Thoracic aortic hybrid graft and surgical method thereof

Abstract

A surgical kit for repairing an aortic aneurysm includes a vascular prosthesis including a primary conduit forming a primary lumen extending from a primary inlet opening to a primary outlet opening and configured to be fluidly connected to a patient's aorta, and a perfusion branch conduit forming a perfusion branch lumen extending from a perfusion branch opening in the primary conduit to a perfusion outlet opening at a distal end of the perfusion branch conduit and in fluid communication with the primary lumen, and a perfusion device including an inlet conduit configured to be fluidly connected at a proximal end to a distal end of the perfusion branch conduit, a plurality of secondary conduits branching from the inlet conduit and configured to be fluidly connected to branches of the aorta, and a valve assembly configured to selectively switch the plurality of secondary conduits between open and closed states.

Description

[Technical field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the primary benefit of U.S. Provisional Patent Application No. 63 / 337,581, filed May 2, 2022, and U.S. Provisional Patent Application No. 63 / 339,287, filed May 6, 2022, the disclosures of which are incorporated by reference in their entireties herein. [Background technology]

[0002] Surgical repair with stents has become the standard of care for the treatment of aortic aneurysms, and recent advances have led to the use of hybrid stent-grafts. While such techniques have been a breakthrough in the treatment of aortic arch aneurysms, their use in the more invasive repair of thoracic and abdominal aortic aneurysms has been challenging. In addition, surgeons are still required to use cardiopulmonary bypass techniques, which makes an already challenging surgical repair even more difficult to complete. Thus, there is a need for hybrid stent-grafts with attached perfusion devices that can repair thoracic and abdominal aneurysms while minimizing the need for cardiopulmonary bypass. Summary of the Invention

[0003] One aspect of the invention may relate to a surgical kit for repairing an aortic aneurysm, the surgical kit including a vascular prosthesis including a primary conduit forming a primary lumen extending from a primary inlet opening to a primary outlet opening and configured to be fluidly connected to a patient's aorta, and a perfusion branch conduit forming a perfusion branch lumen extending from a perfusion branch opening in the primary conduit to a perfusion outlet opening at a distal end of the perfusion branch conduit, the perfusion branch opening being in fluid communication with the primary lumen, and a perfusion device including an inlet conduit configured to be fluidly connected at a proximal end to a distal end of the perfusion branch conduit, a plurality of secondary conduits branching from the inlet conduit and configured to be fluidly connected to branches of the aorta, and a valve assembly configured to selectively switch the plurality of secondary conduits between open and closed states.

[0004] In some embodiments, the surgical kit further includes a perfusion apparatus including an inlet conduit having a proximal end fluidly connectable to a distal end of the perfusion branch conduit; a plurality of secondary conduits branching from the inlet conduit and configured to be fluidly connected to an aortic branch; and a valve assembly configured to selectively alter the plurality of secondary conduits between an open flow-through state and a closed sealing state.

[0005] In one embodiment, the primary conduit of the vascular graft includes a stent-graft section and a tube-graft section connected at a junction, the stent-graft section includes a primary inlet opening and the tube-graft section includes a primary outlet opening, in certain embodiments, the stent-graft section includes a flexible biocompatible membrane attached to a support structure and configured to be radially expandable from a compressed state to a deployed state.

[0006] In some embodiments, the surgical kit further comprises a package containing a vascular graft, a perfusion device, and a valve assembly.

[0007] In some embodiments, the distal end of the perfusion branch conduit comprises a first quick connect member and the proximal end of the inlet conduit of the perfusion device comprises a second quick connect member configured to be matable with the first quick connect member to provide fluid communication between the perfusion branch lumen and the passageway of the inlet conduit.Further, in some embodiments, the first and second quick connect members are selected from a bayonet connector part, a threaded connector part, a snap fit connector part, an interference fit connector part, and combinations thereof.

[0008] Another aspect of the invention may relate to a vascular graft including: a primary conduit forming a primary lumen and extending from a primary inlet opening to a primary outlet opening, the primary conduit configured to fluidly connect the primary inlet opening to a portion of the aorta upstream of an aneurysm and to fluidly connect the primary outlet opening to a portion of the aorta downstream of the aneurysm; a plurality of branch conduits, each branch conduit forming a branch lumen and extending from a branch inlet opening to a branch outlet opening in the primary lumen, the branch inlet opening being fluidly coupled to the primary lumen, a distal end of each branch conduit configured to be fluidly connected to an aortic branch; and a perfusion branch conduit forming a perfusion branch lumen and extending from a perfusion branch opening in the primary conduit to a perfusion outlet opening at a distal end of the perfusion branch conduit, the perfusion branch opening being fluidly coupled to the primary lumen, the distal end of the perfusion branch conduit including a first quick connect member.

[0009] In some embodiments, the first quick connect member is selected from the group consisting of a bayonet connector member, a threaded connector member, a snap-fit ​​connector member, a press-fit connector member, and combinations thereof. In other embodiments, the perfusion branch opening is located closer to the primary inlet opening than either of the branch conduits.

[0010] One aspect of the invention is a vascular graft comprising: a primary conduit including a primary lumen and extending from a primary inlet opening to a primary outlet opening; a plurality of branch inlet openings; and a perfusion branch conduit forming a perfusion branch lumen and extending from a perfusion branch opening in said primary lumen to a perfusion outlet opening at a distal end of the perfusion branch conduit, said perfusion branch opening being fluidly coupled to said primary lumen; In some cases, the present invention relates to an artificial blood vessel including

[0011] Another aspect of the invention may relate to a vascular graft comprising: a primary conduit forming a primary lumen and extending from a primary inlet opening to a primary outlet opening, the primary conduit configured to fluidly connect the primary inlet opening to a portion of the aorta upstream of an aneurysm and to fluidly connect the primary outlet opening to a portion of the aorta downstream of an aneurysm; four branch conduits, each branch conduit forming a branch lumen and extending from a branch inlet opening in the primary conduit to a branch outlet opening, the branch inlet opening being fluidly coupled to the primary lumen, the distal end of each branch conduit configured to be fluidly connected to an aortic branch; and a perfusion branch conduit forming a perfusion branch lumen and extending from a perfusion branch opening in the primary lumen to a perfusion outlet opening at a distal end of the perfusion branch conduit, the perfusion branch opening being fluidly coupled to the primary lumen.

