Liquid compositions for contact lenses and contact lens products

Abstract

The present invention provides a liquid composition for contact lenses and a contact lens product comprising a first hydrophilic component, a second hydrophilic component, inorganic salts, and liquid water. [Solution] The content of the first hydrophilic component is 1% by weight or less. The first hydrophilic component is a polymer having a phosphorylcholine group and a first weight-average molecular weight of 4,000 Da or more. The content of the second hydrophilic component is 1% by weight or less. The second hydrophilic component is hyaluronic acid or a salt thereof and a second weight-average molecular weight of 10,000 Da or less.

Description

[Technical Field]

[0001] The present invention relates to liquid compositions, and more particularly to liquid compositions for contact lenses and contact lens products. [Background technology]

[0002] Conventional liquid compositions for contact lenses typically contain hydrophilic components to improve the lens's moisture retention. However, these compositions often fail to effectively maintain moisture on the lens surface during prolonged wear, leading to dryness and discomfort for the wearer. While the hydrophilic components in currently available liquid compositions can provide some moisturizing effect in the short term, their effect gradually weakens over time, failing to meet the requirements for long-term wear. Furthermore, conventional technologies have not offered a solution that effectively combines multiple components to simultaneously improve moisture retention and water-locking effects. Therefore, there is an urgent need to develop improved liquid compositions that can maintain the moisture retention and comfort of contact lenses for extended periods, thereby reducing the occurrence of dry eye problems during long-term contact lens wear. [Overview of the project] [Problems that the invention aims to solve]

[0003] The technological problem that this invention aims to solve is to provide a liquid composition for contact lenses and a contact lens product that addresses the shortcomings of the prior art. [Means for solving the problem]

[0004] To solve the above technical problems, one of the technical means employed by the present invention is to provide a liquid composition for contact lenses comprising 1% by weight or less of a first hydrophilic component, 1% by weight or less of a second hydrophilic component, 5% by weight or less of inorganic salts, and 80% by weight or more of liquid water. The first hydrophilic component is a polymer having a phosphorylcholine group and a first weight-average molecular weight of 4,000 Da or more, and the second hydrophilic component is hyaluronic acid or a salt thereof and a second weight-average molecular weight of 10,000 Da or less.

[0005] Preferably, the first hydrophilic component is at least one homopolymer and copolymer having a phosphorylcholine group.

[0006] Preferably, the homopolymer having the phosphorylcholine group is poly(2-methacryloyloxyethylphosphocholine), and the copolymer having the phosphorylcholine group is formed by copolymerizing 2-methacryloyloxyethylphosphocholine with methacrylate, wherein the methacrylate is an alkyl methacrylate having a C2-C12 alkyl group or a hydroxyalkyl methacrylate having a C2-C12 hydroxyalkyl group.

[0007] Preferably, the first weight-average molecular weight of the first hydrophilic component is 4,000 Da to 1,000,000 Da, and the second weight-average molecular weight of the second hydrophilic component is smaller than that of the first, with the second weight-average molecular weight being 5,000 Da or less.

[0008] Preferably, the first weight-average molecular weight of the first hydrophilic component is 100,000 Da to 1,000,000 Da, and the second weight-average molecular weight of the second hydrophilic component is 3,000 Da or less.

[0009] Preferably, the second hydrophilic component is a sodium salt or a potassium salt of hyaluronic acid.

[0010] Preferably, the second hydrophilic component is a sodium salt of hyaluronic acid, and the second weight-average molecular weight of the second hydrophilic component is 1,000 Da or less.

[0011] Preferably, the second hydrophilic component is small molecule sodium hyaluronate or hydrolyzed sodium hyaluronate.

[0012] Preferably, with the total weight of the liquid composition for contact lenses being 100% by weight, the content of the first hydrophilic component is 0.005% to 1% by weight, the content of the second hydrophilic component is 0.005% to 1% by weight, the content of the inorganic salts is 0.01% to 5% by weight, and the content of the liquid water is 90% or less by weight.

[0013] Preferably, the content of the first hydrophilic component is 0.05% to 1% by weight, and the content of the second hydrophilic component is 0.01% to 0.08% by weight.

