Biological fluid treatment systems

Abstract

To provide suitable biological fluid treatment systems.SOLUTION: There are provided systems, methods, and apparatuses for treating biological fluids. In some embodiments, a biological fluid treatment system comprises: a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system comprises a scanner. The biological fluid treatment system includes a treatment chamber configured to receive biological fluids, a platform configured to carry the biological fluid to be positioned in the treatment chamber, an array of light sources positioned to illuminate the biological fluid in the treatment chamber, and a display configured for displaying a graphical user interface. The biological fluid treatment system includes a scanner configured to obtain identifying information associated with a first biological fluid, a second biological fluid, or both the first biological fluid and the second biological fluid.SELECTED DRAWING: Figure 3A

Description

[Technical field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U.S. Provisional Patent Application No. 62 / 865,207, filed June 22, 2019, U.S. Provisional Patent Application No. 62 / 869,544, filed July 1, 2019, and U.S. Provisional Patent Application No. 62 / 986,593, filed March 6, 2020, the disclosures of which are incorporated by reference in their entireties herein.

[0002] The present disclosure relates generally to systems, methods, and devices for treating biological fluids, including mixtures of biological fluids and photochemicals, with light. [Background technology]

[0003] Systems and methods for treating biological fluids with light are known. For example, U.S. Patent Nos. 7,459,695, 6,986,867, and 5,593,823 describe systems for treating biological fluids with light to inactivate pathogens in the biological fluid. The light is emitted within a selected wavelength range that is effective to inactivate pathogens in the biological fluid, particularly by photochemical inactivation of the pathogens. Other systems and methods for treating biological fluids with light can include, for example, the systems and methods described in U.S. Patent Nos. 6,843,961, 7,829,867, 9,320,817, and 8,778,263, as well as Schlenke, 2014, Transfus.Med. Hemother. 41:309-325.

[0004] For example, in the case of blood products including platelets and plasma components and their derivatives, it is important to ensure that the blood product is free of pathogens in order to minimize the risk of infection to the individual receiving the blood product. Testing for the presence of pathogens in blood is limited by the pathogens available for testing and the sensitivity of the assay. As an alternative or adjunct to pathogen testing, methods are known in the art for inactivating pathogens to reduce the risk of transfusion transmission using inactivation methods based on various compounds (e.g., chemicals, photochemicals) (e.g., as disclosed in Schlenke et al., Transfus Med Hemother, 2014, 41, 309-325 and Prowse, Vox Sanguinis, 2013, 104, 183-199). Psoralen and ultraviolet light-based photochemical pathogen inactivation systems for processing blood products include the commercially available INTERCEPT® Blood System (Cerus Corporation), which utilizes a disposable processing set and ultraviolet light irradiation device (INT-100). Blood products such as plasma or platelets are mixed with psoralen, amotosalen in the processing set and then irradiated with ultraviolet A light, after which residual amotosalen and its photoproducts are removed in the compound adsorption device (CAD) portion of the processing set. Depending on the type of blood products being processed and the specific characteristics of those blood products, such as volume and platelet count, for example, multiple different disposable processing sets can be used. Different irradiation requirements can limit the ability to process multiple processing sets in the same irradiation device, thereby affecting the efficiency of blood collection centers. Previous irradiator systems may also be horizontally wide and limited to processing chambers with only one horizontal layer.

[0005] While previous systems and methods for processing biological fluids, such as blood products, as described herein have generally performed satisfactorily, it would be desirable to develop improved systems and methods, including those disclosed herein, that include multiple processing chambers and design features that may provide a variety of advantageous benefits for higher throughput processing of biological fluids, ease of use by an operator, and / or reduced instances of user operator error that may affect the system and / or the biological fluid being processed. Summary of the Invention [Means for solving the problem]

[0006] Disclosed herein are systems, methods, and apparatus for processing biological fluids. In some embodiments, the biological fluid processing system includes a processing chamber configured to receive a biological fluid, a platform configured to hold the biological fluid disposed in the processing chamber, a light source array arranged to illuminate the biological fluid in the processing chamber, and a display configured to display a graphical user interface (GUI). In some embodiments, the biological fluid processing system includes a scanner configured to obtain identification information associated with the first biological fluid, the second biological fluid, or both the first biological fluid and the second biological fluid.

[0007] In some embodiments, a biological fluid processing system comprises a first processing chamber configured to receive a first biological fluid, a second processing chamber configured to receive a second biological fluid, a first platform configured to hold the first biological fluid and to be disposed within the first processing chamber, a second platform configured to hold the second biological fluid and to be disposed within the second processing chamber, a first light source array arranged to irradiate the first biological fluid in the first processing chamber and a second light source array arranged to irradiate the second biological fluid in the second processing chamber, a display, one or more processors, and a memory containing instructions that, when executed by the one or more processors, cause the one or more processors to perform a method including providing, for display on the display, a GUI including a plurality of GUI objects associated with processing the first biological fluid with irradiation from the first light source array or associated with processing the second biological fluid with irradiation from the second light source array.

[0008] In some embodiments, the first light source array and the second light source array are configured to irradiate the first biological fluid and the second biological fluid, respectively, with ultraviolet light. In some embodiments, each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 315 nm to about 350 nm. In some embodiments, each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 330 nm to about 350 nm. In some embodiments, each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 340 nm to about 350 nm. In some embodiments, each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array in the range of 345+5 nm. In some embodiments, each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 315 nm to about 335 nm. In some embodiments, each of the light source arrays includes a respective second light source channel configured to emit ultraviolet light having a second peak wavelength of the array, the second peak wavelength differing from the first peak wavelength by at least 5 nanometers.

[0009] In some embodiments, for each of the light source arrays, a respective first light source channel comprises one or more light sources, each emitting light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers. In some embodiments, for each of the light source arrays, a respective second light source channel comprises one or more light sources, each emitting light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers.

[0010] In some embodiments, the system further comprises a third light source array facing in a direction opposite to the first light source array and positioned to irradiate a first biological fluid in the first treatment chamber, and a fourth light source array facing in a direction opposite to the second light source array and positioned to irradiate a second biological fluid in the second treatment chamber, and the method further comprises providing for display on the display a GUI including a plurality of graphical user interface (GUI) objects associated with treating the first biological fluid with irradiation from the third light source array or associated with treating the second biological fluid with irradiation from the fourth light source array.

[0011] In some embodiments, the third and fourth light source arrays each comprise a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 315 nm to about 350 nm. In some embodiments, the third and fourth light source arrays each comprise a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 330 nm to about 350 nm. In some embodiments, the third and fourth light source arrays each comprise a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 340 nm to about 350 nm. In some embodiments, the third and fourth light source arrays each comprise a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array in the range of 345+5 nm. In some embodiments, the third and fourth light source arrays each comprise a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 315 nm to about 335 nm. In some embodiments, the third and fourth light source arrays each include a respective second light source channel configured to emit ultraviolet light having a second peak wavelength of the array, the second peak wavelength differing from the first peak wavelength by at least 5 nanometers.

[0012] In some embodiments, for each of the third and fourth light source arrays, the respective first light source channel comprises one or more light sources each emitting light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers. In some embodiments, for each of the third and fourth light source arrays, the respective second light source channel comprises one or more light sources each emitting light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers.

[0013] In some embodiments, each of the light source arrays (e.g., a first array, a second array, a third array, a fourth array) comprises one or more light sources, each of which is a light emitting diode, and for each of the light source arrays, a respective ultraviolet light is emitted by a respective one or more light sources.

[0014] In some embodiments, the first platform is slidably moveable to introduce and remove a first biological fluid into and out of a first processing chamber, and the second platform is slidably moveable to introduce and remove a second biological fluid into and out of a second processing chamber.

[0015] In some embodiments, the system further comprises a housing configured to house the first processing chamber, the second processing chamber, the first platform, the second platform, the first light source array, the second light source array, a display, one or more processors, and a memory.

[0016] In some embodiments, the system further comprises a scanner configured to obtain identification information associated with the first biological fluid, the second biological fluid, or both the first biological fluid and the second biological fluid. In some embodiments, the scanner is one of a group including a barcode scanner, a QR code scanner, and an RFID scanner. In some embodiments, the identification information is transmitted in radio wave transmittable form of an RFID tag on a container (e.g., a single container) for storing the first biological fluid or the second biological fluid, or on at least one of the one or more containers of a multiple container assembly for storing the first biological fluid or the second biological fluid, and the method further comprises obtaining, by the scanner, the radio wave transmitted identification information from the RFID tag on the container. In some embodiments, the identification information is in visible form of a barcode or a QR code on a container (e.g., a single container) for storing the first biological fluid or the second biological fluid, and the method further comprises obtaining, by the scanner, the barcode or the QR code on the container. In some embodiments, the identification information is in the visible form of a bar code or QR code on at least one of the one or more containers of the dual container assembly for storing the first biological fluid or the second biological fluid, and the method further includes acquiring, by a scanner, the bar code or QR code on at least one of the one or more containers. In some embodiments, the scanner is configured to acquire the identification information transmitted in radio wave form from an RFID tag on the container for storing the first biological fluid or the second biological fluid (e.g., a single container) or on at least one of the one or more containers of the dual container assembly for storing the first biological fluid or the second biological fluid when the container is placed on the first platform or the second platform.In some embodiments, the scanner is configured to acquire identification information in visible form on a container (e.g., a single container) for storing the first biological fluid or the second biological fluid when the container is placed on the first platform or the second platform. In some embodiments, the scanner is configured to acquire identification information in visible form on at least one of one or more containers of a multiple container assembly for storing the first biological fluid or the second biological fluid when the one or more containers are placed on the first platform or the second platform. In some embodiments, the identification information is a plurality of sets of identification information in visible form on a container (e.g., a single container) for storing the first biological fluid or the second biological fluid, and the scanner is a multi-scan scanner configured to acquire the plurality of sets of identification information (e.g., each of the plurality of sets of identification information, all of the plurality of sets of identification information) in a multi-scan operation. In some embodiments, the identification information is a plurality of sets of identification information in visible form on one or more containers of a multiple container assembly for storing the first biological fluid or the second biological fluid, and the scanner is a multi-scan scanner configured to obtain the plurality of sets of identification information (e.g., each of the plurality of sets of identification information, all of the plurality of sets of identification information) in a multi-scan operation. In some embodiments, the identification information is a plurality of sets of identification information transmitted in a transmittable form from a tag on a container (e.g., a single container) for storing the first biological fluid or the second biological fluid, and the scanner is a multi-scan scanner configured to obtain the plurality of sets of identification information (e.g., each of the plurality of sets of identification information, all of the plurality of sets of identification information) in a multi-scan operation.In some embodiments, the identification information is multiple sets of identification information transmitted in a transmittable form from tags on one or more containers of a multiple container assembly for storing the first biological fluid or the second biological fluid, and the scanner is a multi-scan scanner configured to obtain the multiple sets of identification information (e.g., each of the multiple sets of identification information, all of the multiple sets of identification information) in a multi-scan operation.

[0017] In some embodiments, the scanner is integrated or embedded in a fixed position within the housing and is coupled to one or more processors. In some embodiments, the scanner is located inside the first processing chamber, the second processing chamber, or both the first processing chamber and the second processing chamber. In some embodiments, the scanner is located at a first opening of the first processing chamber or a second opening of the second processing chamber. In some embodiments, the scanner is located outside the first processing chamber and the second processing chamber. In some embodiments, the scanner is a handheld scanner wirelessly coupled to one or more processors. In some embodiments, the scanner is a handheld scanner wiredly coupled to one or more processors.

[0018] In some embodiments, the first and second processing chambers are arranged horizontally such that the first and second biological fluids are in the same plane when placed on the first and second platforms, respectively. In some embodiments, the first and second processing chambers are arranged vertically such that the first and second biological fluids are in parallel planes when placed on the first and second platforms, respectively.

[0019] In some embodiments, the system further comprises a first panel movable between a closed position and an open position, the first panel covering the first opening to the first processing chamber in the closed position, the first panel not covering the first opening to the first processing chamber in the open position, and an exterior of the first panel comprising one or more of the group comprising a protruding handle and a recessed handle. In some embodiments, the system further comprises a first panel movable between a closed position and an open position, the first panel covering the first opening to the first processing chamber in the closed position, the first panel not covering the first opening to the first processing chamber in the open position, and an entire exterior of the first panel devoid of any handles. In some embodiments, the first panel is configured to be locked to remain in the closed position and configured to be unlocked in response to an input. In some embodiments, the input is a user input, such as, for example, a user's manual input on a touch screen (e.g., touch or hover), a user's voice command (e.g., detected by a microphone), or a user's visual movement (e.g., a hand movement or gesture, an object in a swipe motion) to unlock the panel.

[0020] In some embodiments, the first platform comprises a first panel. In some embodiments, the first platform comprises an outer region comprising a first panel movable between a closed position and an open position, the first panel being configured to remain in a fixed position when the first panel is in the closed position, and a first support structure, and an inner region configured to move to agitate the first biological fluid during the time the outer region is in the fixed position, the first support structure of the outer region structurally supporting the inner region. In some embodiments, the inner region of the first platform configured to move to agitate the first biological fluid comprises an inner region assembly comprising one or more removable interior region parts configured to hold a container for storing the first biological fluid, and an interior region support structure structurally supporting the one or more removable interior region parts and movable to agitate the first biological fluid held by the one or more removable interior region parts.

[0021] In some embodiments, the outer region includes a motor configured to generate motion, and the inner region is configured to agitate the first biological fluid based on the motion generated by the motor. In some embodiments, the system is configured to control (e.g., adjustably control) one or more aspects of the movement of the inner region to agitate the first biological fluid, such as offset, speed, acceleration, and deceleration. In some embodiments, the motor is positioned at a position to the right or left of where the first biological fluid is held by the first platform. In some embodiments, the motor is positioned at a position in front or behind where the first biological fluid is held by the first platform.

[0022] In some embodiments, the second platform comprises a second panel movable between a closed position and an open position, where the second panel covers a second opening to the second processing chamber in the closed position and where the second panel does not cover the second opening to the second processing chamber in the open position, an outer region comprising the second panel movable between the closed position and the open position, where the outer region is configured to remain in a fixed position when the second panel is in the closed position, and a second support structure, and an inner region configured to move to agitate the second biological fluid during the time the outer region is in the fixed position, and the second support structure of the output region structurally supports the inner region. In some embodiments, the inner region of the second platform configured to move to agitate the second biological fluid comprises an inner region assembly comprising one or more removable interior region parts configured to hold a container for storing the second biological fluid, and an interior region support structure that structurally supports the one or more removable interior region parts and is movable to agitate the second biological fluid held by the one or more removable interior region parts.

[0023] In some embodiments, the first platform and the second platform each comprise a first compartment and a second compartment, the first and second compartments configured to hold a dual container assembly for storing a biological fluid of the respective platform, the first compartment of the first platform configured to hold a first container of the first dual container assembly, the first container storing the first biological fluid and arranged such that when the first platform is disposed within the first processing chamber, the first light source array is configured to illuminate the first container, the second compartment of the first platform configured to hold one or more additional containers of the first dual container assembly, the one or more additional containers do not store the first biological fluid, and the second compartment is configured to illuminate the first container of the first dual container assembly when the first platform is disposed within the first processing chamber. The first light source array is not configured to irradiate one or more additional containers when disposed within the processing chamber, a first compartment of the second platform is configured to hold a first container of a second multi-container assembly, the first container storing a second biological fluid and arranged such that the second light source array is configured to irradiate the first container when the second platform is positioned within the second processing chamber, and a second compartment of the second platform is configured to hold one or more additional containers of the second multi-container assembly, the one or more additional containers do not store a second biological fluid and the second compartment is arranged such that the second light source array is not configured to irradiate the one or more additional containers when the second platform is disposed within the second processing chamber.

[0024] In some embodiments, the display is a touch screen configured to display a GUI including a plurality of GUI objects, the GUI objects responsive to touch input on the touch screen. In some embodiments, the method further includes receiving input associated with a selection of the GUI object and performing a biological fluid processing operation in response to receiving the input.

[0025] In some embodiments, any of the systems provided herein (e.g., the systems described above) may perform a method of treating one or more biological fluids that includes irradiating a first biological fluid of the one or more biological fluids with ultraviolet light (e.g., ultraviolet light having a first peak wavelength of about 315 nm to about 350 nm) emitted by a set of one or more first light sources, where the first biological fluid is mixed with a pathogen inactivating compound (e.g., a photoactive pathogen inactivating compound, psoralen, amotosalen), and where 1) each of the one or more first light sources emits light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers, and / or 2) each of the one or more first light sources is a light emitting diode (LED), and where irradiating the first biological fluid occurs for a duration and with an intensity sufficient to inactivate pathogens in the first biological fluid. In some embodiments, the method of treating one or more biological fluids may further include irradiating a second biological fluid of the one or more biological fluids with ultraviolet light (e.g., ultraviolet light having a second peak wavelength of about 315 nm to about 350 nm) emitted by a set of one or more second light sources, where the second biological fluid is mixed with a pathogen inactivating compound (e.g., a photoactive pathogen inactivating compound, psoralen, amotosalen), and where 1) each of the one or more second light sources emits light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers, and / or 2) each of the one or more second light sources is a light emitting diode (LED), and where irradiating the second biological fluid occurs for a duration and with an intensity sufficient to inactivate pathogens in the second biological fluid.

[0026] In some embodiments, each of the first and second platforms is configured to hold the first and second biological fluids, respectively, in a first and second flexible container, each having a volume capacity of up to about 3000 mL. In some embodiments, each of the first and second platforms is configured to hold the first and second biological fluids, respectively, in a first and second flexible container, each having a volume capacity of up to about 1500 mL. In some embodiments, each of the first and second platforms is configured to hold the first and second biological fluids, respectively, in a first and second flexible container, each having a volume capacity of up to about 1000 mL.

[0027] In some embodiments, the system comprises a heating and / or cooling unit configured to adjust or set a temperature of the first treatment chamber, and the method further comprises controlling the heating / cooling unit to maintain a temperature of the first biological fluid within 2° C. during treatment of the first biological fluid with irradiation from the first light source array. In some embodiments, the method further comprises controlling the system to maintain a temperature of the first biological fluid within 2° C. during treatment of the first biological fluid with irradiation from the first light source array. In some embodiments, the system comprises a heating and / or cooling unit configured to adjust or set a temperature of the second treatment chamber, and the method further comprises controlling the heating / cooling unit to maintain a temperature of the second biological fluid within 2° C. during treatment of the second biological fluid with irradiation from the second light source array. In some embodiments, the method further comprises controlling the system to maintain a temperature of the second biological fluid within 2° C. during treatment of the second biological fluid with irradiation from the second light source array.

