Computer-based method for determining an optimal sunscreen filter composition

Abstract

The present invention relates to the development of a screen filter composition. To efficiently determine a screen filter composition, a computer-implemented method (200) for determining a composition containing one or more UV filter substances is provided. The method includes the following: a) The following: A screen performance target profile including minimum product requirements of the composition, and Providing input data including an optimization objective parameter set including two or more optimization objective parameters through an input unit (210), b) Performing a multi-objective optimization process in a computational model by a processing unit to determine a Pareto-efficient solution set (220), Each solution is a substance composition forming the composition such that the composition meets the minimum product requirements, and Each solution is Pareto-efficient with respect to the optimization objective parameter set (220), c) Providing at least one of the determined substance compositions through an output unit (230) that can preferably be used to guide the production of the screen product.

Description

【Technical Field】 【0001】 The present invention relates to a computer-implemented method and apparatus for determining a composition comprising one or more UV filter substances, a method and apparatus for manufacturing a sunscreen product, a method and apparatus for verifying the validity of the manufacture of a sunscreen product, and a computer program element. 【Background Art】 【0002】 Sunscreen filter compositions are prepared from a palette of different UV filter substances that are known to have different UV absorptivities. When preparing a sunscreen filter composition, the designer selects several substances and combines them and their relative proportions to achieve a target sun protection performance. 【0003】 In the current formulation design of sunscreen products, designers often attempt to find an optimum solution in a multi-dimensional objective space by empirically iteratively varying the formulation parameters within the design space. Typically, this procedure is continued until either a solution that meets a certain requirement is found or some deadline is reached by which a solution must be communicated. For example, European Patent Application Publication No. 3889963A1 describes a computer-based method for determining a sunscreen composition. The user is required to select an optimization objective. This enables a user-defined interactive process, where the objective can be selected according to the general needs of the user and further according to the properties of the sunscreen to be optimized. Specifically, the objective can be changed during the process to repeatedly improve the sunscreen composition. 【0004】 This iterative procedure may lead to favorable results, but it cannot provide any guarantee of optimality. Furthermore, empirical optimization only covers a limited region in both the design space and the objective space, so only limited information regarding the trade-off between different objectives is available, and decisions cannot be made by overlooking the entire solution space. This limitation may result in overlooking the solution of interest. Summary of the Invention Problems to be Solved by the Invention 【0005】 There may be a need to efficiently determine a composition containing one or more UV filter substances. Means for Solving the Problems 【0006】 The object of the present invention is solved by the subject matter of the independent claims, and further embodiments are incorporated in the dependent claims. It should be noted that the following aspects of the present invention also apply to a computer-implemented method and apparatus for determining a composition containing one or more UV filter substances, a method and apparatus for manufacturing a sunscreen product, a method and apparatus for verifying the validity of manufacturing a sunscreen product, and a computer program element. 【0007】 According to a first aspect of the present invention, there is provided a computer-implemented method for determining a composition containing one or more UV filter substances, the method comprising: a) the following: - a sunscreen performance target profile including minimum product requirements of the composition, and - an optimization objective parameter set including two or more optimization objective parameters, providing, via an input unit, input data including the same; b) performing, by a processing unit, a multi-objective optimization process in a computational model to determine a set of Pareto-efficient solutions, - each solution being a material composition forming a composition such that the composition satisfies the minimum product requirements, and - Each solution is Pareto efficient with respect to the optimization objective parameter set, and c) providing, via an output unit, information regarding at least one of the determination substance compositions that can preferably be used to guide the production of the sunscreen product, including. 【0008】 The computer-implemented methods and apparatuses described herein provide a reliable means for the multi-criteria optimization of compositions containing one or more UV filter substances. Instead of finding optimal solutions in a multi-dimensional objective space through empirical iterative changes of formulation parameters within the design space, the proposed computer-implemented methods and apparatuses enable the exploration of the desired optimal compromise points of two or more properties in a simultaneous approach. For this reason, additional information regarding the trade-offs between different objectives is available, and decisions can be made based on this knowledge. The desired optimal solutions are a subset of the feasible solutions. 【0009】 This can help a user (e.g., a customer) identify and produce a suitable product. The number of laboratory experiments will be reduced to an absolute minimum. This will accelerate the development and production of the formulation. 【0010】 In addition, the generated composition can correspond to a sunscreen product with the desired performance characteristics. Thus, each substance containing a UV filter substance can be objectively checked to confirm the validity of the user requirements for the performance characteristics, to confirm the validity of the composition before production / delivery, and to adjust the sunscreen product to the user's needs. For this reason, the evaluation does not require in vitro / in vivo experiments. 【0011】 Furthermore, the computer-implemented methods and apparatuses described herein can be useful for replacing substances in sunscreen products that are prohibited due to competing intellectual property rights, regulatory issues in various countries, or lack of resources. 【0012】 Regarding the computer implementation method, it will be described hereinafter with particular reference to the embodiments shown in FIG. 3. 【0013】 According to one embodiment of the present invention, the input data may further include one or more technical requirements to limit the Pareto efficient solution to satisfy the one or more technical requirements. 【0014】 For example, when one or more solvents are used, one or more UV filters may be dissolved in the one or more solvents, and all given concentrations (i.e., filters and solvents) may conform to the solubility data. To ensure this, the solubility model may be applied using the solubility data of each filter in each solvent. 【0015】 According to one embodiment of the present invention, the one or more technical requirements are as follows: - A solubility model including solubility data of each solid filter in one or more solvents, - Hypothetical limits of the individual concentrations of each solvent, - Hypothetical limits of the individual concentrations of each filter, - Hypothetical limits of the total filter concentration, and - Hypothetical limits of the total solvent concentration, including one or more of the above. 【0016】 For example, in the case of a linear solubility model, i) for a given filter, the total solubility in the solvent mixture is given by the fractional average of the solubilities of that filter in each solvent, and ii) the solubilities of the individual filters in the solvent do not interfere, i.e., it is assumed that i) is applied independently for all filters. 【0017】 According to one embodiment of the present invention, each substance composition is as follows: - One or more UV filter substances, - One or more UV filter substances and one or more solvents, - One or more UV filter substances of a certain formulation type, and - one or more UV filter substances and one or more solvents of a certain formulation type, including at least one of. 【0018】 In one embodiment, the UV filter substance may include specific compounds that impede the passage of ultraviolet light. In other words, the UV filter substance may include soluble or insoluble organic or inorganic agents that protect the skin from damage caused by UVB and / or UVA irradiation from the sun, such as erythema, skin cancer, etc., by absorbing or blocking ultraviolet rays. Soluble UV filter agents function by absorbing ultraviolet rays. It may be soluble or miscible in either a hydrophilic medium or a lipophilic medium. Hydrophilic filters are added to the hydrophilic portion of the formulation. Lipophilic soluble UV filters can be supplied in liquid form and then added directly to the lipophilic phase of the emulsion vehicle. Some, such as ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, bis-ethylhexyloxyphenol methoxyphenyl triazine, butyl methoxydibenzoylmethane, diethylhexyl butamidotriazone, etc., are supplied as solid UV filters and need to be dissolved in the lipophilic phase of the emulsion vehicle containing a solvent. In this case, the solvent is a cosmetic oil. Insoluble or particulate UV filter agents such as tris-biphenyl triazine, methylene bis-benzotriazolyl tetramethylbutylphenol, phenylene bis-diphenyl triazine, bis-(diethylamino hydroxybenzoyl benzoyl) piperazine, titanium dioxide, zinc oxide, etc., function by absorbing ultraviolet rays and additionally reflecting and / or scattering them. Organic particulate filters are generally added to the hydrophilic portion of the emulsion (either the aqueous phase before emulsification or the external hydrophilic phase of an oil-in-water emulsion). Titanium dioxide and zinc oxide can be added to the lipophilic or hydrophilic portion depending on the presence and type of the coating. Different UV filters may be permitted in different jurisdictions. The UV filters permitted in cosmetics in the European Union are listed in Annex VI of Regulation (EC) No. 1223 / 2009 of the European Parliament and of the Council. In the present disclosure, the term "UV filter" is also referred to as "filter". 