Personal care compositions, methods for using such compositions, and improvements in their dispersibility, stability, and adhesion effects

Abstract

The present invention relates to a cosmetic composition comprising at least a biosurfactant and a lipid layer enhancer. The present invention relates to a method for improving or promoting the adhesion of a lipid layer enhancer compound to a keratinous substance such as hair or skin.

Description

Technical Field

[0001] The present invention relates to personal care compositions, methods for using such compositions, and methods for promoting or improving dispersibility, stability, and adhesion when applying such compositions to keratinous materials.

Background Art

[0002] Personal care cleansing products not only remove dirt and dust from the skin but also have the ability to extract the skin's lipids. Thereby, skin roughness and transdermal water loss may increase. This adverse effect will be more pronounced when frequent treatments are carried out using surfactant-based rinse-off type products.

[0003] In addition to considering the use of combinations of mild surfactants to reduce skin roughness and transdermal water loss, another effective method to counteract the adverse effects of damaging the skin's lipids is to blend lipid compounds compatible with surfactants. Such blends will also improve the adhesion of the lipid layer and provide conditioning / care benefits.

[0004] Many personal care or cosmetic compositions contain natural lipid layer enhancers applied to the skin and / or hair in rinse-off type formulations to provide a conditioning effect. European Patent No. 0776658 discloses a mixture of glyceryl monooleate, which is a lipid of sebum, and a mild alkyl polyglycoside. This mixture combines the moisturizing property of the lipid layer enhancer and the mildness of the bio-derived surfactant. This product can be easily formulated by a low-temperature process in a surfactant base and can also impart a specific thickening effect. Broad claims have also been made regarding conditioning benefits, such as smoothness.

[0005] However, this blend has an unstable viscosity and the viscosity increases during storage. When this happens, the dispersion time during compounding will be longer. The reason may be the insufficient dispersibility of glyceryl monooleate in the presence of alkyl polyglycoside. Another drawback of this type of blend is the insufficient adhesion of the lipid layer enhancer to keratinous substances such as skin or hair.

Summary of the Invention

Problems to be Solved by the Invention

[0006] However, it would be a further problem to obtain a surfactant-lipid layer enhancer combination with improved dispersibility, including improved dispersibility and stability. If this combination is obtained, the adhesion of the lipid layer enhancer to the skin may also be improved.

[0007] Sophorolipids are fermentation-derived surfactants that are completely natural and consumer-friendly, produced by several types of yeast. The hydrophilic part of the biosurfactant molecule in Candida bombicola is a disaccharide (i.e., sophorose), and the hydrophobic part is an omega- or (omega-1)-hydroxy fatty acid that is glycosidically linked to sophorose. This fatty acid chain most commonly contains 16 and 18 carbon atoms, may be unsaturated, and may also be lactonized with the disaccharide. Sophorolipids as biosurfactants can meet the requirements as environmentally friendly surfactants and are widely used in detergent and cosmetic formulations. European Patent Application Publication No. 0550276A1 describes personal care compositions containing glycolipids with low irritation and foaming properties, used together with surfactant aids (e.g., SLS). International Publication No. 1998016192A1 pamphlet discloses germicidal compositions suitable for washing fruits, vegetables, skin, and hair. Some of these compositions contain a mixture of an anionic surfactant and a biosurfactant that is sophorolipid. U.S. Patent Application Publication No. 2014 / 0349902A1 discloses hair and skin cleansing compositions containing water, at least one biosurfactant, and at least one fatty acid to improve benefits on skin care and foaming properties.

Means for Solving the Problems

[0008] Here, this application unexpectedly found that a personal care composition containing a glycolipid biosurfactant and a lipid layer enhancer can improve dispersibility, stability, and adhesion to the skin.

[0009] Therefore, the subject of the present invention is a personal care composition comprising at least: a) a glycolipid biosurfactant, preferably a sophorolipid biosurfactant; and b) a chain length of C8 - C 24 , preferably C 12 - C 22a lipid layer enhancer selected from the group consisting of esters of fatty acids and glycerol; relates to a personal care composition comprising the same.

[0010] Preferably, 10 to 90% by weight of the sophorolipid biosurfactant is in the acidic form.

