Oil-in-water emulsion comprising a semiochemical composition, suitable for administration as a mist

Abstract

The invention relates to the field of semiochemical products and describes, in particular, a composition in the form of an oil-in-water emulsion comprising an aqueous phase and an oily phase comprising a semiochemical composition, particularly suitable for administration as a mist, as well as a method for its preparation. The invention also relates to the non-therapeutic use of the composition according to the invention for administration, particularly by spraying with a mist sprayer, onto the skin of an animal or a human, or onto the skin of farm animals treated in groups, or onto an element of the environment such as textiles and / or objects and / or walls, or by spraying into the air, particularly near the nose of an animal or a human.

Description

Title of the invention: Oil-in-water emulsion comprising a semiochemical composition, suitable for administration in the form of a mist Technical field of the invention

[0001] The invention relates to the field of semiochemical products and describes, in particular, a composition in the form of an oil-in-water emulsion comprising an aqueous phase and an oily phase comprising a semiochemical composition, particularly suitable for administration in the form of a mist, as well as a method for its preparation. The invention also relates to the non-therapeutic use of the composition according to the invention for administration, in particular by spraying with a mist sprayer, onto the skin of an animal or a human, or onto the skin of farm animals treated in groups, or onto an element of the environment such as textiles and / or objects and / or walls, or by spraying into the air, particularly near the nose of an animal or a human. Prior art

[0002] The semiochemicals according to the invention correspond to mixtures of several chemical compounds, first described in particular by Silverstein, RM (1977). Semiochemicals are chemical substances emitted by a plant or animal that elicit a non-therapeutic behavioral or physiological response in another organism. When the semiochemical affects an individual of the same species (an "intraspecific" semiochemical), it is called a pheromone (Wyatt TD, 2003). There are several types of pheromones that enable different types of behavioral interactions or communication, for example, calming pheromones, sex pheromones, territorial marking pheromones, and alarm pheromones. When the semiochemical affects an individual of a different species (an "interspecific semiochemical"), it is called an allelochemical.Among allelochemical substances, an allomone is an allelochemical substance that triggers a reaction in the target species, this reaction being favorable to the species that releases the allomone (the opposite is a kairomone).

[0003] Since 1995, products whose active ingredients are semiochemical agents have been placed on the market. Some of their uses require application of the product to the animal's skin, for example, to achieve the desired effects on an animal in an open environment or to protect it against pests such as parasites or biting insects, or on human skin. The physicochemical constraints of semiochemical components, particularly their volatility and insolubility in water, have led to the use of excipients such as ethoxydiglycol in commercially available products. The use of this type of excipient is now increasingly restricted by current regulations, as well as by the general public, who tend to reject them due to their synthesis methods and their potential direct and environmental toxicity. It has therefore become necessary to develop aqueous formulations of semiochemical compounds. Presentation of the invention

[0004] The invention aims to develop a composition based on semiochemical products (also referred to as compounds, active ingredients or agents) in a new galenic form, preferably non-toxic and environmentally friendly, in particular in the form of an oil-in-water (O / W) emulsion, preferably in the form of a stable and homogeneous oil-in-water (O / W) emulsion, for administration, in particular by spraying with a mist sprayer, onto the skin of an animal, in particular a mammal, or a human, or onto the skin of farm animals treated in groups, or onto an element of the environment such as textiles and / or objects and / or walls, or by spraying into the air, in particular near the nose of an animal or a human, in particular to reduce and / or avoid obtaining a wetting effect or staining; or to reach the vomeronasal and olfactory mucosa more quickly.Another objective of the invention is to develop a composition based on semiochemical products that is positively evaluated in acceptability tests by the target animals. Summary of the invention

[0005] The invention is defined by the independent claims. The dependent claims define particular or preferred embodiments of the invention.

[0006] According to a first aspect, the invention relates to a composition in the form of an oil-in-water (O / W) emulsion (referred to as the O / W composition or composition according to the invention), particularly suitable for the release of semiochemical compounds, comprising: a) an aqueous phase comprising water and at least one humectant selected from polyols and sugars, b) an oily phase comprising at least one emollient agent, at least one emulsifying agent, and a semiochemical composition, in which said semiochemical composition comprises: - methyl oleate and methyl palmitate, preferably methyl linoleate, methyl oleate and methyl palmitate; or - of 3-cyclopentylpropionic acid and 3-cyclohexylpropionic acid; or - bis(ethyl-2 hexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate.

[0007] According to a second aspect, the invention relates to a method for preparing a composition in the form of an oil-in-water (O / W) emulsion according to the invention, comprising the following steps: a) at least one gelling agent is mashed in at least one humectant; then water is added under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous aqueous phase; b) said at least one emollient agent, said at least one emulsifying agent, said semiochemical composition and optionally said at least one additive are mixed together under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous oily phase; c) the oily phase from step b) is added under agitation to the aqueous phase from step a) so as to obtain an oil-in-water (O / W) emulsion; d) optionally, the pH of the emulsion obtained in step c) is adjusted; e) optionally a fragrance is added; f) the composition is recovered in the form of an oil-in-water (O / W) emulsion obtained in step c), d) or e).

[0008] According to a third aspect, the invention relates to the non-therapeutic use of a composition according to the invention for administration, in particular by spraying using a mist sprayer, on the skin of an animal or a human, or on the skin of farm animals treated in groups, or on an element of the environment such as textiles and / or objects and / or walls, or by spraying into the air, in particular near the nose of an animal or a human. Detailed description of the invention

[0009] The invention is now described in more detail and without limitation in the following description. Unless otherwise stated, all percentages relating to quantities are mass percentages. Any reference to ranges of values ​​in the description and / or the claims implies, unless otherwise stated, that the bounds of the ranges are inclusive.

[0010] The invention relates to a composition in the form of an oil-in-water (O / W) emulsion comprising: a) an aqueous phase comprising water and at least one humectant selected from polyols and sugars, b) an oily phase comprising at least one emollient agent, at least one emulsifying agent, and a semiochemical composition, in which said semiochemical composition comprises: - methyl oleate and methyl palmitate, preferably methyl linoleate, methyl oleate and methyl palmitate; or - of 3-cyclopentylpropionic acid and 3-cyclohexylpropionic acid; or - bis(ethyl-2-hexyl) adipate and diisobutyrate l-isopropyl-2,2-dimethyltrimethylene.

[0011] In a particular embodiment of the invention, said semiochemical composition comprises: - methyl oleate, methyl linoleate, methyl behenate, methyl palmitate, methyl myristate, and methyl laurate; or - methyl linoleate, methyl oleate, methyl palmitate, methyl myristate, methyl laurate, and methyl decanoate; or - methyl linoleate, methyl oleate, methyl palmitate, methyl stearate, methyl myristate, methyl pentadecanoate, and methyl laurate; or - methyl linoleate, methyl oleate, methyl palmitate, 2-(2-butoxyethoxy)ethanol, dimethyl glutarate, dimethyl adipate, dimethyl succinate, and dodecane; or - methyl oleate, methyl palmitate, methyl linoleate, methyl stearate, methyl myristate, and methyl pentadecanoate; or - methyl oleate, methyl linoleate, methyl palmitate, squalene, methyl myristate, and methyl pentadecanoate; or - methyl oleate, methyl palmitate, dimethyl pimelate, and dimethyl azelate; or - methyl laurate, methyl myristate, methyl palmitate, methyl stearate, methyl oleate, methyl linoleate, dimethyl pimelate, and dimethyl azelate; or - of 3-cyclopentylpropionic acid and 3-cyclohexylpropionic acid; or - bis(ethyl-2-hexyl) adipate and diisobutyrate l-Isopropyl-2,2-dimethyltrimethylene; or - methyl oleate, methyl palmitate, methyl linoleate, dioxolane, methyl laurate and methyl myristate.