[0014] Preferably, the first molar concentration of the first hydrophilic component is 1 × 10⁻⁶. -8 mol / L ~ 2.5 × 10 -4 The concentration is mol / L, and the second molar concentration of the second hydrophilic component is 5 × 10⁻⁶. -7 mol / L ~ 6 × 10 -5 It is mol / L.

[0015] Preferably, the inorganic salts include chloride salts and buffer salts, the chloride salts include at least one of sodium chloride (NaCl), potassium chloride (KCl), and magnesium chloride (MgCl2), and the buffer salts include at least one of boric acid or its salts, phosphoric acid or its salts, carbonic acid or its salts, citric acid or its salts.

[0016] To solve the above technical problems, another technical means employed by the present invention is to provide a contact lens product comprising a packaging container, the above-mentioned liquid composition for contact lenses filled in the packaging container, and a contact lens immersed in the liquid composition for contact lenses. The contact lens is a hydrogel lens or a silicone hydrogel lens. [Effects of the Invention]

[0017] One of the advantageous effects of the present invention is that the liquid composition for contact lenses and the contact lens products according to the present invention can significantly improve the moisturizing properties of the surface of contact lenses due to the following technical characteristics: "The liquid composition for contact lenses contains 1% by weight or less of a first hydrophilic component and 1% by weight or less of a second hydrophilic component, the first hydrophilic component is a polymer having a phosphorylcholine group and having a first weight-average molecular weight of 4,000 Da or more, and the second hydrophilic component is hyaluronic acid or a salt thereof and having a second weight-average molecular weight of 10,000 Da or less." In particular, the liquid composition for contact lenses of the present invention, by combining a polymer having a phosphorylcholine group with hyaluronic acid (or a salt thereof) in a specific amount and with a low molecular weight, can provide superior moisturizing properties and a water-locking moisturizing effect on the surface of contact lenses compared to conventional liquid compositions for contact lenses. [Modes for carrying out the invention]

[0018] Please refer to the following detailed description of the present invention for a better understanding of its features and technical content. However, the detailed description provided is for reference and illustrative purposes only and is not intended to limit the scope of the claims of the present invention.

[0019] Hereinafter, embodiments of the present invention will be described according to certain specific embodiments, and those skilled in the art can understand the advantages and effects of the present invention based on the content disclosed in this specification. The present invention can be implemented or applied according to other different specific embodiments, and for each detail in this specification, various modifications and changes can be made based on different viewpoints and uses without departing from the concept of the present invention.

[0020] Based on the following embodiments, the technical content of the present invention will be described in more detail, but the protection scope of the present invention is not limited by the disclosed content.

[0021] It should be understood that in this specification, terms such as "first", "second", "third", etc. may be used to describe various materials or parameters, but these materials or parameters are not limited by these terms. These terms are mainly used to distinguish one material from another material, or one parameter from another parameter. Also, the term "or" used in this specification may include any one or a combination of multiple items listed in relation to the actual situation.

[0022] [First Embodiment] The first embodiment of the present invention provides a liquid composition for contact lenses, which includes a first hydrophilic component (first moisturizing component), a second hydrophilic component (second moisturizing component), inorganic salts, liquid water, and optionally other additive components. The liquid composition for contact lenses is particularly suitable for use as a storage solution, maintenance solution, and cleaning solution for contact lenses.

[0023] <The First Hydrophilic Component> The first hydrophilic component is a homopolymer having a phosphorylcholine group. In certain embodiments of the present invention, the first hydrophilic component is at least one of a homopolymer having a phosphorylcholine group and a copolymer having a phosphorylcholine group.

[0024] Here, the polymer having the phosphorylcholine group is poly(2-methacryloyloxyethyl phosphorylcholine), poly-MPC. The copolymer having the phosphorylcholine group is formed by copolymerizing 2-methacryloyloxyethyl phosphorylcholine (MPC) and methacrylate (methacrylic acid ester).

[0025] For example, the methacrylate may be an alkyl methacrylate or a hydroxyalkyl methacrylate.

