Improved crushing device in an isolated environment

Abstract

The improved crushing device (1) comprises a cylindrical body (2) with a port (2A) for loading and containing the material to be treated; a pressure piston (5) is sliding, in the operational configuration, within the cylindrical body (2) so as to push and compress the loaded material against a drawing baffle (6), or sieve; still in the operational configuration, a cutting device (7) also operates on the material to be treated and is configured to rotate and make micro-fragmentations with the cutting action exerted by one or more rotating blades and the simultaneous thrust by the pressure piston (5); the device is hermetically closable by means of a closing bottom (8) in turn comprising a passageway and a hydraulic connection (10) to allow the treated material to be attached and thus extracted directly as a result of the action of the pressure piston (5) and of the cutting device (7).

Description

[0001] IMPROVED CRUSHING DEVICE IN AN ISOLATED ENVIRONMENT

[0002] Technical Field

[0003] This invention relates to a fragmentation device for the treatment of a biological material, particularly adipose tissue.

[0004] Background Art

[0005] Adipose-derived stem cells (ADSCs) are mesenchymal stem cells which are able to renew themselves through mitotic cell division and to differentiate into a wide range of specialized cell types.

[0006] As cells that exist abundantly in the SVF (stromal vascular fraction) of adipose tissue, they are ideal as a cell source in the field of regenerative medicine. ADSCs can be obtained from fat deposits and collected from adipose tissue through a simple minimally invasive collecting procedure performed by a surgeon under general or local anesthesia.

[0007] Recent investigations suggest that ADSCs and the stromal vascular fraction (SVF, which consists of connective stroma with a supporting function for adipocytes and blood vessels) are easily isolated from the human adipose tissue, removed surgically or by liposuction, by means of enzymatic digestion.

[0008] In order to obtain ADSCs and SVFs, enzymatic digestion is used, which allows a large number of cells to be obtained rapidly. However, European legislation considers enzymatic digestion as substantial manipulation; this is feasible but is considered “major manipulation” and, therefore, subject to more stringent regulations than a one- step intervention (explantation and implantation at the same surgical time) with only mechanical treatment of the tissue.

[0009] Another well-known method is to isolate tissue micro-grafts using a centrifugation technology that consists in making the adipose tissue to be treated rotate within a container. Using a grid in the device, fragments are selected within which the portion of progenitor cells is statistically significant.

[0010] Other techniques of known type may involve filtration and / or sedimentation. Description of the Invention

[0011] The object of the invention is to develop an improved device which is able to effectively micro-fragment soft tissue under sterile conditions. The invention consists of a closed system so that the biological material is not exposed to external environmental contamination before being re-implanted.

[0012] In order to implement the aforementioned object, the device comprises a cylindrical body and a bottom which, in the operational configuration or operational conditions are coupled in a sealing manner so as to define an inner chamber; a drawing baffle (sieve) is placed within the device so as to divide the interior into two volumes: the first volume and / or the larger volume, on the cylindrical body side, to contain the material to be treated while the second volume and / or the smaller volume, on the bottom side, to pass the treated material towards the collection device.

[0013] The bottom is also configured with a hydraulic connection or connector, preferably central, configured to receive in turn a collection device, such as e.g. a collection syringe, of the material. Therefore, the second volume, the one on the bottom side, serves as a passage space (interspace) to allow the outflow towards the collection device connected to the connector which, preferably, is of the Luer type.

[0014] Thus, while grinders of the prior art allow multiple passages, transferring the material to be treated between two chambers, this improved device allows reducing dead volumes and performing the transfer, from the containment chamber to the collection device into a sterile closed loop via a direct connection, with only one passage, sufficient for most soft tissues.

[0015] In fact, within the cylindrical body there is a pressure piston and a related cutting device or knife configured to rotate and make micro fragmentations of the material to be treated, under the combined thrust action by the related pressure piston. According to a preferred embodiment of the invention, the pressure piston is made to move forward by a screw coaxial to the cylindrical body.

