New dosimetry device for quantification of radiation

Abstract

To provide a dosimetry device for quantifying the dosage of radiation emitted from a radiation source.SOLUTION: A dosimetry device for quantifying the dosage of radiation provided herein comprises (i) a radiation dose indicator, (ii) optical means for capturing color changes, and (iii) software means for comparing optical density of the dose indicator to a predetermined calibration curve, and is configured to quantify the dosage of radiation emitted from the radiation source.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] This application relates to radiation sensitive compositions, optical means, and methods for detecting radiation emitted from a radiation source. The present application further relates to a dosimetry device including software means for quantifying the dose. , and relates to the use of said dosimetry devices in various medical, food and industrial applications. [Background technology]

[0002] Quantifying radiation emitted from various sources is an important function, which is used in medicine, research, food storage, and It finds some applications in storage, transport of radioactive materials, and in production operations. A meter is a device used to indicate or measure exposure to ionizing radiation. can be easily seen and sometimes demonstrates a visual transformation of color without the use of a spectrophotometer. It is a solid object available as a plate or any other shape that can be attached to the plate. Currently, thermoluminescence dosimeter (TLD), optically stimulated luminescence (OSL), radiation luminescence Several types of glass, such as radiation-reflecting glass (RLG), X-ray film, and track etching, are available. There are many types of dosimeters available on the market. These are usually used for measuring radiation such as X-rays, gamma rays, and fast electrons. It is used to measure and monitor both medical and industrial radiation.

[0003] A colour-changing / developing self-indicating instantaneous radiation alarm dosimeter (SIRAD) for monitoring low doses. For example, JP Laboratories Inc. of New Jersey It is commercially sold under the trademark SIRAD®. The SIRAD dosimeter contains There are detection strips made of polymeric materials such as the colorless solid monomer of ethylene. Usually, when exposed to high-energy radiation such as X-rays, gamma rays, electrons, or neutrons, red light turns into red light. or forms a blue polymer / plastic. With increasing exposure to radiation, diacetyl The color of the detector strip containing the fluororesin increases in proportion to the dose.

[0004] U.S. Patent No. 8,242,464 [Gordhanbai N.Patel / JP Lab s] is a self-indicating radiation sensor and reader that allows users to instantly estimate dose. The present invention discloses an identification personal dosimeter including:

[0005] U.S. Patent No. 10,060,786 [assigned to L'Oreal] relates to a UV measuring device and a UV A device that captures radiation and receives specific information about a user's hazardous level of UV exposure. A personal ultraviolet (UV) radiation measurement system is disclosed that includes an apparatus.

[0006] RadSure® irradiation indicators are manufactured by Ashland Specialty A type of dosimetry device sold by Fluoro Ingredients Inc. When applied to blood products, RAD-SURE® The indicator will show whether the blood product has been irradiated. Before the indicator is illuminated, the indicator reads "NOT IRRADIATED" After irradiation, the word "NOT" in the indicator window is hidden and the indicator The indicator reads "IRRADIATED." As shown in Figure 1, Marketed under the trade names RADTAG® and ONPOINT® There are several indicators.

[0007] Identifying exposure dose, reducing contamination, and providing safety protection to warn users about radiation hazards Many variations of the indicators have been made with respect to temperature and visual identification means. However, There is no precise mechanism for measuring the actual amount of radiation emitted by a radioactive source.

[0008] Therefore, in the art, there is a need to provide a method for measuring the actual radiation (X-ray or gamma radiation) exposure at the user's position. There is a need for dosimetry devices that can quantify exposure and provide detailed information about users. It has been done.

[0009] Surprisingly, our dosimetry device can measure with high accuracy the actual radiation emitted by the radiation source. Quantify in degrees. Summary of the Invention

[0010] In one aspect of the invention, the present invention provides a method for quantifying the dose of radiation emitted from a radiation source. A dosimetry device is provided for measuring radiation and determining whether the radiation emitted is A radiation dose indicator comprising a radiation sensitive composition that visually represents the amount of radiation as a color change. (ii) a light source for capturing the color change of a radiation dose indicator after exposure to radiation; and (iii) radiological means to quantify the amount of radiation emitted by a radioactive source. The optical density of the dose indicator was calculated using percent optical density versus cumulative radiation dose. A software means is provided for comparing with a predetermined calibration curve.