[0028] In some embodiments, the housing has a maximum horizontal width in the range of 30-45 cm. In some embodiments, the system is configured to operate within the target operating space such that there is no more than 20 cm of free space on both the left and right sides of the housing.

[0029] In some embodiments, the system further comprises one or more access panels configured to provide access to one or more of the first light source array, the second light source array, and / or the one or more processors. In some embodiments, the system further comprises one or more front access panels configured to provide access to one or more of the first light source array, the second light source array, and / or the one or more processors. In some embodiments, the system further comprises one or more side access panels configured to provide access to one or more of the first light source array, the second light source array, and / or the one or more processors.

[0030] In another aspect, the present disclosure provides a method of treating a biological fluid, the method comprising irradiating the biological fluid with any of the systems provided herein (e.g., the systems described above, systems disclosed below) for a duration and intensity sufficient to inactivate pathogens in the biological fluid (e.g., if present in the biological fluid). In some embodiments, the present disclosure provides a method of treating a biological fluid comprising providing a biological fluid mixed with a pathogen inactivating compound (e.g., a photoactive pathogen inactivating compound, psoralen, amotosalen) and irradiating the biological fluid with any of the systems provided herein (e.g., the systems described above) for a duration and intensity sufficient to inactivate pathogens in the biological fluid (e.g., if present in the biological fluid). In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by one or more first set of light sources (e.g., ultraviolet A, ultraviolet B, ultraviolet C, ultraviolet light having a first peak wavelength of about 315 nm to about 350 nm), where 1) each of the one or more first light sources emits light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers, and / or 2) each of the one or more first light sources is a light emitting diode (LED). In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by one or more first set of light sources having a first peak wavelength of about 315 nm to about 350 nm. In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by one or more first set of light sources having a first peak wavelength of about 330 nm to about 350 nm. In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by one or more first set of light sources having a first peak wavelength of about 340 nm to about 350 nm. In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by a first set of one or more light sources having a first peak wavelength in the range of about 345+5 nm. In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by a first set of one or more light sources having a first peak wavelength of about 315 nm to about 335 nm.In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by one or more first set of light sources having a first peak wavelength and ultraviolet light from one or more second set of light sources having a second peak wavelength, the second peak wavelength differing from the first peak wavelength by at least 5 nanometers. In some embodiments, the duration and intensity of the irradiation is about 0.5 J / cm. 2 or more (for example, about 0.5 J / cm 2 ~about 50J / cm 2 ) of ultraviolet light irradiating the biological fluid. In some embodiments, the intensity is between 1 and 1000 mW / cm 2 (for example, 1 to 100 mW / cm 2 In some embodiments, the period is between 1 second and 2 hours (e.g., between 1 minute and 60 minutes). In some embodiments, the method of treating the biological fluid is sufficient to inactivate at least 1 log of pathogens in the biological fluid. In some embodiments, the method of treating the biological fluid is sufficient to inactivate at least 4 log of pathogens in the biological fluid. In some embodiments, the biological fluid is a blood product (e.g., platelets, plasma). The present invention provides, for example, the following: (Item 1) 1. A biological fluid treatment system comprising: a first processing chamber configured to receive a first biological fluid; a second processing chamber configured to receive a second biological fluid; a first platform configured to hold the first biological fluid and to be disposed within the first processing chamber; a second platform configured to hold the second biological fluid and to be disposed within the second processing chamber; a first light source array positioned to irradiate the first biological fluid in the first treatment chamber, and a second light source array positioned to irradiate the second biological fluid in the second treatment chamber; A display and one or more processors; a memory containing instructions that, when executed by the one or more processors, cause the one or more processors to perform a method including providing, for display on the display, a graphical user interface (GUI) including a plurality of GUI objects associated with treating the first biological fluid with illumination from the first light source array or associated with treating the second biological fluid with illumination from the second light source array; The biological fluid treatment system comprising: (Item 2) 2. The system of claim 1, wherein the first light source array and the second light source array are configured to irradiate the first biological fluid and the second biological fluid, respectively, with ultraviolet light. (Item 3) 3. The system of claim 1, wherein each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 315 nm to about 350 nm. (Item 4) 3. The system of claim 1, wherein each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 330 nm to about 350 nm. (Item 5) 3. The system of claim 1, wherein each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 340 nm to about 350 nm. (Item 6) 3. The system of claim 1, wherein each of the light source arrays includes a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array within a range of 345 nm±5 nm. (Item 7) 3. The system of claim 1, wherein each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array from about 315 nm to about 335 nm. (Item 8) 8. The system of any one of claims 2 to 7, wherein for each of the light source arrays, the respective first light source channel comprises one or more light sources each emitting light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers. (Item 9) a third array of light sources facing in an opposite direction from the first array of light sources and positioned to illuminate the first biological fluid in the first treatment chamber; a fourth array of light sources facing in an opposite direction from the second array of light sources and positioned to illuminate the second biological fluid in the second treatment chamber; The system of any one of items 1 to 8, wherein the method further includes providing, for display on the display, a graphical user interface (GUI) including a plurality of GUI objects associated with treating the first biological fluid with irradiation from the third light source array or associated with treating the second biological fluid with irradiation from the fourth light source array. (Item 10) Item 10. The system of item 9, wherein each of the third and fourth light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 315 nm to about 350 nm. (Item 11) 11. The system of claim 10, wherein for each of the third and fourth light source arrays, the respective first light source channel comprises one or more light sources each emitting light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers. (Item 12) each of the light source arrays comprises one or more light sources, each of the light sources being a light emitting diode; 12. The system of any one of claims 2 to 11, wherein for each of the light source arrays, the respective ultraviolet light is emitted by the respective one or more light sources. (Item 13) 13. The system of any one of items 1 to 12, wherein the first platform is slidably movable to introduce and remove the first biological fluid into and out of the first treatment chamber, and the second platform is slidably movable to introduce and remove the second biological fluid into and out of the second treatment chamber. (Item 14) Further comprising a housing; 14. The system of any one of items 1 to 13, wherein the housing is configured to accommodate the first processing chamber, the second processing chamber, the first platform, the second platform, the first light source array, the second light source array, the display, the one or more processors, and the memory. (Item 15) 15. The system of any one of items 1 to 14, further comprising a scanner configured to obtain identification information associated with the first biological fluid, the second biological fluid, or both the first biological fluid and the second biological fluid. (Item 16) Item 16. The system of item 15, wherein the scanner is one of the group including a barcode scanner, a QR code scanner, and an RFID scanner. (Item 17) the identification information is in the visible form of a bar code or a QR code on a container for storing the first biological fluid or the second biological fluid, or on at least one of one or more containers of a multiple container assembly for storing the first biological fluid or the second biological fluid; The system described in item 15 or item 16, wherein the method further includes acquiring, by the scanner, the barcode or the QR code (registered trademark) on the container for storing the first biological fluid or the second biological fluid, or on at least one of the one or more containers of the multiple container assembly. (Item 18) 18. The system of any one of items 15 to 17, wherein the scanner is configured to acquire the identification information in visible form on a container for storing the first biological fluid or the second biological fluid when the container for storing the first biological fluid or the second biological fluid is placed on the first platform or the second platform, or on at least one of the one or more containers of a multiple container assembly for storing the first biological fluid or the second biological fluid when the one or more containers of the multiple container assembly are placed on the first platform or the second platform. (Item 19) the identification information being a plurality of sets of identification information in visible form on a container for storing the first biological fluid or the second biological fluid, or on one or more containers of a multiple container assembly for storing the first biological fluid or the second biological fluid, or communicated in a transmittable form from a tag on the container for storing the first biological fluid or the second biological fluid, or on one or more containers of the multiple container assembly for storing the first biological fluid or the second biological fluid; 19. The system of any one of items 15 to 18, wherein the scanner is a multi-scan scanner configured to obtain multiple sets of the identification information in a multi-scan operation. (Item 20) 20. The system of any one of items 15 to 19, wherein the scanner is integrated or embedded in a fixed position within the housing and coupled to the one or more processors. (Item 21) 21. The system of any one of items 15 to 20, wherein the scanner is positioned inside the first processing chamber, the second processing chamber, or both the first processing chamber and the second processing chamber. (Item 22) 21. The system of any one of items 15 to 20, wherein the scanner is positioned at a first opening of the first processing chamber or a second opening of the second processing chamber. (Item 23) 21. The system of any one of items 15 to 20, wherein the scanner is positioned outside the first processing chamber and the second processing chamber. (Item 24) 20. The system of any one of items 15 to 19, wherein the scanner is a handheld scanner wirelessly coupled to the one or more processors. (Item 25) 20. The system of any one of items 15 to 19, wherein the scanner is a handheld scanner coupled to the one or more processors via a wired connection. (Item 26) 26. The system of any one of items 1 to 25, wherein the first processing chamber and the second processing chamber are horizontally arranged such that the first biological fluid and the second biological fluid are in the same plane when placed on the first platform and the second platform, respectively. (Item 27) 26. The system of any one of items 1 to 25, wherein the first processing chamber and the second processing chamber are vertically arranged such that the first biological fluid and the second biological fluid are in parallel planes when placed on the first platform and the second platform, respectively. (Item 28) 28. The system of any one of items 1-27, further comprising a first panel movable between a closed position and an open position, wherein the first panel covers a first opening to the first processing chamber in the closed position, and wherein the first panel does not cover the first opening to the first processing chamber in the open position, and an exterior of the first panel includes one or more of the group consisting of a protruding handle and a recessed handle. (Item 29) 28. The system of any one of items 1-27, further comprising a first panel movable between a closed position and an open position, wherein the first panel covers a first opening to the first processing chamber in the closed position, and wherein the first panel does not cover the first opening to the first processing chamber in the open position, and wherein the entire exterior of the first panel is devoid of any handles. (Item 30) 30. The system of any one of claims 28 to 29, wherein the first panel is configured to be locked to remain in the closed position and configured to be unlocked in response to an input. (Item 31) The system of any one of items 28 to 30, wherein the first platform comprises the first panel. (Item 32) The first platform comprises: An outer region, the first panel being movable between a closed position and an open position, the outer region being configured to remain in a fixed position when the first panel is in the closed position; a first support structure; and an inner region configured to move so as to agitate the first biological fluid while the outer region is in a fixed position; the first support structure of the outer region structurally supports the inner region; The system according to any one of items 28 to 31. (Item 33) Item 33. The system of item 32, wherein the outer region comprises a motor configured to generate motion, and the inner region is configured to agitate the first biological fluid based on the motion generated by the motor. (Item 34) Item 34. The system of item 33, wherein the motor is positioned at a position to the right or left of where the first biological fluid is held by the first platform. (Item 35) Item 34. The system of item 33, wherein the motor is positioned at a position in front or behind where the first biological fluid is held by the first platform. (Item 36) The second platform comprises: a second panel movable between a closed position and an open position, the second panel covering a second opening to the second processing chamber in the closed position, and the second panel not covering the second opening to the second processing chamber in the open position; and An outer region, the second panel being movable between a closed position and an open position, the outer region being configured to remain in a fixed position when the second panel is in the closed position; the outer region comprising a second support structure; an inner region configured to move so as to agitate the second biological fluid while the outer region is in a fixed position; the second support structure of the output region structurally supports the inner region; The system according to any one of items 32 to 35. (Item 37) the first platform and the second platform each include a first compartment and a second compartment, the first and second compartments configured to hold a multiple container assembly for storing the biological fluid of the respective platform; the first compartment of the first platform is configured to hold a first container of a first multi-container assembly, the first container storing the first biological fluid, the first compartment being arranged such that when the first platform is disposed within the first processing chamber, the first light source array is configured to illuminate the first container; the second compartment of the first platform is configured to hold one or more additional containers of the first multi-container assembly, the one or more additional containers not storing the first biological fluid, and the second compartment is positioned such that the first light source array is not configured to illuminate the one or more additional containers when the first platform is disposed within the first processing chamber; the first compartment of the second platform is configured to hold a first container of a second multi-container assembly, the first container storing the second biological fluid, the first compartment being arranged such that when the second platform is disposed within the second processing chamber, the second light source array is configured to illuminate the first container; the second compartment of the second platform is configured to hold one or more additional containers of the second multi-container assembly, the one or more additional containers not storing the second biological fluid, and the second compartment is arranged such that the second light source array is not configured to illuminate the one or more additional containers when the second platform is disposed within the second processing chamber. The system according to any one of items 1 to 36. (Item 38) Item 38. The system of any one of items 1 to 37, wherein the display is a touch screen configured to display the GUI including the plurality of GUI objects, and the GUI objects are responsive to touch input on the touch screen. (Item 39) The method further comprising: receiving input associated with a selection of a GUI object; 39. The system of any one of items 1 to 38, further comprising: in response to receiving the input, performing a biological fluid processing operation. (Item 40) The method further comprising: illuminating the first biological fluid with ultraviolet light emitted by a first set of one or more light sources; the first biological fluid is mixed with a pathogen inactivating compound; 1) each of the one or more first light sources emits light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers; or 2) each of the one or more first light sources is a light emitting diode (LED); 40. The system of any one of items 1-39, wherein irradiating the first biological fluid occurs for a duration and with an intensity sufficient to inactivate pathogens in the first biological fluid. (Item 41) The method further comprising: illuminating the second biological fluid with ultraviolet light emitted by a second set of one or more light sources; the second biological fluid is mixed with a pathogen inactivating compound; 1) each of the one or more second light sources emits light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers; or 2) each of the one or more second light sources is a light emitting diode (LED); Item 41. The system of item 40, wherein irradiating the second biological fluid occurs for a duration and with an intensity sufficient to inactivate pathogens in the second biological fluid. (Item 42) 42. The system of any one of items 1 to 41, wherein each of the first platform and the second platform is configured to hold the first and second biological fluids, respectively, in a first flexible container and a second flexible container, each having a volume capacity of up to about 1500 mL. (Item 43) The system comprises a heating and / or cooling unit configured to adjust or set a temperature of the first process chamber, and the method further comprises: 43. The system of any one of claims 1 to 42, further comprising controlling the heating / cooling unit to maintain the temperature of the first biological fluid within 2°C during treatment of the first biological fluid by irradiation from the first light source array. (Item 44) The method further comprising: 44. The system of any one of claims 1 to 43, further comprising controlling the system to maintain the temperature of the first biological fluid within 2°C during treatment of the first biological fluid by irradiation from the first array of light sources. (Item 45) 45. The system of any one of items 14 to 44, wherein the housing has a maximum horizontal width in the range of 30 to 45 cm. (Item 46) 46. ​​The system of any one of items 14 to 45, wherein the system is configured to operate within a target operating space such that there is 20 cm or less of free space on both the left and right sides of the housing. (Item 47) 47. The system of any one of items 1 to 46, further comprising one or more front access panels configured to provide access to one or more of the first light source array, the second light source array, and the one or more processors. (Item 48) 1. A method for treating a biological fluid, comprising: providing said biological fluid in admixture with a pathogen inactivating compound; and irradiating the biological fluid using the system according to any one of items 1 to 47 for a period and intensity sufficient to inactivate pathogens in the biological fluid. [Brief description of the drawings]

[0031] [Figure 1] 1 illustrates an exemplary system for treating a biological fluid. [Figure 2A] 1 illustrates an exemplary system for treating a biological fluid. [Figure 2B] 1 illustrates an exemplary system for treating a biological fluid. [Figure 2C] 1 illustrates an exemplary system for treating a biological fluid. [Figure 3A] 1 illustrates an exemplary system for treating a biological fluid. [Figure 3B] 1 illustrates an exemplary system for treating a biological fluid. [Figure 4A] 1 illustrates an exemplary system for treating a biological fluid. [Figure 4B] 1 illustrates an exemplary system for treating a biological fluid. [Figure 4C] 1 illustrates an exemplary system for treating a biological fluid. [Figure 4D] 1 illustrates an exemplary system for treating a biological fluid. [Figure 4E] 1 illustrates an exemplary system for treating a biological fluid. [Figure 4F] 1 illustrates an exemplary system for treating a biological fluid. [Figure 4G] 1 illustrates an exemplary system for treating a biological fluid. [Figure 4H] 1 illustrates an exemplary system for treating a biological fluid. [Figure 4I] 1 illustrates an exemplary system for treating a biological fluid. [Figure 4J] 1 illustrates an exemplary system for treating a biological fluid. [Figure 4K] 1 illustrates an exemplary system for treating a biological fluid. [Figure 4L] 1 illustrates an exemplary system for treating a biological fluid. [Diagram 5] FIG. 1 is a perspective view of an exemplary system for treating a biological fluid. [Figure 6]FIG. 1 is a perspective view of an exemplary system for treating a biological fluid. [Figure 7] 1 shows a perspective view of an exemplary system for treating a biological fluid. [Figure 8] 1 is an example of a computing device according to one embodiment of the present disclosure. [Figure 9A] 1 illustrates an exemplary system for treating a biological fluid. [Figure 9B] 1 illustrates an exemplary system for treating a biological fluid. [Figure 9C] 1 illustrates an exemplary system for treating a biological fluid. [Figure 9D] 1 illustrates an exemplary system for treating a biological fluid. [Figure 9E] 1 illustrates an exemplary system for treating a biological fluid. [Figure 9F] 1 illustrates an exemplary system for treating a biological fluid. [Figure 10] 1 illustrates an exemplary system for treating a biological fluid. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0032] The following description is presented to enable those skilled in the art to make and use the various embodiments. Descriptions of specific systems, devices, methods, and applications are provided only as examples. Various modifications to the examples described herein will be readily apparent to those skilled in the art, and the general principles defined herein can be applied to other examples and applications without departing from the spirit and scope of the various embodiments. Thus, the various embodiments are not intended to be limited to the examples described and shown herein, but should be accorded the scope consistent with the claims.

[0033] Disclosed herein are systems, methods, and apparatus for processing biological fluids. In some embodiments, the biological fluid processing system includes a processing chamber configured to receive a biological fluid, a platform configured to hold the biological fluid disposed in the processing chamber, a light source array arranged to illuminate the biological fluid in the processing chamber, and a display configured to display a graphical user interface (GUI). In some embodiments, the biological fluid processing system includes a scanner configured to obtain identification information associated with the first biological fluid, the second biological fluid, or both the first biological fluid and the second biological fluid.

[0034] Biological fluids, such as, for example, blood and blood products, may contain contaminating pathogens due to infected donors or introduction of pathogens during processing. As such, it may be desirable to subject such biological fluids to a treatment process (e.g., pathogen inactivation, pathogen reduction) that reduces the risk of contaminating pathogens. Ideally, such a process results in the inactivation of a wide range of pathogens (e.g., viruses, bacteria, parasites) that may be present in the biological fluid. The treatment process may also inactivate other undesirable materials that may be present in the biological fluid, such as, for example, cells (e.g., white blood cells) and nucleic acids. Advantageously, the present disclosure provides improved systems, methods, and devices for treating biological fluids, including mixtures of biological fluids and photochemicals, with light.