【0019】 The formulation vehicle, also referred to as the sunscreen formulation type, should enable uniform dispersion of the active UV filters in the vehicle and on the skin. The formulation type can affect the sun protection performance. Thus, different formulations of the same UV filter composition can exhibit different sun protection performances. 【0020】 From this, in the computer-implemented methods and devices described herein, in addition to the properties of the UV filters, the formulation type (e.g., fluid emulsion, creamy emulsion, etc.) can be considered. The choice of formulation type depends on individual requirements and priorities. If there is a possibility to select the formulation type, the desired solution can be adjusted according to user needs. The desired solution can also reduce the difference between the target sun protection performance index and the in vivo measured sun protection performance, thereby reducing the extensive in vivo testing at the user level. 【0021】 The formulation type can include water-containing formulations or water-free formulations. Examples of formulation types include, but are not limited to, oil-in-water fluid emulsions, oil-in-water creamy emulsions, water-in-oil emulsions, water-in-oil-in-water emulsions, oil-in-water-in-oil emulsions, silicone-in-water emulsions, water-in-silicone emulsions, polymeric gel creams, lipophilic single-phase oils, lipophilic single-phase gels, lipophilic single-phase sticks, lipophilic alcoholic mixtures, hydrophilic single-phase fluids, hydrophilic single-phase gels, and powders. 【0022】 According to one embodiment of the present invention, the method further includes providing a graphical user interface (GUI) for Pareto front visualization, where the GUI provides an interactive user interface that enables the user to navigate on the determined Pareto efficient solution set by adjusting the optimization objective parameter set and / or adjusting the formulation via at least one of the determining substance compositions. 【0023】 For exemplary interactive user interfaces, details will be described with respect to the examples shown in FIGS. 4A and 4B. 【0024】 According to one embodiment of the present invention, interpolation is performed between points in a determination Pareto efficient solution set, and the GUI provides an interactive user interface that enables a user to navigate on an interpolated Pareto efficient solution. 【0025】 This will be described in detail hereinafter, particularly with respect to the example shown in FIG. 5. 【0026】 According to one embodiment of the present invention, the minimum product requirements for a composition include one or more of the following: sun protection factor (SPF), UVA protection factor (UVA-PF), critical wavelength, UVA to UVB protection ratio, UVA1 to UV protection ratio, blue light protection, radical protection factor, environmental impact factor, substance limit concentration, and formulation type. 【0027】 Achievement of one or more minimum product requirements can be addressed by varying one or more minimum product requirements with at least one corresponding mathematical optimization constraint. 【0028】 In one embodiment, the sun protection factor (SPF) may indicate protection of the skin from the occurrence of erythema. This factor indicates how much longer protected skin can be exposed to the sun without sunburn compared to untreated skin. For example, if a sunscreen composition with an SPF of 15 is uniformly applied to the skin of a person who normally sunburns after 10 minutes under the sun, the sunscreen will allow a person skilled in the art to stay under the sun 15 times longer. In other words, SPF 15 means that the sunscreen is 2 milligrams per square centimeter (mg / cm 2) Assuming uniform application at the maximum dose, this means that 1 / 15 of the erythemogenic UV reaches the skin. This can be evaluated in vivo (in accordance with ISO 24444), or calculated in vitro using the BASF Sunscreen Simulator (https: / / sunscreensimulator.basf.com / Sunscreen_Simulator / login), or by measuring the transmittance through a thin film of the sunscreen sample spread on a roughened substrate plate transparent to UV. 【0029】 A suitable substrate is, for example, a PMMA plate. The in vitro transmittance measurement can be carried out at 1 nm intervals from 290 to 400 nm using a Labsphere UV transmittance analyzer UV2000S. In this case, a UV transmittance spectrum is obtained and the in vitro SPF value is calculated according to the following formula. 【Equation】 where ser(λ) is the erythema action spectrum, S(λ) is the spectral irradiance received from the UV source, and T(λ) is the in vitro measured light transmittance. 【0030】 In one embodiment, the UVA Protection Factor (UVA-PF) may indicate protection of the skin from UVA rays and is measurable in accordance with ISO24442 or ISO24443, or can be calculated by the BASF Sunscreen Simulator (https: / / sunscreensimulator.basf.com / Sunscreen_Simulator / login). The European Commission recommends that all sunscreens should have a UV-A protection factor of at least 1 / 3 of the labeled sun protection factor (SPF). For example, if the SPF of a sunscreen composition is 30, the UVA protection factor must be at least 10. In Asia, it is recommended that the PA classification characterize the UVA protection of sunscreens according to the UVA-PF value. As an example, the PA+++ classification suggests a UVA-PF value of 8 - 16, and PA++++ suggests when the UVA-PF value is greater than 16. 【0031】 In one embodiment, the critical wavelength may correspond to the wavelength at which the area under the absorbance curve below that wavelength covers 90% of the area under the absorbance curve from 290 nm to 400 nm. It is an in vitro test used to determine UV absorbance within the UVA range. According to US requirements, a critical wavelength of at least 370 nm is required to achieve broad-spectrum protection. In a proposed order (OTC000008) published on September 24, 2021, the FDA proposed additional requirements for passing the broad-spectrum test, and the product was required to meet at least a UVA1 / UV ratio of 0.7. 【0032】 In one embodiment, the UVA1 to UVB protection ratio may correspond to the protection in the UVA1 range (340 nm - 400 nm) compared to the UV range (290 nm - 400 nm). 【0033】 In one embodiment, the UVA to UVB protection ratio can correspond to the protection of the UVA range (320 nm to 400 nm) compared to the UVB range (290 nm to 320 nm), and it can be evaluated according to the Boots star rating system method. 【0034】 In one embodiment, blue light protection can imply protecting the skin from blue light rays (400 - 500 nm, more preferably 400 - 450 nm). It can be evaluated, for example, by transmittance measurement, giving a reduction in transmittance through a thin film of a sunscreen sample spread on a roughened substrate plate transparent to UV, expressed as a reduction in transmittance within the blue light range. 【0035】 In one embodiment, the radical protection factor can imply protecting the skin from the formation of free radicals that have two maxima, one within the UVB range and one within the UVA range, and whose formation is wavelength - dependent as described by ZASTROW et al. in The missing link - light induced free radical formation in human skin, Skin Pharmacol Physiol, 2009. 【0036】 In one embodiment, the environmental impact factor may indicate the environmental impact of a specific UV filter composition. This can be evaluated, for example, according to the Ecosun Pass criteria described in WO 2019 / 207129 A1 pamphlet, according to which a filter combination with at least 200 Ecosun Pass values is required to obtain the best environmental compatibility. The "environmental impact factor" can also be evaluated, for example, by the eco-score factor described in Kunze et al (New method for connecting sunscreens with consumers via a relative Eco-score, SOFW journal, 147, 11 / 21). The aim is to have the lowest environmental impact factor or, conversely, the highest environmental friendliness. 【0037】 In one embodiment, the minimum product requirements are a specific SPF value and at least a 1 / 3 UVA-PF / SPF ratio and a critical wavelength of at least 370 nm. 【0038】 In another embodiment, the minimum product requirements are a specific SPF value and at least a 1 / 3 UVA-PF / SPF ratio and a critical wavelength of at least 370 nm and at least 200 Ecosun pass values. 【0039】 In another embodiment, the minimum product requirements are a specific SPF value and at least a 0.7 UVA1 / UV ratio and a critical wavelength of at least 370 nm. 【0040】 In a further embodiment, the minimum product requirements are a specific SPF value and at least 16 UVA-PF. 【0041】 In one embodiment, the minimum product requirements are a specific SPF value and at least a 1 / 3 UVA-PF / SPF ratio, a critical wavelength of at least 370 nm, and a given maximum total solvent concentration. 【0042】 In one embodiment, the minimum product requirements are a specific SPF value and at least a 1 / 3 UVA-PF / SPF ratio, a critical wavelength of at least 370 nm, and a given maximum concentration of at least one solvent. 【0043】 In one embodiment, the minimum product requirements are a specific SPF value and at least a 1 / 3 UVA-PF / SPF ratio, a critical wavelength of at least 370 nm, and a given maximum total filter concentration. 【0044】 In one embodiment, the minimum product requirements are of a water-in-oil fluidity formulation type, a specific SPF value and at least a 1 / 3 UVA-PF / SPF ratio, a critical wavelength of at least 370 nm, and a given maximum total filter concentration. 【0045】 According to another embodiment of the present invention, the input data may further include one or more technical requirements to limit the Pareto efficient solutions to meet the one or more technical requirements. 