[0011] In another aspect, the present invention relates to a method for detecting radiation by (i) measuring radiation emitted from a radiation source; A radiation dose indicator comprising a radiation sensitive composition that visually indicates the amount of emitted radiation as a color change. (ii) capturing the color change of a radiation dose indicator after exposure to radiation. and (iii) optical means to quantify the amount of radiation emitted by the radiation source. The optical density of the dose indicator was created using percent optical density versus cumulative radiation dose. A dosimetry device is provided with software means for comparing the measured surface and solution dosimetry data with a predetermined calibration curve. sterilization, medical imaging, quality assurance testing of medical or industrial equipment, UV light measurement, food processing and storage The present invention is also useful for storing, transporting radiation sensitive materials, or banking blood.

[0012] In yet another aspect, the present invention provides a method for quantifying the dose of radiation emitted from a radiation source. A method is provided for quantifying radiation emitted by a device, the method comprising: (i) measuring radiation and visualizing the amount of radiation emitted; A dosimetry device having a radiation sensitive indicator that visually changes color is exposed to radiation. (ii) determining the color of the dose indicator after exposure to radiation using optical means; and (iii) capturing the change in optical density of the dose indicator. The radiation source was compared to a predetermined calibration curve constructed using centrifugal optical density versus cumulative radiation dose. The method includes quantifying the dose of radiation emitted from the

[0013] In yet another aspect, the present specification provides a dosimetry device as shown in Figs. Provided.

[0014] The present invention is better understood from the following detailed description when read in conjunction with the accompanying drawings. It is emphasized that, according to common practice, the various features of the drawing are not to scale. In addition, the dimensions of the various features have been arbitrarily expanded or reduced for clarity. It contains the following diagram: [Brief description of the drawings]

[0015] [Figure 1] Pictorial representation of a RadTag® indicator (top) and an Onpoint® indicator (bottom). [Diagram 2] 1 is a pictorial diagram of the new Rad-Sure®. [Diagram 3] FIG. 1 is a pictorial representation of the production test assembly of Gafchromic® Film #1 inside the X-ray cabinet before (left) and after (right) 10 Gy irradiation. [Figure 4] 1 is a graphical representation of comparative optical density measurements of films versus x-ray exposure levels. [Diagram 5] 1 is a graphic representation of the response of Gafkromic® Film #1 to various degrees of X-ray radiation exposure (no flash). [Figure 6] A graphical representation of Gafkromic® Film #1 RGB data from an image captured on an iPhone. [Figure 7] 1 is a flow diagram of a radiation dosimetry device. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0016] The following detailed description is illustrative only and is intended to provide improved and accurate radiation quantification capabilities. It is not intended that the disclosed dosimeters be limited to those that are within the scope of the present invention. Many variations may occur to those skilled in the art. The following detailed discussion of the embodiments illustrates the general principles of the present invention.

[0017] As used in this disclosure, the following terms shall be understood to have the following meanings, unless otherwise specified: I want to be understood.

[0018] As used herein, percentages, parts, proportions and ratios are defined as follows unless otherwise indicated. By weight of the total composition. All such amounts relating to listed ingredients are Weights are based on activity level and may contain more than the amount present in commercially available materials unless otherwise specified. Contains no potentially harmful solvents or by-products.

[0019] As used herein, "comprises" (and any conjugation thereof), "has" (and and any conjugations thereof), "include" (and any conjugations thereof) or "contain" (and and any variations thereof) are not meant to be limiting.

[0020] All publications, articles, papers, patents, patent documents, and other references cited herein To the extent consistent with the disclosure of this specification, the references are incorporated herein in their entireties for all purposes. To be incorporated.