[0012] In a preferred embodiment of the invention, said semiochemical composition comprises: - 25% to 35% methyl oleate, 20% to 25% methyl linoleate, 20% to 25% methyl behenate, 20% to 25% methyl palmitate, 3% to 6% methyl myristate and 2% to 4% methyl laurate; or - 30% to 40% methyl linoleate, 25% to 35% methyl oleate, 15% with 25% methyl palmitate, 5% to 9% methyl myristate, 5% to 7% methyl laurate and 1% to 3% methyl decanoate; or - 25% to 35% methyl linoleate, 25% to 35% methyl oleate, 15% to 25% methyl palmitate, 10% to 15% methyl stearate, 2% to 7% methyl myristate, 2% to 6% methyl pentadecanoate and 1% to 3% methyl laurate; or - 30% to 40% methyl linoleate, 25% to 35% methyl oleate, 15% to 25% methyl palmitate, 5% to 15% 2-(2-butoxyethoxy)ethanol, 2% to 6% dimethyl glutarate, 1% to 3% dimethyl adipate, 1% to 3% dimethyl succinate, and 1% to 3% dodecane; or - 25% to 35% methyl oleate, 25% to 35% methyl palmitate, 25% to 35% methyl linoleate, 3% to 7% methyl stearate, 3% to 5% methyl myristate and 0.5% to 2% methyl pentadecanoate; or - 30% to 40% methyl oleate, 20% to 26% methyl linoleate, 20% to 26% methyl palmitate, 6% to 10% squalene, 2% to 6% methyl myristate and 3% to 5% methyl pentadecanoate; or - 62% to 70% methyl oleate, 12% to 16% methyl palmitate, 7% to 13% dimethyl pimelate and 6% to 11% dimethyl azelate; or - 2% to 6% methyl laurate, 2% to 6% methyl myristate, 11% to 15% methyl palmitate, 2% to 6% methyl stearate, 42% to 50% methyl oleate, 4% to 8% methyl linoleate, 7% to 13% dimethyl pimelate and 6% to 11% dimethyl azelate; or - 40% to 60% 3-cyclopentylpropionic acid and 40% to 60% 3-cyclohexylpropionic acid; or - 40% to 60% bis(ethyl-2 hexyl) adipate and 40% to 60% l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, - 35% to 45% by weight of methyl oleate, 20% to 30% by weight of methyl palmitate, 20% to 30% by weight of methyl linoleate, 2% to 7% by weight of dioxolane, 1% to 5% by weight of methyl laurate and 1% to 4% by weight of methyl myristate; the total sum of the compounds present in said semiochemical composition being equal to 100%. Pharmaceutical form and method of administration

[0013] The composition according to the invention is in the form of an oil-in-water (O / W) emulsion, in particular an oil-in-water emulsion which is stable and has a homogeneous appearance, particularly to the naked eye.

[0014] In the context of the invention, the term "emulsion" refers to a mixture of two immiscible liquid substances, such as oil and water. In an emulsion In oil-in-water (O / W), the oil is dispersed in the water in the form of droplets, including small droplets.

[0015] In the context of the invention, the term "stable emulsion" refers to an emulsion that does not show any signs of instability (phase separation, increase in droplet size, ...), in particular an emulsion that does not release water or oil and that remains in its initial form over time and under different temperature conditions, for example during 3 months of storage at a temperature between 5°C and 40°C.

[0016] In the context of the invention, the term "homogeneous emulsion" refers to an emulsion whose surface is smooth and uniform to the naked eye.

[0017] In particular, the composition can be administered using a spraying device, in particular using a mist sprayer, in the form of a fluid, opalescent, transparent or translucent mixture, in particular in the form of a mist.

[0018] In the context of the invention, the term "mist" refers to an aqueous dispersion in droplets comparable to a cloud of droplets or light fog.

[0019] In the context of the invention, the term "fluid mixture" refers to a mixture of low viscosity, having the ability to flow under its own weight, unlike a solid composition.

[0020] In the context of the invention, the term "opalescent" refers to a milky, iridescent color, a reflection reminiscent of opal.

[0021] In the context of the invention, the term "transparent" means that the mixture allows light to pass through and allows objects behind it to be seen clearly.

[0022] In the context of the invention, the term "translucent" means that the mixture allows light to pass through but does not allow objects behind it to appear clearly, these objects remaining blurred.

[0023] The H / W composition according to the invention can be applied to small and / or large body areas (for example, the skin of an animal or human skin) and / or material areas (for example, on an element of the environment such as clothing and / or objects and / or walls).

[0024] Preferably, the H / W composition according to the invention is administered in the form of a mist using a misting device.

[0025] Non-limiting examples of misting systems are well known to those skilled in the art.

[0026] Preferably, the mist, in particular the droplets of this mist, is opaque lescent, transparent or translucent, preferably transparent. Aqueous phase

[0027] The composition according to the invention comprises an aqueous phase, in particular a continuous aqueous phase (also called the external phase).

[0028] The aqueous phase of the composition according to the invention comprises water, Preference for demineralized or purified water, and possibly one or more water-miscible or at least partially water-miscible compounds, for example a skin conditioning agent such as ALOE VERA, a hydrosol, urea, an antistatic agent.

[0029] In the context of the invention, the term "skin conditioning agent" refers to an agent that helps to maintain the skin in good condition, e.g., healthy in appearance.

[0030] In the context of the invention, the term "antistatic agent" refers to an agent that reduces static electricity by neutralizing the electric charge on a surface.

[0031] In a particular embodiment of the invention, the composition according to the invention comprises from 60% to 95% by weight of water, preferably from 77% to 87% by weight of water, relative to the total weight of the composition.

[0032] In a preferred embodiment of the invention, the composition according to the invention comprises from 62% to 91% by weight of water, preferably from 77% to 87% by weight of water, even more preferably 82.5% or 83.9% or 85.7% by weight of water, relative to the total weight of the composition.

[0033] The aqueous phase of the composition according to the invention may comprise water and at least one humectant selected from polyols and sugars. Humectant

[0034] According to a particular embodiment, the aqueous phase of the composition according to the invention further comprises at least one humectant selected from polyols and sugars. In particular, the aqueous phase of the composition according to the invention further comprises a single humectant selected from polyols or sugars, preferably polyols. Said at least one humectant is notably soluble in the aqueous phase.

[0035] In the context of the invention, the term "humectant" (also called a moisturizing agent) refers to a compound or mixture of compounds that retains water thanks to their hygroscopic power.

[0036] In the context of the invention, the term "polyol" refers to any organic compound comprising at least two free hydroxyl (-OH) groups such as glycols.

[0037] In the context of the invention, the term "sugar" refers to simple carbohydrates, in particular any organic molecule consisting of one monosaccharide or two monosaccharides.

[0038] In a particular embodiment of the invention, said at least one humectant is chosen from among the polyols selected from the group consisting of glycerol (also called glycerin), propylene glycol, polyethylene glycols (PEG), xylitol, isomalt, maltitol, mannitol, polydextrose, sorbitol, isomaltitol, lactitol, and mixtures thereof; and / or said at least one humectant is chosen from among the sugars selected from the group consisting of fructose, glucose, lactose, and their mixtures.

[0039] In a preferred embodiment of the invention, said at least one humectant is a polyol, in particular glycerol.

[0040] Said at least one humectant, i.e., one or more humectant(s), preferably one humectant, may be present in the composition in a content ranging from 4% to 12% or 4.5% to 12% by weight, preferably from 4% to 6% by weight, relative to the total weight of the composition.

[0041] Preferably, said at least one humectant is glycerol and is present in the composition in a content ranging from 4.5% to 12% by weight, preferably 5% by weight, relative to the total weight of the composition.

[0042] In a particular embodiment of the invention, the aqueous phase of the composition comprises water in a content of 62% to 91% by weight, preferably 77% to 87% by weight, even more preferably 82.5% or 83.9% or 85.7% by weight, and glycerol in a content of 4.5% to 12% by weight, preferably 5% by weight, all the percentages being given in relation to the total weight of the composition. Oily phase

[0043] The composition according to the invention comprises an oily phase, in particular a dispersed oily phase (also called discontinuous or internal phase).

[0044] The oily phase of the composition according to the invention may comprise at least one emollient agent, at least one emulsifying agent, and a semiochemical composition. In particular, said at least one emollient agent, said at least one emulsifying agent, and said semiochemical composition are specifically soluble in the oily phase.

[0045] The oily phase may be present in a concentration ranging from 3% to 45% by weight, preferably from 10% to 25% by weight, relative to the total weight of the composition. Emollient agent

[0046] According to a particular embodiment, the oily phase of the composition according to the invention further comprises at least one emollient agent. In particular, the oily phase of the composition according to the invention further comprises a single emollient agent. Said at least one emollient agent is, in particular, soluble in the oily phase.

[0047] In the context of the invention, the term "emollient agent" refers to an agent that softens and smooths the skin when administered topically, in particular cutaneously, of the composition according to the invention.

[0048] In a particular embodiment of the invention, said at least one emollient agent is chosen from the group consisting of hydrogenated vegetable oils (vegetable oils containing triglycerides of unsaturated fatty acids, for example hydrogenated olive oil, hydrogenated rapeseed oil, hydrogenated sunflower oil, hydrogenated sesame oil, hydrogenated linseed oil, hydrogenated hemp oil, hydrogenated walnut oil, hydrogenated hazelnut oil, hydrogenated coconut oil, hydrogenated argan oil, hydrogenated jojoba oil, hydrogenated sweet almond oil, hydrogenated shea butter, hydrogenated castor oil, hydrogenated avocado oil, hydrogenated apricot kernel oil, hydrogenated macadamia oil, ...), silicone oils (for example dimethicone, ...), mineral oils and waxes (for example, paraffin, ...), fatty alcohols (for example, arachidic alcohol, batyl alcohol, behenyl alcohol, C12-C13 alcohols, cetearyl alcohol, cetyl alcohol, coconut alcohol, isocetyl alcohol, octyldodecanol, palm alcohol, ...), fatty acids and fatty acid esters (e.g., batyl stearate, cetearyl behenate, cetearyl isononanoate, cetyl esters, coco acid, ethyl linoleate, ethyl linolenate, ethyl olivate, ethylhexyl cocoate, ethylhexyl myristate, glyceryl caprylate, glyceryl laurate / oleate, glyceryl ricinoleate, isocetyl salicylate, isostearyl alcohol, linoleic acid, linolenic acid, oleic acid, palm kernel acid, palmitic acid, wheat germ acid, ...), glyceride derivatives (e.g., capric and caprylic acid triglycerides, cocoglycerides, palm glycerides, ...) and glycerol derivatives (e.g., glycerol trioctanoate: Tricaprylin, Glycerol tristearate (Tristearin...), preferably glyceride derivatives such as fatty acid triglycerides.

