MISTING SYSTEM

Abstract

NEBULIZATION SYSTEM The invention relates to a nebulization system comprising a reservoir, a two-fluid nebulization nozzle, a distributor mounted on the reservoir, and a humid gas source capable of injecting a controlled humidity gas into the reservoir. Abstract figure: Fig. 1

Description

Title of the invention: NEBULIZATION SYSTEM FIELD OF INVENTION

[0001] The present invention relates to a nebulization system and its use for generating a time-stable aerosol that exhibits a high concentration, a wide range of droplet sizes and employing liquids over a wide range of viscosities. STATE OF THE ART

[0002] A liquid aerosol is a biphasic mixture comprising droplets and a gas, which is most commonly air. Aerosol therapy consists of administering this aerosol into the respiratory tract (or airways) of a subject.

[0003] Studying the effect of inhaled aerosols on the respiratory tract requires monitoring and determining the amount of active ingredient deposited in the respiratory tract. This amount is calculated based, in particular, on the concentration of the active ingredient in the aerosol.

[0004] In this study context, regulations require stable concentration to produce an aerosol with an active ingredient concentration that varies by less than 20% (relative variation) in the exposure chambers. Since the exposure time during a study can be several hours, it is necessary to generate an aerosol with a concentration that remains stable over time.

[0005] However, known nebulization systems are not satisfactory.

[0006] Indeed, a first known system is pneumatic nebulization, which uses a source of compressed gas continuously injected into a nebulizing chamber (or nebulizer) containing the liquid to be nebulized. The liquid is then atomized, forming droplets suspended in the air of the nebulizing chamber. During nebulization, a recycling and evaporation process occurs within the nebulizer reservoir, resulting in an increase in the concentration of the active ingredient in the nebulizer liquid contained in the reservoir over time.

[0007] Indeed, the liquid to be nebulized is a solution comprising an active ingredient whose saturated vapor pressure is lower than that of the solvent (generally water) in which it is mixed. Thus, the atmosphere in the nebulization chamber formed by the injected gas will cause the solvent to evaporate more rapidly than the active ingredient. As a result, the concentration of the active ingredient in the liquid to be nebulized will increase as the solvent evaporates. The aerosol droplets have (at their creation) the same concentration of active ingredient as the liquid to be nebulized. Thus, the concentration of the active ingredient in the droplets will also increase during nebulization. In addition, during the transport of the droplets towards the outlet of the nebulizer, the phenomenon of evaporation continues to occur on them, which will further increase the concentration of active ingredient in the droplets until they are inhaled.

[0008] Furthermore, the geometric arrangement of certain types of pneumatic nebulizers, such as Pari (registered trademark) or Sidestream (registered trademark) nebulizers, which generate an aerosol flow towards the liquid in the reservoir, promotes droplet impaction within the liquid. A larger volume of liquid promotes greater droplet impaction compared to a smaller volume of liquid in the reservoir. Consequently, the flow rate and particle size increase over time as the liquid is nebulized (as the volume of liquid in the reservoir decreases). Therefore, these types of nebulizers do not generate a stable aerosol over time.

[0009] Another known system is a Blam system, which consists of delivering the liquid to be nebulized into the nebulizer by a pump with a continuous and constant flow rate. The gas, delivered at a constant flow rate, atomizes the injected liquid. A selection process then takes place on the droplets so that only the smallest droplets are transported out of the nebulizer for inhalation. The larger droplets are directed out of the nebulization chamber and are intended for disposal. This system avoids the recycling and evaporation of the liquid before nebulization. However, this system generates a very low concentration of liquid aerosol (0.001 mg / m³ - 0.01 g / m³ as droplet mass concentration) and produces a large amount of waste (typically more than 98% of the aerosol is eliminated).

[0010] Finally, some known systems use vibrating sieve technology. The liquid to be nebulized, in contact with the sieve, is then expelled through the sieve's orifices to mix with the gas. The droplet concentrations produced are higher than with the Blam system. However, this system has problems with sieve orifice clogging, which can impair its operation and therefore the droplet flow rate and consequently the concentration of the active ingredient over time. Furthermore, unlike pneumatic nebulizers, sieve nebulizers cannot nebulize solutions with high viscosity or small droplet sizes (less than 2 µm).

[0011] There is therefore a need for a nebulization system which makes it possible to avoid one or more of these problems by promoting the generation of an aerosol with a high and stable concentration of active ingredient over time, a wide range of droplet sizes and using liquids over a wide range of viscosities.