[0021] As used herein, the term "color space" generally refers to a color model (or color system). It refers to a color range as a tuple or number, typically containing 3 or 4 values ​​or color components (e.g. It is an abstract mathematical model succinctly described as a color space (RGB). Each color in the system is a dot. When defining color spaces, the usual reference standard is CIELAB or CIEXYZ color space. These are spaces that are intended to encompass all the colors that the average human eye can see. It is specially designed for.

[0022] As used herein, the term "Gafkromic® film" means a Generally, radiochromic dosimetry is designed for quantitative measurement of absorbed dose from high-energy photons. It refers to film. The main technical features are: (i) Dynamic dose range: 1 (ii) Real-time development without post-exposure treatment; (iii) Energy -dependence: minimal response difference from 100 keV to the MV range; (iv) near tissue equivalent; (v) high (vi) high spatial resolution (capable of resolving features smaller than 5 μm); (vii) an active coating having a marker dye incorporated therein; Unique new technology: Use of triple channel dosimetry to enable non-uniformity correction and UV / reduced light sensitivity;(viii) temperature stability up to 60°C.

[0023] As used herein, the term "ionizing radiation" generally refers to radiation that causes atoms to lose electrons and become charged. Ionizing radiation refers to radiation that has a high enough energy level to cause ionization or ionization. is a form of high energy particles such as alpha and beta particles, protons and neutrons, The radiation can be in the form of electromagnetic waves such as gamma rays and X-rays. High energy particles and electromagnetic waves cause decay They are emitted from the nuclei of decaying radioactive atoms or by bombarding a metal target with accelerated electrons. It can be generated by

[0024] As used herein, the term "radiation detection medium" generally refers to a medium that is exposed to radiation. This refers to a medium that undergoes a detectable change when exposed to heat. The change may be immediately visible or Image processing may be required.

[0025] As used herein, the term "radiochromic film" or film refers to a Generally, when exposed to ionizing radiation, the color changes and produces a visible image, but when exposed to visible light or other This film shows only slight changes when exposed to certain types of non-ionizing radiation. The system does not require any chemical or physical treatment.

[0026] As used herein, the term "Rad-Sure®" refers to a minimum prescribed dose. Rad-Sur is a blood irradiation indicator that provides positive visual verification of irradiation in blood. There are two types of e(registered trademark) indicators: gamma ray and X-ray. Gamma is cesium-13 Compatible with any 1.7 or Cobalt 60 radiation source, X-rays are delivered through a 0.38mm copper filtered 1 Generated from a 60kVp source or a 150kVp source filtered with 1mm aluminium Compatible with X-ray irradiation equipment that utilizes Gafchromic® Rad-Sure® is the world's highest resolution dosimeter made from film and has a 25-year It has become the standard for blood irradiation indicators.

[0027] In one embodiment, the present application provides a method for (i) measuring radiation and determining the amount of radiation emitted from a radiation source; A radiation dose indicator comprising a radiation sensitive composition that visually indicates the amount as a color change. ii) an optical means for capturing the color change of the dose indicator upon exposure to radiation; and (iii) A dose indicator to quantify the dose of radiation emitted by the radiation source. The optical density was compared to a predefined calibration curve constructed using percent optical density versus cumulative radiation dose. The present invention provides a dosimetry device equipped with software means for comparing the dose of the measured signal.

[0028] Therefore, a radiation dose indicator is a device that measures radiation and indicates changes in radiation. The radiation-sensitive composition includes a radiation-sensitive film, a radiation-sensitive patch, and a , or any other device capable of detecting radiation emitted by a radiation source. .

[0029] Therefore, the radiation-sensitive composition is preferably a radiation-sensitive film such as a radiochromic film. This film contains fluorine and changes color instantly when exposed to ionizing radiation, without the need for chemical treatment. These films have a thickness of at least 0.025 mm. It is widely recognized for its extremely high spatial resolution, which reaches the level of Another advantage of the system is that the absorbed radiation dose truly reflects the dose absorbed by the tissue. The reason for this is its tissue equivalence. The material used in the radiochromic film detection strips is , a unique class of compounds called diacetylenes, represented by the general formula: [ka] Here, R 1 and R 11 is a substituent. Diacetylene is a colorless solid monomer. They usually form red or blue polymers of the general formula: [ka] Here, n is the number of atoms irradiated with high-energy radiation such as X-rays, gamma rays, electrons, and neutrons. With increasing exposure, the number of monomer units in the diacetylene-containing sensing strips increases. The color intensifies in proportion to the dose.