【0046】 By way of example, the one or more technical requirements are as follows: - A solubility model including solubility data of each solid filter in a solvent, - A hypothetical limit of the individual concentration of each solvent, - A hypothetical limit of the individual concentration of each filter, - A hypothetical limit of the total filter concentration, and - A hypothetical limit of the total solvent concentration, may include one or more of the above. 【0047】 For example, in the case of a linear solubility model, i) for a given filter, the total solubility in the solvent mixture is given by the fractional average of the solubility of that filter in each solvent, and ii) the solubility of the individual filters in the solvent does not interfere, that is, it is assumed that i) applies independently to all filters. 【0048】 According to one embodiment of the present invention, the optimization target parameter set includes two or more of the following: minimum required UV filter concentration, filtering efficiency, number of UV filters used, minimum concentration of particulate filter, type of UV filter, minimum concentration of specific UV filter, minimum concentration of specific solvent, concentration of solvent, type of solvent, minimum concentration of solvent, maximum sun protection factor, maximum UVA protection factor, maximum UVA / UVB ratio, maximum UVA1 / UV ratio, maximum blue light protection, maximum environmental friendliness, maximum biodegradability, maximum naturalness, minimum cost of the determination substance composition, and similarity to the provided filter substance composition. 【0049】 The solvent is required to efficiently dissolve the solid UV filter. Examples of solvents used to dissolve the solid UV filter include C12-15 alkyl benzoate, dibutyl adipate, diisopropyl sebacate, dibutyl sebacate, dicaprylyl carbonate, isopropyl palmitate, isopropyl myristate, lauryl lactate, caprylyl capric triglyceride, cetearyl isononanoate, coco glyceride, isononyl isononanoate, propylene glycol dicaprylate / dicaprate, butylene glycol dicaprylate / dicaprate, and the like. 【0050】 The type of filter can mean its solubility, for example, when it is intended to add the filter to the hydrophilic or lipophilic phase of the formulation, or its form, for example, when the filter is particulate or not particulate, or its biodegradation profile, for example, when the filter is mainly readily biodegradable or moderately biodegradable. 【0051】 Examples of UV filters that need to be dissolved are bis-ethylhexyl oxy-phenol methoxy-phenyl triazine, ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, butyl methoxydibenzoylmethane, diethylhexyl butamido triazone. 【0052】 For example, when using "minimize solvent concentration" as the optimization objective parameter, the Pareto efficient solution should ensure that all solid UV filters are dissolved in the solvent. For example, i) for a given filter, the total solubility in the solvent mixture is given by the fractional average of its solubility in each solvent, and ii) the solubility of individual filters in the solvent does not interfere, i.e., a linear solubility model can be used assuming that i) is applied independently to all filters. In other words, when the solvent is used for optimization purposes, the solid UV filters need to be dissolved in an amount of solvent given as either "minimize optimization objective" or "Pareto efficient solution". 【0053】 According to a second aspect of the present invention, a method for manufacturing a sunscreen product is provided, the method comprising: - providing the target performance characteristics of the desired sunscreen product; - based on the target performance characteristics, determining a composition comprising one or more UV filter substances according to the method according to any one of the above claims; - manufacturing a sunscreen product using the composition comprising one or more UV filter substances. This will be described in detail hereinafter, particularly with reference to the example shown in FIG. 6. 【0054】 【0055】 According to one embodiment of the present invention, the method further comprises: - providing the measured performance characteristics of the manufactured sunscreen product; - comparing the measured performance characteristics of the manufactured sunscreen product with the target performance characteristics of the desired sunscreen product to determine whether the manufactured sunscreen product meets predetermined performance quality criteria. This will be described in detail hereinafter, particularly with reference to the example shown in FIG. 6. 【0056】 ​According to a third aspect of the present invention, a method for verifying the validity of manufacturing a sunscreen product is provided. The method includes the following: - providing existing performance characteristics of a sunscreen product produced from one or more substances; - generating a composition based on the existing performance characteristics according to the method of the first aspect and any related examples, wherein the generated composition and the existing sunscreen product include at least one different substance; - producing the generated composition; - comparing the measured performance characteristics of the produced composition with the existing performance characteristics of the sunscreen product to verify the validity of at least one substance; and includes. 【0057】 This will be described in detail hereinafter with particular reference to the example shown in FIG. 7. 【0058】 According to a fourth aspect of the present invention, a determination device for a composition containing one or more UV filter substances is provided. The device includes one or more processing units configured to determine a composition containing one or more UV filter substances for forming a sunscreen composition, and the one or more processing units include instructions for executing the method steps of the method according to the first aspect and any related examples when executed by the one or more processing units. 【0059】 This will be described in detail hereinafter with particular reference to the examples shown in FIGS. 1 and 2. 【0060】 According to a fifth aspect of the present invention, a manufacturing device for a sunscreen product is provided. The device includes a controller module and a manufacturing device. The controller module is configured to control the manufacturing device to manufacture a sunscreen product. 【0061】 This will be described in detail hereinafter with particular reference to the example shown in FIG. 8. 【0062】 According to a sixth aspect of the present invention, there is provided an apparatus for verifying the validity of manufacturing a sunscreen product, the apparatus including one or more processing units configured to verify the validity of the production of the sunscreen product, the processing unit including instructions for performing the method according to the third aspect and any related example when executed by the one or more processing units. 【0063】 This will be described in detail below, particularly with reference to the example shown in FIG. 9. 【0064】 According to a further aspect of the present invention, there is provided a computer program element including instructions for causing a processing unit to perform the steps of the method according to the first aspect and any related example when executed by the processing unit. 【0065】 In one embodiment, the sunscreen product may include a finishing formulation for protecting human skin from ultraviolet rays. The sunscreen contains one or more ultraviolet (UV) filter substances that may include organic and / or inorganic UV filters. In addition, the sunscreen product may contain many other substances such as solvents, emulsifiers, thickeners, waxes, preservatives or stabilizers, fragrances, coloring compounds, and the like. 【0066】 In one embodiment, the input unit may include any item or element that forms a boundary configured to transfer information. Specifically, the input unit may be configured to transfer information onto a computational device, such as on a computer that receives information. The input unit preferably includes one or more separate units configured to receive or transfer information onto a computational device, such as the following: an interface, specifically a web interface and / or a data interface, a keyboard, a terminal, a touch screen, or any other input device considered appropriate by those skilled in the art. More preferably, the input unit includes or is a data interface configured to transfer or exchange information as specifically shown hereinafter in this specification. 【0067】 In one embodiment, the output unit may include any item or element that forms a boundary configured to transfer information. Specifically, the output unit may be configured to transfer information from a computational device, such as a computer that sends or outputs information, onto another device, such as a control unit that controls and / or monitors the production process of a production composition. The output unit preferably includes one or more separate units configured to output or transfer information from a computational device, such as the following: an interface, specifically a web interface and / or a data interface, a screen, a printer, or a touch screen, or any other output device considered appropriate by those skilled in the art. More preferably, the output unit includes or is a data interface configured to transfer or exchange information as specifically shown hereinafter in this specification. 【0068】 Preferably, the input unit and the output unit are configured as at least one or at least two separate data interfaces, that is, preferably provide a data transfer connection, for example, wireless transfer, Internet transfer, Bluetooth, NFC, inductive coupling, etc. As an example, the data transfer connection can be or can include at least one port including one or more of a network port or an Internet port, a USB port, and a disk drive. The output unit and / or the input unit can also be at least one web interface. 