[0011] Also preferably, the lipid layer enhancer is a saturated or unsaturated C8-C 24 glycerol ester of a fatty acid, preferably a saturated or unsaturated C 12 -C 22 glycerol ester of a fatty acid. Even more preferably, the lipid layer enhancer is an unsaturated C 12 -C 22 glycerol ester of a fatty acid, still more preferably, the lipid layer enhancer is an unsaturated C 16 -C 18 glycerol ester of a fatty acid. Even more preferably, the lipid layer enhancer is an unsaturated C 16 -C 18 monoester of glycerol and a fatty acid.

[0012] In a further aspect, the present invention also relates to a method for improving the dispersibility and stability of a personal care composition comprising at least one biosurfactant and at least one lipid layer enhancer. In a further aspect, the present invention relates to a method for improving the attachment of a lipid layer enhancer compound to a keratinous substance, the method comprising at least one step of applying an effective amount of the personal care composition of the present invention to the keratinous substance.

[0013] In another aspect, the present invention also relates to the use of the personal care composition for improving the dispersibility and stability thereof and for enhancing the attachment of a lipid layer enhancer compound to the skin.

Mode for Carrying Out the Invention

[0014] Throughout this specification, including the claims, the term "comprising one" or "comprising a" shall, unless otherwise specified, be understood to be synonymous with the term "comprising at least one", and the term "between" shall be understood to include the boundary values.

[0015] The terms "a", "an" and "the" are used to refer to one or more than one (i.e., at least one) of the grammatical objects of the article.

[0016] The term "and / or" includes, in addition to the meanings of "and" and "or", any other possible combinations of the components related to this term.

[0017] As used herein, the term "rinsing type" refers to the situation where the composition is used when the composition is finally rinsed or washed off from the surface to be treated (e.g., skin or hair) either after or during the application of the product.

[0018] As used herein, the term "keratinous substance" means a keratin-containing layer such as skin, hair, nails, etc., which is arranged as the outer layer of mammalian epidermal tissue.

[0019] As used herein, the term "lipid layer enhancer" means a functional component capable of preventing skin dryness.

[0020] It should be noted that when defining any range of concentration, weight ratio or amount, any specific upper limit concentration, weight ratio or amount may be accompanied by any specific lower limit concentration, weight ratio or amount respectively.

[0021] The present invention is a personal care composition comprising at least: a) a glycolipid biosurfactant, preferably a sophorolipid biosurfactant; b) The chain length is from C8 to C 24 , preferably C 12 to C 22 , and a lipid layer enhancer compound selected from the group consisting of esters of fatty acids and glycerol having such a chain length; and relates to a personal care composition containing the same.

[0022] The composition of the present invention is a personal care composition or a cosmetic composition, preferably a cleansing agent composition for personal care, more preferably a rinsing type cleansing agent composition, that is, a composition used for the purpose of improving the appearance of the human body in the form of cleansing, conditioning, grooming, beautifying or otherwise. As personal care products, among others, skin care products, cosmetics, antiperspirants, deodorants, perfumes, toiletries, soaps, bath oils, feminine care products, hair care products, oral hygiene products, shampoos, conditioners, straightening products and other hair care products such as depilatory agents, colored cosmetics such as lipsticks, creams, makeup cosmetics, skin creams, lotions (preferably composed of water-in-oil or oil-in-water emulsions), shaving creams and gels for beards, aftershave lotions and conditioning compositions for beard shaving, and sunscreen products can be mentioned. In a preferred embodiment, the personal care composition according to the present invention includes hair care and skin care products, particularly shampoos, conditioners, hair rinses, anti-tangling products, hair color products, body washes, makeup cosmetics, lipsticks, skin creams and other skin care products.

[0023] Sophorolipid biosurfactant The composition of the present invention contains at least one sophorolipid biosurfactant.