[0012] The object of the invention is to provide a nebulization system comprising a reservoir suitable for receiving a liquid to be nebulized, including a two-fluid nozzle as well as a source of humid gas injecting a controlled humidity gas into the tank. SUMMARY

[0013] To this end, the present invention relates to a nebulization system comprising:

[0014] a) A device comprising: • A reservoir comprising a gas nozzle defining a nebulization axis and comprising a first opening located inside the reservoir, the reservoir being suitable for receiving a liquid to be nebulized, • A nebulizing nozzle superimposed on the gas nozzle, comprising a second opening, • A dispenser mounted on the tank, the dispenser being aligned with the nebulization axis to convey the aerosol out of the tank, the nebulization nozzle and the gas nozzle forming a two-fluid nebulization nozzle comprising: • A gas channel inside the gas nozzle, • A liquid channel between the nebulizing nozzle and the gas nozzle, and • A nebulization zone at the intersection of the gas channel and the liquid channel, the outlet of the nebulization zone corresponding to the second opening, and b) A source of wet gas which supplies the gas channel so as to inject wet gas of controlled humidity into the reservoir, the injection of wet gas enabling the liquid to be drawn into the liquid channel to be nebulized.

[0015] Indeed, the geometry of the device and the injection of humid gas with controlled humidity allow the production of a highly concentrated aerosol (0.1-1 g / m³ droplet mass concentration) with a wide range of droplet sizes (50 nm-10 microns) and using liquids with a wide viscosity range (0.1-200 cP). Furthermore, this limits the evaporation of the liquid and droplets in the reservoir, thus preventing an increase in the concentration of the active ingredient in the aerosol over time.

[0016] According to another advantageous aspect, the invention has the following characteristics taken individually or in combination: - at least part of the distributor has an angle between 30° and 70° relative to the nebulization axis; - the two-fluid nebulizing nozzle includes a deflector located at the outlet of the nebulizing zone.

[0017] Indeed, both embodiments facilitate the selection of droplets based on their size. Furthermore, the use of the deflector allows for additional droplet fragmentation and therefore an increase in efficiency.

[0018] According to another advantageous aspect of the invention, the first opening has a The first size and the second aperture have a second size larger than the first size, the first aperture being aligned with the second aperture and the first and second apertures being perpendicular to the nebulization axis

[0019] Indeed, this size difference makes it possible to optimize the quantity of aerosol produced and the size of the droplets.

[0020] According to another advantageous aspect, the invention has the following characteristics taken individually or in combination: - the first size is between 0.1 mm and 1 mm and the second size is between 0.2 mm and 2 mm; - the nebulizing nozzle has an internal wall and the gas nozzle has an external wall, the internal wall being separated from the external wall by 0.2 mm to 2 mm; - the wet gas source includes a gas source and a humidification device connected to the gas source and the gas nozzle, the humidification device being configured to humidify a gas coming from the gas source; - the humidification device is a nebulizer; - the humidification device includes a heating plate; - the humidification device includes an outlet filter; - the humidification device is a bubbler.

[0021] Furthermore, the invention also relates to a method for generating an aerosol comprising the steps of: - Provide the nebulization system according to one of the above embodiments, - Introduce a liquid to be nebulized into the reservoir, - To supply, from the source of wet gas, wet gas with a constant pressure between 0.1 bar and 10 bar and a controlled relative humidity above 60%, - Inject the humid gas with controlled humidity into the tank via the gas channel. DEFINITIONS

[0022] In the present invention, the terms below are defined as follows: - "Two-fluid nebulizing nozzle" refers to an arrangement of two Nozzles that draw in the liquid to be nebulized using the Venturi effect. This effect is produced when two nozzles are superimposed, creating a gap between the inner wall of the outer nozzle and the outer wall of the inner nozzle. Thus, when the outer nozzle is partially immersed in a liquid and a gas is injected into the inner nozzle, a vacuum is created. in the gap allowing the liquid to be drawn in. - "Concentration of active ingredient" refers, for an aerosol, to the concentration of active ingredient - distributed in the droplets - at the time of inhalation, that is to say the quantity of active ingredient (in grams) contained in the air (in m3) at the time of inhalation. - "Droplet cluster concentration" refers, for an aerosol, to the mass of aerosol droplet (in grams) contained in the air (in m3). - "Large droplet" refers to a droplet with a diameter greater than greater than or equal to 5 sqm. - "Small droplet" refers to a droplet with a diameter greater than less than or equal to 5 sqm. BRIEF DESCRIPTION OF THE FIGURES

[0023] Other features and advantages of the present invention will become apparent from the description below, with reference to the accompanying drawings which illustrate non-limiting examples of embodiments. In the figures:

[0024] [Fig.1] shows a nebulization system according to an embodiment of the invention.