[0026] Alkyl methacrylate has a C2-C12 alkyl group and may be n-butyl methacrylate (BMA), 2-ethylhexyl methacrylate (EHMA), isodecyl methacrylate (IDMA), or lauryl methacrylate (LMA).

[0027] Furthermore, the hydroxyalkyl methacrylate may have a C2-C12 hydroxyalkyl group and may be 2-hydroxyethyl methacrylate (HEMA) or 2,3-dihydroxypropyl methacrylate (DHPM).

[0028] In the copolymer having the phosphorylcholine group, the number of moles of 2-methacryloyloxyethylphosphocholine (MPC) is greater than the number of moles of methacrylate, but the present invention is not limited thereto.

[0029] In one embodiment of the present invention, the first hydrophilic component (polymer having a phosphorylcholine group) is a copolymer of 2-methacryloyloxyethyl phosphocholine (MPC) and n-butyl methacrylate (BMA) (i.e., poly(MPC-co-BMA), PMB), but the present invention is not limited thereto.

[0030] For example, the first hydrophilic component (polymer having a phosphorylcholine group) applied to the present invention may include, for example, poly(MPC-co-BMA), poly(MPC-co-EMHA), poly(MPC-co-IDMA), poly(MPC-co-LMA), poly(MPC-co-HEMA), poly(MPC-co-DHPM), etc.

[0031] Furthermore, the first hydrophilic component has a first weight-average molecular weight. The first weight-average molecular weight (Mw1) of the first hydrophilic component (polymer having a phosphorylcholine group) is 4,000 Da (i.e., dalton) or more, preferably 4,000 Da to 1,000,000 Da, and particularly preferably 100,000 Da to 1,000,000 Da.

[0032] It should be noted that the molecular weight (weight-average molecular weight) mentioned in the examples of the present invention is measured, for example, by gel permeation chromatography (GPC) according to the ASTM D3593-80 standard test method, but the present invention is not limited thereto.

[0033] With the total weight of the liquid composition for contact lenses being 100% by weight, the content of the first hydrophilic component (polymer having a phosphorylcholine group) is preferably 0.005% to 1.0% by weight (i.e., 50 to 10,000 ppm), more preferably 0.05% to 1.0% by weight (i.e., 500 to 10,000 ppm), and particularly preferably 0.1% to 1.0% by weight (i.e., 1,000 to 10,000 ppm), but the present invention is not limited thereto.

[0034] <Second hydrophilic component> Furthermore, the second hydrophilic component is hyaluronic acid or hyaluronic acid salt.

[0035] Here, the hyaluronic acid is also called hyaluronan. The hyaluronic acid salt may be, for example, the sodium salt of hyaluronic acid (i.e., sodium hyaluronate) or the potassium salt of hyaluronic acid (i.e., potassium hyaluronate).

[0036] Furthermore, the second hydrophilic component has a second weight-average molecular weight, and the second weight-average molecular weight is smaller than the first weight-average molecular weight of the first hydrophilic component. Here, the second weight-average molecular weight (Mw2) of the second hydrophilic component (hyaluronic acid or its hyaluronic acid salt) is 10,000 Da or less, preferably 5,000 Da or less, particularly preferably 3,000 Da or less, and especially preferably 1,000 Da or less.

[0037] In one preferred embodiment of the present invention, the second hydrophilic component is a sodium salt of hyaluronic acid, as well as small molecule sodium hyaluronate or hydrolyzed sodium hyaluronate (Hybloom). TM Minture, or OligoHyaferre (R) (etc.) However, the present invention is not limited thereto. Here, the hydrolyzed sodium hyaluronate is formed by hydrolyzing sodium hyaluronate, and unlike sodium hyaluronate, it is involved in the introduction of water and enzymes during the hydrolysis process.

[0038] Based on the total weight of the liquid composition for contact lenses being 100% by weight, the content of the second hydrophilic component (hyaluronic acid or hyaluronate) is 0.005% to 1.0% by weight (i.e., 50 ppm to 10,000 ppm), preferably 0.01% to 0.08% by weight (i.e., 100 ppm to 800 ppm), and particularly preferably 0.01% to 0.06% by weight (i.e., 100 ppm to 600 ppm), but the present invention is not limited thereto.

