Filtration system and method
JP2026090584APending Publication Date: 2026-06-02REPLIGEN CORP
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- REPLIGEN CORP
- Filing Date
- 2026-03-04
- Publication Date
- 2026-06-02
AI Technical Summary
Technical Problem
Existing filtration systems for bioreactors using hollow fiber filters suffer from inefficient utilization of filter length and premature fouling due to unidirectional fluid flow, leading to prolonged culture exposure outside the bioreactor.
Method used
A fluid filtration system with a pump configuration and flow divider that enables bidirectional flow through a filter housing, utilizing a single pump to alternate fluid flow directions and incorporating a flow sensor and controller for precise control, minimizing exposure time and reducing fouling.
Benefits of technology
The system enhances filter utilization and reduces fouling by allowing alternating tangential flow, ensuring complete culture replacement in each cycle and maintaining filter efficiency.
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Smart Images
Figure 2026090584000001_ABST
Abstract
A method for operating a fluid filtration system and a fluid filtration system are provided. [Solution] A method for operating a fluid filtration system, comprising the steps of: transferring fluid from a fluid storage container 2 to a filter housing 6 through a first pump 140A; filtering the fluid within the filter housing using filter elements arranged within the filter housing; removing the filtered portion of the fluid as permeate from the filter housing using a permeate pump; and synchronizing the flow rate of permeate through the permeate pump with the flow rate through the first pump so that changes in the flow rate of the first pump automatically adjust the flow rate of the permeate pump.
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