[0016] The material to be treated is thus introduced into the compartment between the baffle and the pressure piston then, as a result of the closure of the device, of the actuation of the rotating knife and of the movement of the related pressure piston, is transferred, passing through the drawing baffle and the interspace in the bottom, to the collection device to be used for specific therapy or laboratory purposes.

[0017] Precisely, after loading, everything is carried out in just one step: the material is pushed by the pressure piston moving forward through the screw, is crushed by the knives, extruded through the sieve and pushed into the interspace and therefrom into the collection device through the connector. In fact, as mentioned, the bottom comprises a hydraulic connection adapted to allow the extraction or discharge of the treated material. According to one aspect of the invention, the connection can be closed by a small plug; under operational conditions, the hydraulic connection is normally engaged by the collection device.

[0018] The movement of the pressure piston is an axial movement, i.e., a shift movement, while that of the knife is a rotation.

[0019] In accordance with a preferred embodiment, said axial movement and rotation, e.g., moving forward, is accomplished by means of a screw mechanism.

[0020] Still, according to a further aspect of the invention, there is an anti-rotational system of the pressure piston, which determines the action of shifting movement of the pressure piston as a result of the rotation imparted to the control screw.

[0021] In accordance with one embodiment of the device made of metal material, the system is made with a slider carried out on the cylinders and one or more pins locked together with the piston itself; advantageously, the pin also serves as an indicator of the position of the stroke of the piston itself.

[0022] In accordance with a further embodiment of the device made of plastic material possibly transparent in whole or partly, the anti-rotational system of the piston is provided by means of a coupling of the “male-female” type and which is implemented in an axial cavity obtained on the piston which cavity is configured to engage a corresponding tab formed on the inner skirt of the cylinder within which it slides.

[0023] From the above, it appears that the components may be all or part of a sterilizable material, such as metallic, ceramic, plastic or composite material.

[0024] The device is operated manually by means of knobs or by coupling to one or more motorized electrical equipment. Preferably, said one or more motorized electrical equipment is keyed, directly or indirectly, to the operational screw of the pressure piston and of the rotating blade via a power take-off.

[0025] Another object of the invention is to provide the motorized electrical equipment with electrical and mechanical displacement sensors and safety devices, capable of performing all operational steps for the treatment of the material in a controlled manner.

[0026] According to a further object, the device is provided with one or more hydraulic connections which can be connected to external ducts for a fluidic connection and allows washing the contained material by means of flow of saline or other appropriate liquid, and wherein one of the purposes of such washing is the removal of the oily phase of the preparation. Advantageously, said one or more hydraulic connections are similar to that used for the extraction of the treated material.

[0027] Brief Description of the Drawings

[0028] This and other characteristics will be more evident from the following description of some of the embodiments illustrated purely by way of non-limiting example in the attached drawings, wherein

[0029] Figure 1 is a sectioned view of an improved crushing device in an enclosed, controlled environment, according to the invention,

[0030] Figure 1 A is a view illustrating the drawing baffle;

[0031] Figure 2A shows a section of the drawing baffle shown in Figure 1 A;

[0032] Figures 2 and 2A are views illustrating the device in Figure 1 lacking the bottom; Figure 3 is a sectioned view of a portion of the device without a built-in hydraulic connector and separation baffle, according to the invention;

[0033] Figure 3 A is a detailed view of a part of the device shown in Figure 3;

[0034] Figure 4 is a sectioned view of a portion of the device with the built-in hydraulic connector and separation baffle;

[0035] Figure 5 is a view of the bottom with a collection device of the treated material attached;

[0036] Figure 5 A is a detailed view of a part of the device shown in Figure 5;

[0037] Figures 6, 6A, 7 and 7A are views illustrating an example of the embodiment of the anti-rotational system of the piston and cylinder components; Figures 8 and 8A are views illustrating a multi-bladed knife;

[0038] Figure 9 is a further sectioned view of an improved crushing device, according to the invention.

