium molecular weight) achieve somewhat lower strength values, but the modulus values ​​are significantly lower. This variant is more suitable for the production of surgical gloves, where the primary focus is on a low modulus.

[0090] However, if the molecular weight of the crosslinking agent is in the range of 1,000 g / mol, the 50% modulus value can be reduced to below 1 MPa, but the corresponding ultimate tensile strengths are also below 15 MPa. The results therefore demonstrate that a balance between ultimate tensile strength and modulus can be achieved by adjusting the chain length of the crosslinking agent. Therefore, the chain lengths of the polymeric crosslinking agents listed above are preferred.

[0091] The measurement results of this study are shown in the Figs. 5 and 6 The abscissas represent the concentration of crosslinking agent in phr, and the ordinates represent the measured stresses at 50% strain in MPa.

[0092] In further studies, PolyLac 582N ​​was crosslinked as an alternative latex type with 5 phr DEPEG-200 at different pH values. The results clearly demonstrate that PolyLac 582N ​​can be successfully crosslinked.

[0093] Selected examples of photochemical crosslinking of elastomer latices are presented below. Table 2 summarizes the reactants used for this purpose. Table 2: Materials used name function Description Natural rubber latex latex NR High ammonia, 60% drc Isoprene rubber latex Kraton latex 60% drc 3-Mercaptopropyl trimethoxysilane Monomer for synthesis of the polymer crosslinker ABCR MPTMS 3-Mercaptopropyl-methyldimethoxysilane Monomer for synthesis of the polymer crosslinker ABCR MPMDMS 3-Mercaptomethyl-methyldimethoxysilane Monomer for synthesis of the polymer crosslinker ABCR MMMDMS 3-Acryloxypropyl-methyldimethoxysilane Monomer for synthesis of ABCR polymer crosslinker APMDMS Lucirin TPO-L Photoinitiator BASF Tween 20 Emulsifier Ionol LC Antioxidant

[0094] The polymeric siloxane crosslinking agent can be prepared as follows.

[0095] 0.1 M HCl (aq.) and ethanol are initially charged, heated to 50 °C, and purged with a continuous stream of N 2 . The corresponding siloxane monomers (see Table 2) are then added at selected concentrations of 5% (w / v) and 40% (w / v). After 3 to 9 hours at 50 °C, the reaction is stopped by cooling, and the oily product is washed with deionized water and extracted with chloroform. The solvent is then removed under vacuum, and the product is stored under a N 2 atmosphere.

[0096] The reaction schemes of the synthesized homo- and copolymers are listed below. Synthesis of poly(mercaptopropyl)siloxane:

[0097] Synthesis of poly(mercaptomethylmethyl)siloxane:

[0098] Synthesis of poly(mercaptopropylmethyl)siloxane

[0099] Synthesis of poly(mercaptopropylmethyl-co-acryloxypropylmethyl)siloxane

[0100]

[0101] The molecular weight distribution of the siloxanes was determined using gel permeation chromatography (universal calibration with polystyrene standards). The following results were obtained: Poly(mercaptopropylmethyl)siloxane (3 hours - reaction time) Molecular weight: 200 g / mol - 700 g / mol (2 to 5 units) Poly(mercaptopropylmethyl)siloxane (9 hours - reaction time) Molecular weight: 200 - 1,400 g / mol (2 to 10 units) Poly(mercaptopropylmethyl-co-acryloxypropylmethyl)siloxane (3 hours reaction time) Molecular weight: 200 - 1,300 g / mol Production of latex films and UV crosslinking with polymeric siloxane crosslinking agents

[0102] The synthesized polymeric crosslinkers are emulsified at varying concentrations (1 to 4 phr) with Lucirin TPO-L (1 phr) in deionized water containing Tween 20 (0.1 phr) and then added to the NR latex (40 drc.). An anti-aging agent (0.5 phr Ionol LC) is added to the latex mixture and stirred for two hours at room temperature. The films are then prepared using the following coagulation dip process: Washing the ceramic molds and degreasing with acetone Preheating the ceramic molds for at least 10 min in a drying cabinet at 120°C Immersing the mold for 30 s in the coagulation bath at 70°C Drying the mold for at least 1 min in a drying cabinet at 120°C Immersing the mold in the NR latex mixture for 20 s Drying for 20 min in a drying cabinet at 120°C Peeling off the film

[0103] UV crosslinking of the NR latex films was performed by post-curing the dried films with a UV lamp from Fusion UV Systems Inc. The UV exposure was performed in air using a Ga-doped Hg lamp at a lamp power of 60% and a belt speed of 3.5 m / min. For three passes, the radiation dose corresponds to 15.6 J / cm².