[0030] Therefore, the commercially available radiochromic film model is Ashland Speci Gafchromic (registered trademark) is manufactured by Alty Ingredients Inc. The radiochromic films currently in use are manufactured under the trade name HD -V2, EBT3, EBT-XD, MD-V3, RTQA2, XR-QA2, XR-CT 2, XR-M2, and XR-RV3.

[0031] Therefore, radiochromic film has a radiation intensity of about 0.1 to about 10,000 gray (Gy). The radiation dose range is selected from a range of units per second.

[0032] Thus, the radiochromic film is dispersed in a polymer matrix and Active nanoparticles of radiation-sensitive monomers coated onto an ester film base The active monomer component is ionized. Upon exposure to radiation, a polymerization reaction is initiated to produce the dye polymer. Being dye in nature, coloration occurs in the film upon exposure to light.

[0033] In another embodiment, the color indicator may include a combination of dyes or pigments that act as markers. As a result, when radiation is emitted from the radiation source, a dose indicator becomes active and this change is visually indicated by a color change.

[0034] Therefore, suitable pigment materials are selected from Hanger's "Industrial Organic Pigments", Hall's "Dictionary of Pigments", " and Leach and Pierce's "Manual of Printing Inks."

[0035] Examples of yellow organic and inorganic pigments include CI Pigment Yellow 1, CI Pigment C.I. Pigment Yellow 74, C.I. Pigment Yellow 12 and C.I. Pigment Yellow These include azopigments such as 17 and 18.

[0036] Examples of black pigments include carbon black, titanium black, and aniline black. can be.

[0037] Examples of white pigments include basic lead carbonate, zinc oxide, barium sulfate, titanium dioxide, silver white, titanium dioxide, and titanium dioxide. Strontium titanate and the like are included.

[0038] Examples of red pigments include Naphthol Red (CI Pigment Red 2), CI Pigment C.I. Pigment Red 3, C.I. Pigment Red 176 and C.I. Pigment Red 23 etc.

[0039] Examples of green pigments include Phthalocyanine Green (CI Pigment Green 7), C Examples of pigments that are suitable for this purpose include CI Pigment Green 36, and CI Pigment Green 1.

[0040] Examples of blue pigments include phthalocyanine blue (CI Pigment Blue 15:3), These include CI Pigment Blue 15:6, and CI Pigment Blue 16. do.

[0041] Examples of blue dyes include methylene blue, acid blue 1, basic blue 1, and CI Solvent Blue 7 and others.

[0042] Examples of red dyes include Acid Red 18, Basic Red 1, and CI Solvent. This includes Tread 8 and others.

[0043] Examples of green dyes include Acid Green 1 and Basic Green 1.

[0044] Examples of black dyes include CI Solvent Black 5 and the like.

[0045] In another embodiment, the optical means provided in the dosimetry device detects radiation emitted from the source. The optical means are smartphone cameras, high resolution cameras, Image cameras, magnifying cameras, densitometers, image scanners, video cameras, television cameras, optical cameras The camera is selected from the group consisting of a digital camera, a digital camera for digital imaging, and the like.

[0046] Therefore, the camera is a smartphone camera such as an Apple iPhone. A smartphone consists of a central processing unit (CPU), an I / O interface, and including a network controller, frequency modulation, and Bluetooth combo chip. In addition, the CPU can use cloud computing to execute the instructions of the dosimetry device. It can be implemented as multiple processors operating in cooperation with a computing environment.

[0047] In another embodiment, the software means provided in the dosimetry device may Converts color changes into numerical color data and uses quantification algorithms to compare it to predetermined data do.