[0025] [Fig.2] shows the geometry of the nebulizing device according to a mode of implementation of the invention.

[0026] [Fig.3] schematically illustrates the operation of the system according to the invention.

[0027] [Fig.4] shows the nebulizing device comprising a deflector (137).

[0028] [Fig. 5] shows the nebulizing device in which the distributor (120) is inclined.

[0029] [Fig.6] shows the nebulization system in which the device humidification (210) is a nebulizer.

[0030] [Fig.7] compares the variation in the concentration of the active ingredient as a function of the nebulization duration with a prior art device and a device according to an embodiment of the invention.

[0031] [Fig.8] shows the efficiency of aerosol deposition in the respiratory tract. DETAILED DESCRIPTION

[0032] Fig. 1 shows a nebulization system comprising a device 100 and a source of wet gas 200.

[0033] Device 100 comprises: - A reservoir 111 including a gas nozzle 113, - A nebulizing nozzle 130 superimposed on the gas nozzle 113, and - A 120 distributor mounted on tank 111.

[0034] The reservoir 111 is suitable for receiving a liquid to be nebulized.

[0035] The liquid may include, for example, one or more active ingredients that will act on the respiratory tract or one or more substances or one or more markers that will be injected into the subject's respiratory tract as part of clinical trials or research. The active ingredient may be diluted in a solvent, preferably sterile physiological saline (0.9% NaCl).

[0036] The nozzles of the device (the gas nozzle 113 and the nebulizing nozzle 130) are conventional nozzles or pipes of preferably cylindrical shape having an inner wall, an outer wall and two ends.

[0037] One end of the gas nozzle 113 is located inside the reservoir. This end is partially closed and includes a first opening 113o. The gas nozzle 113 defines a nebulization axis Z that corresponds to the longitudinal axis of the nozzle. The gas nozzle 113 and the reservoir 111 are preferably formed as a single piece.

[0038] The nebulizing nozzle 130 located in the reservoir 111 is superimposed on the gas nozzle 113 in the sense that the nebulizing nozzle 130 surrounds, over part of its length, the gas nozzle 113. The gas nozzle 113 is preferably centered in the nebulizing nozzle 130.

[0039] The two ends of the nebulizing nozzle 130 are located inside the reservoir. One end of the nebulizing nozzle 130 includes a second opening 130°. The nebulizing nozzle 130 is superimposed on the gas nozzle 113 such that the two ends comprising the openings (113°, 130°) are juxtaposed.

[0040] In one embodiment, the first aperture 113° has a first size and the second aperture 130° has a second size preferably larger than the first size. These apertures are shown in detail in [Fig. 2]. The apertures can be of any shape. The size of an aperture then corresponds to its largest dimension. The apertures are preferably circular; the size then corresponds to the diameter. For example, the first size is between 0.1 mm and 1 mm while the second size is between 0.2 mm and 2 mm. Preferably, the first size is between 0.2 mm and 0.8 mm and the second size is between 0.3 mm and 1.6 mm. The first aperture 113° is aligned with the second aperture 130° and the two apertures are preferably aligned on the nebulization axis Z.The first opening 113° and the second opening 130° are preferably perpendicular to the nebulization axis Z.

[0041] The inner wall of the nebulizing nozzle 130 and the outer wall of the gas nozzle 113 are preferably separated from each other by 0.2 mm to 2 mm.

[0042] The nebulizing nozzle 130 and the gas nozzle 113 thus form a nebulizing nozzle two-fluid system as shown in [Fig.2] comprising: - a gas channel 132 (represented by dashed lines) inside the gas nozzle 113, - a liquid channel 134 (represented by solid lines) between the nebula nozzle lisation 130 and the gas nozzle 113, and - a nebulization zone 131 (represented by dotted lines) at the intersection of the gas channel 132 and the liquid channel 134.

[0043] The nebulizing nozzle 130 is arranged so that a gap is present between the end not including the opening 130o and the internal surface of the reservoir 111 to allow the liquid to enter the liquid channel 130.