[0012] Yet another aspect of the invention is a method of repairing an aortic aneurysm comprising the steps of: a) fluidly connecting a proximal end of a primary conduit of a vascular graft to a first portion of a patient's aorta upstream of the aortic aneurysm and a distal end of the primary conduit to a second portion of the aorta downstream of the aortic aneurysm, wherein one or more aortic branches of the patient are located between the first and second portions of the aorta and blood flows through a primary lumen of the primary conduit; b) fluidly connecting an inlet conduit of a perfusion device to a distal end of a perfusion branch conduit of the vascular graft, wherein a valve assembly is in a closed state to prevent blood flow from the primary lumen of the vascular graft to a plurality of secondary conduits branching from the inlet conduit; c) fluidly connecting the distal end of the secondary conduit to the one or more aortic branches; and d) changing the valve assembly to an open state to restore blood flow to the one or more aortic branches. The present invention may relate to a method, including: [Brief description of the drawings]

[0013] The detailed description of the invention will be better understood when read in conjunction with the accompanying drawings, in which it should be noted, however, that the invention is not limited to the arrangements and instrumentalities of the embodiments shown in the drawings.

[0014] [Figure 1] 1 shows a surgical kit according to one embodiment of the present invention;

[0015] [Diagram 2] 1 shows a vascular graft according to one embodiment of the present invention;

[0016] [Diagram 3] Figure 2 shows a cross-sectional view of the artificial blood vessel;

[0017] [Figure 4] 1 shows a perfusion device according to one embodiment of the present invention;

[0018] [Diagram 5] 5 shows the perfusion device of FIG. 4 connected to the vascular graft shown in FIGS. 2 and 3;

[0019] [Figure 6A-6B] Fig. 5 shows the connection mechanism between the artificial blood vessel and the perfusion device;

[0020] [Figure 7] 1 illustrates a portion of the aorta positioned according to one embodiment of the present invention;

[0021] [Fig. 8A-8M] 1 illustrates a surgical method according to one embodiment of the present invention;

[0022] [Figure 9A-9B] 1 shows a vascular prosthesis according to another embodiment of the present invention;

[0023] [Figure 10] 1 illustrates a surgical kit according to one embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0024] The following description of the preferred embodiment is merely an example and is not intended to limit the present invention. Moreover, the drawings should be considered as part of the entire description and are intended to be read together with the description of the illustrated embodiment. In the description of the exemplary embodiment disclosed herein, references to directions and orientations are for convenience only and are not intended to limit the scope of the invention. For example, relative terms such as "lower", "upper", "horizontal", "vertical", "upper", and "lower" should be interpreted according to the positions described and the directions shown in the drawings, and do not require a specific orientation. Furthermore, terms such as "attach", "fix", and "connect" should be interpreted to refer to a relationship in which a structure is directly or indirectly fixed to another structure, including a movable or rigid relationship.

[0025] The term "range" used throughout this specification is intended to be a shorthand for describing each and every value within the range. Any value within the range can be selected as the end point of the range. In addition, all documents cited herein are incorporated by reference in their entirety. In the event of a conflict between the definitions of this disclosure and those of the cited documents, this disclosure shall control.

[0026] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the present invention pertains. As used herein, the terms "proximal" and "distal" refer to locations or portions of a device that are upstream or downstream relative to the blood flow upon insertion.

[0027] 1, a surgical kit 100 is disclosed in accordance with one embodiment of the present invention. The surgical kit 100 generally comprises a vascular graft 200, a perfusion device 300, and at least one surgical accessory 110, all contained within a package 120. The package is a sealed container, such as a sealed plastic bag, box, or the like, that maintains the sterility of the contents.

[0028] In some embodiments, the surgical kit 100 may further include a molding balloon 240 (FIG. 2). The surgical accessories 110 may be tools for cutting, dissecting, suturing, hemostasis, holding, retracting, disinfecting, or soaking. In some embodiments, the surgical accessories 110 may include scalpels, forceps, needles, needle holders, thread, retractors, suction tips, staplers, clips, scissors, hooks, dissectors, hemostats, gauze, saline, trocars, containers, trays, or combinations thereof.

[0029] The at least one surgical accessory 110 can be present in any quantity. In a preferred embodiment, the surgical accessory 110 includes at least one clamp 110. Although FIG. 1 illustrates a clamp 110 as a surgical accessory, one of ordinary skill in the art will appreciate that the surgical kit 100 of the present invention may include other types of surgical accessories. As discussed above, the surgical kit 100 includes a package 120 that includes other components, such as a vascular graft 200, a perfusion device 300, and a clamp 110. In some embodiments, the package 120 can further include a molding balloon 240.

[0030] 2 and 3, vascular graft 200 will now be further described. Vascular graft 200 generally includes a proximal stent graft portion 210 and a distal tube graft portion 220. Vascular graft 200 includes a primary conduit 299. Primary conduit 299 is a tubular structure having a generally cylindrical cross-sectional shape. Primary conduit 299 includes an outer surface 205 and an inner surface 206 that defines a primary lumen 201 that extends longitudinally through vascular graft 200 from a primary inlet opening 202 at a proximal end of primary conduit 299 to a primary outlet opening 203 at a distal end of primary conduit 299. Primary conduit 299 is configured to be fluidly coupled to a patient's aorta to allow fluid, such as blood, to pass through primary lumen 201, and may function similarly to the lumen of a natural aorta. A proximal portion of primary conduit 299 belongs to stent graft portion 210 of vascular graft 200, and a distal portion belongs to tube graft portion 220. Stent graft portion 210 and tube graft portion 220 of primary conduit 299 are joined at a junction region 204 located between the proximal and distal ends of primary conduit 299.

[0031] The stent graft portion 210 of the primary conduit 299 is a compressible tube 211 that includes a support structure 212 and a flexible membrane 213. The support structure 212 provides radial support to the stent graft portion 210 and is configured to expand radially to conform to the diameter of the surrounding vessel upon deployment. The support structure 212 can be comprised of a biocompatible metal, plastic, or derivatives thereof. In some embodiments, the support structure 212 can be fabricated from stainless steel, cobalt chrome, or nitinol. In some embodiments, the support structure 212 can include multiple support elements. The multiple support elements can be unconnected, partially connected, or fully connected. In other embodiments, the support structure 212 can consist of a single support element. The support structure 212 can be a spring, wire, mesh, or other configuration known in the art. In one embodiment, the support structure 212 is a metal mesh. In some embodiments, the support structure 212 is configured to provide radial support to the stent graft portion 210.