[0048] Therefore, the captured color is in the form of a pixel. The color intensity is in the form of a "color space" Color spaces allow users to understand the color capabilities of a particular digital device or file. It is a convenient way to understand what the camera can see, what the monitor displays, and RGB, CMY, HSV There are various color spaces such as , HIS, etc. Each color is represented by a dot. Every dot is unique. They are separated and converted to a specific set of numbers, and are stored in triples or tuples, usually three or four It is measured as color components.

[0049] So RGB (R=Red, G=Green, B=Blue) is a color model using red, green, and blue. RGB is a type of color space that can be created using three colors: red, green, and blue. This can be easily interpreted as "all possible colors." In this way, each pixel in the image are assigned RGB components with intensity values ​​ranging from 0 to 255. Using only the Currently, the RGB color spaces are sRGB and AdobeRGB. sRGB was first developed in 1977. Developed by both HP and Microsoft in 2007, where the "S" stands for "Standard" AdobeRGB is the standard color gamut of Adobe. In terms of the color space used, AdobeRGB offers a wider color space compared to sRGB. , which includes the CMYK color space (sRGB does not). As a result, AdobeRGB is The color layers become richer and less saturated.

[0050] Therefore, the radiation emitted by the radiation source is captured as a change in color, and the color intensity The degrees are identified and converted to numbers using RGB software. Graham is an imaging technologist at the Beckman Institute at the University of Illinois at Urbana-Champaign. The preferred tool is GetRGB from the Interactive Technology Group (ITG), which is a standard for 2D image analysis. Free and open source software developed based on quantitative algorithms It is a software program.

[0051] In another embodiment, the color data is compared to a predetermined calibration curve of color vs. radiation dose response data. A calibration curve is a plot of the measured signal (transmittance or optical density) versus absorbed dose. Since the slope at any absorbed dose point is the film absorbed dose sensitivity for that absorbed dose, In general, the calibration curve for optical density is called the "absorbed dose sensitivity" curve. Linear in the very low dose region, linear or nearly linear in the low to mid dose region, and nonlinear in the high dose region. The linear region is the linear region of the film sensitivity in terms of net optical density per unit absorbed dose. The different optical density measurement data for different radiochromic films are useful for quantizing the degree of The calibration curves for radiation detection media are often obtained from linear accelerators or Using a similar device capable of producing a range of known dose levels, one or more of the detection media It is created by exposing areas of the body to different, known amounts of radiation. Another frequently used The method involves exposing the detection means to continuously varying levels of radiation. This is done by inserting a wedge of material with a continuously changing thickness between the sensor and the detection medium. Alternatively, a radiation-sensitive medium can be sandwiched between two blocks, and the medium is exposed to When the radiation sensitive medium is The dose delivered to the body decreases continuously with depth below the upper surface of the block. Exposure to a given dose is often referred to as deep-dose exposure. Calibration curves are usually drawn at different dose levels. It is produced by measuring the response of a radiation-sensitive medium. In the case of radiographic film, It is common to measure the light transmittance or optical density of a medium at many different radiation dose levels. The color change image measured as density-red value was obtained from the selected software "GetRGB". The software program creates a different calibration curve for each lot of dosimetry film. is created. Thus, a library of calibration curves is provided to the user.

[0052] In another embodiment, radiation, such as x-rays, gamma rays, a nuclear explosion, or any other radiation source. In response to the emission of It produces a red color, which darkens as the dose increases, thereby causing a reddish color to the wearer and medical personnel. The intensity of the detection strip indicates the amount of radiation being The dose increases with increasing. The dose is 20% or more on the color reference chart and the optical density vs. It can be estimated with an accuracy of 10% or better using a calibration curve for the dose or CD camera.

[0053] In another embodiment, the test assembly is subjected to optical density measurements. , used to measure the change in color and shape of the image in HDR or Flash mode Density-red data is captured using radiochromatic imaging in the radiation range of interest (25 Gy). Surprisingly, the response of the radiochromic film is nearly linear. The red linear response of the sphere is determined by fitting experimental results of red optical density to X-ray dose through a linear mathematical equation. The results showed that the ion beam was a suitable candidate for developing a dosimetry application that can be used in conjunction with the ion beam. Figures 3 and 4 show the product test assembly before and after exposure to radiation doses of 20 Gy and 10 Gy, respectively. It is about yellowtail.