[0035] FIG. 1 illustrates an exemplary system 100 for processing biological fluids. As used herein, "biological fluid" refers to any fluid found in or derived from an organism (e.g., human, animal, plant, microorganism), or any fluid that contains one or more components (e.g., biological agents) found in, isolated from, or derived from an organism, including synthetic (e.g., recombinant) versions thereof. Biological fluids can include, but are not limited to, blood and blood products, vaccines, cells (e.g., primary cells, cell lines, cell cultures), natural and recombinant peptides or proteins (e.g., therapeutics, antibodies), bacterial cultures, viral suspensions, and the like. As used herein, "blood product" refers to blood (e.g., whole blood), or components or derivatives of blood, such as, by way of example, red blood cells, white blood cells, platelets, plasma, or components thereof (e.g., clotting factors, albumin, fibrinogen), cryoprecipitate and cryo-depleted (e.g., cryo-reduced) plasma, or combinations of one or more of such components separated from blood. In some embodiments, the biological fluid may further include a non-biological fluid, such as a physiological solution (e.g., a diluent solution), including, by way of example, but not limited to, saline, a buffer solution, a nutrient solution, a platelet additive solution (PAS), and / or an anticoagulant solvent solution. In some embodiments, when the biological fluid is placed in a chamber of the biological fluid processing system (e.g., the biological fluid is in a container such as a processing bag disposed on a platform), the biological fluid is illuminated by light (e.g., visible light, ultraviolet light) having a certain spectral profile at a specified intensity for a predetermined period of time.

[0036] System 100 includes a power switch 110, a display 120, a scanner 130, a platform 140, and a platform 150. Although system 100 in FIG. 1 includes the elements described, examples of system 100 can include different combinations of the elements described or additional elements without departing from the scope of the present disclosure. In some examples, system 100 can be coupled to a computing device (e.g., computer, mobile device) (not shown) via a wired or wireless connection.

[0037] In some embodiments, power is provided to system 100 in response to an input to power switch 110. For example, power switch 110 can be a mechanical button. When system 100 is off, power is provided to system 100 (e.g., system 100 turns on) in response to pressing power switch 110. When system 100 is on, power is stopped from being provided to system 100 (e.g., system 100 turns off) in response to pressing power switch 110. In some examples, during processing, system 100 remains on and is not turned off in response to pressing the power switch.

[0038] As another example, the power switch 110 may be a capacitive switch that can be actuated using touch input (e.g., by placing a user's finger on the power switch). As yet another example, the power switch may be a button with two or more states. When the power switch is in a first position (e.g., not pressed, switched to a first side), the power switch may be in an "off" state. When the power switch is in a second position (e.g., pressed, switched to a second side), the power switch may be in an "on" state.

[0039] In some embodiments, the display 120 is a touch screen. For example, the display 120 may be a capacitive touch screen or a resistive touch screen. In some examples, the display 120 is configured to display a graphical user interface (GUI) for operating the system 100. In some embodiments, the display 120 is configured to receive input from the scanner 130. In some embodiments, the display 120 is configured to receive input on the GUI. For example, one GUI object of a plurality of GUI objects displayed on the GUI may be selected by providing a user's manual input (e.g., touch input or hover input) on the touch screen. In response to receiving the input, the system 100 may perform an operation associated with the selected GUI object. For example, the GUI object may be associated with initiating biological fluid processing, and in response to receiving an input selecting the GUI object, the system 100 initiates a process for processing the biological fluid. In some embodiments, the display 120 is configured to display instructions (e.g., operator instructions) to a user operator on the GUI. In some embodiments, the display 120 is configured to display input from the scanner 130 to the user operator. In some embodiments, display 120 is configured to display on display 120 input from sounds detected by voice input (e.g., one or more microphones) and processed (e.g., speech-to-text conversion) by one or more processors into a visual form (command text, command code) that a user can recognize as an input command, such as, for example, a user's voice command detected by one or more microphones (e.g., positioned in any configuration on the interior, exterior, and / or part of the exterior housing of system 100) and converted by one or more processors into command text on display 120 that the user can recognize as an input command.In some embodiments, display 120 is configured to display input from a user's visual movements (e.g., hand movements or gestures, objects in a swiping motion) on display 120 that are detected by a motion sensor (e.g., one or more cameras) and processed (e.g., motion-to-text conversion, motion-to-graphics conversion) by one or more processors into a visual form (command text, command code, command icon, command graphic) that the user can recognize as an input command, e.g., a user's hand gesture (e.g., hand in a swiping motion) that is detected by one or more cameras (e.g., positioned in any configuration on the interior, exterior, and part of the exterior housing of system 100) and converted by one or more processors into visual command text or visual graphics on display 120 that the user can recognize as an input command. Although one display 120 is shown in FIG. 1, system 100 can include multiple displays in some examples.

[0040] The user interface of the system 100 can be simplified by using a touch screen as an input component and / or input from the scanner 130. For example, the use of a touch screen can reduce the need for physical buttons that correspond to functions that can also be performed using the touch screen. Biological fluid processing using the system 100 can be made more efficient by using a simplified user interface.

[0041] Although power switch 110 and display 120 are described as elements of system 100 that may be configured to receive user input, other elements or input means may be included in system 100 without departing from the scope of the present disclosure. For example, system 100 may include directional input keys, a mouse pad, or a scroll wheel configured to navigate a GUI displayed on display 120. In some embodiments, system 100 is configured to receive user input from sounds that are detected by voice input (e.g., one or more microphones) and processed (e.g., speech-to-text conversion) by one or more processors into a linguistic form (e.g., command text, command code) that system 100 recognizes as an input command, e.g., a user's voice command that is detected by, for example, one or more microphones (e.g., positioned in any configuration on the interior, exterior, and / or part of the exterior housing of system 100) and converted by one or more processors into command text that system 100 recognizes as an input command. In some embodiments, system 100 is configured to receive input from a user's visual movements (e.g., hand movements or gestures, object in a swiping motion) that are detected by a motion sensor (e.g., one or more cameras) and processed (e.g., motion-to-text conversion) by one or more processors into linguistic forms (e.g., command text, command codes), where the forms, e.g., by way of example, a user's hand gesture (e.g., hand in a swiping motion), are detected by one or more cameras (e.g., positioned in any configuration on the interior, exterior, and part of the exterior housing of system 100) and converted by one or more processors into command text that system 100 can recognize as an input command. Alternatively or additionally, system 100 may be configured to receive input other than user input, e.g., by way of example, from one or more sensors implemented for system 100.Non-limiting examples of various sensors that may be implemented (e.g., within the processing chamber) include one or more light sensors configured to measure light intensity at various portions of the processing chamber and / or light intensity incident on various portions of the one or more biological fluids, one or more airflow sensors, one or more thermal sensors for measuring the temperature of the processing chamber and / or the temperature of the one or more biological fluids, one or more sensors for detecting the presence and / or type of one or more biological fluids (e.g., pressure sensors, optical retroreflective sensors, optical transmission sensors, label readers, scanners, barcode scanners, RFID sensors, etc.), one or more sensors for detecting a property (e.g., permeability) of the biological fluid (e.g., optical sensors, spectroscopic sensors), one or more sensors for detecting photochemical compounds in the biological fluid (e.g., fluorescence spectroscopy), and one or more sensors (e.g., ultrasonic sensors) positioned to detect the fluid depth of a portion (e.g., various portions) of the one or more biological fluids.

[0042] In some embodiments, the system 100 may be configured to receive input from one or more scanners implemented for the system 100. In some embodiments, the scanner 130 is configured to obtain information related to the biological fluid. In some examples, the scanner 130 may be configured to obtain identification information related to the biological fluid being processed. For example, the biological fluid may be stored in a container (e.g., a blood-compatible bag, a processing bag) (not shown), and that container or other containers in a multi-container assembly (e.g., a disposable fluid processing set) may include a tag or label or designated area that includes some form of identification information, such as in a visible form (e.g., a bar code, a QR code, etc.) and / or in a transmittable form (e.g., an electronic identifier, a radio frequency identification (RFID)). In some embodiments, the identification information may represent information about the biological fluid, such as biological parameters or other parameters (e.g., donation ID, product code, set code, lot number, type of biological fluid, volume of biological fluid, contents of the biological fluid, e.g., platelet count or concentration), and treatment parameters. In some embodiments, the biological or other parameters may optionally be combined with input from one or more sensors and / or user input to determine processing parameters. In some examples, multiple sets of identifying information may be obtained. For example, multiple sets of identifying information may be located on one or more respective containers associated with the biological fluid (e.g., that contain or are part of a multiple container assembly that contains the biological fluid), and a set of identifying information may be obtained from each respective container by the scanner 130.In some embodiments, the scanner can be a multi-scan scanner (e.g., a camera with multi-scan capabilities, a camera in conjunction with circuitry (e.g., hardware and / or software) having multi-scan processing capabilities, a handheld scanner with multi-scan capabilities, a handheld scanner in conjunction with circuitry (e.g., hardware and / or software) having multi-scan processing capabilities, a label reader with multi-scan capabilities, a label reader in conjunction with circuitry (e.g., hardware and / or software) having multi-scan processing capabilities) that sequentially or substantially sequentially scans multiple sets of identification information (e.g., multiple barcodes, multiple QR codes, multiple labels, optical character recognition (OCR), image recognition of different strings or configurations of alphanumeric text and / or symbols, etc.) disposed on one or more containers. The multi-scanning operation may be configured to simultaneously capture (e.g., acquire) multiple sets of identifying information, for example, in a "batch" mode (e.g., in response to a single user input or a single device input that commands, triggers, or otherwise initiates a multi-scanning operation that acquires multiple sets of identifying information). A single multi-scanning operation may capture multiple sets of identifying information sequentially or substantially simultaneously (e.g., simultaneously) (e.g., in a single operation, the camera may capture one or more images of one or more labels indicating multiple parameters of a biological product, for example, donation ID, product code, set code, lot number, type of biological fluid, volume of biological fluid, contents of biological fluid, and in a single operation, the multi-scanner may perform one or more scans of the one or more labels indicating the above multiple parameters).In some embodiments, the multi-scanner or system 100 is configured to recognize (e.g., recognize (and / or decode) barcodes, QR codes, alphanumeric text, and / or symbols, images) (and / or convert to another form recognized by the multi-scanner or system 100) the multiple sets of captured identification information captured in a multi-scan operation. After capturing the multiple sets of identification information (e.g., captured image(s), performed scan(s)), the multi-scanner can transmit or communicate them to the system 100 (e.g., via a wired or wireless connection) in a recognized (and / or converted) form (e.g., a linguistic form that the system 100 already recognizes, e.g., as parameter data) or in an unrecognized form (e.g., captured image(s), performed scan(s)). If in an unrecognized form, the system 100 can process the multiple sets of captured identification information into a recognized form. When the system 100 displays the GUI of the processing chamber associated with the biological fluid to be processed, the system 100 can assign multiple sets of identifying information to corresponding fields (e.g., auto-fill information fields) of the GUI of the display 120. Thus, a multi-scan operation can provide for data entry of all or most parameter data of the biological fluid into multiple specific data fields via a convenient, efficient, and time-saving auto-fill technique. For example, a multi-scan operation does not require a user to perform multiple scans in a specific order to capture multiple sets of identifying information that may be presented in a specific order (e.g., does not require a user to perform scans for each label on a container in the visual order of the specific data fields presented to the user on the GUI).

[0043] In some embodiments, the scanner 130 is integrated or embedded in a fixed location within the system 100 (e.g., within the housing of the system 100). In some embodiments, the identifying information can come into the field of view of the scanner 130, and the scanner 130 can acquire the identifying information when the information is within the field of view. For example, a user can hold a biological fluid processing container (e.g., a bag) with a barcode toward the scanner 130, the scanner 130 can image, scan, or read the barcode, and based on the acquired barcode, the system 100 can determine information regarding the biological fluid product. In some embodiments, the identifying information can come into the detection range of the scanner 130, and the scanner 130 can acquire the identifying information when the information is within the detection range. For example, a user can hold a biological fluid processing bag with an RFID tag near the scanner 130, the scanner 130 can detect the RFID tag, and based on the information acquired from the detected RFID tag, the system 100 can determine information regarding the biological fluid product.

[0044] 1 as being positioned external to the system 100, the scanner 130 may be positioned at different locations on the system 100. In some embodiments, the scanner 130 is positioned inside the system 100. For example, the scanner 130 may be positioned on top of or at an opening to a processing chamber of the system 100. The scanner 130 can obtain information related to the biological fluid after it is placed on the platform and / or in the chamber.

[0045] In some examples, the scanner 130 may be included in a device coupled to the system 100. For example, the scanner 130 may be included in a handheld scanner (e.g., a barcode scanner, a QR code scanner) coupled to the system 100. In some examples, the handheld scanner couples to the system 100 via a wired connection. In some examples, the handheld scanner couples to the system 100 via a wireless connection.

[0046] Although one scanner 130 is shown in FIG. 1, the system 100 can include multiple scanners 130. For example, the system 100 can include multiple processing chambers, each of which may have a corresponding scanner (e.g., an internal scanner). As another example, the system 100 can include multiple platforms, each of which may have a corresponding scanner (e.g., an external scanner) positioned near or at an opening of the respective platform. As the platforms move through the openings, a container (e.g., a processing bag) containing the biological fluid can cross the field of view of the respective scanners, and information associated with the biological fluid can be acquired by the respective scanners in visible form on the container or containers of an associated dual container assembly.

[0047] In some embodiments, the platform 140 (e.g., tray, well, plate, stage) is configured to hold the biological fluid (e.g., in a vessel that contains the biological fluid) during processing. In some embodiments, the platform is movable (e.g., slidably movable and configured to translate between the interior and exterior of the processing chamber) of the processing chamber. In some embodiments, the system 100 further comprises a first panel 180 movable between a closed position and an open position, where the first panel 180 covers a first opening to the first processing chamber in the closed position and the first panel 180 does not cover the first opening to the first processing chamber in the open position. In some embodiments, the first panel can have a handle (e.g., a protruding handle, a recessed handle). The handle allows a user to manually open and close the first panel to load or unload the biological fluid into or out of the chamber. In some examples, the exterior of the first panel can include an opening or cutout that serves as a recessed handle. In some examples, a handle can be attached to the exterior of the first panel. In some embodiments, the first panel is attached to, integral with, or formed with the platform 140 (e.g., in a drawer configuration). In some embodiments, the first panel 180 is a separate structure from the platform 140 (e.g., a separate hinged door that covers and does not cover the first opening to the first processing chamber), and the platform 140 can slide in and out of the first processing chamber separately from the first panel 180.

[0048] In some examples, the platform and / or the first panel can be locked to remain in a closed position during processing. By locking the first panel to remain in a closed position, the system 100 can prevent a user from prematurely accessing the contents of the platform 140 (e.g., accessing the first processing chamber) during processing. In some embodiments, the first panel can be locked by a pin (e.g., a solenoid and pin) or a magnetic locking mechanism. The system 100 can allow a user to access the contents of the platform 140 before or after processing (e.g., loading biological fluid onto the platform 140, unloading biological fluid from the platform 140), or after an input (e.g., an input on a GUI, an input to open a latch, an input to a button switch) by unlocking the first panel.

[0049] In some embodiments, the exterior of the first panel can be substantially smooth such that the exterior surface is continuous. For example, the surface of the first panel on the exterior (e.g., exterior housing) of the system 100 can be flat. As another example, the surface of the first panel on the exterior of the system 100 can be continuously smooth, i.e., the surface of the first panel on the exterior of the system 100 is devoid of any openings, notches, gaps, etc., or any openings, notches, gaps, etc. are small enough to prevent a user from pulling on the first panel with their fingers. Such sufficiently small openings, notches, gaps, etc. can provide an air vent for the first panel. As yet another example, the entire exterior (e.g., surface) of the first panel is devoid of any handles or protruding members, etc. As a further example, as shown in FIG. 1, the end of the first panel may be flush or substantially flush with an adjacent structure (e.g., adjacent panel(s), frame of an adjacent external housing, etc.) when in the closed position if the opening, notch, gap, etc. between the end of the first panel and the adjacent structure(s) is small enough to prevent a user from pulling the first panel with their finger(s) (e.g., preventing frictional pulling on the side of the edge of the first panel, preventing hooking pulling on the back side of the edge of the first panel). In some embodiments, the continuous exterior surface prevents a user from prematurely opening the first panel by manual handling (e.g., when biological fluid is being processed) or inadvertently damaging the system by forcing the handle. Premature opening of the first panel may damage the biological fluid being processed or may not properly process the biological fluid. If a user pulls forcefully on the handle of the locked first panel, the handle may be damaged, the moving mechanism (eg, track, rail) may be damaged, and the locking portion may be damaged.

[0050] As shown in FIG. 1 , the structure of platform 150 symmetrically mirrors the structure of platform 140 about a vertical axis. In some embodiments, platform 150 is substantially similar in size, shape, or orientation to platform 140. As shown, platforms 140 and 150 are horizontally disposed such that the first biological fluid and the second biological fluid are in the same plane when placed on the first platform and the second platform, respectively. As described above, the first panel 180 may be associated with platform 140, and therefore the second panel 190 may be associated with platform 150. The above teachings regarding the first panel 180 may also be applied to the second panel 190.

[0051] Although two platforms are shown in FIG. 1 as being part of system 100, system 100 may include one platform or three or more platforms that are substantially similar to platform 140 or platform 150 without departing from the scope of the present disclosure. In general, the number of illustrated platforms and processing chambers associated with systems 100-700 are exemplary, and embodiments of systems 100-700 may include different numbers and combinations of platforms, processing chambers, and their associated elements (e.g., scanners, optical arrays, compartments) without departing from the scope of the present disclosure. For example, in some embodiments, a system may include only one chamber with only one platform. In some embodiments, a system may include only one chamber with two or more platforms. In some embodiments, a system may include two chambers, each with only one platform. In some embodiments, a system may include two chambers, each with two or more platforms.

[0052] In some embodiments, the platform comprises a first compartment and a second compartment separate from the first compartment. In some embodiments, the first compartment is configured to hold a vessel (e.g., a vessel of a dual vessel assembly) that contains a biological fluid in a position for irradiation. In some embodiments, the second compartment is configured to hold a vessel (e.g., a vessel of a dual vessel assembly) that does not contain a biological fluid in a position not for irradiation. In some embodiments, the platform is configured to separately hold a first vessel with at least a first biological fluid and a second vessel with a second biological fluid. In some embodiments, the platform is transparent (e.g., substantially transparent, more than 95% transparent, more than 90% transparent, more than 80% transparent, more than 80% transparent) to light with wavelengths within 100 nm (e.g., 75 nm, 50 nm, 40 nm, 30 nm, 20 nm) of the peak wavelength of the light used for irradiation. In some embodiments, the platform is transparent (e.g., substantially transparent, greater than 95% transparent, greater than 90% transparent, greater than 80% transparent, greater than 80% transparent) to ultraviolet light (e.g., UV-A, UV-B, and / or UV-C).