[0032] The membrane 213 is attached to the support structure 212 and configured to be radially expandable with the support structure 212. In some embodiments, the membrane 213 is attached by heat treatment or sewing. The membrane 213 is composed of a flexible biocompatible material that forms a seal. In a preferred embodiment, the membrane 213 is composed of a woven polyester or derivatives thereof. In some embodiments, the membrane 213 may be composed of polyester or derivatives thereof, polyaramid, polyacrylonitrile, nylon, cellulose, polyurethane, polyethylene terephthalate (PET / Dacron), polytetrafluoroethylene (PTFE), or ultra-high molecular weight polyethylene (UHMWPE) or high modulus polyethylene (HMPE), such as thermoplastic polyethylene. The membrane 213 may further include angiographic markers. The markers may be made of any radiopaque material known in the art. In some embodiments, the angiographic markers may be composed of platinum, platinum iridium, tantalum, gold, or combinations thereof. In some embodiments, the stent graft portion 210 does not include the membrane 213 and is composed only of the support structure 212.

[0033] In an embodiment, the stent graft portion 210 of the primary conduit 299 includes a hemostatic collar 214. The hemostatic collar 214 is a flange or ring-like structure that projects radially from the proximal end of the primary conduit 299. The hemostatic collar 214 is shown disposed at the proximal end of the primary conduit 299, but may be disposed at a remote location in other embodiments. The hemostatic collar 214 may be fabricated from any biocompatible material known in the art. In some embodiments, the hemostatic collar 214 is comprised of a biocompatible plastic, metal, or derivatives thereof. In a preferred embodiment, the hemostatic collar 214 is comprised of a biocompatible felt, such as polyglycolic acid felt (PGA) or PTFE felt. The hemostatic collar 214 is configured to secure the proximal end of the vascular graft 200 within the aorta. In some embodiments, the hemostatic collar 214 may include protrusions or barbs positioned to prevent migration of the vascular graft 200.

[0034] In some embodiments, the stent graft portion 210 may also include a hemostatic apron 215. The hemostatic apron 215 is disposed near the coaptation region 204. In an embodiment, the hemostatic apron 215 traverses the coaptation region 204 with an upper portion of the hemostatic apron 215 located above the coaptation region 204 and a lower portion of the hemostatic apron 215 located below the coaptation region 204. The hemostatic apron 215 connects to the primary conduit 299 above the coaptation region 204 and extends downwardly and outwardly to form a generally frustoconical flange. The hemostatic apron 215 may be fabricated from any biocompatible material known in the art. The apron 215 is configured to attach to the aortic wall of the patient and form an anastomosis between the graft 200 and the aorta to prevent backflow from the intercostal arteries.

[0035] The tube graft portion 220 of the primary conduit 299 is a cylindrical tube 221 with multiple inlet openings 222 (described in more detail below). The tube graft portion 220 may be constructed from any biocompatible material known in the art. In some embodiments, the tube graft portion 220 may be fabricated from polyester or its derivatives, polyurethane, polyethylene terephthalate (PET / Dacron), polytetrafluoroethylene (PTFE), or a thermoplastic polyethylene such as ultra-high molecular weight polyethylene (UHMWPE) or high modulus polyethylene (HMPE). In a preferred embodiment, the tube graft portion 220 is fabricated from polyethylene terephthalate (PET / Dacron).

[0036] The plurality of openings 222 fluidly connect the primary lumen 201 to the plurality of branch lumens 231. When discussed in connection with the branch conduits 230, the plurality of openings 222 may be referred to as branch inlet openings 222. In an embodiment, the vascular graft 200 further comprises a plurality of branch conduits 230. Each branch conduit 230 defines a branch lumen 231 that extends from an opening 222 at its proximal end to a branch outlet opening 232 at its distal end. The branch lumen 231 forms part of the tube graft portion 220 of the vascular graft 200.

[0037] Although four branch conduits 230 are shown in the example, more or fewer branch conduits 230 may be provided depending on the requirements of the procedure. Additionally, certain embodiments may not include a branch conduit 230 and may only include a perfusion branch conduit 230a. If the branch conduit 230 is intended to be connected to the aortic bifurcation of the patient, it may be referred to as an aortic branch conduit 230 of the vascular graft 200. In certain embodiments, one or more of the branch conduits 230 may be removable or temporary.

[0038] The distal end of the branch conduit 230 is configured to be fluidly connected to an aortic bifurcation of the patient. In a preferred embodiment, the branch conduit 230 is configured to be fluidly connected to a visceral artery. In some embodiments, multiple branch conduits 230 are connected to multiple aortic bifurcations via a single connection. In other embodiments, the branch conduits 230 are connected to the aortic bifurcations through separate connections.

[0039] The vascular graft 200 further includes a perfusion branch conduit 230a. To accommodate the perfusion branch conduit 230a, the primary conduit 299 includes a perfusion branch opening 222a in its sidewall. The perfusion branch opening 222a is closer to the proximal end of the primary conduit 299 than any of the openings 222 of the branch conduit 230. The axial section of the primary conduit 299 between the perfusion branch opening 222a and the nearest opening 222 forms a clamping zone 207, and application of a clamp to this axial section seals the primary lumen 201 (discussed in more detail below). As illustrated, the perfusion branch conduit 230a is disposed at the proximal end of the tube graft section 220, generally below the junction region 204. The clamping zone 207 is located directly below the perfusion branch conduit 230a and above the other branch conduits 224. The clamping zone 207 is an axial section of the tubular graft portion 220 of the primary conduit 299 where no openings 222 are present.

[0040] Perfusion branch conduit 230a defines a perfusion branch lumen 231a that extends from perfusion branch opening 222a to a perfusion outlet opening 232a at the distal end of perfusion branch conduit 230a. Perfusion branch opening 222a fluidly connects primary lumen 201 and perfusion branch lumen 231a. Perfusion outlet opening 232a fluidly connects vascular graft 200 and perfusion device 300 via first quick connect member 233, as described in more detail below.

[0041] In some embodiments, the diameter of the perfusion branch conduit 230a may be larger than the diameter of the branch conduit 230. In a particular example, the diameter of the perfusion branch conduit 230a may be approximately 10 mm, and the diameter of the branch conduit 230 may range from 6 mm to 8 mm.