[0049] Said at least one emollient agent, i.e., one or more emollient agent(s), is / are present in a content ranging from 0.5% to 8% by weight, preferably from 1% to 3% by weight, relative to the total weight of the composition.

[0050] Preferably, said at least one emollient agent is a derivative of glycerides, in particular a fatty acid triglyceride, in particular a caprylic acid and capric acid triglyceride such as that marketed in particular by BASF under the name Myritol 318®, and is present in the composition in a content ranging from 0.5% to 8% by weight, preferably 2% by weight, relative to the total weight of the composition.

[0051] In a particular embodiment of the invention, the aqueous phase of the composition comprises water in a content of 62% to 91% by weight, preferably 77% to 87% by weight, even more preferably 82.5% or 83.9% or 85.7% by weight, and glycerol in a content of 4.5% to 12% by weight, preferably 5% by weight, and the oily phase of the composition comprises a caprylic acid and capric acid triglyceride such as Myritol 318® in a content of 0.5% to 8% by weight, preferably 2% by weight, all the percentages being given in relation to the total weight of the composition. Emulsifying agent

[0052] The oily phase of the composition according to the invention further comprises at least one emulsifying agent, preferably one or more emulsifying agents. Said at least one emulsifying agent is in particular soluble in the oily phase.

[0053] In the context of the invention, the term "emulsifying agent" (also called emulsifying agent) refers to a small molecule composed of a hydrophilic head soluble in the aqueous phase and a lipophilic tail having an affinity for the oily phase. Said at least one emulsifying agent enables the formation of an interfacial film around the droplets in the dispersed phase, thus forming the emulsion and providing stability to this emulsion.

[0054] Said at least one emulsifying agent may be chosen from non-ionic or ionic (anionic, cationic) surfactants, preferably non-ionic surfactants.

[0055] In the context of the invention, the term "surfactant" refers to a compound that reduces surface tension and promotes a uniform distribution of the composition according to the invention during its use.

[0056] In a particular embodiment of the invention, said at least one emulsifying agent is an ionic surfactant, preferably an anionic surfactant selected from sulfated castor oil, sodium dodecyl sulfate (SDS), sodium coco sulfate (INCI name: Sodium coco sulfate (SCS)), sodium cocoyl isethionate (INCI name: Sodium cocoyl isethionate (SCI)), sodium lauryl sulfoacetate (INCI name: Sodium lauryl sulfoacetate (SLSA)), sodium laureth sulfate (INCI name: Sodium laureth sulfate (SLES)) and sodium lauroyl sarcosinate (INCI name: Sodium Lauroyl Sarcosinate), or a cationic surfactant selected from cetearyl alcohol (INCI name: Cetearyl Alcohol), behentrimonium methosulfate (INCI name: Behentrimonium methosulfate), and sodium lauroyl sarcosinate (INCI name: Sodium Lauroyl Sarcosinate). INCI: Be-hentrimonium Methosulfate (BTMS), Brassica Alcohol (and) Brassicyl Valinate Esylate (INCI Name: Brassica Alcohol (and) Brassicyl Valinate Esylate), Benzalkonium Chlorides (BAC),Didecyldimethylammonium chloride (DDAC), brassicamidopropyl dimethylamine (INCI name: Brassicamidopropyl dimethylamine), polyquaternium-7, polyquaternium-10, polyquaternium-22 and polyquaternium-37.

[0057] In a preferred embodiment of the invention, said at least one emulsifying agent is a non-ionic surfactant, preferably a non-ionic surfactant having an HLB between 8 and 20 to 25°C, and is in particular selected from fatty acid and polyoxyethylene sorbitan esters, fatty acid esters of polyols or ethoxylated vegetable oils, preferably hydrogenated and ethoxylated.

[0058] Examples of fatty acid esters and polyoxyethylene sorbitan (also called ethoxylated sorbitan, sorbitan esters) include, in particular, C8 fatty acid esters -C24, preferably in Ci6-C22 and polyoxyethylene sorbitan which may contain from 1 to 150 oxyethylenated groups, such as polysorbate 20, notably marketed under the name Tween 20® by CRODA, polysorbate 21, notably marketed under the name Tween 21® by CRODA, polysorbate 40, notably marketed under the name Tween 40® by CRODA, polysorbate 60, notably marketed under the name Tween 60® by CRODA, polysorbate 61, notably marketed under the name Tween 61® by CRODA, polysorbate 65, notably marketed under the name Tween 65® by CRODA, polysorbate 80, notably marketed under the name Tween 80® by CRODA, polysorbate 81, notably marketed under the name Tween 81® by the CRODA and polysorbate 85, notably marketed under the name Tween 85® by the company CRODA,preferably polysorbate 80 or polysorbate 20.

[0059] Examples of fatty acid esters of polyols, in particular of polyglycerols, include in particular polyglyceryl-3 beeswax, polyglyceryl-6 distearate, polyglyceryl-4 caprate, or polyglyceryl-3 distearate, in particular marketed by BASF under the name Cremophor GS 32®, preferably Cremophor GS 32®.

[0060] Examples of ethoxylated vegetable oils, preferably hydrogenated and ethoxylated vegetable oils, include in particular ethoxylated and hydrogenated castor oil, in particular PEG-35 or PEG-40 hydrogenated castor oil, preferably PEG-40 hydrogenated castor oil, in particular marketed by BASF under the name Eumulgin CO 40®, preferably Eumulgin CO 40®.

[0061] In a particular embodiment of the invention, said at least one emulsifying agent, i.e., one or more emulsifying agent(s), is / are present in the composition in a content ranging from 1% to 25% by weight, preferably from 5% to 7% by weight, relative to the total weight of the composition.

[0062] In a preferred embodiment of the invention, the composition according to the invention comprises several emulsifying agents, in particular a mixture of emulsifying agents consisting of fatty acid esters and polyoxyethylene sorbitan, fatty acid esters of polyols, and ethoxylated vegetable oils, preferably hydrogenated and ethoxylated.

[0063] Preferably, said emulsifying agents are polyglyceryl-3 distearate, notably marketed by BASF under the name Cremophor GS 32®, PEG-40 hydrogenated castor oil, notably marketed by BASF under the name Eumulgin CO 40®, fatty acid esters and polyoxyethylene sorbitan such as polysorbate 80, notably marketed under the name Tween 80® by CRODA, or polysorbate 20, notably marketed by BASF under the name Tween 80®. marketed under the name Tween 20® by the company CRODA, and said emulsifying agents are present in the composition in a content ranging from 1% to 25% by weight, preferably from 5% to 7% by weight, even more preferably from 6% by weight, relative to the total weight of the composition.In particular, Cremophor GS 32® is present in the composition at a concentration of 0.6% to 8.5% by weight, preferably 2% by weight, relative to the total weight of the composition; and / or Eumulgin CO 40® is present in the composition at a concentration of 0.6% to 8.5% by weight, preferably 2% by weight, relative to the total weight of the composition; and / or polysorbate 80 is present in the composition at a concentration of 0.5% to 7.5% by weight, preferably 2% by weight, relative to the total weight of the composition; and / or polysorbate 20 is present in the composition at a concentration of 0.5% to 7.5% by weight, preferably 2% by weight, relative to the total weight of the composition.

[0064] In a particular embodiment of the invention, the aqueous phase of the composition comprises water in a content of 62% to 91% by weight, preferably 77% to 87% by weight, even more preferably 82.5%, 83.9%, or 85.7% by weight, and glycerol in a content of 4.5% to 12% by weight, preferably 5% by weight, and the oily phase of the composition comprises a caprylic acid and capric acid triglyceride such as Myritol 318® in a content of 0.5% to 8% by weight, preferably 2% by weight, as well as a mixture of emulsifying agents consisting of Cremophor GS 32® in a content of 0.6% to 8.5% by weight, preferably 2% by weight, and Eumulgin CO 40®. in a content ranging from 0.6% to 8.5% by weight, preferably 2% by weight, of polysorbate 80 or polysorbate 20 in a content ranging from 0.5% to 7.5% by weight, preferably 2% by weight, all percentages being given in relation to the total weight of the composition. semiochemical composition

[0065] The oily phase of the composition according to the invention further comprises a semiochemical composition as an active agent, as defined above. This semiochemical composition is, in particular, soluble in the oily phase described herein. Specific semiochemical compositions are described above and in the preferred embodiments and experimental examples that follow. The semiochemical compositions contained in the compositions according to the invention are intended, in particular, for non-therapeutic use, for example, use for their behavioral or protective effect against pests (parasites, insects, etc.) on the animals to which they are administered or on animals interacting with them, or for their beneficial effect on humans.