[0024] A biosurfactant is understood to be a substance produced by microorganisms and often released from cells. Similar to classical surfactants, a biosurfactant is a surface-active substance that promotes the mixing of an aqueous (hydrophilic) phase and a water-repellent (hydrophobic) phase by reducing the surface tension of a liquid. Biosurfactants can be produced under mild production conditions that require little energy. These are generally very environmentally friendly because they can be easily biodegraded. Furthermore, they are non-toxic and do not produce toxic by-products during their production. As raw materials for the production of the biosurfactant by microorganisms, carbohydrates, especially sugars such as glucose and / or lipopholic carbon sources such as fats, oils, partial glycerides, fatty acids, fatty alcohols, long-chain saturated or unsaturated hydrocarbons are used. According to the present invention, the biosurfactant is preferably a biosurfactant produced by fermentation.

[0025] Examples of biosurfactants include glycolipids, lipopeptides, lipoproteins, fatty acids, phospholipids, neutral lipids, and polymeric surfactants, all of which can also be used in the present invention. The glycolipids that can be used in the present invention are compounds in which one or more monosaccharide units are glycosidically bonded to a lipid moiety. Glycolipids as biosurfactants that can be used in accordance with the present invention are, for example, rhamnolipids, sophorolipids, mannosylerythritol lipids, and trehalose lipids.

[0026] Sophorolipids are produced by growing and fermenting yeasts such as Candida Bombicola (also known as Torulopsis bombicola), Yarrowia lipolytica, Candida apicola (Torulopsis apicola), Candida bogoriensis, etc. using sugars, hydrocarbons, vegetable oils or mixtures thereof. Sophorolipids are represented by the following formulas (a) (lactone type) and (b) (free acid), and are usually obtained as a mixture of these two forms.

Chemical formula

[0027] According to the present invention, sophorolipids, which are a mixture of the acidic type and the lactone type, are preferred. Preferably, about 10% to about 90% by weight of the sophorolipids, more preferably about 20% to about 60% by weight, and still more preferably about 25% to 40% by weight are of the acidic type, and the remaining sophorolipids are of the lactone type.

[0028] Sophorolipids suitable for use in the present invention are commercially available. For example, BioToLife TM is commercially available from BASF under the trade name. The sophorolipids provided by BASF are a mixture with the lactone type, in which about 30% by weight exists in the free acid form.

[0029] According to any one embodiment of the present invention, the composition of the present invention contains a sophorolipid surfactant in an amount of 0.1% to 30% by weight, preferably 0.2% to 20% by weight, more specifically 0.2% to 15% by weight, and still more preferably 0.5% to 10% by weight based on the total weight of the composition.

[0030] Lipid layer enhancer compound The composition of the present invention contains at least one lipid layer enhancer compound selected from the group consisting of fatty acids having a chain length of C8 to C 24 and preferably esters of fatty acids of C 12 to C 22 with glycerol. Preferably, the lipid layer enhancer is an ester of glycerol with a saturated or unsaturated C8 to C 24 fatty acid, preferably an ester of glycerol with a saturated or unsaturated C 12 to C 22 fatty acid, more preferably, the lipid layer enhancer is an ester of glycerol with an unsaturated C 12 to C 22 fatty acid, and still more preferably, the lipid layer enhancer is an ester of glycerol with an unsaturated C 16 to C 18It is an ester of glycerol with fatty acids. In this specification, it is preferable to use a monoester of glycerol, and a monoester of glycerol and an unsaturated straight-chain fatty acid is particularly suitable. In the context of the present invention, glycerol monooleate is particularly preferred. These glycerol esters are present in the composition in an amount of 4 to 10% by weight, preferably 5 to 9% by weight, of the total weight of the composition.

[0031] In one embodiment of any one of the present invention, the present invention relates to a personal care composition comprising at least one sophorolipid and at least one saturated or unsaturated C8-C 24 ester of glycerol, preferably saturated or unsaturated C 12 -C 22 ester of glycerol with fatty acids. In some preferred embodiments, the present invention relates to a personal care composition comprising at least one sophorolipid and at least one monoester of glycerol with an unsaturated C 12 -C 22 fatty acid. In some preferred embodiments, the present invention relates to a personal care composition comprising at least one sophorolipid and at least one ester of glycerol with an unsaturated C 16 -C 18 fatty acid. In some preferred embodiments, the present invention relates to a personal care composition comprising at least one sophorolipid and at least one glycerol monooleate.