[0042] In some embodiments of the present invention, a molding balloon 240 (see FIG. 8B) is disposed within the primary lumen 201 of the prosthesis 200. The molding balloon 240 is configured to position the vascular graft 200 within the aorta. In some embodiments, the molding balloon 240, when inflated, seals the primary lumen 201 and prevents blood from flowing from the patient's aorta into (or through) the primary lumen 201. When inflated, the molding balloon 240 prevents blood from passing through the primary lumen 201 and reaching the branch conduit 230 or the perfusion branch conduit 230a. However, while not shown, one of ordinary skill in the art will appreciate that the vascular graft 200 can include additional features not shown. For example, the vascular graft 200 can include additional devices standard in the art, such as guidewires or other deployment devices.

[0043] 4, a perfusion device 300 will be described. The perfusion device 300 generally comprises an inlet conduit 301 and a number of secondary conduits 311a-311d branching off from the inlet conduit 301. The perfusion device 300 may be manufactured from plastic, a plastic derivative, or a combination thereof.

[0044] The secondary conduits 311a-311d have distal ends 314a-314d, respectively, and include secondary conduit outlets 315a-315d. The secondary conduit outlets 315a-315d fluidly connect the internal passages (or lumens) of the secondary conduits 311a-311d to the aortic bifurcation (e.g., visceral arteries) of the patient. The distal portions 314a-314d of the secondary conduits 311a-311d may have tapered outer diameters for easy insertion into the aortic bifurcation of the patient. In some embodiments, the secondary conduits 311a-311d include stabilizing members 313a-313d near the distal ends 314a-314d, respectively. The stabilizing members 313a-313d are configured to ensure a sealed fluid connection between the passages / lumens of the secondary conduits 311a-311d and the aortic bifurcation to which they are connected. In some embodiments, the stabilizing member 313 is a compressible ring structure, such as a fluid-filled balloon.

[0045] The perfusion device 300 further comprises a valve assembly capable of selectively permitting or prohibiting the flow of fluid (e.g., blood) through the inlet conduit 301 and / or the secondary conduits 311a-311d. In an embodiment, the valve assembly comprises a valve operably connected to the inlet conduit 301 and a valve operably connected to each of the secondary conduits 311a-311d. In an embodiment, the valve operably connected to the inlet conduit 301 is in the form of a clamp 302, and the valve operably connected to each of the secondary conduits 311a-311d is in the form of a clamp 312a-312d. Although the valves are illustrated as pinch clamps 302, 312a-312d, other suitable types of valves may be used, such as, for example, globe valves, gate valves, ball valves, butterfly valves, diaphragm valves, plug valves, needle valves, angle valves, or combinations thereof.

[0046] The valve assemblies are arranged to selectively permit or prohibit flow through all, some or selected of the secondary conduits 311a-311d. Thus, in an embodiment, each clamp 302, 312a-312d is individually switchable by a user between an open state (blood flow through each secondary conduit 311a-311d) and a closed state (blood not flow through each secondary conduit 311a-311d). As shown in Figure 4, all clamps 302, 312a-312d are in an open state.

[0047] 5-6B, the proximal end of the inlet conduit 301 is configured to be removably coupled to the perfusion outlet opening 232a to form a fluid tight connection. In an embodiment, this is accomplished by the presence of (and fit between) a first quick connect member 233 of the perfusion branch conduit 230a and a second quick connect member 303 of the inlet conduit 301. The first quick connect member 233 may be formed of a harder material (e.g., plastic) than the material of the perfusion branch conduit 230a.

[0048] The first quick connect member 233 may be a bayonet connector member, a threaded connector member, a snap-fit ​​connector member, a press-fit connector member, or a combination thereof. Similarly, the second quick connect member 303 is in the form of a corresponding member that mates with the structure of the first quick connect member 233 and may be a bayonet connector member, a threaded connector member, a snap-fit ​​connector member, a press-fit connector member, or a combination thereof. When mated, the quick connect members 233, 303 fluidly connect the perfusion branch lumen 231a and the passageway / lumen of the inlet conduit 301 to supply blood.

[0049] Although the perfusion device 300 is shown as a separate component that couples to the artificial blood vessel 200 as illustrated, in other embodiments the perfusion device 300 can be permanently integrated into the artificial blood vessel 200 and provided as a single component.

[0050] 8A-8I, the present application may include a method of repairing an aortic aneurysm using the vascular graft 200 and perfusion device 300 described above.

[0051] Referring to Figure 8A, vascular graft 200 is inserted into the aorta of a patient. In a preferred embodiment, vascular graft 200 is inserted into the descending thoracic-abdominal aorta. In a more preferred embodiment, vascular graft 200 is inserted into the descending thoracic-abdominal aorta below the visceral arteries. As shown in Figures 8B and 8C, sheath 208 surrounding the vascular graft is removed and vascular graft 200 is expanded such that outer surface 205 of vascular graft 200 contacts the wall of the aorta. Molding balloon 240 is inflated to positionally stabilize the proximal end of vascular graft 200 against the wall of the aorta.

[0052] With reference to FIGURE 8D, vascular graft 200 may then be fluidly coupled to the aorta by attaching hemostatic apron 215 to the wall of the aorta. In a preferred embodiment, hemostatic apron 215 is attached to the wall of the aorta with sutures. In some embodiments, a clamp is placed in clamping zone 207 to prevent fluid flow into primary lumen 201 of vascular graft 200. As shown in FIGURE 8E, the portion of the aorta below hemostatic apron 215 may then be opened to expose the remainder of vascular graft 200.

[0053] 8F, an inlet conduit 301 of a perfusion device 300 may then be fluidly connected to the distal end of the perfusion branch conduit 230a. The valve assembly (302, 312) of the perfusion device 300 is in a closed, sealing state to prevent the flow of fluid (e.g., blood) from the primary lumen 201 of the vascular graft 200 into multiple secondary conduits 311 of the perfusion device 300 (portions branching off from the inlet conduit 301).

[0054] 8G and 8H, after the perfusion device 300 is connected to the vascular graft 200, one or more secondary conduits 311 may be fluidly connected to one or more aortic branches. In some embodiments, the secondary conduits are fluidly connected to the aortic branches by inserting one or more tips into the proximal ends of the one or more aortic branches and securing with a soft clamp. The soft clamp is tightened enough to allow fluid flow but not allow the stabilizing member to pass through. Once the secondary conduits are fluidly connected to the aortic branches, the valve assemblies (302, 312) are changed to an open state and blood flow is restored to the one or more aortic branches.

[0055] As shown in Figure 8I, the distal end of vascular graft 200 is then cut to an appropriate length by a surgeon skilled in the art to form a new distal end of vascular graft 200. As shown in Figure 8J, the new distal end of vascular graft 200 is attached to the downstream portion of the aorta. In a preferred embodiment, the new distal end of vascular graft 200 is attached to the downstream portion of the aorta by suturing.