[0044] The two-fluid nebulizing nozzle, when the system is in use, creates a Venturi effect, the operation of which will be described later. The liquid is drawn through the liquid channel 134 to the nebulization zone 131, as shown by arrows 460 in [Fig. 3]. The liquid is then fragmented into droplets by the gas flow injected into the gas channel 132. The liquid is said to be atomized or nebulized to form the aerosol. The droplets exit the nebulization zone 131 through the second opening 130o. The device described above makes it possible to create droplets with a size ranging from 10 nm to 100 µm. Thus, the range of droplet sizes spans four orders of magnitude. This range can be regulated, among other things, by the gas flow rate.

[0045] The distributor 120 is aligned with the nebulization axis Z to convey the aerosol out of the reservoir. For example, the cross-section of the distributor 120 is larger than the cross-section of the gas nozzle 113.

[0046] The dimensions of the reservoir 111 are configured so that the smallest droplets are conveyed out of the reservoir 111 by the dispenser 120, while the larger droplets, which therefore possess greater kinetic energy, impact the walls of the dispenser 120 and then fall back into the reservoir 111. This reduces the amount of waste because the larger droplets will be reused. Consequently, this sizing allows for the distribution of all droplets whose size is less than a limit determined by said sizing. Thus, this makes it possible to select droplets according to their size in order to better adjust the mass concentration of the distributed aerosol droplets and / or to better control the transport of droplets without evaporation to the subject.

[0047] In order to refine the selection of droplet sizes to be distributed and to increase the efficiency of the nebulization, the two-fluid nebulization nozzle may include a deflector 137 located at the outlet of the nebulization zone 131 as shown in [Fig. 4]. The deflector 137 advantageously has a dual role: first, it allows for further fragmentation of the droplets, thereby increasing the number of droplets of the appropriate size to exit Reservoir 111. Secondly, it allows for finer selection of droplet size. Indeed, the deflector also deflects the droplet trajectory towards the edges (lateral surface) of reservoir 111. Thus, droplets with high kinetic energy will impact the surface of reservoir 111. These droplets will then accumulate on the surface of reservoir 111 and return to reservoir 111, just like the larger droplets. Therefore, deflector 137 allows for the distribution of finer droplets and guides them along their trajectory towards the outside of the reservoir.

[0048] To further refine the selection of droplet sizes to be distributed, at least a portion of the distributor 120 can have an angle A between 30° and 70°, preferably between 45° and 60°, with respect to the nebulization axis Z as shown in [Fig. 5]. Thus, droplets with high kinetic energy will impact the surface of the distributor 120. These droplets will then accumulate on the surface of the distributor 120 and return to the reservoir 111, just like the larger droplets. Therefore, the angle A of the distributor 120 advantageously allows the distribution of only droplets whose size falls within a certain range, enabling them to follow the trajectory of the distributor 120's curvature. This embodiment can be combined with the presence of a deflector 137.

[0049] According to the invention, the humid gas source 200 supplies the gas channel 132 so as to inject a humid gas 440 with controlled humidity into the reservoir 111. Controlling the humidity of the injected gas advantageously allows the generation of an aerosol with a stable concentration of active ingredient over time. Indeed, the injection of humid gas saturates (or tends towards saturation of) the atmosphere of the reservoir with humidity. Thus, the evaporation of the solvent contained in the liquid to be nebulized or in the droplets is slowed down or even stopped. Consequently, the concentration of active ingredient in the aerosol becomes stable. This therefore advantageously allows the production of an aerosol with a high concentration of active ingredient (0.1-1 g / m3) exhibiting a wide range of droplet sizes (10 nm-10 microns) and using liquids over a wide viscosity range (up to 200 cP).Compared to known systems where the concentration can reach 0.01 g / m3, the system according to the invention allows the concentration to be increased by at least a factor of 10. The droplet size does not appear to depend on the relative humidity of the wet gas.

[0050] The wet gas source 200 may include a gas source 220 and a humidification device 210 connected to the gas source 220 and to the gas nozzle 113 as shown in [Fig.3].

[0051] The gas source 220 distributes a gas 420 to the humidification device 210. The gas can, for example, be a dry gas. The gas is preferably air. The source The gas source 220 can, for example, be a pressurized gas cylinder or a compressor.