[0039] Embodiments of the Invention

[0040] Although this invention is described below with reference to its embodiment shown in the tables of drawings, this invention is not limited to the embodiment model described below and shown in the attached tables. On the contrary, the embodiment described and shown helps to clarify some features relating to this invention, the scope of which is defined by the relevant claims.

[0041] With reference to the figures, reference numeral 1 globally denotes a device suitable for fragmenting a biological material by operating aseptically in an enclosed environment.

[0042] According to a preferred aspect of the invention, the biological material to be treated comprises soft tissue.

[0043] The device 1 substantially comprises a cylindrical body 2, open at one port or end 2A, the end 2A being in turn configured to receive a corresponding bottom 8. Advantageously, in the operational configuration, the cylindrical body 2 and the bottom 8 are coupled together and define a substantially hermetically sealed system.

[0044] Conveniently, the cylindrical body 2 and the bottom 8 are coupleable to each other in a removable manner.

[0045] Once coupled, thus still in the operational configuration, the cylindrical body 2 and the bottom 8 are jointly coupled in a hermetic manner, preferably by means of at least one seal 11, and define an inner chamber 13, 14 or internal volume.

[0046] The bottom 8 and / or the cylindrical body 2 also houses a drawing baffle 6 (sieve), which is thus placed transversely within the device so as to divide the internal volume into two chambers or sections: the larger volume chamber varies during operation and substantially corresponds to that of the cylindrical body and serves as a loading and containment zone for the material to be treated, while the smaller volume chamber is an interspace for the treated material to pass through the bottom. Conveniently, the smaller volume chamber is of substantially fixed volume.

[0047] In the example, the drawing baffle 6 is held in place by the bottom, which does not detract from the fact that it could be equally placed on the cylinder. The baffle 6 is substantially a perforated disc.

[0048] Specifically, the drawing baffle 6 defines at least one straight portion 16 which, in the operational configuration, abuts against an abutment portion formed on the bottom 8 and / or on the cylindrical body 2, so as to prevent the drawing baffle 6 from rotating.

[0049] In more detail, the drawing baffle 6 defines at least one pair of straight portions 16 preferably arranged on the opposite sides of the same baffle.

[0050] The cylindrical body 2 houses a thrust element, such as a pressure piston 5, free to axially slide according to the main axis of the device 1.

[0051] In addition, said cylindrical body also houses a cutting device or rotating knife 7, preferably with multiple blades, which accomplishes, in the operational configuration, the micro-fragmentation of the introduced material. The knife is rigidly attached to the rotating screw 4 which imparts the rotary motion thereto and is positioned with the cutting surface of the blades close to the baffle 6 and provides for cutting the material until its size allows it to pass through the holes in the disc 6.

[0052] In this way, the device 1, in the operational configuration (coupled bottom and cylinder) is an enclosed environment which, as a result of sterilization, is suitable for the aseptic treatment of the contained biological material.

[0053] In other words, the improved crushing device 1 comprises a cylindrical body 2 with a port 2A for loading and containing the material to be treated.

[0054] In addition, the device comprises a pressure piston 5 sliding, in the operational configuration, within the cylindrical body 2 so as to push and compress the loaded material against a drawing baffle 6, or sieve.

[0055] In addition, again in the operational configuration, on the material to be treated a cutting device 7 also operates which is configured to rotate and make microfragmentations with the cutting action exerted by one or more rotating blades and the simultaneous thrust by the pressure piston 5. Additionally, the device 1 is hermetically closable by means of a closing bottom 8 in turn comprising a passageway and a hydraulic connection 10 to allow the treated material to be attached and thus extracted directly as a result of the action of the pressure piston 5 and of the cutting device 7.