【0069】 In one embodiment, the processing unit can mean any logic circuit configured to implement the operation of a computer or system, and / or a device or unit generally configured to perform computational or logical operations. The processing unit can include at least one processor. Specifically, the processing unit can be configured to process the basic instructions that drive a computer or system. By way of example, the processing unit can include at least one arithmetic logic unit (ALU), at least one floating-point unit (FPU), such as a vector processor or a numeric co-processor, a plurality of registers, and memory, such as cache memory. Specifically, the processing unit can be a multi-core processor. The processing unit can include a central processing unit (CPU), and / or one or more graphics processing units (GPU), and / or one or more application-specific integrated circuits (ASIC), and / or one or more tensor processing units (TPU), and / or one or more field-programmable gate arrays (FPGA), etc. The processing unit can be configured to preprocess input data. The preprocessing can include at least one filtering process for input data that meets at least one quality criterion. For example, the input data can be filtered to remove missing variables. Preferably, the input data can be compared with at least one predefined threshold, such as a threshold temperature, in order to determine whether the implementation of method step (ii) is required anyway. Preferably, the processing unit is configured to perform a multi-criteria optimization, preferably a calculation, of an optimization signal consisting of a list of input parameters to yield an optimized target application profile according to the basic model prediction. Preferably, the multi-criteria optimization is a Pareto optimization, and this list consists of Pareto optimal solutions. Further, the optimization signal can contain a complete or approximate representation of the Pareto frontier based on the basic model function. 【0070】 In one embodiment, the computational model may refer to a model used for simulating sunscreen performance based on the calculation of UV transmission of the sunscreen film. The link to the sun protection factor is given by the fact that the reciprocal of the transmittance at a specific wavelength is the factor by which each radiation is attenuated and has the meaning of a monochromatic protection factor. When this monochromatic protection factor is weighted by the erythema action spectrum and the UV light source spectrum within the relevant UV range of 290 - 400 nm, the sun protection factor is obtained. The data of the erythema action spectrum and the UV light source are available from the literature, but the transmittance has to be determined individually for each sunscreen composition. The calculation of the UV transmittance requires the quantitative UV spectrum of the UV filter, for example, with respect to the decadic molar extinction coefficient. It is possible to obtain the effective UV absorbance of the filter composition from such spectral data. However, to obtain the actual UV transmittance, the irregular structure of the sunscreen film formed on the skin has to be considered. In addition, since some UV absorbers are not photostable, information on the photodynamics of the UV filter is also required. The description of the computational model is given in Bernd Herzog and Uli Osterwalder. Simulation of sunscreen performance. Pure Appl. Chem. 2015;87(9 - 10):937 - 951. 【0071】 It should be recognized that all of the above concepts and combinations of other concepts, to be discussed in more detail below (as long as such concepts are not mutually inconsistent), are intended to be part of the subject matter of the invention disclosed herein. Specifically, all combinations of the claimed subject matter appearing at the end of this disclosure are intended to be part of the subject matter of the invention disclosed herein. 【0072】 These and other aspects of the invention will become apparent and be elucidated with reference to the embodiments described hereinafter. 【0073】 In the drawings, the same reference numerals generally denote the same parts throughout the various figures. Also, the drawings are not necessarily to scale; instead, emphasis is generally placed on illustrating the principles of the present invention. 【Brief Description of the Drawings】 【0074】 【Figure 1】 Illustrates a block diagram of an exemplary determination apparatus for a composition containing one or more UV filter substances. 【Figure 2】 Illustrates an exemplary determination system for a composition containing one or more UV filter substances. 【Figure 3】 Illustrates a flowchart describing a computer-implemented method for determining a composition containing one or more UV filter substances. 【Figure 4A】 Illustrates an exemplary implementation form of a user interface in the form of an interactive movable slider. 【Figure 4B】 Illustrates an exemplary implementation form of a user interface in the form of an interactive movable slider. 【Figure 5】 Illustrates navigation on the Pareto front of two minimization objectives A and B. 【Figure 6】 Illustrates a flowchart describing a method for providing the production of a sunscreen product. 【Figure 7】 Shows an example of a flowchart describing a method for confirming the validity of the production of a sunscreen product. 【Figure 8】 Shows an example of a production line for manufacturing a sunscreen product using a monitoring device in combination. 【Figure 9】 Shows another example of a production line for manufacturing a sunscreen product using a validity confirmation device in combination. 【Modes for Carrying Out the Invention】 【0075】 FIG. 1 illustrates a block diagram of an exemplary determination apparatus 10 of a composition containing one or more UV filter substances. Apparatus 10 includes an input unit 12, a processing unit 14, and an output unit 16. 【0076】 Generally, apparatus 10 may include various physical and / or logical components for communicating and operating information, and these may be hardware components (e.g., computing devices, processors, logic devices), executable computer program instructions (e.g., firmware, software) executed by various hardware components, or any combination thereof, depending on a given set of design parameters or performance constraints as desired. Although FIG. 1 may show a limited number of components by way of example, it should be appreciated that more or fewer components may be utilized in a given implementation. 【0077】 In some implementations, apparatus 10 may be embodied as or within a device or apparatus such as a server, workstation, mobile device, etc. Apparatus 10 may include one or more microprocessors or computer processors that execute appropriate software. The processing unit 14 of apparatus 10 may be embodied by one or more of these processors. The software may be downloaded and / or stored in a corresponding memory, such as volatile memory like RAM or non-volatile memory like flash. The software may include instructions for configuring one or more processors to perform the functions described herein. 【0078】 Device 10 can be implemented with or without using a processor, and can also be implemented as a combination of dedicated hardware that implements some functions and a processor (for example, one or more program microprocessors and associated circuits) that implements other functions. It should be noted that, for example, the functional units of device 10, such as input unit 12, one or more processing units 14, and output unit 16, can be implemented in the form of programmable logic, for example, as a field programmable gate array (FPGA) in a device or apparatus. Generally, each functional unit of the device can be implemented in the form of a circuit. 【0079】 In some embodiments, device 10 can also be implemented in a distributed manner. For example, some or all of the units of device 10 are arranged as separate modules in a distributed architecture and can be connected by a suitable communication network, such as a 3rd Generation Partnership Project (3GPP (registered trademark)) network, a Long Term Evolution (LTE) network, the Internet, a LAN (local area network), a wireless LAN (local area network), a WAN (wide area network), etc. 【0080】 Processing unit 14 can execute instructions to implement the methods described herein. This will be described in detail with respect to the example shown in FIG. 3. 【0081】 FIG. 2 shows an exemplary determination system 100 for a composition containing one or more UV filter substances. System 100 includes a data management system 20, a decision support system 30, an electronic communication device 40, and a network 50. In this example, device 10 is implemented as or embodied within decision support system 30, for example, resident in decision support system 30 as software. 【0082】 Example The example data management system 20 can store databases, applications, local files, or any combination thereof. The data management system 20 can include a UV filter substance database that stores information regarding a plurality of UV filter substances and properties. For example, the information can include an identifier of the UV filter substance (e.g., a UV filter substance ID or a common or scientific name of the UV filter substance) and associated properties. Regulatory limits for some UV filter substances in some specific regions can also be included in the UV filter substance database. In some examples, the UV filter substance database can cover all or most of the common UV filter substances. In some examples, the UV filter substance database can be limited to the UV filter substances of a certain provider. Moreover, it is also possible to limit the UV filter substance database to the UV filter substances permitted in a certain jurisdiction. The UV filter substance database can be provided by a third party. However, the user can also create a UV filter substance database suitable for the purpose by scanning the label of the UV filter substance product intended for use and obtaining information regarding the UV filter substance product from the supplier database. Using the latter, the user can also supplement the UV filter substance database with information regarding additional UV filter substances. 【0083】 The exemplary decision support system 30 can be a server that provides a web service to facilitate data management. The decision support system 30 is configured to search for data from the data management system 20 to identify the data to be extracted from the data management system 20, and to provide the retrieved data to the device 10 to process the extracted data according to the method described herein, and may include a data extraction module (not shown). The processed data and the final output of the device 10 can be provided to a user output device (e.g., the electronic communication device 40) and / or an output database (e.g., of the data management system 20). The user output device, e.g., the electronic communication device 40, can include a computer, a smartphone, a tablet, a smartwatch, a monitor, a data storage device, or any other device, whereby a user, including a human and a robot, can receive data from the decision support system. The output database can include any organized data collection, which can be electronically stored and accessed from a computer system and can receive data output or transferred from the decision support system 30. 