[0052] The humidification device 210 is configured to humidify the gas from the gas source 220. The humidified gas 440 thus has controlled humidity. The humid gas 440 is then routed to the gas channel 132 via a pipe 217 connected to the gas nozzle 113 in order to create the aerosol droplets having the advantageous characteristics described above.

[0053] The humidification device 210 can, for example, be a nebulizer as shown in [Fig. 6]. The gas from the gas source 220 is conveyed to the inlet of the nebulizer 210 via a pipe 215. The liquid contained in the nebulizer of the humidification device 210 is preferably water.

[0054] Alternatively, the humidification device 210 can be a bubbler in order to humidify the gas by micro-bubbling.

[0055] The humidification device 210 may further include a heating plate.

[0056] The humidification device 210 may further include an outlet filter, A perfect absolute filter, such as a fiberglass filter, is preferred, retaining, for example, 99.95% of particles larger than 0.3 µm in diameter. The filter has low resistance and can be changed when saturated with water droplets. The filter is positioned between the humidification unit 210 and the gas nozzle 113. By definition, the filter blocks water particles (or other humidification liquid) and allows only water vapor to pass through.

[0057] The humidification device 210 can also be integrated into the gas source 220 as is the case in a medical compressor.

[0058] The nebulizer may also include a supplementary system for supplying the liquid to be nebulized via a drip system or syringe pump. In this case, the liquid is supplied to the nebulizer reservoir by means of a thin tube passing through the distributor 120. The use of a syringe pump with a flow rate equivalent to the nebulization flow rate thus makes it possible to avoid a large size for the nebulizer reservoir 111 and to operate it indefinitely.

[0059] The invention also relates to a use of the system described above to generate an aerosol.

[0060] The first step in the process of generating an aerosol is to introduce a liquid to be nebulized into the reservoir 111. The reservoir 111 is preferably filled until the surface of the liquid to be nebulized is above the end of the nebulizing nozzle 130 not including the opening 130o.

[0061] The second step consists of supplying, from the wet gas source 200, a wet gas with a constant pressure between 0.1 bar and 10 bar, preferably between 0.5 bar and 5 bar and a controlled relative humidity greater than 60%, preferably above 70%.

[0062] This humid gas with controlled humidity is then injected into reservoir 111 via gas channel 132. The injection is preferably carried out continuously, i.e., at a constant flow rate. Indeed, continuous injection makes it possible to generate a continuous mass concentration of droplets in the atmosphere of the nebulization chamber. Combined with the constant concentration of active ingredient in the droplets thanks to the injection of humid gas with controlled humidity, this further stabilizes the concentration of active ingredient inhaled by the user.

[0063] During operation, the reservoir 111 is preferably held so that the nebulization axis Z is substantially vertical and the distributor 120 is positioned above the two-fluid nebulization nozzle. Thus, when a gas flow is injected into the gas channel 132 towards the interior of the reservoir 111, a vacuum is created by the Venturi effect in the liquid channel 134. The liquid to be nebulized is then drawn through the liquid channel 134, as shown by the arrows 460 in [Fig. 3], to the nebulization zone 131 where the liquid is atomized by the moist gas 440. EXAMPLES

[0064] Experimental tests measuring the effectiveness of the system according to the invention were carried out.

[0065] Example 1: Stability of the concentration of the active ingredient over time

[0066] In this example, the concentration of active ingredient generated with a system according to The invention and a known system are compared. The liquid to be nebulized is a solution of water and fluorescein having a viscosity of 1 cP.

[0067] The system according to the invention comprises a deflector 137. The first opening 113° has a diameter of 0.7 mm while the second opening 130° has a diameter of 1.3 mm.

[0068] The humidification device is a nebulizer comprising a filter at its outlet. The humid gas is air humidified with water. The relative humidity of the humid gas injected into the gas channel is fixed at 72% ± 2%.

[0069] The known system comprises the same nebulizing device as the system according to the invention. The liquid to be nebulized is atomized by a stream of unhumidified gas. The relative humidity of the gas injected into this nebulizer is 12% ±1%.

[0070] The concentration of the active ingredient (fluorescein) dispensed is measured for both systems. The variation in concentration (y-axis) is shown in [Fig. 7] as a function of the nebulization time in minutes (x-axis). The concentration measured for the known system is represented by the dashed line, while the concentration for the system according to the invention is shown by the solid line.

[0071] The concentration of the active ingredient using the system according to the invention exhibits a low variation compared to the concentration generated by the known system, which increases within the first few minutes of use. Furthermore, the variation in the concentration of the active ingredient generated by the system according to the invention remains below the regulatory relative concentration variation of 20% for aerosol testing studies.