[0066] The semiochemical composition may be present in the composition in the form of an oil-in-water emulsion in a content ranging from 1% to 4% by weight, of preferably 1.5% to 2.5% by weight, more preferably 1.98% or 2% by weight of said semiochemical composition, relative to the total weight of the H / W composition according to the invention. Additives

[0067] The composition according to the invention may further comprise at least one additive provided that it does not interfere with the desired properties of the composition, in particular with its property of being an O / W emulsion.

[0068] In a particular embodiment of the invention, said at least one additive is chosen from the group consisting of a preservative agent, in particular an antimicrobial agent or an antioxidant agent, a perfume, a masking agent, and mixtures thereof.

[0069] In the context of the invention, the term "preservative agent" refers to an agent that protects the composition according to the invention from changes in its physical or chemical state, color, or odor, or that protects it from contamination or microbial degradation, for example, by inhibiting the growth of microorganisms during the storage or use of the composition according to the invention. Such an agent must be compatible with the use of the composition according to the invention in contact with an animal or a human, and is advantageously non-irritating to the skin and eyes.

[0070] Examples of preservatives are known to those skilled in the art and include, in particular, benzyl alcohol, didecyldimonium chloride, caprylyl glycol, phenylpropanol, sodium benzoate, phenyl acetate, sorbic acid, dehydroacetic acid, potassium sorbate, phenoxyethanol, cetrimonium bromide, triclosa, parabens, thiazolinones.

[0071] In the context of the invention, the term "antimicrobial agent" therefore refers to a preservative agent that slows down the growth of microorganisms (bacteria, fungi, yeasts, molds) and combats the development of microbes in the composition according to the invention, when stored and / or when used.

[0072] Examples of antimicrobial agents are known to those skilled in the art and include, in particular, Glycerin / phenyl alcohol / caprylhydroxamic acid, notably marketed under the name Aromastat® by the company INOLEX.

[0073] The composition according to the invention may comprise from 0% to 4% by weight, preferably from 0.2% to 3.2% by weight, even more preferably 1% by weight of preservative agent, in particular antimicrobial agent, relative to the total weight of the composition according to the invention.

[0074] In the context of the invention, the term "antioxidant agent" refers to a preservative agent capable of inhibiting reactions favored by oxygen, thus preventing oxidation.

[0075] Examples of antioxidant agents are known to those skilled in the art and include, in particular, compounds of the cinnamic acid family and their derivatives, such as pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, notably marketed under the name Tinogard TT® by BASF, vitamin A (retinol), vitamin C (ascorbic acid) and derivatives (ascobate), vitamin E (tocopherol) and derivatives (tocopheryl), preferably Tinogard TT®.

[0076] The composition according to the invention may comprise from 0% to 2% by weight, preferably from 0.02% to 0.3% by weight, even more preferably 0.1% by weight of antioxidant agent, relative to the total weight of the composition.

[0077] In the context of the invention, the term "perfume" or perfumer refers to any hydrophobic substance, designating a pure body or a mixture insoluble or very slightly soluble in water capable of giving off a pleasant odor.

[0078] The composition according to the invention may comprise from 0% to 3% by weight, preferably from 0.2% to 2.5% by weight, even more preferably 1% by weight of perfume, relative to the total weight of the composition.

[0079] In the context of the invention, the term "masking agent" refers to an agent that reduces or inhibits the basic odor or taste of the product.

[0080] Examples of masking agents are known to those skilled in the art and include, in particular, beta sitosterol, citric acid, bisabolol, calendula offi-cienalis flower extract.

[0081] The composition according to the invention may comprise from 0% to 3% by weight, preferably from 0.2% to 2.5% by weight, even more preferably 1% by weight of a masking agent, relative to the total weight of the composition.

[0082] In a particular embodiment according to the invention, said at least one additive is added to the oily phase, i.e., the oily phase further comprises at least one additive as defined above.

[0083] In another particular embodiment according to the invention, said at least one additive, for example a perfume, is added after the formation of the oil-in-water emulsion, or after a step of adjusting the pH of the oil-in-water emulsion.

[0084] In a preferred embodiment according to the invention, the oily phase further comprises at least one additive selected from the group consisting of a preservative, in particular an antimicrobial agent or an antioxidant agent, a perfume, a masking agent, and mixtures thereof, even more preferably at least one additive selected from the group consisting of a preservative, in particular an antimicrobial agent or an antioxidant agent, a masking agent, and mixtures thereof.

[0085] In another preferred embodiment of the invention, the composition according to the invention further comprises at least one additive such as a fragrance. This fragrance is added, in particular, after the formation of the oil-in-water emulsion or after a step adjusting the pH of the oil-in-water emulsion to prevent fragrance degradation or loss of fragrance scent.

[0086] In a preferred embodiment of the invention, the composition according to the invention comprises: a) an aqueous phase comprising water and glycerol, b) an oil phase comprising polyglyceryl-3 distearate (Cremophor GS 32®, notably marketed by BASF), PEG-40 hydrogenated castor oil (Eumulgin CO 40®, notably marketed by BASF), fatty acid esters and polyoxyethylene sorbitan (polysorbate 80, notably marketed under the name Tween 80® by CRODA, or polysorbate 20, notably marketed under the name Tween 20® by CRODA), caprylic and capric acid triglycerides (Myritol 318®, notably marketed by BASF), glycerin / phenyl alcohol / caprylhydroxydroxamic acid (Aromastat®, notably marketed by INOLEX), pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate (Tinogard TT®, notably marketed by BASF), optionally a fragrance, and a semio-chemical composition, the semiochemical composition being present in the composition in the form of an oil-in-water emulsion in a content ranging from 1% to 4% by weight, preferably from 1.5% to 2.5% by weight, relative to the total weight of the W / E composition according to the invention.

[0087] In an even more preferred embodiment of the invention, the composition according to the invention comprises: a) an aqueous phase comprising water in a content of 62% to 91% by weight, preferably 77% to 87% by weight, even more preferably 82.5% or 83.9% or 85.7% by weight, and glycerol in a content of 4.5% to 12% by weight, preferably 5% by weight, b) an oil phase comprising polyglyceryl-3 distearate (Cremophor GS 32®, notably marketed by BASF) in a content of 0.6% to 8.5% by weight, preferably 2% by weight, preferably x% by weight, PEG-40 hydrogenated castor oil (Eumulgin CO 40®, notably marketed by BASF) in a content of 0.6% to 8.5% by weight, preferably 2% by weight, fatty acid esters and polyoxyethylene sorbitan (polysorbate 80, notably marketed under the name Tween 80® by CRODA, or polysorbate 20, notably marketed under the name Tween 20® by CRODA) in a content of 0.5% to 7.5% by weight, preferably 2% by weight, caprylic acid triglycerides and capric acid triglycerides (Myritol 318®, notably marketed by BASF) in a content ranging from 0.5% to 8% by weight, of preferably 2% by weight, Glycerin / phenyl alcohol / caprylhydroxamic acid (Aromastat®, notably marketed by INOLEX) in a concentration ranging from 0.2% to 3.2% by weight, preferably 1% by weight, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate (Tinogard TT®, notably marketed by BASF) in a concentration ranging from 0.02% to 0.3% by weight, preferably 0.1% by weight, optionally a fragrance in a concentration ranging from 0.2% to 2.5% by weight, preferably 1% by weight, and a semiochemical composition, the semiochemical composition being present in the composition in the form of an oil-in-water emulsion in a concentration ranging from 1% to 4% by weight, preferably 1.5% to 2.5% by weight, the concentrations being expressed as a percentage of the total weight of the W / O composition according to the invention.

[0088] In a particular embodiment of the invention, the composition has a Brookfield viscosity of less than 8500 mPa.s, in particular a viscosity between 1 and 50 cP or mPa.s, or a viscosity between 3500 and 8000 cP or mPa.s, as measured at 25°C. The viscosity within the meaning of the present invention is a Brookfield viscosity measured at room temperature (25°C), preferably after 24 hours, using a viscometer, for example a Brookfield digital viscometer (model LDVI Prime), S 61 swivel and rotation speed 0.6 RPM.

[0089] In a particular embodiment of the invention, the composition in the form of an oil-in-water (O / W) emulsion has a pH between 5 and 8, preferably a pH between 5.5 and 7.5, or a pH between 6.0 and 7.5.

[0090] Preferably, the composition has a pH value compatible with topical application, in particular cutaneous application of the composition on the skin of an animal or human skin.

[0091] Method for preparing the composition according to the invention

[0092] The invention also relates to a first method for preparing a composition according to the invention, comprising the following steps: a) at least one gelling agent is mashed in at least one humectant; then water is added under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous aqueous phase; b) said at least one emollient agent, said at least one emulsifying agent, said semiochemical composition and optionally said at least one additive are mixed together under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous oily phase; c) the oily phase from step b) is added under agitation to the aqueous phase from step a) so as to obtain an oil-in-water (O / W) emulsion; d) optionally, the pH of the emulsion obtained in step c) is adjusted; e) optionally a fragrance is added; f) the composition is recovered in the form of an oil-in-water (O / W) emulsion obtained in step c), d) or e).