【0084】 The exemplary electronic communication device 40 can be a desktop, notebook, laptop, mobile phone, smartphone, and / or PDA. The electronic communication device 40 can include an application configured to interface with web services provided by the decision support system 30. The application can be a software application that enables a user to manipulate data extracted by the decision support system 30 from the data management system 20 to select and specifically indicate actions to be performed on the individual data. For example, the application can be a desktop application, a mobile application, or a web-based application. The application can include a user interface such as, but not limited to, a GUI, a character user interface, and an interactive interface such as a touch screen interface. Through the software application, the user can access the decision support system 30 using, for example, username and password authentication to obtain data from the data management system 20 to determine a composition comprising one or more UV filter substances. 【0085】 Example network 50 is communicatively coupled to data management system 20, decision support system 30, and electronic communication device 40. In some examples, network 50 can be the Internet. Alternatively, network 50 can be any other type and number of networks. For example, network 50 can be implemented by several local area networks connected to a wide area network. For example, data management system 20 can be associated with a first local area network, decision support system 30 can be associated with a second local area network, and electronic communication device 40 can be associated with a third local area network. The first, second, and third local area networks can be connected to a wide area network. Of course, any other configuration and topology can be utilized to implement network 50 including any combination of wired networks, wireless networks, wide area networks, local area networks, etc. 【0086】 Figure 3 illustrates a flowchart depicting a computer-implemented method 200 for determining a composition comprising one or more UV filter substances. The exemplary order of steps according to the present disclosure is described below. 【0087】 Method 200 can be performed by a device, and such device 10 is shown in FIG. 1 or FIG. 2. The device can be a computing device or computing system suitable for executing program code associated with the proposed method, regardless of the platform. As a further example, the device can be embodied as or within a computer system. The device can be embodied as or within a remote server that provides a web service to facilitate the determination of a composition comprising one or more UV filter substances. 【0088】 Below, computer-implemented method 200 of FIG. 3 is described in relation to the exemplary computing environment shown in FIG. 2. 【0089】 In block 210, a user can provide data input to the decision support system 30 via the UI of a software application on the electronic communication device 40. 【0090】 The data input includes a screening performance target profile that includes the minimum product requirements of the composition. The minimum product requirements of the composition can be defined by the user via the UI of the application. For example, the UI of the application can provide a list of properties regarding the screening performance target, such as the estimated sun protection factor (SPF), the estimated UVA protection factor (UVA-PF), the critical wavelength, the UVA to UVB protection ratio, the UVA1 to UV protection ratio, blue light protection, radical protection factor, and environmental impact factor. The user can select one or more of these properties as the screening performance target profile. For example, the user can define the following minimum product requirements for the composition: estimated SPF ≥ 50, critical wavelength ≥ 370 nm, and UVA-PF ≥ 17. In addition, the user can define, as the minimum product requirement for a composition containing a solid UV filter, that the solid UV filter needs to be sufficiently dissolved when the minimum solvent concentration is selected for optimization purposes. 【0091】 The data input further includes an optimization objective parameter set that includes two or more optimization objective parameters. The list of optimization objective parameters can be presented on the UI of the software application. For example, the following list of optimization objective parameters can be presented: minimum required UV filter concentration, minimum concentration of a specific UV filter, minimum concentration of particulate filter, filtering efficiency, number of UV filters used, type of filter, solvent concentration, minimum concentration of a specific solvent, type of solvent, minimum concentration of solvent, highest sun protection factor, highest UVA protection factor, highest blue light protection, highest environmental friendliness, highest biodegradability, highest naturalness, minimum cost of the determination substance composition, and similarity to the provided filter substance composition. The user can select two or more optimization objective parameters from the list of optimization objective parameters. 【0092】 Furthermore, when the determination of the optimized solvent concentration is given by Pareto optimization as a solution, the optimized solvent concentration must ensure that the UV filter of the optimized concentration given by Pareto optimization as a solution can be dissolved. An example is given in FIG. 4B. 【0093】 In some examples, the user may select the actual set of UV filter substances to be considered. For example, a list of UV filter substances may be displayed and the user may select the desired UV filter substance. In some examples, the user may select a desired UV filter database, such as a UV filter substance database of a particular provider or a UV filter substance database permitted in a particular jurisdiction or a user-defined UV filter substance database, from the data management system 20. In some examples, the decision support system 30 may extract information regarding the UV filter substance from the default UV filter substance database of the data management system 20. In this case, the user is not required to select a UV filter substance. In some examples, the user may have the opportunity to define at least some minimum and maximum amounts of the UV filter substance. In some examples, the data support system may define the maximum amount of the substance in accordance with the regulatory limits of the UV filter substance database of the data management system 20. 【0094】 In block 220, after the user provides the decision support system 30 with a screening performance target profile and an optimization objective parameter set, the processing unit 12 of the device 10 implements a multi-objective optimization process in a computational model to determine a set of Pareto-efficient solutions. Each solution is a substance composition that forms a composition such that the composition meets the minimum product requirements. Each solution is Pareto-efficient with respect to the optimization objective parameter set. Each substance composition may include one or more UV filter substances and additionally one or more other components such as emollients. 【0095】 Pareto optimality, as used herein, means the concept that a solution is a Pareto improvement if a change to a different solution makes at least one objective better without making any other objective worse. A Pareto improvement is Pareto optimal or Pareto efficient if no further Pareto improvements can be made. By using the Pareto frontier to limit attention to Pareto optimal sets of objectives, a chemist can make trade - offs within such sets without considering the full range for any parameter. 【0096】 The Pareto frontier is the set of Pareto optimal solutions in an N - dimensional objective space in light of a defined evaluation method for those solutions. For the purpose of forming an optimization signal, the N - dimensional Pareto frontier includes a collection of optimization signals adapted to the objectives of the optimization. 【0097】 In practice, model - based prediction is often done by a model that includes a dimensionality reduction algorithm. Examples are principal component regression models or partial least - squares models. In these models, so - called latent variables are formed, and the target variables that later serve the role of optimization objectives are modeled as functions of these latent variables rather than as functions of the original input variables. If the dimension of the space defined by the latent variables is smaller than the dimension of the space defined by the original input parameters of the considered system, the model exhibits the feature of dimensionality reduction and is called a degenerate model. This degeneracy has technical consequences. If a real - world system is described by a degenerate model with sufficient accuracy, it is possible to systematically vary the original input parameters such that no target variable of interest changes significantly. 【0098】 The space defined by the set of all possible accessible points in the input space having such properties is called the "invariant subspace". In the proposed approach, the principle of statistical optimality on the invariant subspace is combined with applying constraints to the original input parameter space so as to obtain a set of input parameters suitable for sunscreen product design. The input parameters, sometimes referred to as design parameters, are determined in such a way that the resulting set of input parameters exhibits optimal statistical variability while the target objective variable (i.e., the optimization target parameter, the optimization signal) exhibits theoretically zero or practically technically very little variability. The results generated by the proposed approach can be used to cover not only one or very few lead formulations but also the entire class of formulations covered by the invariant subspace. 