2-(2,3-difluorophenyl)acetate ester derivative, and method of producing the same
The use of a 2-(2,3-difluorophenyl)acetic ester derivative as an intermediate in a series of reactions addresses the low yield and high cost issues of conventional methods, achieving efficient production of 1,7,8-trifluoro-2-naphthol derivatives.
Patent Information
- Application Number
- JP2009100914
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2009-04-17
- Publication Date
- 2010-11-04
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Conventional methods for producing 1,7,8-trifluoro-2-naphthol derivatives suffer from low overall yields and high production costs due to the long number of steps and generation of by-products during the reaction.
The use of a 2-(2,3-difluorophenyl)acetic ester derivative as an intermediate, which is synthesized through a series of reactions involving oxalic acid diesters, reducing agents, and fluorinating agents to produce 2-(2,3-difluorophenyl)-2-hydroxyacetic acid ester derivatives, followed by fluorination and vinylation steps to obtain 2-(2,3-difluorophenyl)-2-fluoroacetic ester derivatives, ultimately leading to 1,7,8-trifluoro-2-naphthol derivatives.
This method enables the production of 1,7,8-trifluoro-2-naphthol derivatives at a lower cost with improved yields by optimizing the reaction pathways and minimizing by-product formation.