[0054] Thus, the present application relates to radiation using Gafkromic® film radiation. The dose sensor has a dose range of 0.01 gray (Gy) per second to approximately 2000 Gy (Gy) per second. A new dose measurement device and a photographic densitometer that are expressed as a linear response characteristic of optical density in the red range provides an accurate method of monitoring radiation dosage.

[0055] The test assembly was then subjected to optical density measurements. The results were calculated using an X-Rite 301T photo densitometer. It is measured as dg (density-red), dg (density-green), and db (density-blue). The densitometer changes color from blue to red based on the amount of radiation passing through the subject. The density-red values ​​measured using the

[0056] In yet another important embodiment, the present invention provides a Gafkromic® filter. Radiation dose sensors using neutron radiation can reach 0.01 gray (Gy) per second to approximately 2000 Gy per second. A new dose measurement expressed as a linear response characteristic of optical density-red within the dose range of y (gray). Using a measuring device and a smartphone of your choice from the Apple iPhone, you can measure radiation doses. This provides an accurate way of monitoring the film. A cropped film image is shown in Figure 6.

[0057] In another embodiment, the present application relates to a method for quantifying a dose of radiation emitted from a radiation source. The method includes: (i) measuring radiation and visually displaying the amount of radiation as a color change; (ii) exposing a dosimetry device including a radiation dose indicator to the radiation; capturing a color change of the dose indicator after exposure to radiation using the and (iii) the optical density of the dose indicator as a percentage of optical density versus cumulative radiation. The dose of radiation emitted by the source is determined by comparing it with a predetermined calibration curve created using the amount of radiation. The method includes a step of quantification.

[0058] In another embodiment, the dose data received from the software means is transmitted to a plurality of information networks. The data is then uploaded to a cloud accessible to the network and software management tools.

[0059] In another embodiment, the present application provides a dosimetry device as shown in the figure. The inventive dosimetry device with a sensor is presented in FIG.

[0060] In another embodiment, the general workflow of the dosimetry device is as shown in FIG. It is.

[0061] In another embodiment, the present application provides the use of a dosimetry device, said dosimetry device comprising: Radiation sensitive compositions that measure radiation and visually indicate the amount of radiation emitted as a color change. (ii) a color change of the dose indicator upon exposure to radiation; and (iii) measuring the optical density of the dose indicator in percent. The amount of radiation emitted from the radiation source is compared to a predetermined calibration curve constructed using the optical density of the sample versus the cumulative radiation dose. Sterilization of surfaces and solutions, with software means for quantifying the dose of emitted radiation; Medical imaging, quality assurance testing of medical or industrial equipment, UV measurement, food processing and storage, radiation Used for transporting radiosensitive substances or for storing blood.

[0062] In another embodiment, the dosimetry device of the present application can be used in various applications with blood bags, their storage Blood products are used to treat post-transfusion graft-versus-host disease (TA-GVHD). The desired effect of irradiating the blood is to stimulate lymph It inhibits the function of erythrocytes and therefore prevents GVHD without damaging platelets or other blood fractions. The UK guidelines for blood irradiation state that all parts of a blood pack It is stipulated that a patient must receive at least 2500 cGy. The case states, "The radiation dose (for blood processing) is 2,500 nm toward the center of the container. A minimum dose of 1000 cGy (25 Gy) should be administered at any point, and 1500 cGy (15 Gy) at any other point. From a regulatory perspective, the EU has The accuracy of the dosimeter is required to be CE marked. The regulatory status of the 2015 IEC 61114-1 is as follows: In Article 15.1, a device with a measuring function is Designed and manufactured to provide sufficient accuracy, precision, and stability for their intended purposes The accuracy limits need to be stated by the manufacturer. There are no details on accuracy, but it is useful. Some possible ISO standards: ISO 51929:2013 Blood irradiation dosimetry; I There is SO52628:2013 Standard Practice for Dosimetry in Radiation Processing.