【0099】 Preferably, the GUI enables the user to navigate the interpolation solution by moving the slider corresponding to the objective. Exemplary realizations of the user interface are shown in FIGS. 4A - 4B. 【0100】 In block 230, information regarding at least one of the decision Pareto - efficient material compositions is provided such that it is presented, for example, on the UI of the software application of the electronic communication device 40 or to the data management system 20. In some examples, at least one of the decision material compositions can be randomly selected by the device 10. In some examples, at least one of the decision material compositions can be selected according to predefined rules. For example, the UV filter combination can be selected and presented according to filtering efficiency or minimum UV filter concentration. The output information can further include the amount (concentration) of each substance. In some examples, the output information can include a number of properties characterizing the composition, and such properties can include one or more of achieved performance, UVA - PF / SPF ratio, total solvent concentration, and total UV filter substance concentration. The information can preferably be used to guide the production of sunscreen products. 【0101】 Sun protection products can be formulated as a fluid or creamy water-in-oil emulsion, etc. When applied, the formulation forms a thin film on the skin surface to provide UV protection. Other formulation types include, but are not limited to, oil-in-water emulsions, water-in-oil-in-water emulsions, oil-in-water-in-oil emulsions, silicone-in-water emulsions, water-in-silicone emulsions, polymeric gel creams, lipophilic single-phase oils, lipophilic single-phase gels, lipophilic single-phase sticks, lipophilic alcoholic mixtures, hydrophilic single-phase fluids, hydrophilic single-phase gels, and powders. The formulation can be a spray, cream, lotion, mousse (foam), or powder, and can accordingly be packed in a bottle, jar, pump spray, or aerosol with a suitable applicator. Different formulations of the same UV filter composition can exhibit different sun protection performances because the vehicle used in the composition can affect sun protection performance. In some examples, the computer-implemented method 200 described above can determine the composition according to a specific formulation type (e.g., water-in-oil fluid emulsion, water-in-oil creamy emulsion, etc.). For example, a user can define or select a desired formulation type (e.g., water-in-oil fluid emulsion, water-in-oil creamy emulsion, etc.) via the UI of a software application on the electronic communication device 40. Then, the processing unit 12 of the device 10 determines a set of Pareto-efficient solutions in a computational model that implements a multi-objective optimization process. Each solution is a material composition that forms a composition that meets the minimum product requirements for the desired formulation type. Then, information regarding at least one of the determined Pareto-efficient material compositions of the desired formulation type is provided, for example, on the UI of a software application of the electronic communication device 40 or to the data management system 20. By considering the specific formulation type during the determination of the composition, the difference between the target sun protection performance and the in vivo measured sun protection performance can be reduced, so that extensive in vivo tests can be reduced at the user level. 【0102】 Figures 4A-4B show possible implementations of the user interface 60 in the form of an interactive movable slider. In the example of Figure 4A, three exemplary U filter substances and two optimization objectives are considered. The three exemplary UV filter substances are DHHB (INCI: Diethylamino hydroxybenzoyl hexyl benzoate) (the maximum concentration allowed in Europe is 10%), EHT (INCI: Ethylhexyl triazone) (the maximum concentration allowed in Europe is 5%), and MBBT (INCI: Methylene bis-benzotriazolyl tetramethylbutylphenol) (the maximum concentration allowed in Europe is 10%). The two exemplary optimization objectives are filtering efficiency and minimum solvent concentration. By moving one of the target sliders, the other is automatically adjusted by the system to track the Pareto frontier. At the same time, the amount of UV filter substance resulting in the corresponding position on the Pareto frontier is calculated and suggested by the automatic positioning of the input slider. In this example, the regulatory limits of the three exemplary UV filter substances in a specific region are also specifically shown. 【0103】 In the example shown in Figure 4B, the two optimization objectives are the minimum UV filter concentration and the minimum solvent concentration. The minimum product requirements are as follows: at least 30 SPF, at least 10 UVA-PF, at least 370 nm critical wavelength, and the need to dissolve all solid UV filters. The UV filter substances are DHHB, EHT, BEMT (INCI: bis-ethylhexyl oxy-phenol methoxyphenyl triazine), and DBT (INCI: diethylhexyl butamidotriazone). All are solid UV filters. By moving one of the objective sliders, the other is automatically adjusted by the system to track the Pareto frontier. At the same time, the amount of UV filter substance that results in the corresponding position on the Pareto frontier is calculated and suggested by the automatic positioning of the input slider. The right-angled triangles on each side of the slider can limit the range of the corresponding optimization objective or determined substance concentration. In this example, the optimized concentrations of four emollients including cetyl alcohol AB (INCI: C12-15 alkyl benzoate), cetyl alcohol B (INCI: dibutyl adipate), myritol 331 (INCI: coco glyceride), and cetyl alcohol CC (INCI: dicaprylyl carbonate) are also shown. Each Pareto efficient solution ensures that all solid UV filters (DHHB, BEMT, DBT, EHT) are dissolved at the determined Pareto efficient solvent concentration. 【0104】 Table 1 shows examples of Pareto frontier optimal solutions for sunscreens with SPF50 and at least 1 / 3 UVA-PF / SPF protection. In the example of Table 1, the Pareto frontier optimal solutions are as follows: - Minimum product requirements: Technical requirements that for a specific selection of UV filter combinations, there must be at least 50 SPF and at least 1 / 3 UVA-PF / SPF protection, and the solid UV filters at the determined concentration of the Pareto efficient solution must be dissolved in the solvent. - Optimization objective parameters: Minimum filter concentration and minimum solvent concentration. are obtained based on. 【0105】 Using a linear solubility model that includes the solubility of each solid UV filter in each solvent, the technical requirement is defined that the solid UV filter at the Pareto-efficient solution determination concentration must be soluble in the solvent at the Pareto-efficient solution determination concentration. 【0106】 【Table 1】 【0107】 The optimization signal can be a finite set of points that approximate the Pareto set within a certain accuracy. To assist the decision-making process, it would be preferable to enable real-time navigation on the continuous Pareto set via the UI of the software application. Thus, linear interpolation between points on the Pareto set can be performed. This interpolation is performed not only in the objective space defined by the optimization objective parameter set but also in the design space defined by the substances. The UI of the software application can enable the user to navigate the interpolated solutions by moving the sliders corresponding to the optimization objective parameters. 【0108】 One way the objective slider functions is illustrated in FIG. 5 for the simple case of two optimization objective parameters. When changing one objective slider, the linear problem can be solved to explicitly change all the remaining optimization objective parameters. In this way, the complete Pareto set is navigable and the trade-off between different optimization objective parameters can be visually explored. This visual exploration can be done in two ways. That is, on the one hand, when moving one slider, the displacement of the other slider occurs according to the shape of the Pareto set. Such an interaction between values on the slider makes it possible to indicate the best compromise point of conflicting optimization objectives. On the other hand, the user can limit the range of the slider. Limiting the range of one optimization objective parameter will generally also affect the range of the other optimization objective parameters. Such a restriction of the decision space is also visualized and information is obtained about which alternatives remain feasible and which become infeasible. 【0109】 In another example, it would be possible to limit the range of the slider of the determined concentration of a substance composition, for example the concentration of one or more UV filters (see, for example, solution 3 in Table 1). 【0110】 FIGS. 4A and 4B can illustrate exemplary user interfaces in the form of interactive movable sliders by way of example, recognizing that other types of graphical control elements such as scroll bars can be utilized for a given implementation. 【0111】 FIG. 6 illustrates a flowchart depicting a method 300 for providing the manufacture of a sunscreen product. 【0112】 In block 310, for example, the target performance characteristics of a desired sunscreen product are provided via the UI of a software application on the electronic communication device 40 shown in FIG. 2. Examples of target performance characteristics include, but are not limited to, estimated sun protection factor (SPF), estimated UVA protection factor (UVA-PF), critical wavelength, UVA to UVB protection ratio, UVA1 to UV protection ratio, blue light protection, radical protection factor, and environmental impact factor. The user may have the opportunity to select one or more of these properties as a sunscreen performance target profile presented on the UI of the software application. 【0113】 In block 320, for example, by the apparatus 10 shown in FIGS. 1 and 2, a composition comprising one or more UV filter substances and optionally one or more solvents is determined according to the method described herein based on the target performance characteristics. Information regarding the composition may include identifiers of the substances in the determined composition (e.g., substance ID or common name or scientific name) and the amount of each substance in the composition (e.g., percentage relative to the finished formulation). 