[0056] Specifically, the drawing baffle 6 (sieve) is arranged within the device 1, dividing it into: a first chamber 13, on the side of the cylindrical body 2, of variable volume during operation and serving as a loading and containing zone for the material to be treated; a second chamber 14, on the side of the bottom 8, of substantially fixed volume and defining the interspace for the passage of the treated material.

[0057] Preferably, the first chamber 13 is higher volume, while the second chamber 14 is lower volume (compared to the first chamber 13).

[0058] Specifically, in the operational configuration, the second chamber 14 extends substantially between the drawing baffle 6 and the bottom 8.

[0059] In more detail, in the operational configuration, the first chamber 13 substantially extends between the pressure piston 5 and the drawing baffle 6.

[0060] Conveniently, the pressure piston 5 defines a thrust chamber 15 of the material to be treated towards the port 2 A and / or the drawing baffle 6.

[0061] In more detail, in the operational configuration, the thrust chamber 15 substantially coincides with the first chamber 13.

[0062] In even more detail, the device 1 comprises a single thrust chamber 15.

[0063] Conveniently, the device 1 lacks the thrust means, other than the pressure piston 5, operating within the first chamber 13 and the second chamber 14 to push the material to be treated towards the port 2 A and / or the drawing baffle 6.

[0064] This expedient helps to keep the device 1 compact, thus reducing its overall dimensions.

[0065] Preferably, the cutting device 7 is placed within the first chamber 13.

[0066] Conveniently, the device 1 comprises a screw 4 driving the pressure piston 5 and / or the cutting device 7.

[0067] In addition, the cylindrical body 2 comprises a base portion 3 provided with a hole 17 and arranged opposite the end 2 A and a connecting portion 18 connecting the base portion 3 to the end 2A.

[0068] Specifically, the base portion 3 is made in a single body piece with the connecting portion 18.

[0069] In addition, the screw 4 is inserted within the cylindrical body 2 through the hole 17.

[0070] This expedient helps to make the structure of the device compact and rigid.

[0071] The device is preferably of the disposable type, but can also be produced in multiple-use versions. In the case of the disposable type, the device is typically plastic and sterilized by the manufacturer. In the case of multiple-use device, the item must be washed and sterilized before each use by the user.

[0072] It is also noted, again with reference to the figures shown, that the cylinder and the bottom are closable to each other by means of threading and seals of known type. Loading of the material takes place in the sterile field before the coupling between the cylinder 2 and the bottom 8, while unloading takes place via a hydraulic connection 10 arranged on the bottom. In more detail, the hydraulic connection 10 is normally closed, preferably in a substantially hermetic manner, e.g., by a small screw cap; and it is used, during the operational stages, for the attachment connection and thus direct extraction of the treated material by means of a collection device 12, such as e.g. a syringe.

[0073] In other words, the collection of the treated material is done by means of a collection device 12 connected to the hydraulic connection 10.

[0074] Appropriately, the collection device 12 is connectable to the hydraulic connection in a removable manner.

[0075] In particular, the collection device 12 connected to the hydraulic connection 10 makes a substantially hermetically sealed system with the device 1.

[0076] Advantageously, the hydraulic connection 10 is made axially on the bottom 8.

[0077] In other words, the hydraulic connection 10 extends axially along the main axis of the device 1.

[0078] In more detail, the hydraulic connection 10 is made at the center of the bottom 8. Conveniently, the bottom 8 comprises a fixed bottom wall 19 arranged, in the operational configuration, substantially facing the drawing baffle 6, or sieve, to receive the treated material.

[0079] In particular, the bottom wall 19 is a rigid body.

[0080] In other words, in the operational configuration, as a result of the coupling between the cylindrical body 2 and the bottom 8, the bottom wall 19 is arranged in a fixed position at a predetermined, non-variable distance from the drawing baffle 6.

[0081] In this way, the bottom wall 19 conveys the treated material to the hydraulic connection 10.