[0093] The invention also relates to a second method for preparing a composition according to the invention, comprising the following steps: a) at least one gelling agent is mashed in at least one humectant; then water is added under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous aqueous phase; b) said at least one emollient agent, said at least one emulsifying agent, said semiochemical composition, are mixed under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous oily phase; c) the oily phase from step b) is added under agitation to the aqueous phase from step a) so as to obtain an oil-in-water (O / W) emulsion; d) optionally, the pH of the emulsion obtained in step c) is adjusted; e) optionally, at least one of the said additives is added; f) the composition is recovered in the form of an oil-in-water (O / W) emulsion obtained in step c), d) or e).

[0094] Preferably, the invention relates to the first method of preparing a composition according to the invention.

[0095] The particular / preferred definitions and / or embodiments mentioned in the following paragraphs are applicable to both the first and second methods of preparing a composition according to the invention.

[0096] In the context of the invention, the term "mixing" means that before adding water in step a) of the process, said at least one gelling agent is dispersed in said at least one humectant in order to obtain a smooth and homogeneous paste. This mixing step, known to those skilled in the art, allows the particles to be separated and prevents the formation of lumps.

[0097] In a particular embodiment of the first or second process according to the invention, the mashing step a) is carried out at room temperature; and / or - the homogeneous aqueous phase obtained in step a) is kept under stirring at a temperature between 65°C and 75°C, preferably at a temperature of 70°C; and / or - the homogeneous oily phase obtained in step b) is kept under agitation at a temperature between 65 °C and 75 °C, preferably at a temperature of 70 °C; and / or - step c) is carried out by mixing the oily phase from step b) in the aqueous phase of step a) at a temperature between 65°C and 75°C, preferably at 70°C, and the emulsion is cooled to room temperature; and / or - step d) is carried out by adding a basic solution, for example a NaOH solution, in particular a 10% NaOH solution in order to increase the pH of the emulsion obtained in step c), preferably to obtain a pH between 5 and 8, preferably a pH between 5.5 and 7.5, or a pH between 6.0 and 7.5.

[0098] In a particular embodiment of the process according to the invention, the aqueous phase obtained in step a) is in the form of a homogeneous mixture.

[0099] In a particular embodiment of the process according to the invention, the oily phase obtained in step b) is in the form of a homogeneous mixture.

[0100] In the context of the invention, the term "homogeneous mixture" refers to a mixture whose different constituents cannot be distinguished with the naked eye.

[0101] In a particular embodiment of the process according to the invention, the oil-in-water (O / W) emulsion obtained in step c) is a stable and homogeneous emulsion as defined above.

[0102] In a particular embodiment of the process according to the invention, step d) is mandatory for the preparation of a composition in the form of an oil-in-water (O / W) emulsion, comprising a semiochemical composition comprising 40% to 60% of 3-cyclopentyl propionic acid and 40% to 60% of 3-cyclohexyl propionic acid; preferably 50% of 3-cyclopentyl propionic acid and 50% of 3-cyclohexyl propionic acid (CS9).

[0103] The invention relates in particular to a method for preparing a composition according to the invention, in particular a first or second method for preparing a composition according to the invention as described above, in which the compounds of the aqueous and oily phases are as described above.

[0104] The invention also relates to the use of a composition consisting of an aqueous phase and a composition consisting of an oily phase, as described above and exemplified below, to produce a composition according to the invention comprising, as an active agent, a semiochemical composition (associated with the oily phase) in the form of an oil-in-water (O / W) emulsion, in particular an oil-in-water emulsion that is stable and has a homogeneous appearance. In particular, the composition is suitable for use with a spraying device, in particular a misting system. Non-therapeutic use according to the invention

[0105] According to another aspect, the invention relates to a non-therapeutic use of a composition according to the invention. According to this use, the composition according to the invention is used to obtain the expected semiochemical effect(s) of the composition. semiochemical that it contains. Thus, a composition according to the invention is used to improve the management of the behaviors or interactions of target animals or their well-being, by the transmission of information or signals vectored by semiochemical agents, or to improve the well-being of humans.

[0106] One use of the composition according to the invention is, for example, its use as a tool or means for improving animal husbandry. Another use of the composition according to the invention is, for example, its use as a tool or means for the animal to adapt to its environment.

[0107] The non-therapeutic use of the composition according to the invention includes the topical administration, in particular cutaneous, of said composition to an animal, in particular a mammal, or to a human, or to animals treated in a group.

[0108] The non-therapeutic use of the composition according to the invention includes administration, in particular by spraying with a mist sprayer, onto the skin of an animal or a human, or onto the skin of farm animals treated in groups, or onto an element of the environment such as textiles and / or objects and / or walls, or by spraying into the air, in particular near the nose of an animal or a human, in particular to reduce and / or avoid obtaining a wetting effect or staining; or to reach the vomeronasal and olfactory mucosa more quickly.

[0109] In a particular embodiment according to the invention, the composition is administered topically, in particular cutaneously, onto the skin of an animal or onto human skin, preferably onto the skin of an animal.

[0110] In a particular embodiment according to the invention, the animal is a domestic animal or a farm animal, in particular a mammal, preferably the animal is chosen from the group consisting of companion animals such as rabbits, cats, dogs, birds or from the group of farm animals such as horses or production animals such as pigs, cattle, sheep, poultry, for example chickens.

[0111] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a calming bovine pheromone, comprising 25% to 35% methyl oleate, 20% to 25% methyl linoleate, 20% to 25% methyl behenate, 20% to 25% methyl palmitate, 3% to 6% methyl myristate and 2% to 4% methyl laurate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying with a mist sprayer, in particular topical administration, in particular cutaneous administration to cattle or cattle treated in groups, in particular on the skin of a bovine or cattle, in particular to promote calming states in the bovine.

[0112] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a calming pheromone for pigs, comprising 30% to 40% methyl linoleate, 25% to 35% methyl oleate, 15% to 25% methyl palmitate, 5% to 9% methyl myristate, 5% to 7% methyl laurate and 1% to 3% methyl decanoate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mister, in particular topical administration, in particular cutaneous administration to pigs or groups of pigs, in particular on the skin of a pig or pigs, in particular to promote calming states in pigs.

[0113] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a calming dog pheromone, comprising 25% to 35% methyl linoleate, 25% to 35% methyl oleate, 15% to 25% methyl palmitate, 10% to 15% methyl stearate, 2% to 7% methyl myristate, 2% to 6% methyl pentadecanoate and 1% to 3% methyl laurate;and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mister, in particular topical administration, in particular cutaneous administration to dogs, in particular on the skin of a dog, or administration onto an element of the environment such as textiles and / or objects and / or walls, in particular to facilitate adaptation and prevent stress induced by encounters with unfamiliar dogs, humans or animals, and / or to prevent stress reactions induced by external factors such as fireworks, thunderstorms, loud noises or unusual environments.

[0114] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a calming rabbit pheromone, comprising 30% to 40% methyl linoleate, 25% to 35% methyl oleate, 15% to 25% methyl palmitate, 5% to 15% 2-(2-butoxyethoxy)ethanol, 2% to 6% dimethyl glutarate, 1% to 3% dimethyl adipate, 1% to 3% dimethyl succinate and 1% to 3% dodecane;and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mister, in particular topical administration, in particular cutaneous administration to rabbits, in particular on the skin of a rabbit, or administration onto an element of the environment such as objects and / or walls, in particular to promote the welfare of the rabbit, for example to promote positive emotional states in the rabbit, in particular to facilitate adaptation to transport, during examination by the veterinarian, during encounters with unfamiliar animals or people, upon arrival in an unfamiliar place, or any other circumstance of the daily life of a rabbit.

[0115] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a pheromone calming to a human, comprising 25% to 35% methyl oleate, 25% to 35% methyl palmitate, 25% to 35% methyl linoleate, 3% to 7% methyl stearate, 3% to 5% methyl myristate and 0.5% to 2% methyl pentadecanoate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mist sprayer, in particular topical administration, in particular cutaneous administration to a human, in particular on the skin of a human, or administration on an element of the environment such as textiles and / or objects and / or walls, in particular to promote human well-being.

[0116] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a calming sheep pheromone, comprising 30% to 40% methyl oleate, 20% to 26% methyl linoleate, 20% to 26% methyl palmitate, 6% to 10% squalene, 2% to 6% methyl myristate and 3% to 5% methyl pentadecanoate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying with a mister, in particular topical administration, in particular cutaneous administration to sheep or groups of sheep, in particular on the skin of a sheep or sheep, in particular to promote calming states in sheep.