[0104] It should be noted that the specified parameters are not intended to be limiting, but merely indicate a way to produce the prophylactic products, for example, on a laboratory scale. Slightly different parameters may be required for large-scale applications, but these can be determined through a few tests.

[0105] The following reaction mechanism is the basis of photochemical crosslinking with polymeric siloxane crosslinking agents. (1) Initiation: (2) Propagation: (3) Termination: RS •< + RS •< → RSSR In general, the following parameters can be used for UV curing:

[0106] IR latices - Parameters for UV pre-crosslinking in the falling film reactor: lamp power at 800 W -1000 W (800 W results in an average radiant flux of ~ 500 mW / cm 2 ), two exposure passes, conveying speed (latex mixture) at 1.1 l / min to 1.5 l / min, solids content (latex) at 40% drc., photoinitiator concentration at 0.5 phr to 2 phr, thiol concentration at 0.5 phr to 2 phr.

[0107] NR latices - parameters for UV pre-crosslinking in the falling film reactor: lamp power at 2000 W - 3500 W (3000 W results in an average radiant flux of ~ 1690 mW / cm 2< ) two exposure passes, conveying speed (latex mixture) at 1.1 l / min to 1.5 l / min, solids content (latex) at 40% drc., photoinitiator concentration at 0.5 phr to 2 phr, thiol concentration at 1 phr to 5 phr.

[0108] General parameters for UV post-curing: Residual moisture content of the films preferably below 20%. Post-curing of 0.5 phr to 5 phr of photoinitiator and 1 phr to 7.5 phr of thiol, irradiation dose between 1 J / cm² and 25 J / cm² (240 nm - 420 nm wavelength range).

[0109] Exposure is preferably carried out in air using a Ga-doped Hg lamp.

[0110] The structure of the polymeric crosslinkers was determined using FT-IR spectroscopy and thermogravimetry (TGA). In the FT-IR spectra of the mercaptofunctional siloxane homopolymers poly(mercaptopropyl)siloxane, poly(mercaptomethylpropyl)siloxane, and poly(mercaptomethylmethyl)siloxane, a significant reduction in the Si-O-CH 3 band at approximately 2830 cm -1 and the formation of OH groups (approximately 3370 cm -1) can be observed, which indicate a successful condensation reaction of the siloxane monomers (alkoxysilane monomers). Furthermore, the broadening of the Si-O band at approximately 1060 cm -1 indicates the formation of a polymeric compound. The characteristic SH band (approximately 2558 cm -1) is only weakly pronounced, since the infrared bands of thiol groups generally exhibit very low intensity.In the FT-IR spectrum of the copolymer poly(mercaptopropylmethyl-co-acryloxymethylpropyl)siloxane, the characteristic IR bands of the acrylate group (C=O bands at 1727 cm -1< and C=C bands at 1637 and 1622 cm -1< ) ​​are also detectable.

[0111] During the TGA investigations, it was shown that the homo- and copolymers, depending on their structure, are stable up to a temperature range of 240 °C to 270 °C and then show a multi-stage degradation.

[0112] To determine the reactivity of the polymeric crosslinking agents, a 2 wt.% solution of polyisoprene standard in chloroform was prepared and mixed with 1 phr of Lucirin TPO-L and 5 phr of the corresponding thiol. The mixture was doctor-coated onto CaF2 plates, the solvent was evaporated, and the thin films were then exposed to a UV lamp (Omni-Cure Series 1000; high-pressure lamp, full power: 100 W from EXFO). After different exposure times, IR spectra were recorded, and the decrease in the normalized C=C band (835 cm -1 ) over the exposure time was recorded. Compared to the commercially available high-molecular-weight thiol dipentaerythritol hexa(3-mercaptopropionate) (THIOCURE ® Di-PETMP, Bruno Bock Thiochemicals), the siloxane polymers exhibit significantly higher crosslinking reactivity.While the relative decrease in the C=C bands after an exposure time of 150s is about 5% when using THIOCURE ®< Di-PETMP, a decrease in the range of 12% can be achieved when using poly(mercaptopropylmethyl)siloxane.