[0056] 8J-8M, clamp 110 is removed from clamping zone 207 and one or more secondary conduits 311 are removed from one or more aortic branches. One or more branch conduits 230 of vascular graft 200 are then attached to the one or more aortic branches. In certain embodiments, clamps are placed on the ends of one or more branch conduits 230 of vascular graft 200 to prevent fluid flow within branch lumen 231. Once one or more branch conduits 230 of vascular graft 200 are attached to the one or more aortic branches, clamp 110 is removed and blood flow is restored.

[0057] 9A and 9B, the vascular prosthesis 200 may be adapted for a variety of alternative configurations, and in some embodiments may not include a branch conduit 230. In some embodiments, the openings 222 may be fluidly connected directly to the aortic branches using a Karel patch or the like. In such embodiments, one or more of the branch conduits 230 may be omitted, leaving corresponding openings 222, allowing the openings to be connected directly to the aortic branches using a Karel patch. As shown in FIG. 9B, the size of the openings 222 may vary. In such embodiments, multiple aortic branches may be directly connected to one opening 222.

[0058] 10, the surgical kit 100 may include multiple branch conduits 230 separate from the vascular graft. The branch conduits 230 can be attached as needed during surgery. In some embodiments, multiple aortic branches are connected to the vascular graft using any combination of openings 222 and direct connections of the branch conduits 230.

[0059] Although the present invention has been described based on specific examples, those skilled in the art will appreciate that there are many variations and ramifications of the above invention. It is to be understood that other embodiments may be utilized and structural and material modifications may be made without departing from the scope of the present invention. Accordingly, the spirit and scope should be construed broadly as set forth in the appended claims. Exemplary Claims

[0060] Exemplary claim 1: A surgical kit for repairing an aortic aneurysm, comprising: An artificial blood vessel, a primary conduit defining a primary lumen extending from a primary inlet opening to a primary outlet opening and configured to be fluidly connected to an aorta of the patient; a perfusion branch conduit forming a perfusion branch lumen extending from a perfusion branch opening in said primary conduit to a perfusion outlet opening at a distal end of said perfusion branch conduit, said perfusion branch opening being in fluid communication with said primary lumen; Artificial blood vessels, including 1. A perfusion device comprising: an inlet conduit configured to have a proximal end fluidly connected to a distal end of the perfusion branch conduit; a plurality of secondary conduits branching from the inlet conduit and configured to be fluidly connected to branches of the aorta; a valve assembly configured to selectively switch the plurality of secondary conduits between an open state and a closed state. A surgical kit comprising:

[0061] Exemplary Claim 2: The surgical kit of claim 1, wherein the primary conduit of the artificial blood vessel comprises a stent graft portion and a tube graft portion connected at a junction region, the stent graft portion comprising the primary inlet opening and the tube graft portion comprising the primary outlet opening.

[0062] Exemplary Claim 3: The surgical kit of claim 2, wherein the stent graft portion includes a flexible biocompatible membrane attached to a support structure, the stent graft portion configured to be radially expandable from a collapsed state to a deployed state.

[0063] Exemplary Claim 4: The surgical kit of claim 4, wherein the artificial blood vessel is attached to the primary conduit and further comprises a hemostatic apron circumscribing the primary conduit, the hemostatic apron configured to create an anastomosis between the primary conduit and the aorta to prevent intercostal backflow bleeding.

[0064] Exemplary Claim 5: The surgical kit of claim 4, wherein the hemostatic apron is a frusto-conical flange extending from an upper end to a lower end, the upper end of the hemostatic apron being connected to the primary conduit above the connection area, and the lower end of the hemostatic apron being located below the connection area.

[0065] Exemplary Claim 6: The surgical kit of any one of claims 1-5, wherein the artificial blood vessel further comprises a hemostatic collar projecting radially from the primary conduit.

[0066] Exemplary Claim 7: The surgical kit of claim 6, wherein the hemostatic collar includes protrusions or barbs to prevent the vascular graft from migrating within the aorta.

[0067] Exemplary Claim 8: A surgical kit according to any one of claims 1 to 7, wherein the artificial blood vessel further comprises a plurality of branch conduits, each branch conduit forming a branch lumen extending from a branch inlet opening in the primary conduit to a branch outlet opening, the branch inlet opening being fluidly connected to the primary lumen, and a distal end of each branch conduit configured to be fluidly connected to an aortic branch.

[0068] Exemplary Claim 9: The surgical kit of claim 8, wherein the perfusion branch opening is closer to the primary inlet opening than each of the branch inlet openings.

[0069] Exemplary Claim 10: A surgical kit as described in any one of claims 1 to 9, wherein a distal end of the perfusion branch conduit comprises a first quick connect member, and a proximal end of an inlet conduit of the perfusion device comprises a second quick connect member engageable with the first quick connect member to fluidly connect the perfusion branch lumen and a passage of the inlet conduit.

[0070] Exemplary Claim 11: The surgical kit of claim 10, wherein the first quick connect member and the second quick connect member are selected from a bayonet connector member, a threaded connector member, a snap-fit ​​connector member, a press-fit connector member, and combinations thereof.

[0071] Exemplary Claim 12: The surgical kit of claim 10 or 11, wherein the cross-sectional area of ​​the perfusion branch lumen is less than the cross-sectional area of ​​the primary lumen but greater than the cross-sectional area of ​​any of the plurality of branch lumens.

[0072] Exemplary Claim 13: A surgical kit according to any one of claims 10 to 12, wherein the perfusion branch conduit comprises a main body portion extending from the primary lumen and a distal portion including the distal end, the distal portion being more rigid than the main body portion.

[0073] Exemplary Claim 14: The surgical kit of any one of claims 1 to 13, further comprising an inflatable shaping balloon configured to be positioned within the primary lumen of the primary conduit.

[0074] Exemplary Claim 15: A surgical kit as described in any one of claims 1 to 14, wherein each distal end of the multiple secondary conduits of the perfusion device is configured to be fluidly connected to one of multiple aortic branches.

[0075] Exemplary Claim 16: The surgical kit of claim 15, wherein a distal end of each of the plurality of secondary conduits of the perfusion device comprises a tip portion having a tapered outer diameter.

[0076] Exemplary Claim 17: A surgical kit as described in any one of claims 1 to 16, wherein each secondary conduit of the perfusion device further includes a stabilizing member for ensuring a sealed fluid connection between a passage of the secondary conduit and the aortic branch.