[0117] In a particular embodiment of the invention, the composition comprises a semiochemical composition, in particular comprising a feline facial pheromone, comprising 62% to 70% methyl oleate, 12% to 16% methyl palmitate, 7% to 13% dimethyl pimelate and 6% to 11% dimethyl azelate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying with a mist sprayer, in particular topical administration, in particular cutaneous administration to cats, in particular on the skin of a cat, or administration on an element of the environment such as textiles and / or objects and / or walls, in particular to prevent and manage stress-induced urine marking behavior in cats.

[0118] In a particular embodiment of the invention, the composition comprises a semiochemical composition, in particular comprising a mixture of feline facial pheromone and cat calming pheromone, comprising 2% to 6% methyl laurate, 2% to 6% methyl myristate, 10% to 15% methyl palmitate, 2% to 6% methyl stearate, 42% to 50% methyl oleate, 4% to 8% methyl linoleate, 7% to 13% dimethyl pimelate, and 6% to 11% dimethyl azelate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mister, in particular topical administration, in particular cutaneous administration to cats, in particular on the skin of a cat, or administration onto an element of the environment such as objects and / or walls, in particular to prevent and manage stress-induced urine marking behavior in cats.

[0119] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, comprising 40% to 60% of 3-cyclopentyl propionic acid and 40% to 60% of 3-cyclohexyl propionic acid; and relates to the non-therapeutic use of said composition for administration, in particular by spraying with a mist sprayer, in particular topical administration, in particular cutaneous administration to an animal, in particular a mammal, or to a human, or to animals treated in a group, or administration on an element of the environment such as textiles and / or objects and / or walls, in particular to prevent bites by blood-sucking invertebrates, in particular blood-sucking insects, such as mosquitoes, mites or ticks.

[0120] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising an allomone produced by the uropygial glands of the duck, comprising 40% to 60% of bis(ethyl-2 hexyl) adipate and 40% to 60% of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying with a mister, in particular topical administration, in particular cutaneous administration to poultry such as hens, in particular on the skin of poultry such as hens, in particular as a repellent allomone, in particular to prevent infestation by parasites such as the red poultry mite (Dermanyssus sp. or Omithonyssus sylviarum).

[0121] Another non-therapeutic use of said composition relates to administration, in particular by spraying with a mist sprayer, in particular topical administration, in particular cutaneous administration to an animal, for example birds or mammals, in particular on the skin of birds or mammals, or to a human, in particular on human skin, or administration onto an element of the environment such as textiles and / or objects and / or walls, or by spraying into the air, in particular near the nose of an animal or a human, in particular to prevent infestation or bites by blood-sucking invertebrates, in particular blood-sucking insects, such as mosquitoes, mites or ticks.

[0122] In a particular embodiment of the invention, the composition comprises a semiochemical composition, in particular an equine calming pheromone, comprising 35% to 45% by weight of methyl oleate, 20% to 30% by weight of methyl palmitate, 20% to 30% by weight of methyl linoleate, 2% to 7% in weight of dioxolane, 1% to 5% by weight of methyl laurate and 1% to 4% by weight of methyl myristate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mister, in particular topical administration, in particular cutaneous administration to horses, in particular on the skin of a horse, or administration on an element of the environment such as textiles and / or objects and / or walls, in particular to prevent social stress in the horse and / or aggressive behavior induced by encountering unfamiliar conspecifics, unfamiliar persons or animals of other species.

[0123] The above-mentioned uses of said composition according to the invention are non-therapeutic uses, and exclude any therapeutic use performed on the animal or human body. Examples

[0124] The following examples are given purely for illustrative purposes, and should in no way be interpreted as limiting the invention. Example 1. Oil-in-water emulsions (mist)

[0125] Compositions in the form of an oil-in-water emulsion (mist) according to the invention having the composition shown in the following Table 1 have been prepared.

[0126] [Tables 1] Compound Name Function INCI CAS No. Weight Percentage Aqueous Phase Water AQUA 7732-18-5 q.s. Glycerol Humectant GLYCERIN 56-81-5 5% Oily Phase Cremophor GS 32 Emulsifying Agent POLYGLYCERYL-3 DISTEARATE 9009-32-9 / 94423-19-5 2.0% Eumulgin CO 40 Emulsifying Agent PEG-40 HYDROGENATED CASTOR OIL 61788-85-0 2.0% Polysorbate 80 or 20 Emulsifying Agent POLYSORBATE 80 9005-65-6 or 9005-64-5 2.0% Myritol 318 Emollient Agent CAPRYLIC / CAPRI C TRIGLYCERIDE 73398-61-5 2.0% Aromastat Antimicrobial agent GLYCERIN / PHENE THYL ALCOHOL CAPRYLHYDROX AMIC ACID 56-81-5 60-12-8 7377-03-9 1.0% Tinogard TT Antioxidant agent PENTAERYTHRITYL TETRA-DLT-BUTYL HYDROXYHYDROCINNAMATE 6683-19-8 0.1% Fragrance (optional) Additive / / 1.0% Semiochemical composition (CS1, CS2, CS3, CS4 or CS5, CS6, CS7, CS8, CS9, CS10 or CS11) / / 1.98% 10% NaOH solution (only with CS9) SODIUM HYDROXIDE 1310-73-2 0.40%

[0127] Semiochemical compositions (CS) used as an example in the formulation of Table 1 - CS1: 27.40% methyl oleate, 22.70% methyl linoleate, 21.20% methyl behenate, 21.20% methyl palmitate, 4.50% methyl myristate and 3% methyl laurate; or - CS2: 35% methyl linoleate, 30% methyl oleate, 20% methyl palmitate, 7% methyl myristate, 6% methyl laurate and 2% methyl decanoate; or - CS3: 29% methyl linoleate, 29% methyl oleate, 18% methyl palmitate, 13% methyl stearate, 5% methyl myristate, 4% methyl pentadecanoate and 2% methyl laurate; or - CS4: 35% methyl linoleate, 29% methyl oleate, 18% methyl palmitate, 9.18% 2-(2-butoxyethoxy)ethanol, 4.32% dimethyl glutarate, 1.62% dimethyl adipate, 1.62% dimethyl succinate and 1.26% dodecane; or - CS5: 30.80% methyl oleate, 30% methyl palmitate, 28.80% methyl linoleate, 5.50% methyl stearate, 3.55% methyl myristate and 1.35% methyl pentadecanoate; or - CS6: 35.3% methyl oleate, 23.7% methyl linoleate, 23.3% methyl palmitate, 8.6% squalene, 5.2% methyl myristate and 3.9% methyl pentadecanoate; or - CS7: 67.2% methyl oleate, 13.60% methyl palmitate, 11.40% dimethyl pimelate and 7.80% dimethyl azelate; or - CS8: 4.50% methyl laurate, 4.50% methyl myristate, 13.40% methyl palmitate, 4.50% methyl stearate, 46.6% methyl oleate, 69.50% methyl linoleate, 11% dimethyl pimelate and 9% dimethyl azelate; or - CS9: 50% 3-cyclopentylpropionic acid and 50% 3-cyclohexylpropionic acid; or - CS 10: 50% bis(ethyl-2-hexyl) adipate and 50% l-isopropyl-2,2-dimethyltrimethylene diisobutyrate; or - CS11: 35% to 45% by weight of methyl oleate, 20% to 30% by weight of methyl palmitate, 20% to 30% by weight of methyl linoleate, 2% to 7% by weight of dioxolane, 1% to 5% by weight of methyl laurate and 1% to 4% by weight of methyl myristate.

[0128] Example 2. Process for preparing oil-in-water emulsions (mist) according to Example 1

[0129] The oil-in-water emulsions (mist) according to Example 1 were prepared according to the following protocol: STEP 1: Preparation of the dough / aqueous phase 1. In a container suitable for receiving the final volume of the aqueous phase, the glycerin was weighed and added. The mixture was stirred at room temperature. 2. Once the mashing was complete, all the water was added. 3. After homogenization of the aqueous phase (obtaining a homogeneous mixture), the aqueous phase was maintained at 70°C and under agitation until step 3. STEP 2: Preparation of the oil phase 4. In another container suitable for receiving the final volume of the oily phase, the oily phase compounds were weighed and added, namely Cremophor GS 32, Eumulgin CO 40, Polysorbate 80 or Polysorbate 20, Myritol 318, Tinogard TT, Aromastat and the semiochemical composition (CS1, CS2, CS3, CS4 or CS5, CS6, CS7, CS8, CS9 or CS 10). 5. Once all the compounds were added, the mixture was stirred and heated to 70°C until a homogeneous mixture was obtained. STEP 3: Formation of the oil-in-water emulsion 6. Once the two phases (aqueous and oily) were perfectly homogeneous, the oily phase at 70°C was added to the aqueous phase at 70°C. Thorough agitation of the emulsion was ensured throughout this step. The emulsion was then cooled to room temperature after homogenization. STEP 4: pH adjustment using only the CS9 composition mentioned above 7. In the case of the composition including the semiochemical composition CS9, and in order to increase the pH, a pH adjustment step was carried out by adding a 10% NaOH solution until a pH between 6 and 7 was obtained. STEP 5: Perfume 8. Addition of any fragrance under agitation at room temperature STEP 6: Recovery of the oil-in-water (O / W) emulsion The final emulsion obtained was fluid, opalescent / transparent, of low viscosity.