【0114】 Since different formulation types of the same UV filter composition can exhibit different sun protection performances, the target performance characteristics can be defined for a specific formulation type (e.g., oil-in-water fluid emulsion, oil-in-water creamy emulsion, etc.). In this example, the composition can be determined based on the target performance characteristics and the specific formulation type so as to reduce the difference between the target sun protection performance and the in vivo measured sun protection performance. Examples of formulation types include, but are not limited to, oil-in-water fluid emulsion, oil-in-water creamy emulsion, water-in-oil emulsion, oil-in-water-in-oil emulsion, water-in-oil-in-water emulsion, silicone-in-water emulsion, water-in-silicone emulsion, polymeric gel cream, lipophilic single-phase oil, lipophilic single-phase gel, lipophilic single-phase stick, lipophilic alcoholic mixture, hydrophilic single-phase fluid, hydrophilic single-phase gel, and powder. 【0115】 In some examples, other properties characterizing the composition can be provided based on the substances of the composition and the amounts of each substance in the composition. Examples of properties can include, but are not limited to, UVA protection pass / fail indication of the label category SPF or UVA-PF and the critical wavelength according to the definition of the EC recommendation of September 22, 2006. The information can be preferably used to guide the production of sunscreen products. 【0116】 In block 330, a sunscreen product is manufactured using a composition containing one or more UV filter substances. 【0117】 In block 340, the measured performance characteristics of the manufactured sunscreen product are provided. For example, the measured performance characteristics can include numerous properties such as achieved performance (SPF and / or UVA-PF), UVA / SPF ratio, total UV filter substance concentration, etc. 【0118】 In block 350, the measured performance characteristics of the manufactured sunscreen product are compared with the target performance characteristics of the sunscreen product to determine whether the manufactured sunscreen product meets a predetermined performance quality standard. 【0119】 The comparison can be performed by comparing one or more physical, chemical, or physicochemical properties related to the performance characteristics. For example, the target SPF can be compared with the measured SPF. The calculated critical wavelength can be compared with the measured critical wavelength of the composition. 【0120】 The target performance characteristics can be mapped to the measured performance characteristics. In other words, the values corresponding to the performance characteristics can be determined from the target performance characteristics. In other embodiments, the measured performance characteristics can be mapped to the target performance characteristics. Both options are equally applicable. 【0121】 The target performance characteristics and the measured performance characteristics or any corresponding values derived therefrom are used for validation. Such validation can be performed by comparing the values or value ranges. 【0122】 When the value is within an acceptable range or value, for example, within one or two standard deviation intervals, the measured production composition may be valid in the sense that it meets one or more performance criteria. When the value is not within the acceptable range, for example, not within one or two standard deviation intervals, the measured production composition may not be valid in the sense that it does not meet one or more performance criteria. 【0123】 When the production composition is valid, in block 360, for example, a control signal to the production process can be triggered. Such a control signal can be associated with the composition of the production product. It can control the input equipment according to the input of different substances of the manufactured product in the production process. 【0124】 When the manufactured product is not valid, in block 370, for example, a warning signal to the operator of the production process can be triggered. Such a warning signal can be an indicator of the invalidity of the manufactured product. If it is invalid, a stop signal to the production process can be triggered. In such a case, the optimization signal for the production of the manufactured product can be updated to achieve the target performance characteristics of the production product. 【0125】 Figure 7 shows an example of a flowchart depicting a method 400 for verifying the validity of the manufacture of a sunscreen product. 【0126】 In block 410, existing performance characteristics of a sunscreen product manufactured from one or more substances (for example, one or more measured physical, chemical, and / or physicochemical properties) are provided. Examples of existing performance characteristics can include one or more of SPF, UVA-PF, critical wavelength, UVA-to-UVB protection ratio, UVA1-to-UV protection ratio, blue light protection, radical protection factor, and environmental impact factor. 【0127】 In some examples, the existing performance characteristics of a specific formulation type can be provided. For example, if an existing sunscreen product is formulated as an oil-in-water cream emulsion, the existing performance characteristics can be defined as the performance characteristics of the oil-in-water cream emulsion formulation. 【0128】 In block 420, a composition is generated according to the method described herein based on the existing performance characteristics. The generated composition and the existing production sunscreen product include at least one different substance, for example, to exchange substances in the sunscreen product. The exchange of substances may be desired for various reasons such as the existence of competing intellectual property rights, regulatory issues in different countries, and lack of resources. 【0129】 In some examples, the composition can be determined based on the target performance characteristics and the specific formulation type (e.g., oil-in-water cream emulsion) to reduce the difference between the target sun protection performance and the in vivo measured sun protection performance. 【0130】 In block 430, a product is manufactured based on the generated composition. 【0131】 In block 440, the performance characteristics of the manufactured product are compared with the existing performance characteristics of the sunscreen product to confirm the validity of at least one different substance. If the comparison is within an acceptable range, at least one new substance is valid. On the other hand, if the comparison is not within an acceptable range, at least one new different substance is not valid. 【0132】 If at least one different substance is valid, in block 450, for example, a control signal can be generated and triggered to a production process based on at least one substance. Such a control signal can be associated with the composition of a sunscreen product containing at least one new substance. It can control the input equipment configured to input different substances of the sunscreen product in the production process. 【0133】 If at least one different substance is not appropriate, at block 460, for example, a warning signal to the operator of the production process can be triggered. Such a warning signal can be an indicator that at least one new substance is not valid. This can trigger a stop signal to the production process. 【0134】 FIG. 8 shows an example of a production line 500 for manufacturing a sunscreen product using a monitoring device 520 in combination. 【0135】 The production line 500 can include input equipment 510 configured to input different substances of the sunscreen product during the manufacturing process. The production line 500 can include, for example, a conveyor system 530 that conveys bottles, plastic packages, or other packages suitable for filling the sunscreen product. The production line 500 can include monitoring equipment 520 configured to monitor the quality of the sunscreen product during the production process. 【0136】 The monitoring equipment 520 and / or the input equipment 510 can be configured to receive the target performance characteristics of the sunscreen product. The target performance characteristics can specifically indicate the composition data of a sunscreen product containing one or more UV filter substances. The target performance characteristics can include quality criteria such as SPF. The monitoring equipment 520 can be configured to provide the composition data to the input equipment. The input equipment 510 can be configured to control the input based on the provided composition data. 【0137】 The monitoring equipment 520 can be configured to measure one or more performance characteristics of the produced product. The monitoring equipment 520 can be configured to compare either a physiochemical property or any value derived from the physiochemical property with the measured performance characteristics. If the comparison is within an acceptable range or value, the production composition meets the quality criteria. If the comparison is not within the acceptable range or value, the production composition does not meet the quality criteria. In the latter case, the monitoring unit can be configured to notify the operator or provide adjusted composition data to the input equipment 510. 【0138】 FIG. 9 shows another example of a production line 600 for manufacturing a sunscreen product using the validity confirmation device 610 in combination. 【0139】 The production line 600 may include input equipment 620 configured to input different substances of the sunscreen product in the production process. The production line 600 may include, for example, a conveyor system 630 that conveys bottles, plastic packages, or other packages suitable for filling the sunscreen product. The production line 600 may include a validity confirmation device 610 configured to confirm the validity of the production of the sunscreen product. 