[0039] In certain embodiments of the present invention, the first weight molar concentration of the first hydrophilic component (a polymer having a phosphorylcholine group) is 1×10 -8 mol / L to 2.5×10 -4 mol / L, and the second weight molar concentration of the second hydrophilic component (hyaluronic acid or hyaluronate) is between 5×10 -7 mol / L and 6×10 -5 mol / L.

[0040] <Inorganic salts> The inorganic salts may include, for example, chloride salts and buffer salts.

[0041] Here, the chloride salts include, for example, at least one of sodium chloride (NaCl), potassium chloride (KCl), and magnesium chloride (MgCl2). The chloride salt is preferably sodium chloride (NaCl). By controlling the osmotic pressure of the contact lens storage solution to approach the osmotic pressure of natural tears of the eye with the chloride salt, the discomfort in the eye when wearing the contact lens can be reduced, and the electrolyte balance of the tears can be simulated to maintain the normal physiological state of the surface of the eye. Here, the content of the chloride salt is 0.01% to 5% by weight.

[0042] The buffer salts are for adjusting the pH value of the contact lens storage solution.

[0043] The buffer salts include, for example, at least one of boric acid or its salts, phosphoric acid or its salts, carbonic acid or its salts, or citric acid or its salts. Preferably, the buffer salts include at least one of boric acid or its salts, or phosphoric acid or its salts.

[0044] Here, the boric acid or its salt is, for example, at least one of boric acid, sodium borate, and sodium tetraborate. Also, the phosphoric acid or its salt is, for example, at least one of sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, and dipotassium hydrogen phosphate.

[0045] With the total weight of the liquid composition for contact lenses being 100% by weight, the content of the buffer salts is 0.01% to 5% by weight.

[0046] <liquid water> Liquid water is the solvent component (also referred to as a balance substance) of the liquid composition for contact lenses, and its content is 80% by weight or less, preferably 85% by weight or less, and particularly preferably 90% by weight.

[0047] It should be noted that the pH value of the liquid composition for contact lenses is preferably 6 to 8, and the osmotic pressure is preferably 250 osmol / kg to 450 osmol / kg.

[0048] <Other additives> In one embodiment of the present invention, the liquid composition for contact lenses may optionally contain trace amounts of other additives. These other additives may include, for example, polyvinyl alcohol (PVA), polyethylene glycol (PEG), and a third hydrophilic component (third moisturizing component) such as cellulose or a derivative thereof. The cellulose or its derivative may be, for example, hydroxypropyl methylcellulose (HPMC), carboxymethylcellulose (CMC), methylcellulose (MC), hydroxyethylcellulose (HEC), or a cationized cellulose derivative.

[0049] The liquid composition for contact lenses may further contain a surfactant (e.g., DLS, SLL, SDS, SBFA30, TWEEN20, or Tween80) and / or a vitamin (e.g., vitamin B or vitamin C), but the present invention is not limited thereto.

[0050] [Second Embodiment] In a second embodiment of the present invention, a contact lens product is provided, comprising a packaging container, the above-mentioned liquid composition for contact lenses, and contact lenses.

[0051] The packaging container may be, for example, a plastic cup. For example, it may be a polypropylene (PP) plastic cup, and the packaging container may have a storage space.

[0052] The aforementioned liquid composition for contact lenses is filled into the storage space of the packaging container.

[0053] The contact lens liquid composition comprises a first hydrophilic component, a second hydrophilic component, inorganic salts, liquid water, and selectively other additive components. The material characteristics and content ratios of each component in the contact lens liquid composition are as shown in the first embodiment described above and will not be explained again here.

[0054] The contact lens is stored in the storage space of the packaging container and immersed in the liquid composition for contact lenses. Here, both the contact lens and the liquid composition for contact lenses are packed in the packaging container. The liquid composition for contact lenses is for wetting the contact lens and can improve the wettability of the surface of the contact lens.

[0055] In an embodiment of the present invention, the contact lens may be, for example, a hydrogel lens or a silicone hydrogel lens.