[0053] FIG 2A illustrates an exemplary system 200 for processing a biological fluid. In some embodiments, system 200 is substantially similar to system 100, as shown in FIG 1. Power switch 210 can correspond to power switch 110. Display 220 can correspond to display 120. Platforms 240 and 250 can correspond to platforms 140 and 150, respectively. Panels 280 and 290 can correspond to panels 180 and 190, respectively.

[0054] In some embodiments, the system 200 includes an external scanner 230. In some embodiments, the external scanner 230 is present in addition to a scanner integrated or embedded in a fixed location of the system 200. As shown, the external scanner 230 is external to the housing that houses the other elements and can be operably coupled to the processor of the system 200. In some embodiments, the external scanner 230 is a handheld scanner. Although the external scanner 230 is shown with a wireless connection in FIG. 2A, the external scanner 230 can be operably coupled using a wired connection.

[0055] As shown in Figure 2A, platforms 240 and 250 are in a pull-out configuration in an open position, in contrast to platforms 140 and 150, which are in a closed position in Figure 1. Although both platforms 240 and 250 are illustrated as open in a pull-out configuration in Figure 2A, only one platform in the pull-out configuration can be open at a time (e.g., while the other remains closed).

[0056] In some embodiments, the first panel 280 and the second panel 290 associated with the platforms 240 and 250 lack any handles. In some embodiments, in the closed position, the panels can be opened by applying a force opposite to the opening direction (e.g., pushing the exterior of the panel to engage a push latch that releases the panel to open). In some embodiments, in the closed position, the panels can be opened using a mechanical component (e.g., a motor, a servo) to actuate the panel (e.g., as a hinged door, as part of the platform in a drawer configuration). In some embodiments, the system can allow a user to access the contents of the platform by opening the panel (e.g., by a spring mechanism) and allow the user to further manually slide out the platform. For example, following a determination that a processing procedure has started or completed, the system can mechanically open one or more panels corresponding to the processing to load or unload one or more biological fluid containers (e.g., processing bags).

[0057] In some embodiments, the platform includes a compartment 260 substantially similar to the compartments described herein. Although Figure 2A illustrates the platform such that one compartment is visible (e.g., for the platform in a drawer configuration in an open position), each of the platforms of system 200 can include any number of compartments without departing from the scope of application.

[0058] In some embodiments, the panels can include handles. Figure 2B illustrates a panel associated with platform 250 as having a protruding handle 270 physically coupled to the panel. Figure 2C illustrates a panel associated with platform 250 as having a recessed handle 270 that is part of the panel. In some embodiments, with or without a handle, the panel can be flush or substantially flush with an adjacent structure (e.g., an adjacent panel(s), a frame of an adjacent outer housing, etc.), as shown in Figures 2A-2C.

[0059] 3A shows an exemplary system 300 for processing biological fluids. In some embodiments, the system 300 is substantially similar to the system 100, with the difference that the processing chamber and the platform are vertically arranged. The power switch 310 can correspond to the power switch 110. The display 320 can correspond to the display 120. The scanner 330 can correspond to the scanner 130. In contrast to the system 100, in which the platforms 140 and 150 are horizontally arranged, the platforms 340 and 350 are vertically arranged such that the first biological fluid and the second biological fluid are in parallel planes when placed on the first platform and the second platform, respectively. Also, in contrast to the system 300, in which the panels 180 and 190 are horizontally arranged, the panels 380 and 390 are vertically arranged.

[0060] In some embodiments, system 300 can include air vents. Figure 3B shows panels 380 and 390 with air vents 385 and 395, respectively. The air vents 385 and 395 can provide one or more air inlets (e.g., air intakes) through which air can be drawn into system 300, for example, to provide cooling or heat dissipation, or other temperature control functions. The air vents 385 and 395 can provide one or more air outlets through which air can be exhausted from system 300, for example, to provide cooling or heat dissipation, or other temperature control functions. For example, air can be drawn into and / or exhausted from system 300 by operation of one or more fans within system 300. The air vents 385 and 395 are shown as vents (e.g., circular vents) but are not limited to such and may be embodied in any variation or combination of variations, such as horizontal vents, vertical vents, grids, oval vents, rectangular or square vents, polygonal vents, or any combination thereof. The air vents 385 and 395 are shown as occupying a majority of the area of ​​the panel but are not limited to such and may be embodied in any variation or combination of variations, such as occupying all of the area of ​​the panel, occupying a portion of the area of ​​the panel, separate horizontal vent strips, separate vertical vent strips, circular or oval vent strips, rectangular or square vent strips, polygonal vent strips, or any combination thereof. The air vents 385 and 395 are not limited to being located on the panels, but may be located in other locations (e.g., in addition to or instead of the panels), such as, for example, as part of the housing, on or near the front side of the housing (e.g., above, below, or next to the panels). In some embodiments, with or without air vents, the panels may be flush or substantially flush with adjacent structures (e.g., adjacent panel(s), frames of adjacent outer housings, etc.), as shown in Figures 3A-3B.

[0061] In some embodiments, the system 300 may include one or more access panels (e.g., a front access panel, a side access panel, an upper access panel) through which maintenance or service personnel can access and then perform maintenance or service on the internal components or structures of the system 300. FIG. 3B illustrates an exemplary side access panel 302 of the system 300 located on a side of the outer housing. The side access panel 302 may open in any manner, such as, for example, a vertical hinge (e.g., located on a rear vertical edge of the side access panel 302), a horizontal hinge (e.g., located on the top or bottom of the side access panel ##), a fastener (e.g., a screw that holds the side access panel in place), etc. The side access panel 302 is illustrated as encompassing the area between the two horizontal lines shown in FIG. 3B, but is not limited thereto, and may be embodied in any variation or combination of variations, such as, for example, encompassing the entire side of the outer housing, encompassing a portion of the side of the outer housing, encompassing multiple side access panels (e.g., one for each processing chamber), etc.

[0062] 4A illustrates an exemplary system 400 for processing a biological fluid. In some embodiments, system 400 is substantially similar to system 300, as illustrated in FIG. 3. Power switch 410 can correspond to power switch 310. Display 420 can correspond to display 320. Scanner 430 can correspond to scanner 330. Platforms 440 and 450 can correspond to platforms 340 and 350, respectively. Panels 480 and 490 can correspond to panels 380 and 390, respectively.

[0063] As shown, platform 440 is in a pull-out configuration in an open position in Fig. 4A as opposed to platform 340 being in a closed position in Fig. 3. Although one platform is shown as open in the pull-out configuration in Fig. 4A, both platforms in the pull-out configuration can be open simultaneously.

[0064] In some embodiments, the first panel 480 and the second panel 490 associated with the platforms 440 and 450 lack any handles. In some embodiments, in the closed position, the panels can be opened by applying a force opposite to the opening direction (e.g., pushing the exterior of the panel to engage a push latch that releases the panel to open). In some embodiments, in the closed position, the panels can be opened using a mechanical component (e.g., a motor, a servo) to actuate the panel (e.g., as a hinged door, as part of the platform in a drawer configuration). In some embodiments, the system can allow a user to access the contents of the platform by opening the panel (e.g., by a spring mechanism) and allow the user to further manually slide out the platform. For example, following a determination that a processing procedure has started or completed, the system can mechanically open one or more panels corresponding to the processing to load or unload one or more biological fluid containers (e.g., processing bags).

[0065] In some embodiments, the platform includes compartments 460A and 460B substantially similar to the compartments described herein. Although Figure 4A illustrates the platform as having two compartments, each of the platforms in system 400 may include any number of compartments without departing from the scope of application.

[0066] In some embodiments, the panel can include a handle. Figure 4B illustrates a panel associated with platform 440 as having a protruding handle 470 physically coupled to the panel. Figure 4C illustrates a panel associated with platform 440 as having a recessed handle 470 that is part of the panel. In some embodiments, with or without a handle, the panel can be flush or substantially flush with an adjacent structure (e.g., an adjacent panel(s), a frame of an adjacent outer housing, etc.), as shown in Figures 4A-4C.

[0067] In some embodiments, the system 400 can provide an agitation function for agitating the biological fluid during treatment of the biological fluid by irradiation. Agitation can facilitate processing, for example, by providing mixing of compounds (e.g., photochemical compounds, pathogen inactivation compounds) in the biological fluid or by maintaining components of the biological fluid (e.g., platelets, cells) in suspension. The system 400 can provide the agitation function via the structural elements of FIGS. 4A-4I. For example, the first platform 440 can include an outer region and an inner region. The outer region can include a first panel 480 movable between a closed position and an open position, for example, as the outer region slidably moves in and out of the first (upper) processing chamber via an outer rail or track 462. In the closed position, the first panel 480 covers a first opening to the first processing chamber. In the open position, the first panel 480 does not cover the first opening to the first processing chamber. The outer region may also include a first support structure that structurally supports the inner region, for example, the outer region may include an inner rail or track 464 that structurally supports the compartments 460A and 460B of the inner region. In FIG. 4A, the protruding structures on the sidewalls of the compartments 460A and 460B may fit onto the inner rail, and in some embodiments, the edges of the compartments 460A and 460B form lips on the inner and outer rails. The inner region may be configured to move to agitate the first biological fluid during the period when the outer region is in a fixed position. For example, while the system 400 is irradiating the first biological fluid in the compartments 460A and / or 460B, the outer region including the first panel 480 may be fixed in a closed position, but the inner region may move to agitate the first biological fluid. Both the first panel 480 and the outer rail 462 may be part of the structure of the outer region, but the first panel 480 may not be attached to the compartments 460A and 460B.If the first panel 480 is part of the structure of the outer region of the first platform 440, the first panel 480 may be integral with the outer region structure (e.g., in one single formed piece) or attached to the outer region structure (e.g., as a separately formed piece).

[0068] The movement of the inner region may be based on motion generated by one or more motors or servos. For example, the outer region may include one or more electric motors configured to generate motion. The inner region may be configured to agitate the first biological fluid in the compartments 460A and / or 460B based on the generated motion. The system 400 may be configured to control (e.g., adjustably control) one or more aspects of the motion of the inner region, such as the offset (i.e., stroke length of the reciprocating (linear, back and forth, etc.) motion during agitation), speed, acceleration, and deceleration. The motion of the inner region may be forward and backward (e.g., along the inner rail of the outer region) or may encompass motion in other directions. In some embodiments, the system 400 may be configured to control the motion of the inner region to change its position for purposes of calibration (e.g., calibration of the light source array).

[0069] The one or more motors or servos may be located in front or behind where the first biological fluid is to be retained by the first platform 440. For example, an electric motor may be in a location in front of the compartment 460B between the first panel 480 and the compartment 460B. As another example, an electric motor may be in a location in back of the compartment 460A in the system 400. As yet another example, an electric motor may be in a location in front of the compartment 460B between the first panel 480 and the compartment 460B while another electric motor may be in a location in back of the compartment 460A in the system 400.

[0070] 4D-4F show another embodiment in which one or more motors or servos may be positioned in a position in front or behind where the first biological fluid is to be held by the first platform 440. In this embodiment, the outer region of the first platform 440 comprises a first support structure that structurally supports the inner region via an inner rail or track 464 that contacts the inner region (e.g., the edge of the compartment of the inner region) and provides structural support above, below, and / or adjacent to the edge. In this embodiment, one or more motors or servos 466, 468 may be positioned in front of the compartment (e.g., behind the first panel 480, within the first panel 480, etc.) and / or behind the compartment (e.g., the outer region of the first platform 440 in a position behind the compartment 460A). FIGS. 4D-4F show this embodiment with the inner region in different positions during agitation or calibration. FIG. 4D shows the position when the inner region is positioned near or adjacent to the first panel 480 during agitation. FIG. 4E shows the position when the inner region moves rearward along the inner rail away from the first panel 480 to a mid-position during agitation. FIG. 4E shows the position when the inner region moves further rearward along the inner rail away from the first panel 480 to a rearmost position during agitation. During agitation or calibration, the outer region may be fixed in position, but the inner region may move forward and rearward through the positions shown in FIGS. 4D-4F.

[0071] The one or more motors or servos may be located at a position to the right or left of where the first biological fluid is held by the first platform 440. For example, an electric motor may be at a position to the right of the compartment 460A (or 460B) between the right outer rail and the compartment 460A (or 460B). As another example, an electric motor may be at a position to the left of the compartment 460A (or 460B) between the left outer rail and the compartment 460A (or 460B). As yet another example, an electric motor may be at a position to the right of the compartment 460A (or 460B) between the right outer rail and the compartment 460A (or 460B), while another electric motor may be at a position to the left of the compartment 460A (or 460B) between the left outer rail and the compartment 460A (or 460B).

[0072] 4G-I show another embodiment in which one or more motors or servos 465 may be positioned at a position to the left of where the first biological fluid is to be held by the first platform 440. In this embodiment, the outer region of the first platform 440 comprises a first support structure that structurally supports the inner region via an inner rail or track 464 that contacts the inner region (e.g., the edge of the inner region compartment) and provides structural support above, below, and / or adjacent to the edge. To the left of the inner region compartment, the outer region comprises a relatively wide structure that houses one or more motors or servos. FIG. 4G-I show this embodiment with the inner region in different positions during agitation or calibration. FIG. 4G shows the position when the inner region is positioned near or adjacent to the first panel 480 during agitation. FIG. 4H shows the position when the inner region is moved back along the inner rail away from the first panel 480 to an intermediate position during agitation. Figure 4I shows the position as the inner region moves further rearward along the inner rail away from the first panel 480 to its rearmost position during agitation. During agitation or calibration, the outer region may remain fixed in position, but the inner region may move forward and rearward through the positions shown in Figures 4G-4I.

[0073] In some embodiments, the system 400 can provide an agitation function via the second platform 450 for agitating the biological fluid during treatment of the biological fluid by irradiation. The second platform 450 can implement teachings similar to those above regarding the agitation function of the first platform 440. For example, the second platform 450 can include an outer region and an inner region. The outer region can include a second panel 490 movable between a closed position and an open position, for example, as the outer region slidably moves in and out of the second (lower) processing chamber via an outer rail. In the closed position, the second panel 490 covers the second opening to the system 400, i.e., the opening to the second processing chamber. In the open position, the second panel 490 does not cover the second opening, i.e., the opening to the second processing chamber. The outer region can also include a second support structure that structurally supports the inner region, for example, the outer region can include an inner rail or track that structurally supports a section of the inner region. The inner region may be configured to move to agitate the second biological fluid during the period when the outer region is in a fixed position. For example, while the system 400 irradiates the second biological fluid in the compartment of the inner region, the outer region including the second panel 490 may be fixed in a closed position, but the inner region may move to agitate the second biological fluid. The second panel 490 and the outer rail of the second platform 450 may both be part of the structure of the outer region of the second platform 450, but the second panel 490 may not be attached to the compartment of the inner region. If the second panel 490 is part of the structure of the outer region of the second platform 450, the second panel 490 may be integral with the outer region structure (e.g., in one single formed piece) or attached to the outer region structure (e.g., as a separately formed piece). The outer region of the second platform 450 may include one or more electric motors or servos configured to generate motion and thereby provide movement of the inner region.In some embodiments, the system 400 may be configured to control the movement of an inner region of the second platform 450 to vary its position for purposes of calibration (eg, calibration of a light source array).

[0074] FIG. 4J shows a side view of the interior of the system 400. This side view at the top shows an upper stage including a display 420 (e.g., touch screen) and control circuitry and / or a computer system. Moving down, there is a first light source array 406 positioned above and facing the first platform 440, with light sources oriented to shine light down in the first processing chamber to illuminate the first biological fluid disposed on the first platform 440. Moving down, there is a second light source array 408 positioned above and facing the first platform 440, with light sources oriented to shine light up in the first processing chamber to illuminate the first biological fluid disposed on the first platform 440. Moving down, there is a third light source array 416 positioned above and facing the second platform 450, with light sources oriented to shine light down in the second processing chamber to illuminate the second biological fluid disposed on the second platform 450. At the bottom is a fourth light source array 418 positioned below and facing the second platform 450, with light sources oriented to shine light upwards in the second processing chamber to irradiate the second biological fluid disposed on the second platform 450. In some embodiments where the illumination comes from below the platform, the bottom of that platform (e.g., the bottom of its compartment for the biological fluid(s)) may be transparent to the illumination so that the illumination can reach the biological fluid(s) of that platform. In some embodiments, the platform is transparent (e.g., fully or partially transparent, at least 85% transparent, sufficiently transparent to process the biological fluid, and sufficiently transparent to achieve the desired processing result) to light having a wavelength within 100 nm (e.g., 75 nm, 50 nm, 40 nm, 30 nm, 20 nm) of the peak wavelength of the light used for illumination.In some embodiments, the platform is transparent to ultraviolet light (e.g., UV-A, UV-B, and / or UV-C) (e.g., fully or partially transparent, at least 85% transparent, sufficiently transparent to treat biological fluids, sufficiently transparent to achieve desired treatment results).

[0075] Electrical wiring for providing power to and / or controlling the electric motor(s) or servo(s) may be located inside or along the outer region, for example, inside the inner rail, or along a sidewall (interior or exterior), or on the top or bottom surface of the outer region. Such a location for the electrical wiring outside the platform compartment (e.g., outside the platform interior region) avoids blocking illumination from an array of light sources illuminating the compartment from above or below.