[0032] In one embodiment of any one of the present invention, the personal care composition contains a glycolipid surfactant and a lipid layer enhancer in a weight ratio of 1:0.8 to 1:2, preferably 1:1 to 1:2, more preferably 1:1 to 1:1.5. In some preferred embodiments, the present invention relates to at least one sophorolipid and at least one saturated or unsaturated C8-C 24 ester of glycerol, preferably saturated or unsaturated C 12 -C 22Relates to a personal care composition comprising esters of glycerol and fatty acids in a weight ratio of 1:0.8 to 1:2, preferably 1:1 to 1:2, more preferably 1:1 to 1:1.5. In some preferred embodiments, the present invention provides at least one sophorolipid and at least one unsaturated C 12 ~C 22 Relates to a personal care composition comprising monoesters of glycerol and fatty acids in a weight ratio of 1:0.8 to 1:2, preferably 1:1 to 1:2, more preferably 1:1 to 1:1.5. In some preferred embodiments, the present invention provides at least one sophorolipid and at least one unsaturated C 16 ~C 18 Relates to a personal care composition comprising monoesters of glycerol and fatty acids in a weight ratio of 1:0.8 to 1:2, preferably 1:1 to 1:2, more preferably 1:1 to 1:1.5. In some preferred embodiments, the present invention provides at least one sophorolipid and at least one glycerol monooleate in a weight ratio of 1:0.8 to 1:2, preferably 1:1 to 1:2, more preferably 1:1 to 1:1.5.

[0033] In one embodiment of the present invention, the sophorolipid used in the personal care composition is a mixture of the acidic and lactone forms; preferably about 10 to about 90 wt%, more preferably about 20 to about 60 wt%, still more preferably about 25 wt% to 40 wt% of the sophorolipid is in the acidic form, and the remaining sophorolipid is in the lactone form.