[0056] The diameter of the contact lens (unit: mm) is indicated as Dia, the base curve radius of the contact lens (unit: mm) is indicated as BC, the water content of the contact lens is indicated as WC%, and each of the above parameters needs to satisfy the following conditions. That is, (1) 13.0 < Dia < 15.0, (2) 7.0 < BC < 9.0, and (3) 30.0% < WC% < 70.0% (preferably 38% - 58%).

[0057] Furthermore, the contact lens is formed, for example, by curing a lens composition. The lens composition may include a hydrophilic monomer (such as NVP, HEMA, MAA, or DMA, etc.), a crosslinking agent, and an initiator (such as a photoinitiator or a thermal initiator), and may selectively include a tint and a siloxane monomer (the composition of a silicone hydrogel lens contains a siloxane monomer).

[0058] [Experimental Data and Measurement Results] The following experimental data are used to explain in detail specific aspects of the present invention so that those skilled in the art can implement the present invention. However, the following experimental data should not be used to limit the present invention.

[0059] [[ID=​​In the following experiments, hyaluronic acid with different molecular weights and polymers containing phosphorylcholine groups were selectively added to buffer salt aqueous solutions, and the relevant measurements were performed.

[0060] Preservation solution 1 contained 0.708% by weight of sodium chloride, 0.470% by weight of boric acid, and 0.05% by weight of sodium borate, with water as the solvent (balancing substance), and no hyaluronic acid or polymers containing phosphorylcholine groups were added. In other words, preservation solution 1 was the control group.

[0061] Preservation solution 2 contained 0.708% by weight of sodium chloride, 0.470% by weight of boric acid, 0.05% by weight of sodium borate, and 0.06% by weight (600 ppm) of high molecular weight hyaluronic acid (weight-average molecular weight Mw is 80k-120kDa, for example, sodium hyaluronate with 100kDa), with water as the solvent (balancing substance), and no polymers containing phosphorylcholine groups were added. Preservation solution 2 was the comparison group.

[0062] Preservative solution 3 consists of 0.708% by weight of sodium chloride, 0.470% by weight of boric acid, 0.05% by weight of sodium borate, and low molecular weight hyaluronic acid (with a weight-average molecular weight Mw of less than 1,000 Da, for example, sodium hyaluronate with a molecular weight of 900 Da, Hybloom TM The solution used was Minture, containing 0.06% by weight (600 ppm), with water as the solvent (balancing agent), and no polymer containing a phosphorylcholine group was added. Preservation solution 3 was the comparison group.

[0063] Preservative solution 4 consists of 0.708% by weight of sodium chloride, 0.470% by weight of boric acid, 0.05% by weight of sodium borate, and low molecular weight hyaluronic acid (with a weight-average molecular weight Mw of 1,000 Da, for example, sodium hyaluronate with a weight-average molecular weight of 900 Da, Hybloom TMThe storage solution contained 0.06 wt% (600 ppm) of minture and 0.1 wt% (1,000 ppm) of a polymer having a phosphorylcholine group (poly(MPC-co-BMA) was used, with a weight-average molecular weight of approximately 550,000 Da, and the molar ratio of MPC:BMA in poly(MPC-co-BMA) was approximately 3:1), and the solvent (balancing substance) was water. Storage solution 4 was the experimental group corresponding to the present invention.

[0064] Preservation solution 5 consisted of 0.708 wt% sodium chloride, 0.470 wt% boric acid, 0.05 wt% sodium borate, 0.06 wt% (600 ppm) ultra-high molecular weight hyaluronic acid (weight-average molecular weight Mw less than 850k-1,600kDa, for example, sodium hyaluronate with 1,225kDa), and 0.1 wt% (1,000 ppm) a polymer having a phosphorylcholine group (the same poly(MPC-co-BMA) as in preservation solution 4 was used), with water as the solvent (balancing substance). Preservation solution 5 was the comparison group.

[0065] The conditions for adding hyaluronic acid and polymers containing phosphorylcholine groups in the above preservative solutions 1 to 5 are summarized in Table 1 below.