[0077] Exemplary Claim 18: The surgical kit of claim 17, wherein the stabilizing member comprises a compressible ring structure.

[0078] Exemplary Claim 19: The surgical kit of any one of claims 1 to 18, wherein the perfusion device comprises four of the secondary conduits.

[0079] Exemplary Claim 20: A surgical kit as described in any one of claims 1 to 18, wherein the valve assembly is configured to enable each of the plurality of secondary conduits to be individually altered between an open state and a closed state independent of the other secondary conduits.

[0080] Exemplary Claim 21: The surgical kit of claim 20, wherein the valve assembly is further configured to allow the inlet conduit of the irrigation device to be alternating between an open state and a closed state.

[0081] Exemplary Claim 22: The surgical kit of claim 20 or 21, wherein the valve assembly comprises a plurality of valves, each valve operably connected to one of the plurality of secondary conduits.

[0082] Exemplary Claim 23: The surgical kit of claim 22, wherein each of the plurality of valves is a clamp.

[0083] Exemplary Claim 24: The surgical kit of any one of claims 1 to 23, further comprising a sealed package containing the artificial blood vessel, the perfusion device, and a valve assembly.

[0084] Exemplary claim 25: An artificial blood vessel, a primary conduit forming a primary lumen and extending from a primary inlet opening to a primary outlet opening, the primary conduit configured to fluidly connect the primary inlet opening to a portion of the aorta upstream of the aneurysm and to fluidly connect the primary outlet opening to a portion of the aorta downstream of the aneurysm; a plurality of branch conduits, each branch conduit forming a branch lumen and extending from a branch inlet opening in the primary lumen to a branch outlet opening, the branch inlet opening being fluidly coupled to the primary lumen, a distal end of each branch conduit configured to be fluidly connected to an aortic branch; a perfusion branch conduit forming a perfusion branch lumen and extending from a perfusion branch opening in said primary conduit to a perfusion outlet opening at a distal end of said perfusion branch conduit, said perfusion branch opening being fluidly coupled to said primary lumen, said perfusion branch conduit having a first quick connect member at its distal end; Including artificial blood vessels.

[0085] Exemplary Claim 26: The artificial blood vessel of claim 25, wherein the primary conduit of the artificial blood vessel includes a stent graft portion and a tube graft portion joined at a junction region, the stent graft portion including the primary inlet opening and the tube graft portion including the primary outlet opening.

[0086] Exemplary Claim 27: The artificial blood vessel of claim 25 or 26, further comprising a hemostatic apron attached to the primary conduit and circumferentially surrounding the primary conduit, the hemostatic apron configured to be attached to a wall of the patient's aorta to create an anastomosis between the primary conduit and the aorta and prevent intercostal backflow bleeding.

[0087] Exemplary Claim 28: The vascular prosthesis of any one of claims 25-27, further comprising a hemostatic collar projecting radially from the primary conduit.

[0088] Exemplary Claim 29: The vascular graft of claim 28, wherein the hemostatic collar includes protrusions or barbs to prevent migration of the vascular graft within the aorta.

[0089] Exemplary Claim 30: The artificial blood vessel according to any one of claims 26 to 29, further comprising a hemostatic apron projecting radially from the joining region.

[0090] Exemplary Claim 31: The artificial blood vessel according to any one of claims 25 to 30, further comprising a clamping zone, the clamping zone being located between the perfusion branch conduit and the plurality of branch conduits.

[0091] Exemplary Claim 32: The artificial blood vessel described in any one of claims 25 to 31, wherein the first quick connect member is selected from a bayonet connector member, a threaded connector member, a snap-fit ​​connector member, a press-fit connector member, and combinations thereof.

[0092] Exemplary Claim 33: An artificial blood vessel according to any one of claims 25 to 32, wherein the perfusion branch opening is closer to the primary inlet opening than each of the branch inlet openings.

[0093] Exemplary claim 34: An artificial blood vessel, a primary conduit including a primary lumen and extending from a primary inlet opening to a primary outlet opening; A plurality of branch inlet openings; a perfusion branch conduit forming a perfusion branch lumen and extending from a perfusion branch opening in said primary lumen to a perfusion outlet opening at a distal end of the perfusion branch conduit, said perfusion branch opening being fluidly coupled to said primary lumen; An artificial blood vessel comprising:

[0094] Exemplary Claim 35: The artificial blood vessel of claim 34, wherein the primary conduit is configured such that the primary inlet opening is fluidly connected to a portion of the aorta upstream of the aneurysm and the primary outlet opening is fluidly connected to a portion of the aorta downstream of the aneurysm.

[0095] Exemplary Claim 36: The artificial blood vessel of claim 34, further comprising a stent graft portion and a tubular graft portion connected to the stent graft portion at a junction region, the stent graft portion including the primary inlet opening, the tubular graft portion including the primary outlet opening, and the multiple branch inlet openings being located in the tubular graft portion.

[0096] Exemplary Claim 37: The artificial vascular prosthesis of claim 36, wherein the tubular graft portion is constructed of a material selected from polyester, polyurethane, polyethylene terephthalate (PET / Dacron), polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (ePTFE), and thermoplastic polyethylene.

[0097] Exemplary Claim 38: The artificial blood vessel according to any one of claims 34 to 37, wherein the plurality of branch inlet openings include a first branch inlet opening and a second branch inlet opening, and the first branch inlet opening is larger than the second branch inlet opening.

[0098] Exemplary Claim 39: The vascular prosthesis of any one of claims 34 to 38, further comprising a hemostatic apron attached to the primary conduit and circumferentially surrounding the primary conduit, the hemostatic apron configured to create an anastomosis between the primary conduit and the aorta and prevent intercostal backflow bleeding.

[0099] Exemplary Claim 40: The artificial blood vessel of claim 39, wherein the hemostatic apron is a frusto-conical flange extending from an upper end to a lower end, the upper end of the hemostatic apron being connected to the primary conduit above the junction area, and the lower end of the hemostatic apron being located below the junction area.

[0100] Exemplary Claim 41: The vascular prosthesis of any one of claims 34-40, further comprising a hemostatic collar projecting radially from the primary conduit.

[0101] Exemplary Claim 42: The vascular graft of claim 41, wherein the hemostatic collar includes protrusions or barbs to prevent migration of the vascular graft within the aorta.