[0082] Preferably, the hydraulic connection 10 is made on the bottom wall 19.

[0083] In particular, the bottom wall 19 has a substantially sloping conformation and converging towards the hydraulic connection 10 to convey the treated material towards the latter.

[0084] Conveniently, the device 1 comprises driving means 20 kinematically connected to the cutting device 7 and to the pressure piston 5.

[0085] Specifically, the driving means 20 are adapted to move the cutting device 7 in rotation and the pressure piston 5 by sliding.

[0086] Appropriately, the driving means 20 are kinematically connected to the cutting device 7 and to the pressure piston 5 by interposition of the screw 4.

[0087] Specifically, the screw 4 transmits the motion of the driving means 20 to the cutting device 7 and to the pressure piston 5.

[0088] Conveniently, the driving means 20 are manually operated by a user of the device 1.

[0089] In this way, the thrust and cutting action (e.g., the cutting and thrust speed) are completely manually managed by the user who, in this way, adjusts the mechanical stress to which the material being treated is subjected, substantially minimizing it.

[0090] In particular, this expedient minimizes the cutting effort that might otherwise damage the cells contained in the tissue being treated.

[0091] Mechanical stress is further reduced by the drilling of the drawing baffle 6, preferably having larger holes with respect to the size of the structures of the tissue to be treated.

[0092] Advantageously, the driving means 20 define a bearing base 21 arranged, in use, resting on a stable surface.

[0093] In other words, the driving means 20 allow the device 1 to rest stably on a stable surface, in addition to enabling the movement of the cutting device 7 and of the pressure piston 5.

[0094] Preferably, the bearing base 21 is substantially a flat surface.

[0095] Specifically, when the bearing base 21 is arranged to rest on the stable surface, the main axis of the device 1 is arranged substantially orthogonal to the same surface.

[0096] Preferably, the stable surface is a substantially horizontal, preferably flat surface. Conveniently, the driving means 20 comprise a revolving handwheel 22 provided with a plurality of spokes 23 (or arms) defining the bearing base 21.

[0097] Specifically, the spokes 23 extend radially from a central point to facilitate the rotation of the handwheel 22, i.e., the use of the driving means 20.

[0098] Preferably, the handwheel 22 comprises four spokes 23 spaced angularly apart from each other by 90°.

[0099] Conveniently, the driving means 20 are arranged opposite the port 2A, so as to facilitate access to the latter by a user with the bearing base 21 arranged resting on the stable surface.

[0100] In fact, in this way, the device 1 remains stably resting on the stable surface by means of the bearing base 21, substantially keeping the port 2A facing upwards. This expedient greatly simplifies the loading of the device 1, that is, the insertion of the tissue inside the cylindrical body 2 before coupling to the bottom 8.

[0101] The method of treatment carried out with the present improved device comprises: loading the material to be treated into the loading cavity of the cylindrical body 2, which lacks the bottom and the drawing baffle, sealing the chamber by means of a hermetic closure coupling of the bottom

[0102] 8 and the simultaneous presence of the drawing baffle 6, e.g., by means of a gripping ring 9, operating the screw 4 through the driving means 20 so as to make the rotating knife 7 rotate and move the pressure piston 5, so as to transfer the material through the drawing baffle 6, collecting the material thus treated by means of a collection device 12 (only one portion thereof is illustrated in the tables) through the hydraulic connection 10 made axially on the bottom, which enables its attachment and thus the direct extraction of the treated material.

[0103] In fact, therefore, in the operational stages, the passage of the material occurs from the loading cavity to the collection device and the chamber between the baffle and the bottom is of minimal volume in order to collect as much material as possible on the syringe.

[0104] In one embodiment, the movement of the piston (shift) and of the knife (rotation) is accomplished by means of a screw mechanism 4 that engages in the base portion 3 of the cylindrical body 2 and is operable by the operator by means of a corresponding knob.