[0066] [Table 1]

[0067] Next, hydrogel lenses with a water content of 38%, hydrogel lenses with a water content of 58%, and silicone hydrogel lenses with a water content of 50% were immersed in the prepared storage solutions 1 to 5.

[0068] The immersion time for the aforementioned lens was approximately 12 hours, and the immersion temperature was room temperature (e.g., 25°C).

[0069] Subsequently, a moisture resistance test was performed on the immersed lenses. The moisture resistance test included dynamic contact angle (DCA), weight loss over time, and breaking-up time (BUT). The relevant measurement methods and results are as follows.

[0070] <Dynamic contact angle, DCA> The dynamic contact angle of the above lens was measured using a dynamic contact angle measuring instrument and the captive bubble method, and the numerical value (in degrees) of the dynamic contact angle was determined. A smaller numerical value indicated better surface moisture retention.

[0071] Table 2 below shows the measurement results for dynamic contact angle. These measurement results are for hydrogel lenses with a water content of 38%, hydrogel lenses with a water content of 58%, and silicone hydrogel lenses with a water content of 50%, taken after being immersed in storage solutions 1 to 5.

[0072] [Table 2]

[0073] According to the experimental results in Table 2 above, storage solution 4 (the experimental group, containing 600 ppm small molecule hyaluronic acid and 1,000 ppm PMB) was able to impart the lowest dynamic contact angle to all three types of lenses. In other words, storage solution 4 was able to impart the best surface moisture to the three types of lenses. Notably, storage solution 4 showed even more remarkable performance with silicone hydrogel lenses, and its dynamic contact angle was at least 10 degrees lower (for example, from 36.12 to 73.77 degrees to less than 5 degrees) compared to the group using a different storage solution.

[0074] In other words, as can be seen from the above experiment, the dynamic contact angle (DCA) of the lens decreased by adding hyaluronic acid with different molecular weights. In particular, under conditions containing PMB, adding small molecular weight hyaluronic acid with Mw < 10,000 Da (i.e., storage solution 4) resulted in a better lens dynamic contact angle (DCA) than adding ultra-large molecular weight hyaluronic acid with Mw 850 kDa - 1,600 kDa, indicating superior surface moisture retention. Furthermore, storage solution 4 showed more remarkable performance for the silicone hydrogel lens group.

[0075] <Weight loss over time> Weight loss over time was measured by removing the lens from the storage solution, leaving it in an external environment (temperature 25°C, relative humidity (RH) 50%, etc.), and observing the weight loss over time (15 minutes or 30 minutes, etc.). The weight loss over time was calculated as (original weight W1 of the lens removed from the storage solution - weight W2 of the lens after a predetermined time) / (original weight W1 of the lens removed from the storage solution). Then, the calculated value was multiplied by 100%.

[0076] Table 3-1 below shows the results of the weight loss over time of hydrogel lenses with a water content of 38% taken from different non-different storage solutions (storage solutions 1-5).

[0077] [Table 3]

[0078] As can be seen from the experimental results in Table 3-1 above, the hydrogel lenses with a water content of 38% immersed in storage solution 4 showed the least weight loss over time (only 13.86% loss in 15 minutes, and only 24.93% loss in 30 minutes), indicating that storage solution 4 provides the best moisturizing effect for hydrogel lenses with a water content of 38%.

[0079] Table 3-2 below shows the results of the weight loss over time of hydrogel lenses with a water content of 58% taken from different storage solutions (storage solutions 1-5).

[0080] [Table 4]

[0081] According to the experimental results in Table 3-2 above, hydrogel lenses with a water content of 58% immersed in storage solution 4 showed the least weight loss over time (only 12.38% loss in 15 minutes, and only 24.53% loss in 30 minutes), indicating that storage solution 4 provides the best moisturizing effect for hydrogel lenses with a water content of 58%.

[0082] Table 3-3 below shows the results of weight loss over time for silicone hydrogel lenses with a water content of 50% taken from different storage solutions (storage solutions 1-5).