[0076] In some embodiments, one or more platforms of system 400 may each include an inner zone assembly 461 providing one or more removable inner zone portions, as shown in FIG. 4K. Inner zone assembly 461 may include one or more removable portions 463 (e.g., in the form of a tray, well, plate, stage, etc.) and a cradle 467 portion of the inner zone for receiving one or more removable portions 463. Removable portions 463 may include a rear compartment 460A with a compartment floor 469 made of a material that is fully or partially transparent (e.g., at least 85% transparent, sufficiently transparent to process biological fluids, and sufficiently transparent to achieve a desired processing result) to light (e.g., peak wavelength of light) emitted by the light source arrays provided herein (e.g., ultraviolet light, UV-A, UV-B, and / or UV-C), e.g., glass, Plexiglas® (e.g., Plexiglas® G-UVT). The compartment floor 469 itself may be removable from the rear compartment 460A so as to be replaceable and / or cleanable. The rear compartment 469 may be configured to hold one or more containers storing one or more biological fluids in one or more positions for irradiation of the containers from above and / or below. The front compartment 460B may be configured to hold one or more other containers, but not in positions for irradiation. The containers in the front and rear compartments may all be part of a dual container assembly. The cradle 467 may hold one or more removable portions 463 in a stable position and in a desired orientation. The cradle 467 may be supported by the outer region of the platform, for example, on or within an inner rail or track 464 included in the outer region of the platform. One or more motors or servos 468 may be mounted to or on the platform (e.g., the outer region of the platform) and positioned on the rear side of the rear compartment ##.One or more motors or servos 468 may be physically coupled to the cradle 467 and may move the cradle 467 back and forth (e.g., along an inner rail or track 464 in an outer region of the platform) to agitate the biological fluid held on the platform (e.g., biological fluid in a container). The one or more motors or servos 468 may be part of any suitable agitation design (e.g., a lead screw design in which the one or more motors or servos move a lead screw attached to the cradle, a belt drive design in which the one or more motors or servos move one or more belts which rotate one or more gears (e.g., gears with teeth) which engage and move one or more tracks attached to the cradle) and may operate based on control signals from electrical wiring electrically connected to a control circuit. In some embodiments, the agitation speed may be adjustable (e.g., adjusted to have different speeds during different treatments, adjusted to have different speeds during a single treatment, adjusted based on a predetermined speed schedule, dynamically adjusted in real time based on user input in real time), and such control circuitry may control the one or more motors or servos 468 based on a control program implemented as software and / or hardware in the control circuitry. The outer rail or track 462 may be part of the structure of the outer region of the platform, which may be slidably moved in and out of the processing chamber of the platform via the outer rail or track 462.The platform sensors may include, for example, a platform position / lock / latch sensor for detecting whether the platform is in a closed position and / or locked / latched, a cradle position sensor for detecting the position of the cradle along the inner rail or track 464, a removable interior area portion sensor for detecting whether one or more removable interior area portions are in the cradle, temperature sensor(s) for detecting the temperature of the platform or the temperature of a biological fluid held on the platform at one or more positions (e.g., the position of the rear section 460A, the position of the front section 460B, the position(s) of one or more motors or servos 468), sensor(s) for detecting the presence and / or weight of a biological fluid held on the platform (e.g., a biological fluid in a container), etc.

[0077] FIG. 4L shows a rear perspective view of the platform shown in FIG. 4K. In this rear perspective view, the backside of the front panel of the platform is shown. Inside the front panel, the front panel may include a filter compartment 472, which may include an air filter 474 that may filter incoming air. The filter compartment 472 may be accessible to allow the air filter 474 to be replaceable and / or cleanable. FIG. 4L shows one or more motors or servos 468 mounted to or on the platform (e.g., the outer region of the platform) and positioned rearward of the rear compartment 460A. The one or more motors or servos 468 may be physically coupled (e.g., by a lead screw, by a belt and gears and tracks) to a cradle 467 in the inner region and move the cradle 467 back and forth (e.g., along an inner rail or track 464 in the outer region of the platform) to agitate the biological fluid when in the rear compartment 460A. FIG. 4L shows a platform locking assembly 476 physically coupled to a structure in the outer region of the platform. When the platform locking assembly is in an unlocked state, the front panel may be opened and the outer region may be slidably moved in and out of the processing chamber via the outer rails or tracks 462. When the platform locking assembly is in a locked state, the platform locking assembly engages a locking mechanism to prevent the front panel from opening to allow the outer region to move.In some embodiments, the locking mechanism may be a motor base (e.g., locks a motor / servo physically coupled to the outer region or front panel to prevent the outer region from moving), a latch base (e.g., moves a rigid member (e.g., a latch or pin or hook) to engage a receiving structure (e.g., a slot or hole or groove) physically coupled to the outer region or front panel to prevent the outer region from moving), a magnetic base (e.g., engages an electromagnet(s) to magnetically hold a structure of the outer region of the platform and a fixed structure of the system 100 together (the electromagnets may be located on the structure of the outer region of the platform or on the fixed structure of the system 100 or both)), etc. FIG. 4L shows a lateral side of the platform (e.g., a lateral side of the outer region of the platform) supported by a fixed structure that may support an outer rail or track 462 of the outer region of the platform.

[0078] 1-4L as having platforms arranged horizontally or vertically, the platform arrangements shown are not limiting. For example, a four process chamber platform and / or four platform system may be arranged in a two row by two column array.

[0079] 1-4L above and 9A-9F below are generally directed to teachings regarding system form factors, user interface elements, housing configurations, and processing chamber configurations. All of the systems in FIGS. 1-4L and 9A-9F are capable of processing biological fluids by illumination. For the systems in FIGS. 1-4L and 9A-9F, further details regarding their illumination capabilities (e.g., light source arrays, light source channels, peak wavelengths, light intensity, light type, spectral bandwidth) are provided throughout FIGS. 5-8 and the corresponding disclosure below.

[0080] FIG. 5 is a perspective view of an exemplary system 500 for processing biological fluids. In some embodiments, the system 500 is substantially similar to the system 100 as shown in FIG. 1. The exemplary system 500 for processing biological fluids includes a first processing chamber 502 and a second processing chamber 504 for receiving one or more biological fluids 510, and a light source array 506 arranged to irradiate the one or more biological fluids 510 (e.g., arranged below and irradiating upward toward the biological fluid(s)). In some embodiments, the light source array 506 may comprise the only light source in the chambers 502 and 504 arranged to irradiate the one or more biological fluids 510. In other embodiments described below with respect to FIG. 7, multiple light source arrays may be used to irradiate one or more biological fluids arranged in various embodiments of the chambers 502 and 504 (e.g., two light source arrays arranged vertically (above and below each other), each light source array used to irradiate one or more biological fluids in FIG. 7). As used herein, a "light source array" refers to one or more light sources arranged on any two- or three-dimensional surface (eg, continuous or non-contiguous).

[0081] One or more light source channels may be included in the light source array of the present disclosure. In some embodiments, one or more light source channels 508 are included in the light source array 506. Although a particular light source is shown as belonging to a particular light source channel, it is understood that different combinations of light sources may form different light source channels. Each light source channel 508 may be a set of one or more light sources having substantially the same wavelength (e.g., peak wavelength, maximum peak wavelength). In an exemplary set, one light source may have one peak wavelength. In another exemplary set, two light sources may have the same peak wavelength as each other. In yet another exemplary set, each of the multiple light sources may have a different peak wavelength from each other. In a further exemplary set, a first subset of one or more light sources may have one peak wavelength and a second subset of one or more light sources may have a different peak wavelength. In a light source channel having multiple light sources, all of the light sources can have respective peak wavelengths (e.g., maximum peak wavelength) that are all within the wavelength range of the light source channel (e.g., 1-20 nm, 1-10 nm range, e.g., 1 nm, 2 nm, 3 nm, 4 nm, 5 nm, or more above and / or below a particular wavelength). For example, in some embodiments, in a light source channel having multiple light sources, all of the light sources can have peak wavelengths within the ranges described in this disclosure, e.g., about 315 nm to about 350 nm (e.g., about 315 nm to about 335 nm, about 330 nm to about 350 nm, about 340 nm to about 350 nm). In a light source channel, each light source can be any light source that provides light with the desired characteristics (e.g., peak wavelength, maximum peak wavelength, spectral bandwidth), including, but not limited to, solid-state illumination (SSL), light-emitting diodes (LEDs), organic light-emitting diodes (OLEDs), polymer light-emitting diodes (PLEDs), and laser diodes. The light source channels of the light source array can be connected in series, parallel, or a combination of series and parallel circuits. In a light source channel having multiple light sources, the light sources can be controlled together or separately.

[0082] Each light source channel can be adjusted or set to emit light (e.g., adjust the dose of light, adjust the dose of energy) at different intensities where one or more peak wavelengths of light are applied to one or more portions of the biological fluid. For example, each light source channel can emit light at a maximum intensity (e.g., 100%) or at an intensity less than maximum (e.g., about 90%, about 80%, about 70%, about 60%, about 50%, about 40%, about 30%, about 20%, or less).

[0083] Each light source channel may emit a different type of light. For example, each light source channel may emit ultraviolet light, ultraviolet A light, ultraviolet B light, ultraviolet C light, and / or visible light. Additionally, each light source channel may emit light of a different peak wavelength. For example, the emitted peak wavelength(s) may be in the ultraviolet A spectrum (e.g., 315-400 nm), the ultraviolet B spectrum (e.g., 280-315 nm), the ultraviolet C spectrum (e.g., 100-280 nm, 200-280 nm, 240-280 nm), or the visible light spectrum (e.g., 400-800 nm). In some embodiments, the peak wavelength(s) emitted can be between about 240 nm to about 250 nm, about 245 nm to about 255 nm, about 250 nm to about 260 nm, about 255 nm to about 265 nm, about 260 nm to about 270 nm, about 265 nm to about 275 nm, about 270 nm to about 280 nm, or about 275 nm to about 285 nm. In some embodiments, the peak wavelength(s) emitted can be between about 280 nm to about 290 nm, about 285 nm to about 295 nm, about 290 nm to about 300 nm, about 300 nm to about 310 nm, about 305 nm to about 315 nm, or about 310 nm to about 320 nm. In some embodiments, the emitted peak wavelength(s) can be between about 315 nm to about 325 nm, about 320 nm to about 330 nm, about 325 nm to about 335 nm, about 330 nm to about 340 nm, about 335 nm to about 345 nm, about 340 nm to about 350 nm, about 345 nm to about 355 nm, about 350 nm to about 360 nm, about 355 nm to about 365 nm, about 360 nm to about 370 nm, about 365 nm to about 375 nm, about 370 nm to about 380 nm, about 375 nm to about 385 nm, about 380 nm to about 390 nm, about 385 nm to about 395 nm, or about 390 nm to about 400 nm.In some embodiments, the peak wavelength emitted can be about 240 nm, about 245 nm, about 250 nm, about 255 nm, about 260 nm, about 265 nm, about 270 nm, about 275 nm, about 280 nm, about 285 nm, about 290 nm, about 295 nm, about 300 nm, about 305 nm, about 310 nm, about 315 nm, about 320 nm, about 325 nm, about 330 nm, about 335 nm, about 340 nm, about 345 nm, about 350 nm, about 355 nm, about 360 nm, about 365 nm, about 370 nm, about 375 nm, about 380 nm, about 385 nm, about 390 nm, about 395 nm, or about 400 nm. In some embodiments, the peak wavelength emitted may be between about 255 nm and about 275 nm (e.g., between about 260 nm and about 270 nm, about 265 nm). In some embodiments, the peak wavelength emitted may be between about 275 nm and about 295 nm (e.g., between about 280 nm and about 290 nm, about 285 nm). In some embodiments, the peak wavelength emitted may be between about 300 nm and about 320 nm (e.g., between about 305 nm and about 315 nm, about 310 nm). In some embodiments, the peak wavelength emitted may be between about 315 nm and about 335 nm (e.g., between about 320 nm and about 330 nm, about 325 nm). In some embodiments, the peak wavelength emitted may be between about 330 nm and about 350 nm (e.g., between about 335 nm and about 345 nm, between about 340 nm and about 350 nm, about 340 nm, about 345 nm). In some embodiments, the peak wavelength emitted can be between about 355 nm and about 375 nm (e.g., between about 360 nm and about 370 nm, about 365 nm). In some embodiments, the peak wavelength emitted can be between about 375 nm and about 395 nm (e.g., between about 380 nm and about 390 nm, about 385 nm). In some embodiments, the peak wavelength emitted can be in (1) the UV-A spectrum (e.g., 315-400 nm), and (2) the UV-B spectrum (e.g., 280-315 nm) or the UV-C spectrum (e.g., 100-280 nm, 200-280 nm, 240-280 nm).In some embodiments, the peak wavelength emitted can be in the ultraviolet A spectrum, between about 315 nm and about 350 nm (e.g., between about 320 nm and about 345 nm, between about 315 nm and about 335 nm, between about 330 nm and about 350 nm, between about 340 nm and about 350 nm).

[0084] In some embodiments, all light source channels of a light source array may emit light of approximately the same peak wavelength (e.g., maximum peak wavelength) (e.g., within a variability range of ±1 nm, ±2 nm, ±3 nm, ±4 nm, ±5 nm, ±6 nm, ±7 nm, ±8 nm, ±9 nm, ±10 nm). For example, in some embodiments, all light source channels of a light source array may emit light of a peak wavelength of 325±10 nm, 330±10 nm, 335±10 nm, 340±10 nm, 325±5 nm, 330±5 nm, 335±5 nm, 340±5 nm, 345±5 nm, 345±4 nm, 345±3 nm, or 345±2 nm. A light source channel may include multiple light sources with different peak wavelengths (e.g., measured peak wavelengths) within a certain variability range. In some embodiments, the average peak wavelength across multiple light sources of a single light source channel may be the same as the specific peak wavelength of a specific light source within a single light source channel. In other embodiments, the average peak wavelength across the multiple light sources of a single light source channel may be different (e.g., about 1 nm, 2 nm, 3 nm, 4 nm, 5 nm, or more higher or lower) than any particular peak wavelength of each light source within a single light source channel. In some embodiments, some light source channels may emit light of a first peak wavelength and other light source channels may emit light of a second peak wavelength. The first peak wavelength may differ from the second peak wavelength by at least (e.g., by more than) 5 nm, 10 nm, 15 nm, or 20 nm, or more. For example, in non-limiting embodiments, the first light source channel can emit light having a peak wavelength in the ultraviolet-A spectrum, e.g., as described above (e.g., between about 315 nm and about 335 nm, between about 330 nm and about 350 nm, between about 340 nm and about 350 nm), and the second light source channel can emit light having a peak wavelength in the ultraviolet-C spectrum, e.g., as described above (e.g., between about 250 nm and about 260 nm, between about 260 nm and about 270 nm) or the ultraviolet-B spectrum, e.g., as described above (e.g., between about 305 nm and about 315 nm).In another non-limiting embodiment, the first light source channel can emit light having a peak wavelength in the ultraviolet A spectrum, e.g., as described above (e.g., between about 330 nm and about 350 nm, between about 340 nm and about 350 nm), and the second light source channel can emit light having a peak wavelength similarly in the ultraviolet A spectrum, e.g., as described above (e.g., between about 315 nm and about 335 nm, between about 355 nm and about 375 nm). In some embodiments, the first peak wavelength is the average peak wavelength of one or more light sources in the first light source channel. In some embodiments, the light source array can include first, second, and third light source channels, each emitting light at the first, second, and third peak wavelengths, respectively. In some embodiments, the first peak wavelength may differ from the second peak wavelength by at least (e.g., by more than) 5 nm, 10 nm, 15 nm, or 20 nm, or more, and / or the second peak wavelength may differ from the third peak wavelength by at least (e.g., by more than) 5 nm, 10 nm, 15 nm, or 20 nm, or more. Alternatively, each of the first, second, and third peak wavelengths may differ from each other by at least (e.g., by more than) 5 nm, 10 nm, 15 nm, or 20 nm, or more. In some embodiments, the light source array may comprise first, second, third, and fourth light source channels, each emitting light at the first, second, third, and fourth peak wavelengths, respectively. In some embodiments, at least two, at least three, or at least four of the first, second, third, and fourth peak wavelengths may differ from one another by at least (e.g., by more than) 5 nm, 10 nm, 15 nm, or 20 nm, or more. Alternatively, each of the first, second, third, and fourth peak wavelengths may differ from one another by at least (e.g., by more than) 5 nm, 10 nm, 15 nm, or 20 nm, or more.Alternatively, the first peak wavelength may be approximately the same as the third peak wavelength (e.g., equal to it with a variation range of ±1 nm, ±2 nm, ±3 nm, ±4 nm, ±5 nm), the second peak wavelength may be approximately the same as (e.g., equal to) the fourth peak wavelength, and the first peak wavelength may differ from the second peak wavelength by at least (e.g., by more than) 5 nm, 10 nm, 15 nm, or 20 nm.

[0085] In some embodiments, each light source channel may emit light with a narrow spectral bandwidth. For example, the full width at half maximum (FWHM) spectral bandwidth (e.g., the spectral bandwidth of the maximum peak intensity) of the light emitted by each light source channel may be less than 20 nm, less than 18 nm, less than 16 nm, less than 14 nm, less than 12 nm, less than 10 nm, less than 9 nm, less than 8 nm, less than 7 nm, less than 6 nm, or less than 5 nm. In some embodiments, the full width at half maximum (FWHM) spectral bandwidth of the light emitted by each light source channel is within 10 nm below and / or above the peak wavelength (e.g., not more than 10 nm higher than the peak wavelength, not more than 10 nm lower). In some embodiments, the full width at half maximum (FWHM) spectral bandwidth of the light emitted by each light source channel may be greater than 1 nm, greater than 2 nm, greater than 3 nm, or greater than 4 nm, or more. In other examples, 50% of the maximum peak intensity of the light emitted by each light source channel is within 10 nm, 9 nm, 8 nm, 7 nm, 6 nm, 5 nm, 4 nm, or 3 nm of the peak wavelength (e.g., not more than 10 nm higher than the peak wavelength, not more than 10 nm lower than the peak wavelength; not more than 10 nm below the peak wavelength, not more than 10 nm above the peak wavelength). In other examples, the light intensity of 50% of the maximum peak intensity of the light emitted by each light source channel is within a spectral width of less than 20 nm, less than 18 nm, less than 16 nm, less than 14 nm, less than 12 nm, less than 10 nm, less than 9 nm, less than 8 nm, less than 7 nm, less than 6 nm, or less than 5 nm (e.g., not more than 10 nm higher than the peak wavelength, not more than 10 nm lower than the peak wavelength; not more than 10 nm below the peak wavelength, not more than 10 nm above the peak wavelength). Commercially available LEDs and laser diodes are non-limiting examples of light sources capable of providing such narrow spectral bandwidth illumination at the peak wavelengths discussed above.

[0086] In some embodiments, one or more of the peak wavelength of the emission, the spectral bandwidth of the emission, the duration of the emission, and the intensity of the emission of each light source channel 508 can be adjusted or set.

[0087] Adjustment of these various light source channel parameters can be performed by a control circuit 520 operably coupled (e.g., communicatively coupled) to the processing chambers 502 and 504, the light source array 506, and / or the computer system 524. As used herein, "operably coupled" refers to any wired or wireless connection between two or more components that allows the two or more components to exchange information, control instructions, and / or control signals. As discussed in more detail below, the control circuit 520 can receive control instructions and / or control signals from the computer system 524 and can send control instructions and / or control signals to the various components of the processing chambers 502 and 504 to adjust or set various parameters associated with the various components of the chambers 502 and 504. Adjustment of various parameters of the chambers 502 and 504 may be desirable to ensure that the processing parameters of the chambers follow the processing profile of one or more biological fluids 510. It should be appreciated that in some examples, the control circuit 520 and / or the functionality of the control circuit 520 can be included within the computer system 524. In some examples, the control circuitry 520 may include a computer system 524 and / or functionality of the computer system 524. In some examples, the control circuitry 520 may be structurally attached to the processing chambers 502 and 504 (e.g., attached to the outside, top, and / or bottom of the processing chambers 502 and 504). In some examples, the control circuitry 520 may be structurally integrated into the processing chambers 502 and 504 (e.g., positioned inside or forming part of the structure of the processing chambers 502 and 504).