[0034] Further benefit agent The composition of the present invention can further contain one or more beneficial agents that can bring favorable and / or beneficial effects to the substrate to be cleaned, such as the skin and hair. Those skilled in the art can select such optional components suitable for the purpose of application according to the common knowledge in the technical field of formulating personal care compositions such as shampoos, shower gels, and liquid hand soaps and the vast literature related thereto. In one embodiment, the composition of the present invention contains one or more beneficial agents, such as emollients, moisturizers, conditioners, skin conditioners or hair conditioners, such as silicones, such as volatile silicones, rubbers or oils or non-amino silicones and mixtures thereof, mineral oils, esters, such as butyl myristate, cetyl palmitate, decyl oleate, glyceryl laurate, glyceryl ricinoleate, glyceryl stearate, glyceryl isostearate, hexyl laurate, isobutyl palmitate, isocetyl stearate, isopropyl isostearate, isopropyl laurate, isopropyl linoleate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, propylene glycol monolaurate, propylene glycol ricinoleate, propylene glycol stearate and propylene glycol isostearate, acetylated lanolin alcohol, lanolin, lard, mink oil and tallow and other animal fats, and fatty acids and alcohols such as behenic acid, palmitic acid, stearic acid, behenyl alcohol, cetyl alcohol, eicosanyl alcohol, isocetyl alcohol, vitamins and their derivatives, such as vitamin B complex including thiamine, nicotinic acid, biotin, pantothenic acid, choline, riboflavin, vitamin B6, vitamin B12, pyridoxine, inositol, etc., carnitine, vitamins A, C, D, E, K and their derivatives, such as vitamin A palmitate and provitamins, such as panthenol (provitamin B5), panthenyl triacetate and mixtures thereof; antioxidants; free radical scavengers; natural or synthetic abrasives; dyes; hair colorants; bleaching agents; hair bleaching agents;UV absorbers, such as benzophenone, borneol, PABA (para - aminobenzoic acid), butyl PABA, cinnamidopropyltrimethylammonium chloride, disodium distyrylbiphenyl disulfonic acid, potassium methoxycinnamate; UV protectants, such as butyl methoxydibenzoylmethane, octyl methoxycinnamate, oxybenzone, octocrylene, octyl salicylate, phenylbenzimidazole sulfonic acid, ethyl hydroxypropylaminobenzoate, menthyl anthranilate, aminobenzoic acid, cinoxate, diethanolamine methoxycinnamate, glyceryl aminobenzoate, titanium dioxide, zinc oxide, oxybenzone, octyl dimethyl PABA (padimate O), red petrolatum; antimicrobial agents; antibacterial agents, such as bacitracin, erythromycin, triclosan, neomycin, tetracycline, chlortetracycline, benzethonium chloride, phenol, parachlorometaxylenol (PCMX), triclocarban (TCC), chlorhexidine gluconate (CHG), zinc pyrithione, selenium sulfide; antifungal agents; melanin regulators; tanning accelerators; pigmentation inhibitors, such as retinoids like retinol, kojic acid and its derivatives, such as kojic dipalmitate, hydroquinone and its derivatives, such as arbutin, tranexamic acid, vitamins, such as niacin, vitamin C and its derivatives, azelaic acid, placertia, licorice, extracts of chamomile, green tea, etc. (among which retinol, kojic acid and hydroquinone are preferred); skin whitening agents, such as hydroquinone, catechol and its derivatives, ascorbic acid and its derivatives; skin coloring agents, such as dihydroxyacetone; lipid regulators; weight loss agents; anti - acne agents; anti - seborrheic agents; anti - aging agents; anti - wrinkle agents; keratolytic agents; anti - inflammatory agents;Anti-acne agents, for example, tretinoin, isotretinoin, motretinide, adapalene, tazarotene, azelaic acid, retinol, salicylic acid, benzoyl peroxide, resorcinol, antibiotics, for example, tetracycline and its isomers, erythromycin, anti-inflammatory agents, for example, ibuprofen, naproxen, hetoprofen, plant extracts, for example, plants of the genus alnus, plants of the genus arnica, artemisia capillaris, cycin, plants of the genus calendula, chamomile, nidium, comfrey, wikyo, galla rhois, Japanese quince, plants of the genus houttuynia, plants of the genus hypericum, jujube, kiwi, licorice, plants of the genus magnolia, olive, perilla, plants of the genus philodendron, plants of the genus salvia, sasa albomarginata, imidazoles, for example, ketoconazole and elviol; cooling agents; scar-forming agents; blood vessel protectants;An agent for suppressing dandruff (anti-dandruff agent), seborrheic dermatitis or psoriasis, for example, a pyrithione salt such as zinc pyrithione formed from heavy metals such as zinc, tin, cadmium, magnesium, aluminum, sodium, zirconium, etc., shale oil and its derivatives, for example, sulfonated shale oil, selenium sulfide, sulfur, salicylic acid, coal tar, povidone iodine, imidazoles, for example, ketoconazole, dichlorophenyl imidazolodioxalan, clotrimazole, itraconazole, miconazole, climbazole, tioconazole, sulconazole, butoconazole, fluconazole, miconazole nitrite and any possible stereoisomers and derivatives thereof, for example, anthralin, piroctone olamine (Octopirox), selenium sulfide, ciclopirox olamine, anti-psoriasis agents, for example, vitamin D analogs, for example, calcipotriol, calcitriol and tacaleitrol, vitamin A analogs, for example, esters of vitamin A such as vitamin A palmitate, retinoids, retinol and retinoic acid, corticosteroids, for example, hydrocortisone, clobetasone, butyrate ester, clobetasone propionate; antiperspirants or deodorants, for example, chlorohydroxyaluminum, aluminum zirconium chlorohydrate; immunomodulators; hair tonics; depilatory agents, for example, calcium thioglycolate, magnesium thioglycolate, potassium thioglycolate, strontium thioglycolate; an agent for counteracting hair loss; a reducing agent for permanent waves; reflective materials, for example, mica, alumina, calcium silicate, glycol dioleate, glycol distearate, silica, fluorosilicic acid (sodium / magnesium); further comprising essential oils and fragrances.;

[0035] In some embodiments of the present invention, the composition of the present invention can further include a polymeric or non-polymeric thickening agent to obtain a viscosity sufficient for the intended use of the composition. The composition can contain less than 10% by weight of an additional thickening agent. Examples of suitable thickening agents for the present composition include, but are not limited to, sodium chloride, potassium chloride, ammonium chloride, sodium sulfate, fatty acid alkanolamide, cellulose derivatives, carboxylic acid polymers, crosslinked polyacrylate polymers, polyacrylamide polymers, polysaccharides, gums, and mixtures thereof. Non-limiting examples of suitable thickening agents are described in CTFA International Cosmetic Ingredient Dictionary, 10 th Ed. (2004), pp. 2294-96.