[0102] Exemplary claim 43: An artificial blood vessel, a primary conduit forming a primary lumen and extending from a primary inlet opening to a primary outlet opening, the primary conduit configured to fluidly connect the primary inlet opening to a portion of the aorta upstream of the aneurysm and to fluidly connect the primary outlet opening to a portion of the aorta downstream of the aneurysm; four branch conduits, each branch conduit forming a branch lumen and extending from a branch inlet opening in the primary conduit to a branch outlet opening, the branch inlet opening being fluidly coupled to the primary lumen, a distal end of each branch conduit configured to be fluidly connected to an aortic branch; a perfusion branch conduit forming a perfusion branch lumen and extending from a perfusion branch opening in a primary lumen to a perfusion outlet opening at a distal end of the perfusion branch conduit, said perfusion branch opening being fluidly coupled to said primary lumen; Including artificial blood vessels.

[0103] Exemplary claim 44: A method for repairing an aortic aneurysm, comprising: a) fluidly connecting a proximal end of a primary conduit of a vascular graft to a first portion of a patient's aorta upstream of the aortic aneurysm and a distal end of the primary conduit to a second portion of aorta downstream of the aortic aneurysm, wherein one or more aortic branches of the patient are located between the first and second portions of the aorta and blood flows through a primary lumen of the primary conduit; b) fluidly connecting an inlet conduit of a perfusion device to a distal end of a perfusion branch conduit of the vascular graft, the valve assembly being in a closed state to prevent blood flow from the primary lumen of the vascular graft to a plurality of secondary conduits branching from the inlet conduit; c) fluidly connecting a distal end of the secondary conduit to the one or more aortic branches; d) altering the valve assembly to an open state to restore blood flow to the one or more aortic branches; A method comprising:

Claims

1. A surgical kit for repairing aortic aneurysms, It is an artificial blood vessel, A primary conduit is formed to create a primary lumen extending from a primary inlet opening to a primary outlet opening, and is configured to be fluidly connected to the patient's aorta. A perfusion branch conduit, wherein a perfusion branch lumen extends from a perfusion branch opening in the primary conduit to a perfusion outlet opening at the distal end of the perfusion branch conduit, and the perfusion branch opening is in fluid communication with the primary lumen, Including artificial blood vessels, A perfusion device, An inlet conduit is configured such that its proximal end is fluidly connected to the distal end of the perfusion branch conduit, Multiple secondary conduits are configured to branch off from the aforementioned inlet conduit and be fluidly connected to the branches of the aorta, A perfusion apparatus including a valve assembly configured to selectively switch the plurality of secondary conduits between an open state and a closed state. A surgical kit including [item name].

2. The surgical kit according to claim 1, wherein the primary conduit of the artificial blood vessel includes a stent graft portion and a tube graft portion, which are connected at a junction region, the stent graft portion includes a primary inlet opening, and the tube graft portion includes a primary outlet opening.

3. The surgical kit according to claim 2, wherein the stent graft portion includes a flexible biocompatible membrane attached to a support structure, and the stent graft portion is configured to be radially expandable from a folded state to an unfolded state.

4. The surgical kit according to claim 1, wherein the artificial blood vessel is attached to the primary conduit, and the kit further comprises a hemostatic apron surrounding the primary conduit, the hemostatic apron being configured to create an anastomosis between the primary conduit and the aorta to prevent intercostal reflux bleeding.

5. The surgical kit according to claim 4, wherein the hemostatic apron is a frustoconical flange extending from an upper end to a lower end, the upper end of the hemostatic apron is connected to the primary conduit above the joining region, and the lower end of the hemostatic apron is located below the joining region.

6. The surgical kit according to claim 1, further comprising a hemostatic collar in which the artificial blood vessel protrudes radially from the primary conduit.

7. The surgical kit according to claim 6, wherein the hemostatic collar includes projections or barbs to prevent the artificial blood vessel from moving within the aorta.

8. The surgical kit according to claim 1, wherein the artificial blood vessel further comprises a plurality of branch conduits, each branch conduit forming a branch lumen extending from a branch inlet opening to a branch outlet opening in the primary conduit, the branch inlet opening being fluidically connected to the primary lumen, and the distal end of each branch conduit being fluidically connected to an aortic branch.

9. The surgical kit according to claim 8, wherein the perfusion branching opening is closer to the primary inlet opening than each of the branch inlet openings.

10. The surgical kit according to claim 1, wherein the distal end of the perfusion branch conduit is provided with a first quick connect member, and the proximal end of the inlet conduit of the perfusion device is provided with a second quick connect member that can be fitted with the first quick connect member in order to fluidly connect the lumen of the perfusion branch conduit and the passage of the inlet conduit.

11. The surgical kit according to claim 10, wherein the first quick-connect member and the second quick-connect member are selected from a bayonet connector member, a screw-in connector member, a snap-fit ​​connector member, a press-fit connector member, and a combination thereof.

12. The surgical kit according to claim 10, wherein the cross-sectional area of ​​the perfusion branching lumen is smaller than the cross-sectional area of ​​the primary lumen, but larger than the cross-sectional area of ​​any of the plurality of branching lumen.

13. The surgical kit according to claim 10, wherein the perfusion branch conduit comprises a main body portion extending from the primary lumen and a distal portion including the distal end, the distal portion having higher rigidity than the main body portion.

14. The surgical kit according to claim 1, further comprising an inflatable molding balloon configured to be positioned within the primary lumen of the primary conduit.

15. The surgical kit according to claim 1, wherein each distal end of the plurality of secondary conduits of the perfusion device is configured to be fluidly connected to one of the plurality of aortic branches.

16. The surgical kit according to claim 15, wherein each distal end of the plurality of secondary conduits of the perfusion device is provided with a tapered tip portion having an outer diameter.

17. The surgical kit according to claim 1, wherein each secondary conduit of the perfusion device further includes a stabilizing member for ensuring a sealed fluid connection between the passage of the secondary conduit and the aortic bifurcation.

18. The surgical kit according to claim 17, wherein the stabilizing member includes a compressible ring structure.

19. The surgical kit according to claim 1, wherein the perfusion device comprises four secondary conduits.

20. The surgical kit according to claim 1, wherein the valve assembly is configured to allow each of the plurality of secondary conduits to be individually changed between an open state and a closed state independently of the other secondary conduits.

21. The surgical kit according to claim 20, wherein the valve assembly is further configured to change the inlet conduit of the perfusion device between an open state and a closed state.

22. The surgical kit according to claim 20, wherein the valve assembly comprises a plurality of valves, each valve being operably connected to one of the plurality of secondary conduits.