[0113] The reactivity of the polymer crosslinkers in the UV-initiated thiol-ene reaction was confirmed in further experiments. For this purpose, the crosslinking agents (1 phr) were mixed together with a photoinitiator (1 phr Lucirin TPO-L) in a polyisoprene standard solution (2 wt. % in chloroform). Thin films (40 µm) were then doctored, dried, exposed in a patterned manner, and developed in chloroform. Similar to a negative resist, the thiol-ene reaction crosslinks the exposed areas of the layer, and in the subsequent development in chloroform, only the unexposed areas could be dissolved and removed. This experiment was carried out using a mask aligner at a very low exposure dose (~20 mW / cm 2 < , 80 s) in order to minimize the influence of direct CC bonding of the polymer chains by the photoinitiator radicals.The results demonstrate that even a low concentration (1 phr) of the polymeric crosslinkers is sufficient to achieve very high spatially resolved crosslinking of the polyisoprene standard. The results thus confirm the high reactivity and efficiency of the synthesized polymeric crosslinkers in the thiol-ene reaction.

[0114] Due to its chemical structure (high concentration of free Si-OH groups), poly(mercaptopropyl)siloxane can crosslink via a condensation reaction during storage (even under an inert atmosphere). The polymer compound therefore has only a limited shelf life (approximately 1 week). UV-cured NR latex films (before aging and gamma sterilization) with 1 and 2 phr crosslinking agents exhibit a tensile strength of 12 MPa - 15 MPa.

[0115] To minimize potential post-reactions (especially crosslinking) during storage of the polymeric crosslinking agents, disiloxane monomers were used in further synthesis approaches. Due to the lower concentration of free Si-OH groups, this polymeric compound is characterized by a significantly longer storage stability, and no change in viscosity was observed even after storage for 1 month (under interatmosphere). The influence of various parameters (including reaction time, monomer content) during the synthesis on the corresponding mechanical strength and aging resistance of NR latex films was further investigated.

[0116] In the first step, the synthesis of poly(mercaptopropylmethyl)siloxane was stopped at a constant monomer concentration in the reaction mixture (9% (w / v)) after different reaction times (3, 6 and 9 hours), the polymeric product was processed and corresponding cross-linking experiments were carried out.

[0117] At a crosslinker concentration of 1 phr, the polymer with the shorter reaction time (3 hours) exhibits the better mechanical strengths (20 ± 2 MPa). However, at higher concentrations (2 phr) of the polymer crosslinkers, only a slight difference in the mechanical strengths can be observed, and the values ​​are in a range of 22 to 24 MPa. The results are shown in the Fig. 7 to 9 shown.

[0118] In further work, the monomer concentration in the synthesis was varied (9 and 18% w / v) while maintaining a constant reaction time of 3 hours. While at lower monomer concentrations (9 w / v) an increase in tensile strength (from 20 to 26 ± 2 MPa) with increasing crosslinker concentration in the latex mixture (from 1 to 3 phr) can be observed, at a higher monomer concentration (18% w / v) an optimum is achieved at 2 phr of crosslinker in the latex mixture (27 ± 2 MPa). The results of this study are presented in the Figures 10 to 12 shown.

[0119] Additionally, NR latex films were prepared with higher concentrations of polymeric crosslinkers, exposed to UV light, and the influence of the crosslinker concentration on the mechanical properties was investigated. Poly(mercaptopropylmethyl)siloxane (monomer concentration: 18% w / v; reaction time: 3 h) was chosen as the polymeric crosslinker. The results suggest that a further increase in the crosslinker concentration from 3 phr to 4 phr does not lead to a significant improvement in the ultimate tensile strengths. Although an increase in the stress value at 50% elongation can be achieved, indicating a higher degree of crosslinking, the ultimate tensile strengths remain in the range of 25 MPa.

