NEW TYPE II CITRATE SYNTHASE VARIANT AND METHOD FOR PRODUCING L-LYSINE USING THE SAME
DE602021055966T2Active Publication Date: 2026-06-17CJ CHEILJEDANG CORP
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Patent Information
- Application Number
- DE602021055966
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2021-02-26
- Filing Date
- 2021-04-02
- Publication Date
- 2026-06-17
- Estimated Expiration
- 2041-04-02
AI Technical Summary
Technical Problem
Existing methods for producing L-lysine in microorganisms like Corynebacterium glutamicum are not sufficiently efficient, necessitating improvements to enhance production capabilities.
Method used
Introduction of a type II citrate synthase variant with an alanine substitution at position 169 to valine (A169V) in the Corynebacterium glutamicum strain, along with a polynucleotide encoding this variant, to increase L-lysine production.
Benefits of technology
The A169V variant enhances L-lysine production by up to 20% or 1.3 times compared to unmodified strains, improving the efficiency of L-lysine biosynthesis.
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