[0063] Therefore, the dosimetry device of the present application allows a user to process blood products and measure the infusion rate after blood processing. take a picture of the indicator window, then the software application processes the picture, It allows the determination of the dose to be administered to the blood product. Stability is the shelf life. is accurately measured.

[0064] Current dosimetry devices are easy to use and require little training for the end user. The new indicators will continue to function the same way as they were originally conceived. The indicator of the present invention provides data relating to the actual radiation level received by the group. , users develop new procedures, data and information regarding blood processing processes This makes it possible.

[0065] Within the scope of the present invention, the current radiation level indicator is hold, wireless data interface, dosimetry to simplify decisions on appropriate blood treatment, Possibility of direct result file sharing with hospital / treatment center IT systems.

[0066] The following non-limiting examples illustrate important aspects of the present invention and in no way limit the scope of the invention. It is not something to do.

[0067] example

[0068] Example 1 : Comparison data for radiochromic films

[0069] To demonstrate the potential of the dosimeter function, various existing radiochromic film products were The films or products evaluated are shown in Table 1.

[0070] [Table 1]

[0071] Example 2 : Exposure to X-ray machines

[0072] The films or products listed in Table 1 are from the Pantak® Unipolar Series. The subjects were exposed to 10, 20, 30, 40, 50 and 60 Gy in a 2HF160 X-ray unit. The X-ray cabinet was marked XRAD-160. CNMC K602 was used to determine the actual dose delivered to the film in grays (Gy). A precision dosimeter was fitted in a similar manner in another series of film exposures. A Gafchromic® film assembly was also tested. An example of this is shown in Figure 3.

[0073] Example 3 : optical density measurement

[0074] The films or products were also evaluated for optical density. The equipment used to measure optical density was , X-Rite 310T Densitometer with Reflective Head Assembly (Model 310-06) This device was a meter that measured dv (density-visual), dr (density-red), and dg (density-green). ), and db (density-blue). Table 2 shows the results of the densitometer tests.

[0075] [Table 2]

[0076] Analysis of the densitometer results shows that the dr (density-red) data is Linear response for fchromic® film #1. Comparison of dr results The plot is shown in Figure 6. The red linear response of Film #1 indicates that this film technology is linear. This is a good candidate for development of quantitative measurement applications, and the experimental results of this red optical density are linear. It is shown that the equation can be used to adjust the X-ray dose.

[0077] Example 4 : Radiation measured as a change in color and captured in the form of an image

[0078] Used a mobile phone camera to measure the color change of radiochromic film Apple iPhone with software version 11.2.1(15C153) ne 5S (model A1533) in HDR mode or without flash (H The radiochromic film cropped in this test was photographed in the DR mode. The image is shown in Figure 5.

[0079] I used my iPhone to capture the photos in HDR mode. These images are The color information of these images was converted to RGB format and saved in jpg format. To achieve this, we have developed the Imaging Software called "GetRGB" by ITG Technology Group The results (point-selected, not averaged) are The conversion of these raw data to RGB format is shown in Table 3. show.

[0080] [Table 3]

[0081] The red data from Table 3 are for radiochromic film #1 in the radiation range of interest. This effect is more easily visualized in the graph shown in Figure 5. The results shown in Figure 6 demonstrate that a linear calibration curve relating color to dose is feasible. Either way.