[0036] In any one of the embodiments of the present invention, the personal care composition is used in a manner known in the art. For example, in the case of a cleansing agent or shampoo, the cleansing agent or shampoo is applied to the skin and / or hair, and optionally, the cleansing agent or shampoo is rinsed off with water from the skin and / or hair. In any one of the embodiments of the present invention, the pH of the composition of the present invention can be between 4 and 11, for example, between 4 and 6.

[0037] The personal care composition of the present invention can be prepared by mixing the individual components using any conventional compounding technique known in the prior art, such as conventional stirring, shaking, or tumbling. These components can be supplied as concentrated solutions that are diluted and / or mixed in appropriate ratios by those skilled in the art. The present invention encompasses any concentrate used as a raw material (component ingredient) for the components to prepare the composition of the present invention, particularly a concentrate containing a limited amount of water for several reasons in terms of cost and the environment.

[0038] The present invention also relates to a method for improving the dispersibility and stability of a personal care composition comprising at least one lipid layer enhancer as described above. The lipid layer enhancer can be used in combination with at least one sophorolipid to obtain a dispersion with improved dispersibility and stability.

[0039] The present invention is a method for improving the dispersibility and stability of a personal care composition comprising at least one lipid layer enhancer, which comprises combining the lipid layer enhancer with at least one glycolipid biosurfactant; preferably, the lipid layer enhancer is an ester of glycerol with saturated or unsaturated C8 - C 24 fatty acids, preferably an ester of glycerol with saturated or unsaturated C 12 - C 22 fatty acids, and the glycolipid biosurfactant is sophorolipid; more preferably, the lipid layer enhancer is an ester of glycerol with C 12 - C 22 unsaturated straight-chain fatty acids, and the glycolipid biosurfactant is sophorolipid; even more preferably, the lipid layer enhancer is an ester of glycerol with unsaturated C 16 - C 18 fatty acids, and the glycolipid biosurfactant is sophorolipid; still more preferably, the lipid layer enhancer is a monoester of glycerol with unsaturated C 16 - C 18 unsaturated straight-chain fatty acids, and the glycolipid biosurfactant is sophorolipid; yet more preferably, the lipid layer enhancer is glycerol monooleate, and the glycolipid biosurfactant is sophorolipid.

[0040] The present invention is a method for improving the dispersibility and stability of a personal care composition comprising at least one lipid layer enhancer, which comprises combining the lipid layer enhancer with at least one glycolipid biosurfactant. The present invention also relates to at least one ester of glycerol with unsaturated C8 - C 24 fatty acids, preferably an ester of glycerol with unsaturated C 12 - C 22A method for improving the dispersibility and stability of a personal care composition comprising esters of glycerol with fatty acids, which comprises combining esters of glycerol with fatty acids with at least one sophorolipid. Unsaturated C 12 ~C 22 Also targeted is a method that includes combining esters of glycerol with fatty acids with at least one sophorolipid. The present invention also relates to a method for improving the dispersibility and stability of a personal care composition comprising at least one monoester of glycerol with an unsaturated C 12 ~C 22 fatty acid, preferably an unsaturated C 16 ~C 18 Also targeted is a method for improving the dispersibility and stability of a personal care composition comprising at least one monoester of glycerol with an unsaturated C 12 ~C 22 fatty acid, which comprises combining the monoester of glycerol with an unsaturated C

[0041] The present invention also relates to a method for improving the adhesion of a lipid layer enhancer to a keratinous substance, which comprises at least one step of applying to the keratinous substance an effective amount of the personal care composition of the present invention comprising at least one sophorolipid and at least one ester of glycerol with an unsaturated C8-C 24 fatty acid, preferably an unsaturated C 12 ~C 22 Also targeted is a method for improving the adhesion of a lipid layer enhancer to a keratinous substance, which comprises at least one step of applying to the keratinous substance an effective amount of the personal care composition of the present invention comprising at least one sophorolipid and at least one unsaturated C 12 ~C 22A method is provided that includes at least one step of applying to a keratinous substance, in an effective amount, the personal care composition of the present invention comprising a monoester of glycerol and a fatty acid. The present invention also provides a method for improving the adhesion of a lipid layer enhancer to a keratinous substance, the method including at least one step of applying to the keratinous substance, in an effective amount, the personal care composition of the present invention comprising at least one sophorolipid and at least one glycerol monooleate.