[0105] Possibly, in accordance with one embodiment not illustrated, the device 1 can operate in conjunction with a motorized electrical equipment, e.g. by directly keying the screw to an appropriate power take-off; advantageously this can be provided with one or more displacement sensors and appropriate electrical and mechanical safety devices capable of carrying out all actions required of the operator in a controlled manner.

[0106] Conveniently, the device 1 is made, at least partly, of transparent, semitransparent and / or opaque material to enable the interior of the device itself to be inspected in the operational configuration.

[0107] Specifically, the cylindrical body 2 and / or the bottom 8 is made of transparent, semitransparent and / or opaque material.

[0108] Preferably, the drawing baffle 6 and / or the cutting device 7 are made of metal material.

[0109] It cannot, however, be ruled out that the drawing baffle 6 and / or the cutting device 7 are made of ceramic, sintered, composite or other hard materials.

[0110] According to one aspect of the invention, there is an anti-rotational system of the pressure piston that: wherein the device is made of metal material, the system is made with a slider obtained on the cylinders and one or more pins locked together with the piston itself; advantageously, the pin also operates as an indicator of the position of the stroke of the piston itself; while in the event of the device being made of either transparent or opaque plastic material, with particular reference to Figures 6 and 7, the anti-rotational system of the piston is made by means of a coupling of the “male-female” type and which is implemented in an axial cavity formed on the piston and which is configured to engage a corresponding tab formed on the inner skirt of the cylinder within which it slides.

[0111] Still, and again in accordance with one embodiment not illustrated, one version might involve additional hydraulic connections, similar to that used for the extraction of the treated material, to be connected to external ducts to wash the biological contents by flowing saline or other appropriate liquid. One of the purposes of such washing is to remove the oily phase of the preparation.

[0112] This invention has been described with reference to the specific embodiment shown in the illustrations; it should, however, be noted that this invention is not limited to said specific embodiment presented and described herein. On the contrary, further versions of the described embodiment are also part of the object of this invention, as detailed in the relevant claims.

[0113] In particular, with regard to the actuation of the pressure piston, this system may be implemented by other systems than the screw system shown herein.