[0072] Example 2: Aerosol deposition efficiency in the respiratory tract

[0073] In this example, the aerosol deposition efficiency (nebulization yield) in the respiratory tract using a system according to the invention is measured. The liquid to be nebulized is a radioactive solution.

[0074] The system of the invention used is the same as in Example 1.

[0075] The system is used on a model for 10 minutes. At the end of the nebulization session, the efficiency of aerosol deposition in the model's respiratory tract is measured by scintigraphic imaging.

[0076] Figure 8 shows satisfactory deposition in the respiratory tract. Thus, this shows that the aerosol is effectively delivered into the respiratory tract. DIGITAL REFERENCES

[0077] 100 - Nebulizing device / / 111- Reservoir / / 113- Gas nozzle / / 113o - First opening / / 120 - Distributor / / 130 - Nebulizing nozzle / / 130 - Second opening / / 131 - Nebulizing zone / / 132 - Gas channel / / 134 - Liquid channel / / 137 - Deflector 200 - Humid gas source / / 210 - Humidification device 215 - Hose 217 - Hose 220 - Gas source 420 - Gas flow 440 - Humidity-controlled humid gas flow 460 - Liquid intake by Venturi effect A - Distributor angle Z - Nebulizing axis

Claims

1.

2.

3.

4. Demands A nebulization system comprising: a) A device (100) comprising: • A reservoir (111) comprising a gas nozzle (113) defining a nebulization axis (Z) and comprising a first opening (113o) located inside the reservoir (111), the reservoir (111) being suitable for receiving a liquid to be nebulized, • A nebulizing nozzle (130) superimposed on the gas nozzle (113) comprising a second opening (130o), • A dispenser (120) mounted on the reservoir (111), the dispenser (120) being aligned with the nebulization axis (Z) to convey the aerosol out of the reservoir, the nebulizing nozzle (130) and the gas nozzle (113) forming a two-fluid nebulizing nozzle comprising: • A gas channel (132) inside the gas nozzle (113), • A liquid channel (134) between the nebulizing nozzle (130) and the gas nozzle (113), and • A nebulization zone (131) at the intersection of the gas channel (132) and the liquid channel (134), the outlet of the nebulization zone corresponding to the second opening (130o), and b) A source of wet gas (200) which supplies the gas channel (132) so as to inject a wet gas (440) of controlled humidity into the reservoir (111), the injection of wet gas (440) allowing the liquid to be drawn into the liquid channel (134). The nebulization system according to claim 1 in which at least a part of the distributor (120) has an angle (A) between 30° and 70° with respect to the nebulization axis (Z). The nebulizing system according to any one of claims 1 to 2 in which the two-fluid nebulizing nozzle includes a deflector (137) located at the outlet of the nebulizing zone (131). The nebulization system according to any one of claims 1 to 3, wherein the first aperture (113°) has a first size and the second aperture (130°) has a second larger size at the first size, the first opening (113o) being aligned with the second opening (130o) and the first opening (113o) and the second opening (130o) being perpendicular to the nebulization axis (Z).

5. The nebulization system according to claim 4 wherein the first size is between 0.1 mm and 1 mm and the second size is between 0.2 mm and 2 mm.

6. The nebulizing system according to any one of claims 1 to 5 wherein the nebulizing nozzle (130) has an inner wall and the gas nozzle (113) has an outer wall, the inner wall being separated from the outer wall by 0.2 mm to 2 mm.

7. The nebulizing system according to any one of claims 1 to 6 wherein the wet gas source (200) comprises a gas source (220) and a humidification device (210) connected to the gas source (220) and the gas nozzle (113), the humidification device (210) being configured to humidify a gas from the gas source (220).

8. The nebulizing system according to claim 7 wherein the humidification device (210) is a nebulizer.

9. The nebulizing system according to claim 7 or 8 wherein the humidification device (210) includes an outlet filter.

10. Method of generating an aerosol comprising the steps of: - Providing the nebulizing system according to any one of claims 1 to 9, - Introducing a liquid to be nebulized into the reservoir (111), - Providing, from the wet gas source (200), a wet gas with a constant pressure between 0.1 bar and 10 bar and a controlled relative humidity greater than 60%, - Injecting the wet gas of controlled humidity into the reservoir (111) via the gas channel (132).

Images