[0083] [Table 5]

[0084] According to the experimental results in Table 3-3 above, the silicone hydrogel lenses with a water content of 50% immersed in storage solution 4 showed the least weight loss over time (only 16.08% loss in 15 minutes, and only 33.72% loss in 30 minutes), indicating that storage solution 4 provides the best moisturizing effect for silicone hydrogel lenses with a water content of 50%. Notably, storage solution 4 exhibits a more pronounced water-locking moisturizing effect on the silicone hydrogel lens group, thereby effectively improving the moisture retention of the silicone-containing hydrophobic surface.

[0085] <Time until the water film is destroyed, BUT> The lens was removed from the storage solution and left to stand in the external environment. The time it took for the water film on the lens to break down was observed using a camera and measured in seconds.

[0086] Table 4 below shows the measurement results of the time until the observed water film was destroyed (BUT) after immersing hydrogel lenses with a water content of 38%, hydrogel lenses with a water content of 58%, and silicone hydrogel lenses with a water content of 50% in storage solutions 1 to 5, respectively, and then removing them.

[0087] [Table 6]

[0088] As can be seen from the experimental results in Table 4 above, the time until the water film was broken (BUT) was longest for each type of lens immersed in storage solution 4. The hydrogel lens with 38% water content lasted 97 seconds, the hydrogel lens with 58% water content lasted 107 seconds, and the silicone hydrogel lens with 50% water content lasted 78 seconds. The experimental results showed that the lenses immersed in storage solution 4 had the best water-locking moisturizing effect. In other words, the moisturizing properties of the lenses can be effectively improved by adding small molecule hyaluronic acid and PMB with a molecular weight of less than 1,000.

[0089] Overall, small-molecule hyaluronic acid has the function of retaining moisture, while large-molecule PMB has a water-locking function. Small-molecule hyaluronic acid draws moisture into the lens, and large-molecule PMB further forms a moisturizing film on the outer layer of the lens to trap moisture and suppress moisture loss. As a result, the water film on the outer layer of the lens lasts longer, reducing the problem of dry eye caused by prolonged contact lens wear. Therefore, the BUT results of contact lenses in storage solution 4 (experimental group) were confirmed to be superior to those of the control group and other comparison groups.

[0090] Below, we measured the effect of different concentrations of hyaluronic acid and PMB under experimental conditions on the dynamic contact angle (DCA) of a 50% water-content silicone hydrogel lens.

[0091] [Table 7]

[0092] As can be seen from the experimental results above, the preservation solution, by containing low molecular weight hyaluronic acid with a weight-average molecular weight of 1,000 Da to 10,000 Da and a concentration in the range of 1,000 ppm to 10,000 ppm, can achieve a relatively low dynamic contact angle DCA (less than 45 degrees) for silicone hydrogel lenses with a water content of 50%.

[0093] In this study, the dynamic contact angle DCA measured for both preservation solution 4 (experimental group), which used 600 ppm hyaluronic acid with a molecular weight of less than 1,000 and 1,000 ppm PMB, and preservation solution 9 (experimental group), which used 600 ppm hyaluronic acid with a molecular weight of less than 1,000 and 10,000 ppm PMB, was less than 5 degrees, indicating superior moisturizing properties.

[0094] [Advantageous effects of the embodiment] One of the advantageous effects of the present invention is that the liquid composition for contact lenses and the contact lens products according to the present invention can significantly improve the moisturizing properties of the surface of contact lenses due to the following technical characteristics: "The liquid composition for contact lenses contains 1% by weight or less of a first hydrophilic component and 1% by weight or less of a second hydrophilic component, the first hydrophilic component is a polymer having a phosphorylcholine group and having a first weight-average molecular weight of 4,000 Da or more, and the second hydrophilic component is hyaluronic acid or a salt thereof and having a second weight-average molecular weight of 10,000 Da or less." In particular, the liquid composition for contact lenses of the present invention, by combining a polymer having a phosphorylcholine group with hyaluronic acid (or a salt thereof) in a specific amount and with a low molecular weight, can provide superior moisturizing properties and a water-locking moisturizing effect to the surface of contact lenses compared to conventional liquid compositions for contact lenses.