Claims

CLAIMS1) Improved crushing device (1), characterized by the fact that it comprises a cylindrical body (2) with a port (2A) for loading and containing the material to be treated; a pressure piston (5) is sliding, in the operational configuration, within said cylindrical body (2) so as to push and compress the loaded material against a drawing baffle (6), or sieve; still in the operational configuration, a cutting device (7) also operates on the material to be treated and is configured to rotate and make micro-fragmentations with the cutting action exerted by one or more rotating blades and the simultaneous thrust by said pressure piston (5); the device is hermetically closable by means of a closing bottom (8) in turn comprising a passageway and a hydraulic connection (10) to allow the treated material to be attached and thus extracted directly as a result of the action of said pressure piston (5) and of said cutting device (7).2) Device (1) according to claim 1, characterized by the fact that, once coupled, said loading port (2A) of said cylindrical body (2) is hermetically sealed by said bottom (8) by means of at least one seal (11).3) Device (1) according to one or more of the preceding claims, characterized by the fact that the collection of the treated material is carried out by means of a collection device (12) connected to said hydraulic connection (10).4) Device (1) according to one or more of the preceding claims, characterized by the fact that said collection device (12) connected to said hydraulic connection (10) makes with said device (1) a substantially hermetically closed system.5) Device (1) according to one or more of the preceding claims, characterized by the fact that said drawing baffle (6), or sieve, is positioned in the proximity of said port (2 A) of said cylindrical body (2), in a special seat formed on said bottom (8).6) Device (1) according to one or more of the preceding claims, characterized by the fact that it comprises an anti-rotational system of said pressure piston (5) made by means of a slider on said cylindrical body (2) and one or more pins locked together with the same pressure piston; said pin also serving as an indicator of the position of the stroke of the same pressure piston.7) Device (1) according to one or more of claims 1 to 5, characterized by the fact that it comprises an anti-rotational system of said pressure piston (5) made by means of a coupling of the “male-female” type and implemented in an axial cavity formed on said pressure piston (5) configured to engage a corresponding tab formed on the inner skirt of said cylindrical body (2) within which it slides.8) Device (1) according to one or more of the preceding claims, characterized by the fact that it is made, at least partly, of transparent, semitransparent and / or opaque material to enable the interior of said device (1) to be inspected in the operational configuration.9) Device (1) according to one or more of the preceding claims, characterized by the fact that said pressure piston (5) defines a thrust chamber (15) of the material to be treated towards said port (2A) and / or said drawing baffle (6) and by the fact that said device (1) comprises a single thrust chamber (15).10) Device (1) according to one or more of the preceding claims, characterized by the fact that said hydraulic connection (10) is made axially on said bottom (8).11) Device (1) according to one or more of the preceding claims, characterized by the fact that said bottom (8) comprises a fixed bottom wall (19) arranged, in the operational configuration, substantially facing said drawing baffle (6), or sieve, to receive the treated material.12) Device (1) according to one or more of the preceding claims, characterized by the fact that said hydraulic connection (10) is made on said bottom wall (19).13) Device (1) according to one or more of the preceding claims, characterized by the fact that said bottom wall (19) has a substantially sloping conformation and converging towards said hydraulic connection (10) to convey the treated material towards the latter.14) Device (1) according to one or more of the preceding claims, characterized by the fact that said hydraulic connection (10) is made at the center of said bottom (8).15) Device (1) according to one or more of the preceding claims, characterized by the fact that it comprises driving means (20) kinematically connected to said cutting device (7) and to said pressure piston (5), said driving means (20) beingadapted to move said cutting device (7) in rotation and said pressure piston (5) by sliding.16) Device (1) according to one or more of the preceding claims, characterized by the fact that said driving means (20) defines a bearing base (21) arranged, in use, resting on a stable surface.17) Device (1) according to one or more of the preceding claims, characterized by the fact that said driving means (20) comprise a revolving handwheel (22) provided with a plurality of spokes (23) defining said bearing base (21).18) Device (1) according to one or more of the preceding claims, characterized by the fact that said driving means (20) are arranged opposite said port (2A), so as to facilitate the access to the latter by means of a user with said bearing base (21) arranged resting on the stable surface.19) Device (1) according to one or more of the preceding claims, characterized by the fact that said drawing baffle (6) (sieve) is arranged within said device (1), dividing it into: a first chamber (13), on the side of the cylindrical body (2), of variable volume during operation and serving as a loading and containing zone for the material to be treated, and a second chamber (14), on the side of the bottom (8), of fixed volume and defining said interspace for the passage of the treated material.20) Device (1) according to one or more of the preceding claims, characterized by the fact that it lacks thrust means, other than said pressure piston (5), operating within said first chamber (13) and said second chamber (14) to push the material to be treated towards said port (2 A) and / or said drawing baffle (6).21) Device (1) according to one or more of the preceding claims, characterized by the fact that in said operational configuration said thrust chamber (15) coincides with said first chamber (13).22) Device (1) according to one or more of the preceding claims, characterized by the fact that said second chamber (14), in the operational configuration, extends between said drawing baffle (6) and said bottom wall (19).23) Device (1) according to one or more of the preceding claims, characterizedby the fact that it comprises a screw (4) driving the pressure piston (5) and / or the cutting device (7) and by the fact that: said cylindrical body (2) comprises a base portion (3) provided with a hole(17) and arranged opposite said end (2A) and a connecting portion (18) connecting said base portion (3) to said end (2A), said base portion (3) being made in a single body piece with said connecting portion (18); said screw (4) is inserted within said cylindrical body (2) through said hole (17).

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