[0042] In one embodiment of any one of the present invention, the sophorolipid biosurfactant used in the method described above is a mixture of the acidic type and the lactone type; preferably about 10% to about 90% by weight, more preferably about 20% to about 60% by weight, and still more preferably about 25% to 40% by weight of the sophorolipid is of the acidic type, and the remaining sophorolipid is of the lactone type.

Example

[0043] Materials

[0044]

Table 1

[0045] All of the materials described above are commercially available from BASF.

[0046] I. Stability and Dispersibility Tests: Preparation of a combination of biosurfactant and lipid layer enhancer · Heat 500 g of the lipid layer enhancer (glycerol ester, containing active substance) above its melting point until completely melted. · Then, while continuously stirring the melted lipid layer enhancer at 100 rpm, gradually add 500 g of the pre-heated sophorolipid (containing active substance). · Add deionized water with a solids content of 65% based on the total weight of the composition to the mixture, and stir for 30 minutes while homogenizing completely at 100 rpm until a viscous dispersion is obtained after cooling.

[0047] Measurement of Transmittance and Stability The LUMiSizer® 611 from LUM GmbH was used as the device for analyzing transmittance and stability. Irradiation was performed at a wavelength of 865 nm with a light factor of 1. The obtained formulation (prepared by the method described above in this specification) was diluted to 5 wt%, and 0.4 mL of the suspension was filled into a rectangular synthetic polycarbonate cell with an optical path length of 2 mm. The measurement was carried out at 25 °C, and the data were analyzed with the software SEPView® provided by LUM GmbH under the following settings: - Rotation speed - 1000 rpm - Detection interval - 120 times × 10 seconds - Measurement time - 20 minutes - During the measurement, the transmittance was recorded by the software at this adjusted interval. The initial transmittance at a position 120 mm along the longitudinal direction of the cell is shown in the following table. - To quantitatively evaluate the stability of the formulation, the instability index was calculated and described in the following table. This is a specific value in the range of 0 to 1 that combines Stokes' law and Lambert-Beer's law, representing the relative value of the sume of the transparency change during centrifugation with respect to the highest clarity.

[0048] The lower the instability index, the higher the stabilization performance. The higher the transmittance value, the higher the homogeneity of the appearance (higher dispersibility) was observed.

[0049] Transmittance and Stability Test Results

[0050] [Table 2]

[0051] [Table 3]

[0052] [Table 4]

[0053] II. Adhesion Test of Lipid Layer Enhancer: Details of the formulation:

[0054] [Table 5]

[0055] Explanation of the test method: - Preliminary cleaning: Preliminarily clean the forearm with about 6 mL (2 pipette volumes) of a 10% solution of Plantapon® 818UP. Gently rub in a circular motion 20 times. Rinse off with slowly flowing deionized water while rubbing in a circular motion 20 times. Gently pat dry with a paper towel. - Application of the formulation: Mark a corner within a range of 4 cm × 10 cm with a wax pen. Apply 0.5 g of the rinse-off type formulation to the center of this range using a pipette with the discharge volume adjusted. Immediately spread 0.5 g of this rinse-off type formulation while drawing 20 circles. Ensure that the formulation is evenly distributed throughout the pre-marked 4 cm × 10 cm range. Immediately after the previous step, place the forearm under slowly flowing deionized water and gently rub while drawing 20 circles. Remove the forearm from the water and gently pat dry with a paper towel. - Recovery of glycerol monooleate and measurement of the adhesion amount: Use an alcohol swab to wipe the test area about 20 times to ensure the extraction of glycerol monooleate. Transfer the alcohol swab to 5 mL of absolute alcohol and examine the concentration by liquid chromatography (using the parameters in the following table). Express the result as μg GMO per 10 cm 2 of area.