[0120] In a further step, a polymeric thiol crosslinker with a shorter intermediate group (between the thiol group and the polymeric main chain) was synthesized. A methyl group was chosen instead of the propyl group. The monomer concentration in the synthesis was 9% (w / v), and the reaction time was three hours. This polymeric compound is also storage-stable, and no viscosity changes were observed over a storage period of one month.

[0121] Compared to poly(mercaptopropylmethyl)siloxane, higher mechanical strengths can be achieved during UV crosslinking of NR latex using poly(mercaptomethylmethyl)siloxane at the same crosslinker concentrations (1 phr or 2 phr). The tensile strengths for non-sterile and unaged films are approximately 23 MPa at a poly(mercaptopropylmethyl)siloxane concentration of 1 phr and approximately 26 MPa at 2 phr. The 50% moduli for non-sterile and unaged films are approximately 0.45 MPa at a poly(mercaptopropylmethyl)siloxane concentration of 1 phr and approximately 0.5 MPa at 2 phr.

[0122] In addition to the mercapto-functional homopolymers, copolymers with acryloxypropylmethyl units were also synthesized and used as crosslinking agents in the UV crosslinking of NR latex. The acrylate groups as the second monomer unit are intended, on the one hand, to prevent the formation of disulfides (a side reaction of the thiol-ene reaction) and, on the other hand, to provide a reactive group (acrylate) for the bonding of the polymeric crosslinking agent to the rubber chain. The total concentration of both monomers in the synthesis was 9% (w / v), and the reaction time was three hours. This polymeric compound is also storage-stable, and no changes in viscosity were observed over a storage period of one month. Compared to the corresponding homopolymer (poly(mercaptopropylmethyl)siloxane), significantly higher tensile strengths (up to 30 MPa) can be achieved with the copolymer at the same crosslinking agent concentration in the latex mixture.

[0123] In further work, the influence of comonomer composition on mechanical properties was investigated. The concentration of 3-acryloxypropylmethylsiloxane was doubled from 8.4 to 16.8% (mol / total mol). The tensile test results show that with 2 phr of P(MPMS-co-APMS), an increase in the number of acrylate units in the polymer chain is associated with a slight decrease of approximately 8% in mechanical properties.

[0124] As a reference, an acrylate homopolymer was also synthesized (analogous to the synthesis of the crosslinking agents described above) and used as a crosslinking agent. Due to the high reactivity of the acrylate groups, photochemical crosslinking is achieved via direct CC bond formation with the isoprene units. Although the successful patterned exposure of polyisoprene films with poly(acryloxypropylmethyl)siloxane as a crosslinking agent suggests sufficiently high reactivity in UV crosslinking, the mechanical properties of corresponding NR latex films (with 1 phr and 2 phr of crosslinking agent) are significantly lower (14 to 17 MPa) compared to the mercapto-functional homopolymers and copolymers. In addition, the films are characterized by insufficient aging resistance (7 days of hot air aging at 70°C) (<3 MPa and severe yellowing).

[0125] In further experiments, the influence of pre- and post-crosslinking on the crosslinking of NR latex and IR latex with poly(mercaptomethylmethyl) siloxane as polymeric crosslinking agent was investigated. Pre-crosslinking:

[0126] The synthesized polymeric crosslinkers (0.5 phr) were emulsified with Lucirin TPO-L (0.5 phr) in deionized water containing Tween 20 (0.1 phr) and then added to the NR latex (40 drc.) or the IR latex (40 drc., Kraton). The latex mixture was stirred for 2 hours at room temperature. The respective latex mixture was then poured into a Petri dish (approximately 1 mm layer thickness) and exposed to UV radiation using a UV lamp from Fusion UV Systems Inc. The NR latex mixtures were irradiated in air with a Ga-doped Hg lamp at a lamp power of 60% and a belt speed of 3.5 m / min in four passes (corresponding to a radiation dose of 20.8 J / cm²). The IR latex mixtures were irradiated in air with a Ga-doped Hg lamp at a lamp power of 60% and a belt speed of 3.5 m / min in two passes (corresponding to a radiation dose of 10.4 J / cm 2< ).