[0082] Although the invention has been shown and described with reference to specific embodiments, various modifications may be made thereto as set forth herein. It will be apparent to one of ordinary skill in the art upon reading and understanding the present invention and the appended claims. The disclosure includes all such modifications and variations and is limited only by the scope of the claims. do. [Prior art documents] [Patent documents]

[0083] [Patent Document 1] U.S. Patent No. 8,242,464 [Patent Document 2] U.S. Pat. No. 10,060,786

Claims

1. A dose measuring device for quantifying the dose of radiation emitted from a radiation source, wherein the device is (i) A radiation dose indicator comprising a radiosensitive film prepared from polyacetylene, lithium, sodium, potassium, or a zinc salt of polyacetylene, capable of measuring the amount of radiation emitted from a radiation source, wherein the radiation to be measured has a radiation dose range of 0.01 gray (Gy) to 2,000 gray (Gy), (ii) Optical means for capturing the change in color of the radiation dose indicator after exposure to radiation, and (iii) Software means for quantifying the amount of radiation emitted from the radiation source, comparing the optical density of the radiation dose indicator with a predetermined calibration curve created using percentage optical density versus cumulative radiation dose, Equipped with, A dose measuring device characterized in that the predetermined calibration curve is based on the linear response characteristics of the red optical density of a radiation-sensitive film and is created from red optical density data.

2. The dose measuring device according to claim 1, wherein the radiation-sensitive film is a radiochromic film.

3. The dose measuring device according to claim 1, wherein the radiosensitive composition includes a marker.

4. The dose measuring device according to claim 3, wherein the marker is a dye or pigment.

5. The dosimeter according to claim 1, wherein the optical means for capturing the change in the color of the indicator is selected from the group consisting of a smartphone camera, a high-definition camera, a magnifying camera, a magnifying microscope, a densitometer, an image scanner, a video camera, a TV camera, or an optical imaging device.

6. The dose measuring device according to claim 1, wherein the software includes a software program based on a quantification algorithm that characterizes the color change in the form of a color space, converts the identified color space into a numerical dose measurement dataset, and compares the data with predetermined color-to-radiation dose response data.

7. The dose measurement device according to claim 6, wherein the dose measurement data is uploaded to a cloud with access to multiple information networks and software management tools.

8. The dose measuring device according to claim 1, wherein the dose measuring device complies with regulations and is used for the safe storage of blood in a blood bag.

9. (i) A radiation dose indicator comprising a radiosensitive composition for measuring radiation emitted from a radiation source and visually representing the amount of emitted radiation as a change in color, wherein the radiosensitive composition is a radiosensitive film prepared from polyacetylene, lithium, sodium, potassium, or a zinc salt of polyacetylene, and the radiosensitive film has a radiation dose range of 0.01 gray (Gy) to 2,000 gray (Gy), and (ii) Optical means for capturing the change in color of the radiation dose indicator after exposure to radiation, and (iii) Software means for comparing the optical density of the dose indicator with a predetermined calibration curve created using percent optical density versus cumulative radiation dose in order to quantify the amount of radiation emitted from the radiation source, wherein the dose measuring device is used for sterilization of surfaces and solutions, medical imaging, quality assurance testing of medical or industrial equipment, UV light measurement, food processing and storage, transport of radiosensitive materials, or blood storage. The use of a dose measuring device characterized in that the predetermined calibration curve is based on the linear response characteristics of the red optical density of the radiochromic film and is created from red optical density data.

10. A method for quantifying the dose of radiation emitted from a radiation source, wherein the method is: (i) Exposing a dosimeter equipped with a radiosensitivity indicator to radiation, the radiosensitivity indicator comprising a radiosensitivity composition that measures radiation and visually represents the amount of emitted radiation as a change in color, wherein the radiosensitivity composition is a radiosensitivity film prepared from polyacetylene, lithium, sodium, potassium, or a zinc salt of polyacetylene, and the radiosensitivity film has a radiation dose range of 0.01 gray (Gy) to 2,000 gray (Gy); (ii) the step of capturing the change in color of a dose indicator after exposure to radiation using optical means, and (iii) A step of quantifying the dose of radiation emitted from a radiation source by comparing the optical density of a dose indicator with a predetermined calibration curve created using percentage optical density versus cumulative radiation dose. Includes, The method is characterized in that the predetermined calibration curve is based on the linear response characteristics of the red optical density of the radiochromic film and is created from red optical density data.

11. The method according to claim 10, wherein the optical means is a photographic densitometer.

12. The method according to claim 10, wherein the optical means is a smartphone.

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