[0130] Example 3. Organoleptic measurements of oil-in-water emulsions (mist) according to example 1

[0131] 3 criteria (appearance, color, odor) were selected for organo measurements leptics. Appearance: Free-flowing liquid Color: White or opalescent / transparent / translucent Odor: Characteristic odor.

[0132] Example 4. pH measurements of oil-in-water emulsions (mist) according to example 1

[0133] The pH measurements were carried out using a LE 438 IP 67 electrode marketed by Mettler Toledo®. This is a 2-in-1 glass pH electrode with integrated temperature sensor and liquid electrolyte for rapid laboratory measurements; for aqueous samples, such as acids, bases, etc.

[0134] The specifications of this electrode are mentioned in the following Table 2.

[0135] [Tables2] Measuring range pH 0 - 14 Zero point 7.00 ± 0.25 Temperature range 0 - 80 °C Temperature probe NTC 30 kQ Membrane resistance (25 °C) < 250 MQ Reference electrolyte 3 mol / L KCl solution saturated with AgCl Reference system Ag / AgCl Reference diaphragm Gel

[0136] Before any measurement was taken, the pH meter used was calibrated. Indeed, the nature of the semiochemical composition can affect the pH of the emulsion because some semiochemicals have an acidic pH. For topical application, particularly cutaneous application, it is therefore necessary to measure the pH of each emulsion obtained and, if necessary, adjust the pH to obtain a pH between 5 and 8, preferably between 5.5 and 7.5, or between 6.0 and 7.5.

[0137] pH measurements were carried out after obtaining each emulsion, and are reported below: MIST with CS1: 5.0 < pH < 7.5 MIST with CS2: 5.0 < pH < 7.5 MIST with CS3: 5.5 < pH < 7.5 MIST with CS4: 5.5 < pH < 7.5 MIST with CS5: 5.5 < pH < 7.5 MIST with CS6: 5.5 < pH < 7.5 MIST with CS7: 5.5 < pH < 7.5 MIST with CS8: 5.5 < pH < 7.5 MIST with CS10: 5.5 < pH < 7.5 MIST with CS11: 5.5 < pH < 7.5 MIST with CS9: 3.5 < pH < 4.5.

[0138] In order to get as close as possible to the pH of animal or human skin, and to avoid causing skin irritation, a pH adjustment was made for the formulation corresponding to BRUME with CS9. Following this adjustment, new pH measurements were taken and are reported below: MIST with CS9: 6.0 < pH < 7.5.

[0139] For formulations corresponding to BRUME with CS1, CS2, CS3, CS4, CS5, CS6, CS7, CS8, CS10 and CS11, no pH adjustment step was performed.

[0140] Example 5. Measurement of the viscosity of oil-in-water emulsions (mist) according to Example 1

[0141] Viscosity is the resistance of a fluid to sliding from one layer relative to another.

[0142] For each formulation, the viscosity must be checked after each batch. Viscosity is influenced by several factors, including temperature, the measuring instrument used, the measurement speed, and the time of measurement relative to the batch (measurements at T0 and T+24h, T+48h). Viscosity measurement should be performed when the solution is at room temperature, preferably at T+24h.

[0143] The measurement of the viscosity of the oil-in-water emulsions according to example 1 was carried out using the Brookfield digital viscometer (model DV-I Prime), mobile S 61 (large mobile) and at a rotation speed of 0.6 RPM.

[0144] The Brookfield DV-I Prime viscometer measures the viscosity of fluids at a given velocity gradient. The operating principle consists of rotating a spindle (which is immersed in the liquid to be tested) by means of a calibrated spring. The measurement range (in centipoise or millipascal-seconds) is determined by the rotational speed of the spindle, the size and shape of the spindle, the section in which the spindle is rotating, and the full-scale torque of the calibrated spring.

[0145] The specifications of the Brookfield DV-I Prime viscometer are reported in the Table 3 follows.

[0146] [Table 3]: Speeds (rpm) 0.0; 0.3; 0.6; 1.5; 3; 6; 12; 30; 60; 0.5; 1; 2; 2.5; 4; 5; 10; 20; 50; 100 Viscosity range (cP) 15 - 2,000,000 Operating environment Temperature range 0°C to 40°C (32°F to 104°F) 20% to 80% RH: none Condensation Analog output of the 0-1 Vcc torque (0 to 100% torque) Viscosity measurement accuracy ± 1 °C: - of full scale Viscosity measurement reproducibility 0.2% of full scale Used mobiles S61; S62; S63; S64

[0147] Following these measurements, all the oil-in-water emulsions (mist) according to Example 1 had a viscosity between 1 and 50 cP or mPa.s, with the exception of the emulsion comprising the semiochemical composition CS9 which had a viscosity between 3500 and 8000 cP or mPa.s. The viscosity was notably lower in the presence of a perfume or a NaOH solution (the percentage of water being higher).

[0148] Example 6. Test for identifying the presence or absence of stains following spraying of the semiochemical composition CS9 on different textiles of different materials

[0149] Protocol - Place the garment on a hanger, take a photo before application (T0) - Spray the CS9 semiochemical composition from 20-30 cm away on different areas of the garment [10 sprays per garment, if the garment is in 2 parts (example: trousers) perform 5 sprays per side] - Photo after application (Tl) - Take a photo Ih after application (T2) - Wash the clothes using a washing machine (standard program at 30°C) - Take a photo after washing (T3).

[0150] Equipment Solution used Semiochemical composition CS9 Clothing and its composition The compositions and types of clothing used are reported in the following Table 4.

[0151] [Table 4]: Composition | Garment Type | 100% Cotton | White Polo Shirt | Blue T-shirt | 100% Polyester | Blue T-shirt | Black Polo Shirt | 35% Polyamide, 30% Wool, 30% Viscose | Blue Sweater 5% cashmere, 100% wool. Cardigan: 60% recycled wool, 35% polyester, 5% polyamide. Trousers: 100% silk. Tie: 100% synthetic. Black dress.

[0152] Results The results of the tests carried out by the inventors are reported in the following Table 5.

[0153] [Table 5]: Clothing Type Material T0 Tl T2 T3 White Polo Shirt 100% Cotton N / A N / A N / A N / A N / A Blue T-shirt Watermark N / A N / A Blue T-shirt 100% Polyester N / A N / A N / A Black Polo Shirt Droplets settling on fibers N / A N / A Blue Sweater 35% Polyamide, 30% Wool, 30% Viscose, 5% Cashmere N / A N / A Cardigan 100% Wool N / A N / A N / A (has shrunk) Pants 60% Recycled Wool, 35% Polyester, 5% Polyamide Watermarks settling on fibers N / A Tie 100% Silk Watermark N / A Black Dress Synthetic Watermarks settling on fibers N / A

[0154] RAS = "Nothing to report", i.e., no changes observed. The results mentioned above showed that no task was observed on the different textiles of different materials following the spraying of the semiochemical composition CS9.

[0155] Example 7. Acceptability tests in cats and rabbits

[0156] The results of the acceptability tests in cats carried out by the inventors are reported in the following Table 6.

[0157] [Table 6]: Acceptance Questionnaire Results - Cat Reaction DURING application High-pitched cries, without flight or defensive movements Ears pinned back, hissing, active defensive reactions The cat remains in place, but tail wagging is observed The cat tries to free itself without a sudden reaction, during application The cat remains in place, but with ears pinned back or in a "gendarme's hat" position The cat shows no particular reaction Number of reactions observed 0 0 0 4 0 9 Reaction AFTER APPLICATION The cat hides and becomes unapproachable (threatening facial expressions and vocalizations) The cat remains in place, but cannot be touched (threatening facial expressions and vocalizations) The cat exhibits very active and prolonged grooming behavior After a short period of licking, the cat resumes its usual activities Number of reactions observed: 0 0 3 10 Product odor analog scale: Average 7 / 10

[0158] The results of the acceptability tests in rabbits carried out by the inventors are reported in the following Table 7.

[0159] [Table?]: Acceptance Questionnaire Results - Rabbit Reaction DURING application Sudden flight movements (jumping, forward movements) Defensive movements with hind legs Cries The rabbit flattens itself on the table No reaction or shakes slightly Number of reactions observed 0 0 0 0 4 Reaction AFTER APPLICATION The rabbit no longer allows itself to be approached (flight) The rabbit remains flat on the ground, trembling The rabbit exhibits very prolonged grooming behavior The rabbit shows no reaction and resumes its usual activities Number of reactions observed 0 0 1 3 Product odor analog scale Average 7 / 10 References

[0160] - Silverstein, R.M., 1977. "Complexity, diversity and specificity of behavior- modifying Chemicals; examples from Coleoptera and Hymenoptera," Chemical Control of Insect Behavior:Theory and Application. Editeurs H.H. Shorey & J.J.McKelvey pp.231-251 New York : Plénum Press); - Wyatt T.D., 2003 "Pheromones and Animal Behavior. Communication by smell and taste, pp.1-4 New York : Cambridge University Press.