[0056] [Table 6]

[0057] Test results of the adhesion amount:

[0058]

Table 7

[0059] These test results show that the adhesion of glyceryl monooleate to the skin is more excellent and it is significantly improved when used in combination with sophorolipids in a rinse-off type personal care preparation.

Claims

1. A personal care composition, comprising at least: a) a glycolipid biosurfactant, preferably a sophorolipid; b) a lipid layer enhancer; Includes, The lipid layer enhancer is saturated or unsaturated C ８ ~C ２４ A fatty acid glycerol ester, preferably C １２ ~C ２２ It is an ester of glycerol from fatty acids; Preferably, the personal care composition comprises at least one sophorolipid and at least one unsaturated C １２ ~C ２２ The personal care composition comprises a glycerol ester of a fatty acid, and more preferably, at least one sophorolipid and at least one unsaturated C １６ ~C １８ A composition comprising a fatty acid glycerol ester.

2. The composition according to claim 1, wherein the sophorolipid biosurfactant is a mixture of acidic and lactone forms; preferably, about 10 to about 90% by weight, more preferably about 20 to about 60% by weight, and even more preferably about 25% to 40% by weight of the sophorolipid is in the acidic form, and the remaining sophorolipid is in the lactone form.

3. The lipid layer enhancer is C １２ -C ２２ The composition according to claim 1, which is a monoester of glycerol of an unsaturated straight-chain fatty acid, preferably glycerol monooleate.

4. The composition according to claim 1, wherein the glycolipid biosurfactant and the lipid layer enhancer are present in a weight ratio of 1:0.8 to 1:2, preferably 1:1 to 1:2, and more preferably 1:1 to 1:1.

5.

5. The composition according to claim 1, further comprising one or more types of anionic surfactants, nonionic surfactants, or amphoteric surfactants.

6. The composition according to claim 1, further comprising one or more additional beneficial agents.

7. A method for improving the dispersibility and stability of a personal care composition comprising at least one lipid layer enhancer, wherein the method comprises combining the lipid layer enhancer with at least one glycolipid biosurfactant; preferably, the lipid layer enhancer is saturated or unsaturated C ８ ~C ２４ Glycerol esters of fatty acids, preferably saturated or unsaturated C １２ ~C ２２ The glycerol ester of a fatty acid, and the glycolipid biosurfactant is a sophorolipid; more preferably, the lipid layer enhancer is C １２ ~C ２２ The glycolipid biosurfactant is a glycerol ester of an unsaturated linear fatty acid, and the lipid layer enhancer is a sophorolipid; more preferably, the lipid layer enhancer is C １６ ~C １８ A method wherein the lipid layer enhancer is a monoester of glycerol of an unsaturated linear fatty acid, and the glycolipid biosurfactant is a sophorolipid; more preferably, the lipid layer enhancer is glycerol monooleate, and the glycolipid biosurfactant is a sophorolipid.

8. A method for improving the adhesion of a lipid layer enhancer, comprising at least one step of applying an effective amount of the personal care composition according to any one of claims 1 to 6 to a keratinous substance, wherein the lipid layer enhancer is saturated or unsaturated C ８ ~C ２４ Glycerol esters of fatty acids, preferably saturated or unsaturated C １２ ~C ２２ It is an ester of fatty acid glycerol; preferably, the personal care composition comprises at least one sophorolipid and at least one unsaturated C １２ ~C ２２ Esters of fatty acid glycerols, more preferably C １６ ~C １８ A method comprising a monoester of glycerol of an unsaturated linear fatty acid, most preferably glycerol monooleate.

9. A personal care composition according to any one of claims 1 to 6, for the purpose of improving or promoting the adhesion of a lipid layer enhancer to a keratinous substance, wherein the lipid layer enhancer is saturated or unsaturated C ８ ~C ２４ Glycerol esters of fatty acids, preferably saturated or unsaturated C １２ ~C ２２ It is an ester of fatty acid glycerol; preferably, the personal care composition comprises at least one sophorolipid and at least one unsaturated C １２ ~C ２２ Esters of fatty acid glycerols, more preferably C １６ ~C １８ Uses include monoesters of glycerols of unsaturated linear fatty acids, most preferably glycerol monooleate.