[0127] When producing pre-crosslinked films (without subsequent post-crosslinking), the latex mixture was mixed with the anti-aging agent (0.5 phr Ionol LC) after pre-crosslinking and stirred for 2 hours at room temperature. The latex films were then immersed using the coagulation immersion process. The following steps were performed: Washing the ceramic molds and degreasing with acetone Preheating the ceramic molds for at least 10 minutes in a drying cabinet at 120 °C Immersing the mold for 30 seconds in the coagulation bath at 70 °C Drying the mold for at least 1 minute in a drying cabinet at 120 °C Immersing the mold in the NR latex mixture for 20 seconds Drying for 20 minutes in a drying cabinet at 120 °C Stripping Post-crosslinking:

[0128] Optionally, post-crosslinking was also performed. In this case, the respective latex mixtures (pre-crosslinked or non-pre-crosslinked) were mixed with an emulsion consisting of the synthesized polymeric crosslinking agent (2 phr), Lucirin TPO-L (1 phr), deionized water (2 phr), and Tween 20 (0.1 phr). Subsequently, an anti-aging agent (0.5 phr of Ionol LC) was added to the latex mixture and stirred for 2 hours at room temperature.

[0129] Corresponding films were produced using the coagulation dip process, and post-curing was carried out by UV exposure of the dried films (post-curing) with a UV lamp from Fusion UV Systems Inc. Both NR latex films and IR latex films were irradiated in air with a Ga-doped Hg lamp at a lamp power of 60% and a belt speed of 3.5 m / min in three passes (corresponding to a radiation dose of 15.6 J / cm 2 ).

[0130] Photochemical crosslinking of the NR latex showed that the highest mechanical strengths can be achieved through post-crosslinking. The tensile strength of the NR latex films (non-sterile, non-aged) was approximately 22.5 MPa for the pre-crosslinked sample, approximately 18 MPa for the pre- and post-crosslinked sample, and approximately 25 MPa for the exclusively post-crosslinked sample. This result is surprising given that the pre- and post-crosslinked sample exhibited the lowest tensile strength.

[0131] A similar trend is also observed with UV pre-crosslinking of IR latex. Here, the tensile strength of pre-crosslinked IR latex films is in the range of 3.5 MPa. In contrast to NR latex films, however, combined pre- and post-crosslinking significantly increases the tensile strength to 16 MPa.

[0132] To further evaluate the polymeric crosslinkers, additional mercaptopolymers were synthesized. For a more controlled polymerization (production of polymers with a lower polydispersity index), poly(mercaptomethylmethyl)siloxane and poly(mercaptopropylmethyl-co-acryloxypropylmethyl)siloxane were prepared in the presence of 2 phr and 3 phr of methoxytrimethylsilane, respectively, as a terminating reagent. The synthesis was carried out analogously to the synthesis described above, with the additional addition of 2 phr and 3 phr of methoxytrimethylsilane (Sigma-Aldrich) to the reaction mixture.

[0133] The tear strengths of the UV-crosslinked NR latex films (non-sterile, non-aged) are consistently between 25 MPa and 27 MPa.

[0134] To determine the extractable crosslinker concentration, post-crosslinked NR latex films were extracted using a Soxhlet extraction (10 hours / toluene). The solvent was removed using a rotary evaporator, and the extract was dried to constant weight in a vacuum drying oven at 35°C and 100 mbar.

[0135] The extractable S compounds (thiols and proteins of the NR latex) were determined in triplicate using C / H / N / S.

[0136] The results of the elemental analysis show a significantly lower extractability (75%) of the crosslinking agent compared to low molecular weight thiols (such as trimethylolpropane trimercaptopropionate, TMPMP). Table 3 - S concentration in the extract of UV-crosslinked NR latex films sample Photoinitiator Thiol Extractable S content / mgS / gLatex reference Lucirin TPO-L (1phr) TMPMP (2phr) 2,074 Homopolymer Lucirin TPO-L (1phr) Poly(mercaptopropylmethyl methyl)siloxane (2phr) 0,534 Copolymer Lucirin TPO-L (1phr) Poly(mercaptopropylmethyl-co-acryloxypropylmethyl)siloxane (2phr) 0,522

