Method for loading biological particles with a molecule of interest

The microfluidic and nanofluidic chip device addresses dead volumes and fragility issues by directly connecting nanochannels to microchannels, ensuring efficient and reliable cargo loading suitable for GMP applications.

EP4759411A1Pending Publication Date: 2026-06-17XOMEXBIO
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Patent Information

Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
XOMEXBIO
Filing Date
2024-12-16
Publication Date
2026-06-17

AI Technical Summary

Technical Problem

Existing microfluidic and nanofluidic chips for cargo loading of biological particles suffer from significant dead volumes, clogging issues, fragility, and scalability limitations, making them unsuitable for pharmaceutical and good manufacturing practices (GMP) applications.

Method used

A microfluidic and nanofluidic chip device with a design featuring directly connected nanochannels to microchannels and reinforced fluid outlet chambers, reducing dead volumes and enhancing structural integrity, allowing efficient and reliable cargo loading of biological particles with minimal waste and breakage.

Benefits of technology

The device achieves high cargo-loading efficiency with minimal dead volumes, reduced clogging, and increased robustness, enabling scalable and cost-effective production compatible with GMP standards.

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Abstract

A method for loading biological particles with a molecule of interest comprising selecting a microfluidic and nanofluidic chip device (1), mixing the biological particles with a solution comprising the molecule of interest, applying the mixed biological particles solution to a fluid inlet (2.1) of the chip device (1), applying a pressure to the chip device (1) forcing the mixed biological particles solution to pass through a inlet microchannel (4.1), then to a nanochannel (4.3) so that pressure on the biological particle cause the molecule of interest to enter the said biological particle and, then through an outlet microchannel (4.2), recovering the said loaded biological particles
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