【0140】 The validity confirmation device 610 may be configured to receive the existing performance characteristics (such as SPF, UVA-PF, etc.) of the sunscreen product. The validity confirmation device 610 may be configured to generate an optimization signal based on the existing performance characteristics. The optimization signal may include information regarding at least one new substance. The validity confirmation device 610 may be configured to confirm the validity of at least one new substance for the production of the sunscreen product. The validity confirmation device 610 may be configured to compare the performance characteristics of the sunscreen product produced using the new optimization signal with the existing performance characteristics. The validity confirmation device 610 may be configured to provide composition data including at least one new substance to the input equipment. The composition data may include the amount of at least one new substance. 【0141】 Combinations and modifications of the embodiments shown in FIGS. 8 and 9 are similarly possible. Both of these methods illustrate the strengths of the methods described herein. This enables a simpler and more reliable production through monitoring the production of the sunscreen product or through validating the validity of new substances used in the manufacture of the sunscreen product. 【0142】 In another exemplary embodiment of the present invention, there is provided a computer program or a computer program element characterized by being adapted to execute the method steps of the method according to one of the above embodiments on a suitable system. Accordingly, the computer program element can be stored on a computer unit which can also be part of an embodiment of the present invention. The computing unit can be adapted to perform or induce the performance of the method steps described above. Moreover, it can be adapted to operate the components of the device described above. The computing unit can be adapted to automatically operate and / or execute user commands. The computer program can be loaded into the working memory of a data processor. For this purpose, the data processor can be equipped to perform the method of the present invention. 【0143】 This exemplary embodiment of the present invention covers both a computer program for using the present invention from scratch and a computer program for converting an existing program into a program using the present invention by utilizing updates. 【0144】 Furthermore, the computer program element may be able to provide all the steps necessary to fulfill the procedure of the exemplary embodiment of the method described above. According to a further exemplary embodiment of the present invention, a computer-readable medium such as a CD-ROM is presented, in which case the computer-readable medium stores the computer program element, and the computer program element is as described in the above section. 【0145】 The computer program can be stored and / or distributed on a suitable medium such as an optical storage medium or a solid-state medium, supplied together with or as part of other hardware, but can also be distributed in other forms, for example, via the Internet or other wired or wireless telecommunication systems. 【0146】 However, a computer program can also be presented via a network such as the World Wide Web and can be downloaded from such a network into the working memory of a data processor. According to a further exemplary embodiment of the invention, there is provided a medium that makes available a computer program element that is arranged to carry out the method according to one of the embodiments of the invention described above.

Claims

[Claim 1] A computer implementation method (200) for determining a composition containing one or more UV filter materials, wherein: a) Below: - Sunscreen performance target profile including minimum product requirements for the composition, and - An optimization objective parameter set containing two or more optimization objective parameters, The steps include providing input data including via an input unit (210), b) A step (220) in which a multi-objective optimization process is performed by a processing unit in a computational model to determine a set of Pareto-efficient solutions, - Each solution is a material composition that forms the composition such that the composition satisfies the minimum product requirements, and - Each solution is Pareto efficient with respect to the set of optimization objective parameters, step (220), c) A method comprising the step (230) of providing via an output unit at least one of the determined material compositions which is preferably usable to guide the production of a sunscreen product. [Claim 2] The computer implementation method according to claim 1, wherein the input data further includes one or more technical requirements and restricts the Pareto efficient solution to satisfy the one or more technical requirements. [Claim 3] The one or more of the above technical requirements are as follows: - A solubility model that includes solubility data for each solid filter in one or more solvents. - Assumed limits for the individual concentrations of each solvent, - Assumed limits for the individual concentrations of each filter, - Assumed limits for total filter concentration, and - Assumed limit of total solvent concentration, The computer implementation method according to claim 2, comprising one or more of the above. [Claim 4] Each substance composition is as follows: - One or more UV filter materials, - One or more UV filter materials and one or more solvents, - One or more UV filter materials of a certain formulation type, and, - One or more UV filter materials of a certain formulation type and one or more solvents, The computer implementation method according to claim 1, comprising at least one of the following. [Claim 5] below: - A computer implementation method according to claim 1, further comprising providing a graphical user interface GUI for Pareto front visualization, wherein the GUI provides an interactive user interface (60) that enables the user to navigate the determined Pareto efficient solution set via adjustment of the optimization objective parameter set and / or adjustment of formulation in at least one of the determined material compositions. [Claim 6] The computer implementation method according to claim 5, wherein interpolation is performed between points in the determined set of Pareto efficient solutions, and the GUI provides the interactive user interface that enables the user to navigate the interpolated Pareto efficient solutions. [Claim 7] The minimum product requirements for the aforementioned composition are as follows: - Sun Protection Factor SPF, - UVA Protection Factor (UVA-PF) - critical wavelength, - UVA vs. UVB protection ratio, - UVA1 to UV protection ratio, - Blue light protection, - Radical protection factor, - Limit concentration of substance - Formulation type, and - Environmental impact factor, The computer implementation method according to claim 1, comprising one or more of the above. [Claim 8] The aforementioned set of parameters for optimization purposes is as follows: - Minimum required UV filter concentration, - Filtering efficiency, - Number of UV filters used, - The type of filter used, - Solvent concentration, - The type of solvent used, - Minimum solvent concentration, - Highest sun protection factor, - Highest UVA protection factor, - Superior blue light protection, - Highest environmental friendliness, - Highest biodegradability, - maximum naturalness, - Minimizing the cost of the aforementioned material composition, and - Similarity to the provided filter material composition, The computer implementation method according to claim 1, comprising two or more of the above. [Claim 9] A method (300) for manufacturing a sunscreen product, wherein: - Step (310) of providing the target performance characteristics of the desired sunscreen product, - A step (320) of determining a composition comprising one or more UV filter materials according to the method of claim 1 based on the target performance characteristics, - A step (330) of manufacturing a sunscreen product using the composition containing one or more UV filter substances, A method including (300). [Claim 10] below: - Step (340) of providing the measurement performance characteristics of the manufactured sunscreen product, - A step (350) of comparing the measured performance characteristics of the manufactured sunscreen product with the target performance characteristics of the desired sunscreen product to determine whether the manufactured sunscreen product meets predetermined quality standards, The method according to claim 9, further comprising: [Claim 11] A method (400) for verifying the validity of the manufacture of sunscreen products, the following: - A step (410) of providing existing performance characteristics of a sunscreen product produced from one or more substances, - Step (420) of generating a composition based on the existing performance characteristics according to claim 1, wherein the generated composition and the existing produced sunscreen product comprise at least one different substance, - A step (430) of producing a product based on the composition generated, - A step (440) to confirm the validity of the at least one substance by comparing the measured performance characteristics of the produced product with the existing performance characteristics of the sunscreen product, A method including (400). [Claim 12] An apparatus (10) for determining a composition comprising one or more UV filter materials, wherein the apparatus comprises one or more processing units configured to determine a composition of filter materials to form a sunscreen composition, and the one or more processing units include instructions for performing the steps of the method according to claim 1 when performed in the one or more processing units. [Claim 13] Equipment for manufacturing sunscreen products, including: - Controller module (520), and - Manufacturing device (510), Includes, The controller module is configured to control the manufacturing device for manufacturing the sunscreen product described in claim 9. [Claim 14] Apparatus (610) for verifying the manufacture of a sunscreen product, comprising one or more processing units configured to verify the manufacture of a sunscreen product, wherein the processing units include instructions for performing the method of claim 11 when performed in the one or more processing units. [Claim 15] A computer program element comprising an instruction causing a processing unit to perform the steps of the method according to claim 1 when executed by the processing unit.

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