[0088] The computer system 524 can be operatively coupled (wired or wirelessly) to the control circuitry 520 and / or any of the various sensors discussed herein. The computer system can include one or more processors 544 (644 in FIG. 7, 744 in FIG. 7), memory 542 (642 in FIG. 7, 742 in FIG. 7), input / output (I / O) interfaces 546 (646 in FIG. 7, 746 in FIG. 7), and a user interface (UI) 548 (648 in FIG. 6, 748 in FIG. 7). The one or more processors 544 can be one or more of any type of general-purpose computer processor. The memory or computer readable medium 542 can include one or more of readily available memory, such as random access memory (RAM), read-only memory (ROM), floppy disks, hard disks, optical storage media (e.g., compact disks or digital video disks), flash drives, or any other form of digital storage, local or remote. In some examples, the non-transitory computer-readable storage medium of memory 542 can be used to store instructions for irradiating one or more biological fluids according to the one or more treatment profiles thereof, as discussed below. Computer system 524 can include any type of computer, such as a personal computer (PC), desktop computer, laptop, computer terminal, server computer, tablet computer, smartphone, personal digital assistant (PDA), etc. In some examples, control circuitry 520 and / or functionality of control circuitry 520 can be included within computer system 524.

[0089] In the UI 548, a user can input one or more features of a feature set of one or more biological fluids (e.g., biological fluid 510). Alternatively or additionally, one or more features of the feature set of one or more biological fluids may be determined based on feedback input from one or more sensors in the processing chambers (e.g., processing chambers 502, 504) to the computer system 524 and / or control circuitry 520. Features of the feature set of a biological fluid may include, for example, the type of biological fluid (e.g., blood product, e.g., plasma, platelets, red blood cells; cells, e.g., eukaryotic cells; proteins, e.g., antibodies; vaccines), photochemicals in the biological fluid (e.g., type, volume, concentration), volume of the biological fluid, optical transparency of the biological fluid, type and / or shape of a container holding the biological fluid, and temperature of the biological fluid.

[0090] In the UI 548, a user can input one or more parameters comprising a processing profile of one or more biological fluids (e.g., biological fluid 510). Alternatively or additionally, the computer system 524 can automatically determine one or more parameters of the processing profile of one or more biological fluids (e.g., biological fluid 510) based on a respective set of characteristics of the one or more biological fluids. In particular, the memory 542 can store a computer program including instructions for mapping one or more characteristics of the biological fluid to one or more parameters of the processing profile of the biological fluid, for each biological fluid. The instructions for mapping one or more characteristics of the biological fluid to one or more parameters of the processing profile of the biological fluid, for each biological fluid, can be implemented as a set of user-programmable rules.

[0091] In some embodiments, the light source array 506 may be thermally coupled to a heat exchanger 528 (e.g., a heat sink, fin heat sink, heat exchanger that may be operably coupled and controlled by the control circuitry 520). The heat exchanger 528 may remove thermal energy from the array 506 facing the one or more biological fluids 510, thereby minimizing exposure of the biological fluids 510 to thermal energy (e.g., thermal energy that may damage biological function). Further control of the temperature of the chambers 502 and 504 and / or the temperature of the one or more biological fluids 510 may be provided by a heating / cooling unit 526 that may be operably coupled to and controlled by the control circuitry 520 and configured to adjust or set the temperature of the chambers 502 and 504. The heating / cooling unit 526 may be any suitable technology known in the art, such as, for example, a fan, a heat pump, a Peltier cooler, and / or a heat pipe, or any combination of such technologies. The heating / cooling unit 526 may be external to, internal to, and / or integrated with the chambers 502 and 504. For example, one or more fans may be located at the rear of the processing chamber(s) to draw air in through an inlet in the outer housing of the system 500 and exhaust the air through an outlet exhaust at the rear of the outer housing.

[0092] In some embodiments, the heating / cooling unit 526 can be a heating unit or a cooling unit or a heating-cooling unit. Through the use of the heating / cooling unit 526, the system 500 can control the heating / cooling unit 526 to maintain the temperature of the biological fluid within a certain temperature range (e.g., a 1° C. range, a 2° C. range, a 3° C. range, etc.) during treatment of the biological fluid by irradiation. For example, a heat or temperature sensor can provide a temperature indication or measurement to the control circuitry 520, or via the control circuitry 520 to the computer system 524. When the control circuitry 520 and / or the computer system 524 processes or interprets the temperature indication or measurement as indicative of the crossing of a particular threshold or condition associated with a target temperature value or profile, the control circuitry 520 and / or the computer system 524 can instruct or command or enable or engage or actuate the heating / cooling unit 526 to take action to adjust the temperature of the chambers 502 or 504 and / or the temperature of one or more biological fluids 510. For example, the control circuitry 520 and / or computer system 524 can instruct or command or enable or engage or activate one or more fans to begin blowing air to begin cooling, to blow air faster to provide an increased cooling rate, to blow air slower to provide a decreased cooling rate, or to stop blowing air to stop cooling. During treatment of the biological fluid by irradiation, the one or more fans may operate in an operational cycle under the control of the control circuitry 520 and / or computer system 524 to maintain the temperature of the biological fluid within a certain temperature range (e.g., a 1° C. range, a 2° C. range, a 3° C. range, etc.).The control circuitry 520 and / or computer system 524 may, for example, direct or command or enable or engage or actuate any other suitable technology known in the art, such as, by way of example, fans, heat pumps, Peltier coolers, and / or heat pipes, or any combination of such technologies, to take action to adjust the temperature of the chambers 502 or 504 and / or the temperature of the one or more biological fluids 510.

[0093] In some embodiments, the one or more fans may be located at the rear of the processing chamber(s). The one or more fans may blow air in a front-to-back or back-to-front direction, or both. In some embodiments, the one or more fans may take air in and pass it through the processing chamber and exhaust the air through an exhaust port at the rear of the system. Inlet air to the one or more fans may enter through a vent at or near the front or side(s) of the processing chamber(s), and outlet air from the one or more fans may exit through a vent at the rear of the processing chamber(s).

[0094] The processing chambers 502 and 504 may further include a plurality of interior surfaces configured to absorb light (e.g., each configured to absorb light), such as, for example, one or more walls made of or coated with a material that substantially absorbs light of a particular wavelength (e.g., black plastic, black silicate, black paint). Alternatively or additionally, in some embodiments, the processing chambers 502 and 504 may further include one or more interior surfaces configured to reflect light (e.g., each configured to reflect light), such as, for example, one or more walls made of or coated with a material that substantially reflects light of a particular wavelength.

[0095] The processing chambers 502 and 504 may further comprise a platform 530 configured to hold one or more biological fluids 510 (e.g., a container of biological fluid). The platform 530 may be any support suitable for holding a biological fluid or a container of biological fluid. The platform 530 may be arranged in a "drawer configuration" such that it is slidably movable manually into and out of the chambers 502 and 504. The platform 530 may also be slidably movable automatically by any suitable actuator, such as an electric motor or servo. The platform 530 holding the biological fluid 510 may be positioned above the light source array 506 with the light source array 506 facing the platform 530. However, in other embodiments, the platform 530 holding the one or more biological fluids may be positioned below the light source array 506 with the light source array 506 facing the platform 530.

[0096] In some embodiments, the system 500 includes one or more scanners 532 in the processing chambers 502 and 504. The one or more scanners 532 may be positioned above the biological fluid 510 when the fluid is placed for processing (e.g., scanner 532A in the first processing chamber, scanner 532B in the second processing chamber). As shown, one or more scanners 532 (e.g., scanner 532C) can also be positioned on the exterior (e.g., exterior housing, exterior) of the system 500 between the first and second processing chambers. The one or more scanners 532 can be substantially similar to the scanners described herein. In some embodiments, when the biological fluid is placed in the respective processing chambers, each scanner in the respective chamber can obtain identifying information regarding the biological fluid as described herein. In some embodiments, one or more scanners can be positioned at or near a first opening of the first processing chamber 502, at or near a second opening of the second processing chamber 504, or at or near the openings of both chambers, for example, to obtain identification information about the biological fluid before the biological fluid is placed into the respective processing chamber.

[0097] Each platform 530A and 530B can be configured to hold a first biological fluid 510A and a second biological fluid 510B in a first container (e.g., flexible container, bag) and a second container (e.g., flexible container, bag), respectively. Each container may have a volume capacity, for example, up to about 3000 mL, up to about 2500 mL, up to about 2000 mL, up to about 1500 mL, up to about 1400 mL, up to about 1300 mL, up to about 1200 mL, up to about 1100 mL, up to about 1000 mL, up to about 950 mL, up to about 900 mL, up to about 850 mL, up to about 800 mL, up to about 750 mL, up to about 700 mL, up to about 650 mL, up to about 600 mL, up to about 550 mL, up to about 500 mL.

[0098] 6 is a perspective view of an exemplary system 600 for processing biological fluids. In some embodiments, the system 600 is substantially similar to the system 500 as shown in FIG. 5. The exemplary system 600 for processing biological fluids includes a first processing chamber 602 and a second processing chamber 604 for receiving one or more biological fluids 610, a first light source array 606 in each chamber arranged to illuminate the one or more biological fluids 610 from below, a second light source array 608 in each chamber arranged to illuminate the one or more biological fluids 610 from above, a platform 630 in each chamber configured to hold one or more biological fluids 510 (e.g., a container of biological fluid), and a sensor (e.g., a scanner) 632 configured to obtain an identity of the biological fluid loaded into the processing chambers. A first light source array 606 and a second light source array 608 positioned above and below one or more biological fluids 610 in each of the processing chambers 602 and 604 provide illumination of the biological fluid from either one (i.e., above or below) or two (i.e., both) directions.

[0099] The system 600 may include, for example, a scanner 632A disposed outside (e.g., on an external housing, exterior) of the system 600 at a location associated with the first processing chamber 602 (e.g., at or near an opening of the first processing chamber 602) and a scanner 632B disposed outside (e.g., on an external housing, exterior) of the system 600 at a location associated with the second processing chamber 604 (e.g., at or near an opening of the second processing chamber 604) to obtain identification information regarding the biological fluid before the biological fluid is disposed in the respective processing chamber, by way of example. The system 600 may also include a scanner 632C disposed inside (e.g., on an interior wall, ceiling, floor) of the system 600 between the first processing chamber 602 and the second processing chamber 604. In some embodiments, the scanner 632C may be configured to obtain information from a container disposed in either or both processing chambers.

[0100] FIG. 7 is a perspective view of an exemplary system 700 for processing biological fluids. In some embodiments, the system 700 is substantially similar to the system 300 shown in FIG. 3 and the system 500 shown in FIG. 5, except that a first processing chamber 702 and a second processing chamber 704 are arranged vertically (above and below each other) in the system 700. The exemplary system 700 for processing biological fluids includes a first processing chamber 702 and a second processing chamber 704 for receiving one or more biological fluids 710, a first light source array 706 in each chamber arranged to illuminate the one or more biological fluids 710 from below, a platform 730 in each chamber configured to hold the one or more biological fluids 710 (e.g., a container of biological fluid), and a sensor (e.g., a scanner) 732 configured to obtain an identity of the biological fluid loaded in the processing chamber. The platform 730 for holding the biological fluid 710 may be positioned above the light source array 706 with the light source array 706 facing the platform 730. However, in other embodiments, a platform 730 holding one or more biological fluids can be positioned below the light source array 706 with the light source array 706 facing the platform 730. Each of the light source chambers 702 and 704 can further include a second light source array (not shown) positioned above or below the one or more biological fluids 710, e.g., similar to system 600, as shown in FIG.

[0101] The system 700 can include scanners 732A and 732B disposed inside the first processing chamber 702 (e.g., in the ceiling above the compartments for biological fluids 710A and 710B) and two scanners similarly disposed inside the second processing chamber 704 (e.g., in the ceiling above the compartments for biological fluids 710C and 710D). Alternatively or additionally, the system 600 can include a scanner 732E disposed outside the system 600 (e.g., in the external housing, exterior surface) between the first processing chamber 702 and the second processing chamber 704. In some embodiments, the scanner 732E can be configured to acquire information from containers disposed in either or both processing chambers (e.g., when a platform in a drawer configuration is in an open position within the field of view of the scanner 732E, when an RFID tag is within the detection range of the scanner 732E).

[0102] In some embodiments, any of the above-mentioned processing systems can be used to process (e.g., inactivate pathogen(s) therein) one or more biological fluids, preferably biological fluids mixed with one or more pathogen inactivation compounds (e.g., photoactive pathogen inactivation compounds, psoralens). In particular, any of the above-mentioned processing systems can irradiate a mixture of one or more pathogen inactivation compounds and a biological fluid, such as, for example, blood or blood products (e.g., platelet compositions, plasma compositions, and derivatives thereof), with light of a certain wavelength (e.g., ultraviolet light) to cause a photochemical reaction to inactivate pathogen(s) that may be present in the biological fluid, such as viruses, bacteria, parasites, and other contaminants, such as, for example, cellular contaminants (e.g., white blood cells). In some embodiments, the pathogen inactivation compounds target nucleic acids to photochemically form adducts and / or crosslinks. For example, the device of the present disclosure may be used in a method of treating a biological fluid, the method including providing a biological fluid mixed with a photoactive pathogen inactivation compound (e.g., psoralen, amotosalen) and irradiating the biological fluid with ultraviolet light having a first peak wavelength of about 315 nm to about 350 nm (e.g., about 315 nm to about 335 nm, about 330 nm to about 350 nm, about 340 nm to about 350 nm, about 340 nm, about 345 nm) emitted by a set of one or more first light sources, wherein irradiating the biological fluid occurs for a duration and intensity sufficient to inactivate pathogens in the biological fluid. In some embodiments, each of the one or more first light sources emits light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers. In some embodiments, each of the one or more first light sources is a light emitting diode (LED).

[0103] The term "pathogen inactivating compound" refers to any suitable compound, e.g., a small molecule organic compound, that can be used to inactivate pathogens that may be present in a biological fluid, e.g., blood or blood products, for example. Pathogen inactivating compounds that are "photoactive" or "light activated" or "photochemical" or "photosensitizing" compounds are suitable compounds that require some level of light to fully inactivate the pathogen. Such compounds are preferred in the inactivation of pathogens in biological products because they provide control over the inactivation process. In some embodiments, the pathogen inactivating compound is a photoactive pathogen inactivating compound selected from the group consisting of psoralens, isoalloxazines, alloxazines, phthalocyanines, phenothiazines, porphyrins, and merocyanine 540. In some embodiments, the pathogen inactivating compound is a psoralen. In some embodiments, the pathogen inactivating compound is amotosalen (e.g., S-59). Such photoactivation or photochemical pathogen inactivation compounds described herein may include, but are not limited to, psoralens, isoalloxazines, alloxazines, phthalocyanines, phenothiazines, and porphyrins, where these terms are understood to encompass the general classes of compounds, i.e., core compounds and suitable derivatives thereof. For example, psoralens or singular generally refers to a psoralen core compound and any derivatives thereof (e.g., amotosalen), isoalloxazines or singular generally refers to an isoalloxazine core and any derivatives thereof (e.g., riboflavin), and so forth. Such derivatives include the core compound structure as well as additional substituents at the core. Descriptions of such compounds include any salts thereof.

[0104] The term "amotosalen" refers to the compound 3-(2-aminoethoxymethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one and any salts thereof. This compound may also be referred to as 4'-(4-amino-2-oxa)butyl-4,5',8-trimethylpsoralen. When the method of the present disclosure includes adding amotosalen HCl (HCl salt of amotosalen), removing this compound from a biological fluid, such as, for example, a blood product (e.g., a platelet composition, a platelet unit, a plasma composition, a whole blood composition, a plasma composition) is not limited to removing amotosalen HCl, since amotosalen may be present in solution as other salts or as a free base. As used in the methods described herein, removal of amotosalen refers to removal of this compound in any form, such as the free base or any salt, as measured by the assays described herein.

[0105] In some embodiments, the pathogen inactivating compound is a 4-primaryamino substituted psoralen, which is a psoralen compound having an NH group linked to the 4' position of the psoralen by a hydrocarbon chain having a total length of 2-20 carbons, where 0-6 of those carbons are independently replaced by NH or O, each point of replacement being at least 2 carbons away from each other and at least 1 carbon away from the psoralen. 4'-primaryamino substituted psoralens may have additional substitutions at the 4, 5', and 8 positions of the psoralen, including, but not limited to, the following groups: H and (CH) n CH3, where n=0-6. In some embodiments, the 4'-primary amino substituted psoralen is a) -(CH2) u -NH2, -(CH2) w -R2-(CH2) z -NH2, -(CH2) w -R2-(CH2) x -R3-(CH2)z-NH2, and -(CH2) w -R2-(CH2) x -R3-(CH2) y -R4-(CH2) za) a substituent R1 on the 4' carbon atom selected from the group including -NH2, where R2, R3, and R4 are independently selected from the group including O and NH, u is an integer from 1 to 10, w is an integer from 1 to 5, x is an integer from 2 to 5, y is an integer from 2 to 5, and z is an integer from 2 to 6; and b) H and (CH2). v and R5, R6, and R7 (wherein v is an integer from 0 to 5) on the carbon atoms at positions 4, 5', and 8, respectively, independently selected from the group including CH3 or a salt thereof.

[0106] In some embodiments, the pathogen inactivating compound is a 5-primary amino substituted psoralen, which is a psoralen compound having an NH group linked to the 5' position of the psoralen by a hydrocarbon chain having a total length of 1-20 carbons, where 0-6 of those carbons are independently replaced by NH or O, each point of replacement being at least 2 carbons away from each other and at least 1 carbon away from the psoralen. 5'-primary amino substituted psoralens may have additional substitutions at the 4, 4', and 8 positions of the psoralen, including, but not limited to, the following groups: H and (CH) n CH3, where n=0-6. In some embodiments, the 5'-primary amino substituted psoralen is a) -(CH2) u -NH2, -(CH2) w -R2-(CH2) z -NH2, -(CH2) w -R2-(CH2) x -R3-(CH2)z-NH2, and -(CH2) w -R2-(CH2) x -R3-(CH2) y -R4-(CH2) z a) a substituent R1 on the 5' carbon atom selected from the group including -NH2, where R2, R3, and R4 are independently selected from the group including O and NH, u is an integer from 1 to 10, w is an integer from 1 to 5, x is an integer from 2 to 5, y is an integer from 2 to 5, and z is an integer from 2 to 6; and b) H and (CH2). vR5, R6, and R7, independently selected from the group consisting of -CH3 or a salt thereof, on the 4, 4', and 8 carbon atoms, respectively (wherein v is an integer from 0 to 5, and R1 is -(CH2) u When selected from the group including -NH2, R7 is (CH2) v CH3, and R5, R6, and R7 are (CH 2 ) v When u is CH3, u is an integer from 3 to 10. Exemplary psoralen compounds are described, for example, in U.S. Patent No. 5,593,823.