[0137] The following examples demonstrate that thermal crosslinking of XNBR latex films is not only possible with polar, water-soluble epoxy crosslinking agents but also with non-polar epoxy derivatives. Example A - Crosslinking with bisphenol A diglycidyl ether

[0138] 3 phr of bisphenol A diglycidyl ether (Huntsman) is emulsified in 6 phr of deionized water with 0.3 phr of Tween 20. The emulsion is then added to the latex mixture (pH = 10.2; ~25 drc.), and the latex mixture is stirred for 60 minutes at room temperature. The films are prepared analogously to the procedure described above, and thermal crosslinking occurs during drying of the films in a convection oven. Bisphenol A diglycidyl ether Example B - Crosslinking with a hydrogenated bisphenol A diglycidyl ether

[0139] The preparation is analogous to example A - only instead of the bisphenol A diglycidyl ether, 3 phr or 5 phr of a hydrogenated bisphenol A diglycidyl ether (EPALLOY ®< 5000 and EPALLOY ®< 5001 from CVC Thermoset Specialities) are used. Hydrogenated bisphenol A diglycidyl ether Example C - Crosslinking with a hexahydrophthalic acid diglycidyl ether

[0140] The preparation is analogous to example A - only instead of the bisphenol A diglycidyl ether a hexahydrophthalic acid diglycidyl ether (3 phr and 5 phr EPALLOY ®< 5200 from CVC Thermoset Specialities) is used Hexahydrophthalic acid diglycidyl ether Example D - Crosslinking with a 1,4-cyclohexanedimethanol diglycidyl ether

[0141] The preparation is analogous to example A - only instead of the bisphenol A diglycidyl ether, a 1,4-cyclohexanedimethanol diglycidyl ether (3 phr and 5 phr ERISYS ™< GE 22 from CVC Thermoset Specialities) is used. 1,4-Cyclohexanedimethanol diglycidyl ether

[0142] The measured mechanical properties of the XNBR latices crosslinked according to Examples AD are summarized in Table 4. Table 4 - Mechanical properties of thermally crosslinked XNBR latex films using different epoxies Epoxy crosslinker Concentration of crosslinker [phr] Tensile strength [MPa] Tension [%] Stress at 50% strain [MPa] Bisphenol A diglycidyl ether 3 42,2 700 1,58 EPALLOY ®< 5000 3 39,3 700 1,53 EPALLOY ®< 5000 5 39,9 670 1,53 EPALLOY ®< 5001 3 36,9 680 1,62 EPALLOY ®< 5001 5 38,4 670 1,59 EPALLOY ®< 5200 3 36,8 690 1,59 EPALLOY ®< 5200 5 38,4 690 1,46 ERISYS™< GE22 3 34,0 680 1,60 ERISYS™< GE22 5 34,9 670 1,48

[0143] The embodiments describe possible variants of the method, and various combinations of the individual variants are also possible.

Claims

1. Process for producing a prophylactic article, in particular a glove, from a diene rubber and / or a carboxylated diene rubber, in which at least one layer of a diene latex and / or a carboxylated diene latex is applied to a mold, and the diene latex and / or the carboxylated diene latex is crosslinked with a crosslinking agent, wherein a multifunctional monomer and / or polymer with two or more repeating units is used as crosslinking agent, which is added to the diene latex and / or the carboxylated diene latex and is dissolved or emulsified respectively dispersed therein, wherein the crosslinking agent is added to the diene latex and / or the carboxylated diene latex in a proportion of 1 phr to 10 phr, based on the total composition of the diene latex and / or the carboxylated diene latex, and is selected from a group consisting of multifunctional epoxides, multifunctional silanes, multifunctional polymeric thiols, and mixtures thereof, characterized in that only the multifunctional monomer and / or polymer with at least two or more repeating units is used as crosslinking agent, and that the pH value of the diene latex and / or the carboxylated diene latex is adjusted to a value greater than or equal to 9.

2. Process according to claim 1, characterized in that the crosslinking of the diene latex molecules and / or carboxylated diene latex molecules is carried out thermally and / or photochemically by ultraviolet radiation.