[0095] The information disclosed herein represents only preferred and feasible embodiments of the present invention, and the claims of the present invention are not limited thereto. Therefore, all equivalent technical modifications made using the description and drawings of the present invention are included within the scope of the claims of the present invention.

Claims

1. A liquid composition for contact lenses comprising 1% by weight or less of a first hydrophilic component, 1% by weight or less of a second hydrophilic component, 5% by weight or less of inorganic salts, and 80% by weight or more of liquid water, The first hydrophilic component is a polymer having a phosphorylcholine group and a first weight-average molecular weight of 4,000 Da or more. A liquid composition for contact lenses, characterized in that the second hydrophilic component is hyaluronic acid or a salt thereof and has a second weight-average molecular weight of 10,000 Da or less.

2. The liquid contact lens composition according to claim 1, wherein the first hydrophilic component is at least one of homopolymers and copolymers having a phosphorylcholine group.

3. The homopolymer having the phosphorylcholine group is poly(2-methacryloyloxyethylphosphocholine), The contact lens liquid composition according to claim 2, wherein the copolymer having the phosphorylcholine group is formed by copolymerizing 2-methacryloyloxyethylphosphocholine with methacrylate, and the methacrylate is an alkyl methacrylate having a C2-C12 alkyl group or a hydroxyalkyl methacrylate having a C2-C12 hydroxyalkyl group.

4. The liquid composition for contact lenses according to claim 1, wherein the first weight-average molecular weight of the first hydrophilic component is 4,000 Da to 1,000,000 Da, and the second weight-average molecular weight of the second hydrophilic component is smaller than the first weight-average molecular weight, and the second weight-average molecular weight is 5,000 Da or less.

5. The liquid composition for contact lenses according to claim 4, wherein the first weight-average molecular weight of the first hydrophilic component is 100,000 Da to 1,000,000 Da, and the second weight-average molecular weight of the second hydrophilic component is 3,000 Da or less.

6. The liquid composition for contact lenses according to claim 1, wherein the second hydrophilic component is a sodium salt of hyaluronic acid or a potassium salt of hyaluronic acid.

7. The liquid composition for contact lenses according to claim 6, wherein the second hydrophilic component is a sodium salt of hyaluronic acid, and the second weight-average molecular weight of the second hydrophilic component is 1,000 Da or less.

8. The liquid contact lens composition according to claim 7, wherein the second hydrophilic component is small molecule sodium hyaluronate or hydrolyzed sodium hyaluronate.

9. The contact lens liquid composition according to claim 1, wherein, with the total weight of the contact lens liquid composition being 100% by weight, the content of the first hydrophilic component is 0.005% to 1% by weight, the content of the second hydrophilic component is 0.005% to 1% by weight, the content of the inorganic salts is 0.01% to 5% by weight, and the content of the liquid water is 90% or more by weight.

10. The liquid composition for contact lenses according to claim 9, wherein the content of the first hydrophilic component is 0.05% to 1% by weight, and the content of the second hydrophilic component is 0.01% to 0.08% by weight.

11. The first molar concentration of the first hydrophilic component is 1 × 10⁻⁶ －８ mol / L~2.5×10 －４ The concentration is mol / L, and the second molar concentration of the second hydrophilic component is 5 × 10⁻⁶. －７ mol / L ~ 6 x 10 －５ A liquid composition for contact lenses according to claim 1, wherein the concentration is mol / L.

12. The inorganic salts include chloride salts and buffer salts, wherein the chloride salts are sodium chloride (NaCl), potassium chloride (KCl), and magnesium chloride (MgCl). ２ ) including at least one of the following, The liquid contact lens composition according to claim 1, wherein the buffer salts include at least one of boric acid or a salt thereof, phosphoric acid or a salt thereof, carbonic acid or a salt thereof, and citric acid or a salt thereof.

13. packaging container, A liquid contact lens composition according to any one of claims 1 to 12, filled in the aforementioned packaging container, and A contact lens product comprising a contact lens immersed in the aforementioned liquid composition for contact lenses, The contact lens product is characterized in that the contact lens is a hydrogel lens or a silicone hydrogel lens.

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