[0107] In some embodiments, the biological fluid (e.g., a platelet composition) is mixed with a pathogen inactivation compound (PIC) in a platelet additive solution (PAS). In some embodiments, the PIC is mixed with the PAS prior to mixing with the biological fluid. Platelet additive solutions are known in the art, for example, as described by Alhumaidan et al. and Ringwald et al. (Alhumaidan, H. and Sweeney, J., J Clin Apheresis, 27: 93-98 (2012); Ringwald et al., Transfusion Medicine Reviews, 20: 158-64(2006)), which are incorporated herein by reference in their entireties. In some embodiments, the platelet additive solution (PAS) comprises one or more of chloride, acetate, citrate, potassium, magnesium, phosphate, gluconate, glucose, and bicarbonate. In some embodiments, the platelet additive solution (PAS) is a PAS approved by a regulatory agency or a certification body generally accepted in the art.

[0108] In some embodiments, the method further comprises agitating the biological fluid. In some embodiments of any of the methods provided herein, the total dose of ultraviolet light irradiated onto the biological fluid (e.g., emitted by one or more light sources, emitted by one or more sets of light sources, emitted by a light source array) is about 0.5 J / cm 2~about 50J / cm 2 , for example, about 0.5 J / cm 2 ~about 10J / cm 2 , about 0.5J / cm 2 ~About 15J / cm 2 , about 0.5J / cm 2 ~About 25J / cm 2 , about 1J / cm 2 ~About 10J / cm 2 , about 1J / cm 2 ~About 15J / cm 2 , about 1J / cm 2 ~About 25J / cm 2 , about 3J / cm 2 ~about 10J / cm 2 , about 3J / cm 2 ~About 15J / cm 2 , about 3J / cm 2 ~About 25J / cm 2 , about 5J / cm 2 ~about 10J / cm 2 , about 5J / cm 2 ~About 15J / cm 2 , about 5J / cm 2 ~About 25J / cm 2 , about 10J / cm 2 ~About 30J / cm 2 , about 10J / cm 2 ~About 20J / cm 2 , about 15J / cm 2 ~about 50J / cm 2 , about 15J / cm 2 ~About 35J / cm 2 , about 20J / cm 2 ~About 30J / cm 2 , about 25J / cm 2 ~about 50J / cm 2 , about 30J / cm 2 ~About 40J / cm 2 , or about 40 J / cm 2 ~about 50J / cm 2 In some embodiments, the total dose of ultraviolet light applied to the biological fluid is about 0.5 J / cm 2 More than, for example, approximately 1 J / cm 2 More than 2J / cm 2 More than 3J / cm 2More than 4J / cm 2 More than 5J / cm 2 More than 6J / cm 2 More than 7J / cm 2 More than 8J / cm 2 Above, 9J / cm 2 More than 10J / cm 2 More than 15J / cm 2 Above, 20J / cm 2 Above, 25J / cm 2 Above, 30J / cm 2 Above, 35J / cm 2 Above, 40J / cm 2 Above, 45J / cm 2 or more than 50J / cm 2 In some embodiments, the total dose of ultraviolet light applied to the biological fluid is about 50 J / cm 2 Less than 40J / cm 2 Less than 30J / cm 2 Less than 25J / cm 2 Less than 20J / cm 2 Less than 15J / cm 2 Less than or about 10 J / cm 2 In some embodiments, irradiating the biological fluid occurs for a duration and intensity sufficient to inactivate pathogens in the biological fluid (e.g., if present in the biological fluid). For example, in some embodiments, irradiating the biological fluid occurs for a duration and intensity sufficient to provide a desired total dose of ultraviolet light (e.g., a total dose as described above) to irradiate the biological fluid (e.g., any suitable combination of duration and intensity sufficient to provide a total dose of ultraviolet light). In some embodiments, the intensity is between 1 and 1000 mW / cm. 2 (for example, 1 to 100 mW / cm 2 In some embodiments, the period of time is between 1 second and 2 hours (eg, between 1 minute and 60 minutes).

[0109] It is understood that the treatment of a biological fluid to inactivate a pathogen(s) that may be present does not necessarily completely inactivate all pathogens that may be present, but rather substantially reduces the amount of pathogens to significantly reduce the risk arising from the presence of the pathogens (e.g., infections associated with administration of pathogen-contaminated biological fluids, transfusion-associated illnesses from blood products, transfusion-transmitted infections from blood products). Pathogen inactivation can be assayed by measuring the number of infectious pathogens (e.g., virus particles, bacteria) in a certain volume, and the level of inactivation is typically expressed as a log reduction in the infectivity of the pathogen, i.e., log reduction in titer. Methods for assaying log reduction in titer and its measurement to assess the level of pathogen inactivation are well known in the art. In some embodiments, the system, device, and / or method for treating is sufficient to inactivate at least 1 log (e.g., at least 2 log, at least 3 log, at least 4 log, or more) of the pathogen in the biological fluid when present. In some embodiments, the biological fluid after irradiation is suitable for injection into a subject without further processing to remove residual pathogen inactivating compound or its photoproduct(s). In some embodiments, the system, device, and / or method for treating is sufficient to inactivate at least 1 log (e.g., at least 2 logs, at least 3 logs, at least 4 logs, or more) of pathogens in the biological fluid when present, and the biological fluid comprises 10 μM or less of the pathogen inactivating compound after irradiating the biological fluid. In some embodiments, the system, device, and / or method for treating is sufficient to inactivate at least 1 log (e.g., at least 2 logs, at least 3 logs, at least 4 logs, or more) of pathogens in the biological fluid when present, and the biological fluid comprises 7.5 μM or less of the pathogen inactivating compound after irradiation.In some embodiments, the systems, devices, and / or methods for treating are sufficient to inactivate at least 1 log (e.g., at least 2 logs, at least 3 logs, at least 4 logs, or more) of pathogens in the biological fluid when present, and the biological fluid contains 5 μM or less (e.g., 4 μM or less, 3 μM or less, 2 μM or less, 1 μM or less, 0.5 μM or less) of the pathogen inactivating compound after irradiation. In some embodiments, the concentration of the pathogen inactivating compound mixed with the biological fluid before irradiation is at least about 10 μM (e.g., at least about 30 μM, at least about 60 μM, at least about 90 μM, at least about 110 μM). In some embodiments, the concentration of the pathogen inactivating compound mixed with the biological fluid before irradiation is about 15 μM to about 150 μM (e.g., about 30 μM to about 110 μM, about 60 μM to about 90 μM, about 75 μM). In some embodiments, the concentration of the pathogen inactivating compound mixed with the biological fluid after irradiation is at most ⅓ of the concentration of the pathogen inactivating compound mixed with the biological fluid before irradiation, in some embodiments, the biological fluid after irradiation maintains sufficient biological activity such that the biological fluid is suitable for injection into a subject.

[0110] FIG. 8 illustrates an example of a computing device according to one embodiment. The device 800 may be a host computer connected to a network. The device 800 may be a client computer or a server. As illustrated in FIG. 8, the device 800 may be any suitable type of microprocessor-based device, such as one of the systems 100-700, the computing system 524, a personal computer, a workstation, a server, or a handheld computing device (portable electronic device) such as a phone or tablet. The device may include, for example, one or more of a processor 802, an input device 806, an output device 808, storage 810, and a communication device 804. The input device 806 and the output device 808 may generally correspond to those described above and may be connectable or integrated with the computer.

[0111] The input device 806 may be any suitable device that provides input, such as any of the displays disclosed herein, a touch screen, a keyboard or keypad, a mouse, or a voice recognition device. The output device 808 may be any suitable device that provides output, such as a touch screen, a tactile device, or a speaker.

[0112] Storage 810 can be any suitable device that provides storage, for example, electrical, magnetic, or optical memory, including RAM, cache, a hard drive, or a removable storage disk. Communications device 804 can include any suitable device that can send and receive signals over a network, for example, a network interface chip or device. The components of a computer can be connected in any suitable manner, for example, via a physical bus or wirelessly.

[0113] Software 812 that may be stored in storage 810 and executed by processor 802 may include, for example, programming that embodies functions of the present disclosure (eg, embodied in the devices described above).

[0114] The software 812 may also be stored and / or transported in any non-transitory computer-readable storage medium for use by or in connection with an instruction execution system, apparatus, or device, such as those described above, that can retrieve and execute instructions associated with the software from an instruction execution system, apparatus, or device. In the context of this document, a computer-readable storage medium may be any medium that can contain or store a program for use by or in connection with an instruction execution system, apparatus, or device, such as storage 840.

[0115] The software 812 may also be propagated in any transport medium for use by or in connection with an instruction execution system, apparatus, or device, such as those described above, that can retrieve and execute instructions associated with the software from an instruction execution system, apparatus, or device. In the context of this disclosure, a transport medium may be any medium that can communicate, propagate, or transport programming for use by or in connection with an instruction execution system, apparatus, or device. Transport-readable media include, but are not limited to, electronic, magnetic, optical, electromagnetic, or infrared wired or wireless propagation media.

[0116] The device 800 may be connected to a network, which may be any suitable type of interconnected communication system. The network may implement any suitable communication protocol and may be protected by any suitable security protocol. The network may include any suitable configuration of network links capable of implementing transmission and reception of network signals, such as wireless network connections, T1 or T3 lines, cable networks, DSL, or telephone lines.

[0117] Device 800 may implement any operating system suitable for operation over a network. Software 812 may be written in any suitable programming language, such as C, C++, Java, or Python. In various embodiments, application software embodying functionality of the present disclosure may be deployed in different configurations, such as, for example, in a client / server configuration or as a web-based application or web service via a web browser.

[0118] 9A shows a perspective view of the system 400, showing the exterior housing from the front and the internal components from the side. Similar to FIG. 4J, this side view shows an upper stage including a display 420 (e.g., a touch screen), control circuitry and / or a computer system, a first light source array 406 positioned above and facing the first platform 440 to irradiate a first biological fluid on the first platform 440 in a first process, a second light source array 408 positioned below and facing the first platform 440 to irradiate a first biological fluid disposed on the first platform 440, a third light source array 416 positioned above and facing the second platform 450 to irradiate a second biological fluid disposed on the second platform 450 in a second process chamber, and a fourth light source array 418 positioned below and facing the second platform 450 to irradiate a second biological fluid disposed on the second platform 450. Similar to Figure 4A, the front outer housing shows the display 420, scanner 430, and panels 480 and 490 of platforms 440 and 450, respectively, in their closed, drawer configuration. Figure 9A also shows fan 426 located at the rear of the first processing chamber, and fan 436 located at the rear of the second processing chamber.

[0119] Figure 9B shows a perspective view of system 400, showing the front exterior housing and the internal components from the side. Similar to Figure 9A, the front exterior housing shows display 420, scanner 430, and panels 480 and 490 of platforms 440 and 450, respectively, in a drawer configuration but in an open position. Also shown are the interior regions of platforms 440 and 450, which include compartments 460A and 460B, and the exterior regions of platforms 440 and 450, which slidably move in and out of first (upper) and second (lower) processing chambers, respectively, via exterior rails or tracks 462.

[0120] In some embodiments, system 400 may include one or more access panels through which maintenance or service personnel may access and then perform maintenance or service on internal components or structures of system 400. Figures 9C-9E show example access panels of system 400.

[0121] FIG. 9C shows a perspective view of the system 400, showing the front exterior housing and the internal components from the side. The front exterior housing shows four access panels in the closed position: a user interface access panel 422, an upper access panel 482, a middle access panel 484, and a lower access panel 486. The user interface access panel 422 is positioned at the height of the touch screen 420 and includes the touch screen 420 and adjacent housing area. The upper access panel 482 is positioned above the first panel of the first platform 440. The middle access panel 484 is positioned between the panels of the first platform 440 and the second platform 450. The lower access panel 486 is positioned below the second panel of the second platform 450. In other examples, the single middle access panel can be replaced by two middle access panels. FIG. 9C also shows the fan 426 located at the rear of the first processing chamber and the fan 436 located at the rear of the second processing chamber.

[0122] 9D shows a perspective view of the system 400, showing three of the four access panels in the open position. The user interface access panel 422 is still in the closed position. The top access panel 482 is flipped up to the open position, and the first light source array 406 can be slidably moved in and out of the system 400 through the opening in the open top access panel 482. The middle access panel 484 is flipped up to the left to the open position, and the second light source array 408 and the third light source array 416 can be slidably moved in and out of the system 400 through the opening in the open middle access panel 484. The bottom access panel 484 is flipped up to the open position, and the fourth light source array 418 can be slidably moved in and out of the system 400 through the opening in the open bottom access panel 484. Through these three access panels, maintenance or service personnel can access internal components or structures of the system 400, such as the four light source arrays 406, 408, 416, 418, before performing maintenance or service.

[0123] FIG. 9E shows a perspective view of the system 400, showing one of the four access panels in the open position. The top access panel 482, the middle access panel 484, and the bottom access panel 486 are in the closed position. The user interface access panel 422 is flipped up to the open position, and components such as the touch screen 420 and the control circuitry and / or computer system are accessible. The rear side of the touch screen is accessible at the rear side of the open user interface access panel. The control circuitry and / or computer system can be slidably moved in and out of the system 400 through the opening of the open user interface access panel 422. An exemplary control circuitry and / or computer system may include one or more processors, input devices, output devices, storage, and / or communication devices. Through the user interface access panel 422, maintenance or service personnel can access the internal components or structures of the system 400, such as the touch screen 420 and the control circuitry and / or computer system, before performing maintenance or service.

[0124] All of the embodiments shown in Figures 9A-9E can incorporate any or all of the air vent teachings discussed above in connection with Figure 3B. For example, Figure 9F shows the embodiment of Figure 9A having a panel with air vents 485 and 495. The air vents 485 and 495 can provide one or more air inlets and / or one or more air outlets, for example, to provide cooling or heat dissipation or other temperature control functions. Air can be drawn into and / or exhausted from the system 400 by, for example, operation of fan 426 located at the rear of the first processing chamber and fan 436 located at the rear of the second processing chamber. In some embodiments, with or without air vents, the panels can be flush or substantially flush with adjacent structures (e.g., adjacent panel(s), adjacent frames of an external housing, etc.) as shown in Figures 9A-9F.

[0125] All of the embodiments shown in Figures 9A-9F can incorporate any or all of the side access panel teachings discussed above in connection with Figure 3B. The open side views shown in all of Figures 9A-9F may be the view that a maintenance or service person would see when one or more side access panels are open or removed.

[0126] FIG. 10 shows two adjacent systems 400, one of which is also adjacent to a wall 1002 or other equipment 1004. In some embodiments, the housing of each system may have a maximum horizontal width 1010 in the range of 30-60 cm with any width interval. In some embodiments, the housing of each system may have a maximum horizontal width 1010 of 60 cm, 58 cm, 56 cm, 54 cm, 52 cm, 50 cm, 48 cm, or 46 cm. In some embodiments, the housing of each system may have a maximum horizontal width 1010 in the range of 30-45 cm. In some embodiments, the housing of each system may have a maximum horizontal width 1010 of 45 cm, 43 cm, 41 cm, 39 cm, 37 cm, 35 cm, 33 cm, or 31 cm. Reducing the maximum horizontal width 1010 of the housing of each system allows adjacent systems 400 to occupy a more compact space, thereby enabling a blood product processing facility to operate more systems and increase throughput processing of biological fluids for a given amount of space within the facility.

[0127] For each system 400, the system may be configured (e.g., according to the manufacturer's operating instructions or documentation) to operate within a target (e.g., minimum) operating space 1020 such that there is free space 1012, 1014 on both the left and right sides of the housing of the system 400 (e.g., any target operating space including an operating space of 20 cm or less on both the left and right sides of the housing). The free space or minimum operating space on the left and / or right side may be 30 cm or less, 25 cm or less, 20 cm or less, 15 cm or less, 10 cm or less, or 5 cm or less, e.g., about 30 cm, about 25 cm, about 20 cm, about 15 cm, about 10 cm, about 5 cm, or about 0 cm. In some embodiments, there is no free space (e.g., operating space) requirement on either side of the system. Reducing the free space between adjacent systems 400 allows adjacent systems 400 to occupy a more compact space, which allows a blood product processing facility to operate more systems and increase throughput processing of biological fluids for a given amount of space in the facility. Prior illuminator systems may require significantly more free space (e.g., operating space) on either or both sides of the system of the present disclosure, for example, due to, for example, the thermal radiation range (e.g., airflow requirements) of each adjacent prior illuminator system. Outside the thermal radiation range of a first prior illuminator system, an adjacent second prior illuminator system may operate properly without thermal radiation from the first prior illuminator system and without adversely increasing the target operating temperature of the adjacent second prior illuminator system.

[0128] Previous irradiator systems were generally limited to processing chambers that were wide horizontally and had only one horizontal layer. The improved systems and methods disclosed herein may provide irradiator systems with multiple processing chambers that may be controlled and used for processing independently of one another, and design features that may provide various advantageous benefits. For example, due to the front-to-back agitation direction of the platform of the system 400, the system may not need to have a wide housing that would be required to accommodate a left-to-right agitation direction. As another example, with a relatively more compact and narrower form factor, multiple (e.g., two, two-and-a-half, three) entire systems 400 may fit into the operating space of a single previous irradiator system. As yet another example, due to the front-to-back or back-to-front fan airflow, it may not be necessary to have lateral operating space on the left and / or right side of the system 400 to accommodate the left-to-right airflow. Each of these examples provides an exemplary advantageous benefit over previous irradiator systems, but the improved systems and methods disclosed herein are not limited to these exemplary advantageous benefits and may provide further advantageous benefits in accordance with the present disclosure.