Claims

Demands

1. Composition in the form of an oil-in-water (O / W) emulsion comprising: a) an aqueous phase comprising water and at least one humectant selected from polyols and sugars, b) an oily phase comprising at least one emollient agent, at least one emulsifying agent, and a semiochemical composition, wherein said semiochemical composition comprises: - methyl oleate and methyl palmitate, preferably methyl linoleate, methyl oleate and methyl palmitate; Or - of 3-cyclopentylpropionic acid and 3-cyclohexylpropionic acid; or - bis(ethyl-2 hexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate.

2. Composition in the form of an oil-in-water (O / W) emulsion according to claim 1, characterized in that said semiochemical composition comprises: - methyl oleate, methyl linoleate, methyl behenate, methyl palmitate, methyl myristate, and methyl laurate; or - methyl linoleate, methyl oleate, methyl palmitate, methyl myristate, methyl laurate, and methyl decanoate; or - methyl linoleate, methyl oleate, methyl palmitate, methyl stearate, methyl myristate, methyl pentadecanoate, and methyl laurate; or - methyl linoleate, methyl oleate, methyl palmitate, 2-(2-butoxyethoxy)ethanol, dimethyl glutarate, dimethyl adipate, dimethyl succinate, and dodecane; or - methyl oleate, methyl palmitate, methyl linoleate, methyl stearate, methyl myristate, and methyl pentadecanoate; or - methyl oleate, methyl linoleate, methyl palmitate, squalene, methyl myristate, and methyl pentadecanoate; or - methyl oleate, methyl palmitate, pimelate dimethyl and dimethyl azelate; or - methyl laurate, methyl myristate, methyl palmitate, methyl stearate, methyl oleate, methyl linoleate, dimethyl pimelate, and dimethyl azelate; or - 3-cyclopentylpropionic acid and 3-cyclohexylpropionic acid; or - bis(2-ethylhexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate; or - methyl oleate, methyl palmitate, methyl linoleate, dioxolane, methyl laurate and methyl myristate.

3. Composition in the form of an oil-in-water (O / W) emulsion according to claim 1 or 2, characterized in that said semio-chemical composition comprises: - 25% to 35% methyl oleate, 20% to 25% methyl linoleate, 20% to 25% methyl behenate, 20% to 25% methyl palmitate, 3% to 6% methyl myristate and 2% to 4% methyl laurate; or - 30% to 40% methyl linoleate, 25% to 35% methyl oleate, 15% to 25% methyl palmitate, 5% to 9% methyl myristate, 5% to 7% methyl laurate and 1% to 3% methyl decanoate; or - 25% to 35% methyl linoleate, 25% to 35% methyl oleate, 15% to 25% methyl palmitate, 10% to 15% methyl stearate, 2% to 7% methyl myristate, 2% to 6% methyl pentadecanoate and 1% to 3% methyl laurate; or - 30% to 40% methyl linoleate, 25% to 35% methyl oleate, 15% to 25% methyl palmitate, 5% to 15% 2-(2-butoxyethoxy)ethanol, 2% to 6% dimethyl glutarate, 1% to 3% dimethyl adipate, 1% to 3% dimethyl succinate and 1% to 3% dodecane; or - 25% to 35% methyl oleate, 25% to 35% methyl palmitate, 25% to 35% methyl linoleate, 3% to 7% methyl stearate, 3% to 5% methyl myristate and 0.5% to 2% methyl pentadecanoate; or - 30% to 40% methyl oleate, 20% to 26% methyl linoleate, 20% to 26% methyl palmitate, 6% to 10% squalene, 2% to 6% methyl myristate and 3% to 5% of methyl pentadecanoate; or - 62% to 70% of methyl oleate, 12% to 16% of methyl palmitate, 7% to 13% of dimethyl pimelate and 6% to 11% of dimethyl azelate; or - 2% to 6% of methyl laurate, 2% to 6% of methyl myristate, 10% to 15% of methyl palmitate, 2% to 6% of methyl stearate, 42% to 50% of methyl oleate, 4% to 8% of methyl linoleate, 7% to 13% of dimethyl pimelate and 6% to 11% of dimethyl azelate; or - 40% to 60% of 3-cyclopentyl propionic acid and 40% to 60% of 3-cyclohexyl propionic acid; or - 40% to 60% of bis(ethyl-2 hexyl) adipate and 40% to 60% of l-isopropyl-2,2-dimethyltrimethylene dü-sobutyrate, - 35% to 45% by weight of methyl oleate, 20% to 30% by weight of methyl palmitate, 20% to 30% by weight of methyl linoleate, 2% to 7% by weight of dioxolane, 1% to 5% by weight of methyl laurate and 1% to 4% by weight of methyl myristate;the total sum of the compounds present in said semio-chemical composition being equal to 100%.

4. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 3, characterized in that said at least one humectant is selected from polyols from the group consisting of glycerol, propylene glycol, polyethylene glycols (PEG), xylitol, isomalt, maltitol, mannitol, polydextrose, sorbitol, isomaltitol, lactitol, and mixtures thereof; and / or said at least one humectant is selected from sugars from the group consisting of fructose, glucose, lactose; preferably said at least one humectant is glycerol.

5. Composition in the form of an oil-in-water (O / W) emulsion of any one of claims 1 to 4, characterized in that said at least one humectant is present in a content of 4% to 12% by weight, preferably 4% to 6% by weight, relative to the total weight of the composition.

6. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 5, characterized in that it comprises from 60% to 95% by weight of water, preferably from 77% to 87% by weight of water, relative to the total weight of the composition, and / or in that it comprises from 1% to 4% by weight, preferably from 1.5% to 2.5% in weight of said semiochemical composition, relative to the total weight of the composition.

7. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 6, characterized in that said at least one emollient agent is selected from the group consisting of hydrogenated vegetable oils, silicone oils, mineral oils and waxes, fatty alcohols, fatty acids and fatty acid esters, glyceride derivatives, and glycerol derivatives, preferably glyceride derivatives.

8. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 7, characterized in that said at least one emollient agent is present in a content of 0.5% to 8% by weight, preferably 1% to 3% by weight, relative to the total weight of the composition.

9. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 8, characterized in that said at least one emulsifying agent is selected from fatty acid and polyoxyethylene sorbitan esters, fatty acid polyol esters or ethoxylated vegetable oils, preferably hydrogenated and ethoxylated.

10. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 9, characterized in that said at least one emulsifying agent is present in a content of 1% to 25% by weight, preferably 5% to 7% by weight, relative to the total weight of the composition.

11. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 10, characterized in that the oil phase further comprises at least one additive selected from the group consisting of a preservative, in particular an antimicrobial agent or an antioxidant agent, a perfume, a masking agent, and mixtures thereof.

12. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 11, characterized in that it is administered in the form of a mist, in particular using a misting device.

13. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 12, characterized in that it comprises: a) an aqueous phase comprising water and glycerol, b) an oily phase comprising polyglyceryl-3 distearate, PEG-40 hydrogenated castor oil, fatty acid esters and polyoxyethylene sorbitan, caprylic acid and capric acid triglycerides, glycerin / phenyl alcohol / caprylhydroxamic acid, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, optionally a fragrance, and a semiochemical composition, the semiochemical composition being present in the composition in the form of an oil-in-water emulsion in a content ranging from 1% to 4% by weight, preferably from 1.5% to 2.5% by weight, relative to the total weight of the composition.

14. A method for preparing a composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 13, comprising the following steps: a) at least one gelling agent is mashed in at least one humectant; then water is added under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous aqueous phase; b) said at least one emollient agent, said at least one emulsifying agent, said semiochemical composition and optionally said at least one additive are mixed together under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous oily phase; c) the oily phase from step b) is added under agitation to the aqueous phase from step a) so as to obtain an oil-in-water (O / W) emulsion; d) optionally, the pH of the emulsion obtained in step c) is adjusted; e) optionally a fragrance is added; f) the composition is recovered in the form of an oil-in-water (O / W) emulsion obtained in step c), d) or e).

15. The method according to claim 14, characterized in that: - the dough-making step a) is carried out at room temperature; and / or - the homogeneous aqueous phase obtained in step a) is kept under stirring at a temperature between 65°C and 75°C, preferably at a temperature of 70°C; and / or - the homogeneous oily phase obtained in step b) is kept under agitation at a temperature between 65°C and 75°C, preferably at a temperature of 70°C; and / or - step c) is carried out by mixing the oily phase from step b) in the aqueous phase of step a) at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, and the emulsion is cooled to room temperature; and / or - step d) is carried out by adding a basic solution, for example a NaOH solution.

16. Non-therapeutic use of a composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 13, for administration, in particular by spraying with a mist sprayer, onto the skin of an animal or a human, or onto the skin of farm animals treated in groups, or onto textiles and / or objects and / or walls, or by spraying into the air, in particular near the nose of an animal or a human.