23. The surgical kit according to claim 22, wherein each of the plurality of valves is a clamp.

24. The surgical kit according to any one of claims 1 to 23, further comprising a sealed package including the artificial blood vessel, the perfusion device, and the valve assembly.

25. It is an artificial blood vessel, A primary conduit forming a primary lumen and extending from a primary inlet opening to a primary outlet opening, wherein the primary conduit is configured to fluidly connect the primary inlet opening to the aortic portion upstream of the aneurysm and to fluidly connect the primary outlet opening to the aortic portion downstream of the aneurysm, A plurality of branch conduits, each branch conduit forming a branch lumen, extending from a branch inlet opening to a branch outlet opening in the primary lumen, the branch inlet opening being fluidly connected to the primary lumen, and the distal end of each branch conduit being fluidly connected to an aortic branch, A perfusion branch conduit forms a perfusion branch lumen and extends from a perfusion branch opening in the primary conduit to a perfusion outlet opening at the distal end of the perfusion branch conduit, wherein the perfusion branch opening is fluidly connected to the primary lumen, and the distal end of the perfusion branch conduit is provided with a first quick connect member. Including artificial blood vessels.

26. The artificial blood vessel according to claim 25, wherein the primary conduit of the artificial blood vessel includes a stent graft portion and a tube graft portion joined at a junction region, the stent graft portion includes the primary inlet opening, and the tube graft portion includes the primary outlet opening.

27. The artificial blood vessel according to claim 25 or 26, further comprising a hemostatic apron attached to the primary conduit and surrounding the primary conduit in a circumferential direction, wherein the hemostatic apron is attached to the wall of the patient's aorta to create an anastomosis between the primary conduit and the aorta to prevent intercostal reflux bleeding.

28. The artificial blood vessel according to claim 25 or 26, further comprising a hemostatic collar that protrudes radially from the primary conduit.

29. The hemostatic collar includes projections or barbs to prevent the artificial blood vessel from moving within the aorta, according to claim 28.

30. The artificial blood vessel according to claim 26, further comprising a hemostatic apron projecting radially from the joining region.

31. The artificial blood vessel according to claim 25 or 26, further comprising a clamp zone, the clamp zone located between the perfusion branch conduit and the plurality of branch conduits.

32. The artificial blood vessel according to claim 25 or 26, wherein the first quick-connect member is selected from a bayonet connector member, a screw-in connector member, a snap-fit ​​connector member, a press-fit connector member, and a combination thereof.

33. The artificial blood vessel according to claim 25 or 26, wherein the perfusion branching opening is closer to the primary inlet opening than each of the branch inlet openings.

34. It is an artificial blood vessel, A primary conduit, including a primary lumen, extends from the primary inlet opening to the primary outlet opening, Multiple branch inlet openings, A perfusion branch conduit, which forms a perfusion branch lumen, extends from a perfusion branch opening in the primary lumen to a perfusion outlet opening at the distal end of the perfusion branch conduit, and the perfusion branch opening is fluidly connected to the primary lumen, Artificial blood vessels, including those containing artificial blood vessels.

35. The artificial blood vessel according to claim 34, wherein the primary conduit is configured such that the primary inlet opening is fluidly connected to the aortic portion upstream of the aneurysm, and the primary outlet opening is fluidly connected to the aortic portion downstream of the aneurysm.

36. The artificial blood vessel according to claim 34, further comprising a stent graft portion and a tube graft portion joined to the stent graft portion at a junction region, wherein the stent graft portion includes the primary inlet opening, the tube graft portion includes the primary outlet opening, and the plurality of branch inlet openings are located in the tube graft portion.

37. The artificial blood vessel according to claim 36, wherein the tube graft portion is made of a material selected from polyester, polyurethane, polyethylene terephthalate (PET / Dacron), polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (ePTFE), and thermoplastic polyethylene.

38. The artificial blood vessel according to any one of claims 34 to 37, wherein the plurality of branch inlet openings include a first branch inlet opening and a second branch inlet opening, and the first branch inlet opening is larger than the second branch inlet opening.

39. The artificial blood vessel according to any one of claims 34 to 37, further comprising a hemostatic apron attached to the primary conduit and surrounding the primary conduit in a circumferential direction, wherein the hemostatic apron is configured to create an anastomosis between the primary conduit and the aorta to prevent intercostal reflux bleeding.

40. The artificial blood vessel according to claim 39, wherein the hemostatic apron is a frustoconical flange extending from an upper end to a lower end, the upper end of the hemostatic apron is connected to the primary conduit above the joining region, and the lower end of the hemostatic apron is located below the joining region.

41. The artificial blood vessel according to any one of claims 34 to 37, further comprising a hemostatic collar projecting radially from the primary conduit.

42. The hemostatic collar includes projections or barbs to prevent the artificial blood vessel from moving within the aorta, according to claim 41.

43. It is an artificial blood vessel, A primary conduit forming a primary lumen and extending from a primary inlet opening to a primary outlet opening, wherein the primary conduit is configured to fluidly connect the primary inlet opening to the aortic portion upstream of the aneurysm and to fluidly connect the primary outlet opening to the aortic portion downstream of the aneurysm, A four-branch conduit, each branch conduit forming a branch lumen, extending from a branch inlet opening to a branch outlet opening within the primary conduit, the branch inlet opening being fluidly connected to the primary lumen, and the distal end of each branch conduit being fluidly connected to an aortic branch, A perfusion branch conduit, which forms a perfusion branch lumen and extends from a perfusion branch opening in the primary lumen to a perfusion outlet opening at the distal end of the perfusion branch conduit, the perfusion branch opening being fluidly connected to the primary lumen, Artificial blood vessels, including those mentioned above.

44. A method for repairing an aortic aneurysm, a) A step of fluidly connecting the proximal end of the primary conduit of an artificial blood vessel to a first portion of the patient's aorta upstream of the aortic aneurysm, and the distal end of the primary conduit to a second portion of the aorta downstream of the aortic aneurysm, wherein one or more aortic branches of the patient are located between the first and second portions of the aorta, and blood flows through the primary lumen of the primary conduit; b) A step of fluidly connecting the inlet conduit of the perfusion device to the distal end of the perfusion branch conduit of the artificial blood vessel, wherein the valve assembly is in a closed state, preventing blood flow from the primary lumen of the artificial blood vessel to the multiple secondary conduits branching from the inlet conduit; c) A step of fluidly connecting the distal end of the secondary conduit to one or more aortic branches, d) A step of changing the valve assembly to an open state and restoring blood flow to one or more aortic branches, Methods that include...

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