[0129] The present disclosure provides a method of treating a biological fluid, the method comprising irradiating the biological fluid with any of the systems provided herein (e.g., the systems described above, systems disclosed below) for a duration and intensity sufficient to inactivate pathogens in the biological fluid (e.g., if present in the biological fluid). In some embodiments, the present disclosure provides a method of treating a biological fluid comprising providing a biological fluid mixed with a pathogen inactivating compound (e.g., a photoactive pathogen inactivating compound, psoralen, amotosalen) and irradiating the biological fluid with any of the systems provided herein (e.g., the systems described above) for a duration and intensity sufficient to inactivate pathogens in the biological fluid (e.g., if present in the biological fluid). In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by one or more first set of light sources (e.g., ultraviolet A, ultraviolet B, ultraviolet C, ultraviolet light having a first peak wavelength of about 315 nm to about 350 nm), where 1) each of the one or more first light sources emits light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers, and / or 2) each of the one or more first light sources is a light emitting diode (LED). In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by one or more first set of light sources having a first peak wavelength of about 315 nm to about 350 nm. In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by one or more first set of light sources having a first peak wavelength of about 330 nm to about 350 nm. In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by one or more first set of light sources having a first peak wavelength of about 340 nm to about 350 nm. In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by a first set of one or more light sources having a first peak wavelength in the range of about 345+5 nm. In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by a first set of one or more light sources having a first peak wavelength of about 315 nm to about 335 nm.In some embodiments, the biological fluid is irradiated with ultraviolet light emitted by a first set of one or more light sources having a first peak wavelength and ultraviolet light from a second set of one or more light sources having a second peak wavelength, the second peak wavelength differing from the first peak wavelength by at least 5 nanometers. In some embodiments, the duration and intensity of the irradiation is about 0.5 J / cm. 2 or more (for example, about 0.5 J / cm 2 ~about 50J / cm 2 ) of ultraviolet light irradiating the biological fluid. In some embodiments, the intensity is between 1 and 1000 mW / cm 2 (for example, 1 to 100 mW / cm 2 In some embodiments, the period is between 1 second and 2 hours (e.g., between 1 minute and 60 minutes). In some embodiments, the method of treating the biological fluid is sufficient to inactivate at least 1 log of pathogens in the biological fluid. In some embodiments, the method of treating the biological fluid is sufficient to inactivate at least 4 log of pathogens in the biological fluid. In some embodiments, the biological fluid is a blood product (e.g., platelets, plasma).

[0130] Treatment of biological fluids with psoralen pathogen inactivation compounds and irradiation using the disclosed system was performed. More specifically, photochemical inactivation of both viruses and bacteria was performed using the psoralen amotosalen (S-59) and ultraviolet light irradiation using the disclosed system incorporating an array of ultraviolet A LEDs emitting at a peak wavelength of 346-349 nm. In studies evaluating viral inactivation, platelets in platelet additive solution (PAS) were spiked with a stock of vesicular stomatitis virus (VSV) and processed with 150 μM amotosalen (nominal concentration) using commercially available INTERCEPT® Blood System large volume (LV) and small volume (SV) sets (Cerus Corp., Concord, CA). For platelets in the LV set, 335 mL of VSV-spiked platelet preparations were processed in triplicate, yielding 3.9 J / cm. 2For the SV set of platelets, 285 mL of VSV-spiked platelet preparation was treated in triplicate, receiving 3.6 J / cm 2 The plates were irradiated at 37 °C for 10 min. Both pre- and post-irradiation samples were taken to determine the VSV titer and log inactivation of virus, as well as pre- and post-irradiation S-59 concentrations, and the percent photoconversion and residual amotosalen after irradiation were calculated. The data are shown in Table 1 below, showing 4.0 ± 0.5 and 4.5 ± 0.3 log inactivation of VSV in platelets / PAS using the LV and SV sets, respectively. Additionally, the percent residual S-59 was shown to be 16.5 ± 1.2 and 14.3 ± 4.6 for platelets / PAS in the LV and SV sets, respectively (calculated from the pre- and post-irradiation data).

[0131] In a study evaluating the inactivation of bacteria in different blood products, either plasma or platelets in platelet additive solution (PAS) were spiked with a stock of Klebsiella pneumoniae and processed with 150 μM amotosalen (nominal concentration) using the commercially available Plasma or Platelet LV Set of the INTERCEPT® Blood System, respectively. For plasma, the K. pneumoniae-spiked plasma preparation was processed in triplicate in the INTERCEPT® Plasma Set, yielding 6.4 J / cm 2 For platelets, K. pneumoniae spiked plasma preparations were treated in triplicate with the INTERCEPT® Plasma Set and irradiated with 3.9 J / cm 2 Both pre- and post-irradiation samples were taken to determine the titer and log inactivation of virus in K. pneumoniae, as well as pre- and post-irradiation S-59 concentrations, and to calculate the percent photoconversion and residual amotosalen after irradiation. The data are shown in Table 1 below, and the log inactivation of K. pneumoniae in plasma and platelets / PAS was 6.3±0.3 and 7.2±0.2 log, respectively. Additionally, the percent residual S-59 was 55.8±3.6 for plasma samples and 15.2±1.7 for platelets / PAS, respectively (calculated from pre- and post-irradiation data). [Table 1]

[0132] Although specific components, configurations, features, and functions have been provided above, one of ordinary skill in the art will appreciate that other variations may be used. In addition, while features may appear to be described in connection with particular embodiments, one of ordinary skill in the art will recognize that various features of the described embodiments may be combined. Furthermore, aspects described in connection with an embodiment may be standalone.

[0133] Although the embodiments have been described in detail with reference to the accompanying drawings, it should be noted that various changes and modifications will be apparent to those skilled in the art, and such changes and modifications are to be understood as being included within the scope of the various embodiments as defined by the appended claims.

[0134] Variations of the embodiments provided herein may become apparent to those skilled in the art upon reading the foregoing description. It is expected that those skilled in the art may use such variations, as well as implementations of the systems, methods, and devices described herein other than those specifically described herein, as appropriate. Accordingly, the systems, methods, and devices described herein include all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law. Moreover, any combination of the above-described elements in all possible variations thereof is encompassed by this description, unless otherwise indicated herein or clearly contradicted by context.

[0135] In one aspect, a biological fluid processing system comprises a first processing chamber configured to receive a first biological fluid, a second processing chamber configured to receive a second biological fluid, a first platform configured to hold the first biological fluid and to be disposed within the first processing chamber, a second platform configured to hold the second biological fluid and to be disposed within the second processing chamber, a first light source array arranged to irradiate the first biological fluid in the first processing chamber and a second light source array arranged to irradiate the second biological fluid in the second processing chamber, a display, one or more processors, and a memory containing instructions that, when executed by the one or more processors, cause the one or more processors to perform a method including providing, for display on the display, a graphical user interface (GUI) including a plurality of GUI objects associated with processing the first biological fluid with irradiation from the first light source array or associated with processing the second biological fluid with irradiation from the second light source array.

[0136] In some embodiments of the above systems, the first light source array and the second light source array are configured to irradiate the first biological fluid and the second biological fluid, respectively, with ultraviolet light. In some embodiments of each of the above systems, each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 315 nm to about 350 nm. In some embodiments of each of the above systems, each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 330 nm to about 350 nm. In some embodiments of each of the above systems, each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 340 nm to about 350 nm. In some embodiments of each of the above systems, each of the light source arrays comprises a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array within the range of 345+5 nm. In some embodiments of each of the above systems, each of the light source arrays includes a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array from about 315 nm to about 335 nm.

[0137] In some embodiments of each of the above systems, for each of the light source arrays, a respective first light source channel comprises one or more light sources that each emit light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers.

[0138] In some embodiments of each of the above systems, the system further comprises a third light source array facing in a direction opposite to the first light source array and positioned to irradiate a first biological fluid in the first treatment chamber, and a fourth light source array facing in a direction opposite to the second light source array and positioned to irradiate a second biological fluid in the second treatment chamber, and the method further includes providing for display on the display a GUI including a plurality of graphical user interface (GUI) objects associated with treating the first biological fluid with irradiation from the third light source array or associated with treating the second biological fluid with irradiation from the fourth light source array.

[0139] In some embodiments of each of the above systems, the third and fourth light source arrays each include a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 315 nm to about 350 nm. In some embodiments of each of the above systems, the third and fourth light source arrays each include a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 330 nm to about 350 nm. In some embodiments of each of the above systems, the third and fourth light source arrays each include a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array of about 340 nm to about 350 nm. In some embodiments of each of the above systems, the third and fourth light source arrays each include a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array within a range of 345+5 nm. In some embodiments of each of the above systems, the third and fourth light source arrays each include a respective first light source channel configured to emit ultraviolet light having a first peak wavelength of the array from about 315 nm to about 335 nm.

[0140] In some aspects of each of the above systems, for each of the third and fourth light source arrays, the respective first light source channel includes one or more light sources that each emit light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers.

[0141] In some embodiments of each of the above systems, each of the light source arrays includes one or more light sources, each light source being a light emitting diode, and for each of the light source arrays, a respective ultraviolet light is emitted by a respective one or more light sources.

[0142] In some embodiments of each of the above systems, the first platform is slidably movable to introduce and remove a first biological fluid into and out of a first processing chamber, and the second platform is slidably movable to introduce and remove a second biological fluid into and out of a second processing chamber.

[0143] In some embodiments of each of the above systems, the system further comprises a housing configured to house the first processing chamber, the second processing chamber, the first platform, the second platform, the first light source array, the second light source array, a display, one or more processors, and a memory.

[0144] In some embodiments of each of the above systems, the system further comprises a scanner configured to obtain identification information associated with the first biological fluid, the second biological fluid, or both the first and second biological fluids. In some embodiments of each of the above systems, the scanner is one of a group including a barcode scanner, a QR code scanner, and an RFID scanner. In some embodiments of each of the above systems, the identification information is in the visible form of a barcode or QR code on the container for storing the first biological fluid or the second biological fluid, or on at least one of the one or more containers of a dual container assembly for storing the first biological fluid or the second biological fluid, and the method further includes obtaining, by the scanner, a barcode or QR code on the container for storing the first biological fluid or the second biological fluid, or on at least one of the one or more containers of the dual container assembly. In some embodiments of each of the above systems, the scanner is configured to acquire visible identification information on a container for storing the first biological fluid or the second biological fluid when the container for storing the first biological fluid or the second biological fluid is placed on the first platform or the second platform, or to acquire visible identification information on at least one of one or more containers of a multiple container assembly for storing the first biological fluid or the second biological fluid when the one or more containers of the multiple container assembly are placed on the first platform or the second platform.In some embodiments of each of the above systems, the identification information is a plurality of sets of identification information transmitted in visible form on the container for storing the first biological fluid or the second biological fluid, or on one or more containers of a multiple container assembly for storing the first biological fluid or the second biological fluid, or in transmittable form from a tag on the container for storing the first biological fluid or the second biological fluid, or on one or more containers of a multiple container assembly for storing the first biological fluid or the second biological fluid, and the scanner is a multi-scan scanner configured to obtain the plurality of sets of identification information in a multi-scan operation. In some embodiments of each of the above systems, the scanner is integrated or embedded in a fixed position in the housing and is coupled to one or more processors. In some embodiments of each of the above systems, the scanner is positioned inside the first processing chamber, the second processing chamber, or both the first processing chamber and the second processing chamber. In some embodiments of each of the above systems, the scanner is positioned at a first opening of the first processing chamber or a second opening of the second processing chamber. In some embodiments of each of the above systems, the scanner is located outside the first and second processing chambers. In some embodiments of each of the above systems, the scanner is a handheld scanner wirelessly coupled to the one or more processors. In some embodiments of each of the above systems, the scanner is a handheld scanner coupled to the one or more processors by a wired connection.

[0145] In some embodiments of each of the above systems, the first and second processing chambers are disposed horizontally such that the first and second biological fluids are in the same plane when disposed on the first and second platforms, respectively. In some embodiments of each of the above systems, the first and second processing chambers are disposed vertically such that the first and second biological fluids are in parallel planes when disposed on the first and second platforms, respectively.

[0146] In some aspects of each of the above systems, the system further comprises a first panel movable between a closed position and an open position, the first panel covering the first opening to the first processing chamber in the closed position, the first panel not covering the first opening to the first processing chamber in the open position, and an exterior of the first panel comprising one or more of the group comprising a protruding handle and a recessed handle. In some aspects of each of the above systems, the system further comprises a first panel movable between a closed position and an open position, the first panel covering the first opening to the first processing chamber in the closed position, the first panel not covering the first opening to the first processing chamber in the open position, and the entire exterior of the first panel is devoid of any handles. In some aspects of each of the above systems, the first panel is configured to be locked to remain in the closed position and configured to be unlocked in response to an input.

[0147] In each of the above systems, the first platform comprises a first panel. In some of the above systems, the first platform comprises an outer region comprising a first panel movable between a closed position and an open position, the outer region configured to remain in a fixed position when the first panel is in the closed position, and a first support structure, and an inner region configured to move to agitate the first biological fluid during the time the outer region is in the fixed position, the first support structure of the outer region structurally supporting the inner region. In some of the above systems, the first platform comprises an outer region comprising a first panel movable between a closed position and an open position, the outer region configured to remain in a fixed position when the first panel is in the closed position, and a first support structure, and an inner region configured to move to agitate the first biological fluid during the time the outer region is in the fixed position, the first support structure of the outer region structurally supporting the inner region.

[0148] In some embodiments of each of the above systems, the outer region includes a motor configured to generate motion, and the inner region is configured to agitate the first biological fluid based on the motion generated by the motor. In some embodiments of each of the above systems, the system is configured to control (e.g., adjustably control) one or more aspects of the movement of the inner region to agitate the first biological fluid, such as offset, speed, acceleration, and deceleration. In some embodiments of each of the above systems, the motor is positioned to the right or left of where the first biological fluid is held by the first platform. In some embodiments of each of the above systems, the motor is positioned to the front or rear of where the first biological fluid is held by the first platform.

[0149] In some aspects of each of the above systems, the second platform comprises a second panel movable between a closed position and an open position, where the second panel covers a second opening to the second processing chamber in the closed position and where the second panel does not cover the second opening to the second processing chamber in the open position, an outer region comprising the second panel movable between the closed position and the open position, where the outer region is configured to remain in a fixed position when the second panel is in the closed position, and a second support structure, and an inner region configured to move to agitate the second biological fluid during the period when the outer region is in the fixed position, and the second support structure of the output region structurally supports the inner region.

[0150] In some aspects of each of the above systems, the first platform and the second platform each include a first compartment and a second compartment, the first and second compartments configured to hold a multiple container assembly for storing a biological fluid of the respective platform, the first compartment of the first platform configured to hold a first container of the first multiple container assembly, the first container storing the first biological fluid and arranged such that when the first platform is disposed within the first processing chamber, the first light source array is configured to illuminate the first container, the second compartment of the first platform configured to hold one or more additional containers of the first multiple container assembly, the one or more additional containers do not store the first biological fluid, and the second compartment is configured to illuminate the first container when the first platform is disposed within the first processing chamber. a first compartment of the second platform configured to hold a first container of the second multi-container assembly, the first container storing a second biological fluid, the first compartment being arranged such that the second light source array is configured to irradiate the first container when the second platform is positioned within the second processing chamber; a second compartment of the second platform configured to hold one or more additional containers of the second multi-container assembly, the one or more additional containers not storing a second biological fluid, and the second compartment being arranged such that the second light source array is not configured to irradiate the one or more additional containers when the second platform is positioned within the second processing chamber.

[0151] In some embodiments of each of the above systems, the display is a touch screen configured to display a GUI including a plurality of GUI objects, the GUI objects responsive to touch input on the touch screen. In some embodiments of each of the above systems, the method further includes receiving input associated with a selection of the GUI object and performing a biological fluid processing operation in response to receiving the input.

[0152] In some aspects of each of the above systems, any of the systems provided herein (e.g., the systems described above) may perform a method of treating one or more biological fluids comprising irradiating a first biological fluid of the one or more biological fluids with ultraviolet light (e.g., ultraviolet light having a first peak wavelength of about 315 nm to about 350 nm) emitted by a set of one or more first light sources, the first biological fluid being mixed with a pathogen inactivating compound (e.g., a photoactive pathogen inactivating compound, psoralen, amotosalen), and wherein 1) each of the one or more first light sources emits light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers, and / or 2) each of the one or more first light sources is a light emitting diode (LED), and the irradiating the first biological fluid occurs for a duration and with an intensity sufficient to inactivate pathogens in the first biological fluid. In some embodiments of each of the above systems, the method of treating the one or more biological fluids may further include irradiating a second biological fluid of the one or more biological fluids with ultraviolet light (e.g., ultraviolet light having a second peak wavelength of about 315 nm to about 350 nm) emitted by a set of one or more second light sources, where the second biological fluid is mixed with a pathogen inactivating compound (e.g., a photoactive pathogen inactivating compound, psoralen, amotosalen), and where 1) each of the one or more second light sources emits light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers, and / or 2) each of the one or more second light sources is a light emitting diode (LED), and where irradiating the second biological fluid occurs for a duration and intensity sufficient to inactivate pathogens in the second biological fluid.

[0153] In some embodiments of each of the above systems, the first platform and the second platform are each configured to hold the first and second biological fluids in a first flexible container and a second flexible container, respectively, each having a volume capacity of up to about 3000 mL (e.g., a volume capacity of 3000 mL or less), up to about 2500 mL, up to about 2000 ml, up to about 1500 mL, up to about 1200 mL, up to about 1000 mL, or up to about 800 mL.

[0154] In some embodiments of each of the above systems, the system includes a heating and / or cooling unit configured to adjust or set a temperature of the first treatment chamber, and the method further includes controlling the heating / cooling unit to maintain a temperature of the first biological fluid within 2° C. during treatment of the first biological fluid with irradiation from the first light source array. In some embodiments of each of the above systems, the method further includes controlling the system to maintain a temperature of the first biological fluid within 2° C. during treatment of the first biological fluid with irradiation from the first light source array.

[0155] In some embodiments of each of the above systems, the housing has a maximum horizontal width in the range of 30-45 cm. In some embodiments of each of the above systems, the system is configured to operate within a target operating space such that there is 20 cm or less of free space on both the left and right sides of the housing.

[0156] In some aspects of each of the above systems, the system further includes one or more front access panels configured to provide access to one or more of the first light source array, the second light source array, and the one or more processors.

[0157] In another aspect, the disclosure provides a method of treating a biological fluid, comprising providing a biological fluid mixed with a pathogen inactivation compound (e.g., a photoactive pathogen inactivation compound, psoralen, amotosalen) and irradiating the biological fluid with any of the systems provided herein (e.g., the systems described above) for a period and intensity sufficient to inactivate pathogens in the biological fluid. In some aspects of each of the above systems, the biological fluid is irradiated with ultraviolet light (e.g., ultraviolet light having a first peak wavelength of about 315 nm to about 350 nm) emitted by a set of one or more first light sources, where 1) each of the one or more first light sources emits light having a full width at half maximum (FWHM) spectral bandwidth of less than 20 nanometers, and / or 2) each of the one or more first light sources is a light emitting diode (LED). In some embodiments, the method of treating the biological fluid is sufficient to inactivate at least 1 log of pathogens in the biological fluid. In some embodiments, the method of treating the biological fluid is sufficient to inactivate at least 4 log of pathogens in the biological fluid.

Claims

[Claim 1] The invention described in this specification.

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