Novel natural systems with technical lubrication properties

Abstract

This invention provides lubricants that are 100% natural products, capsules, tablets, or solid toothpastes containing lubricants, and methods for their use and preparation. [Solution] A lubricant comprising a mixture of powders of three different species of seeds, wherein the powder from each of the species contains C16-C18 fatty acids in a proportion exceeding 45% w / w of total fatty acids, and at least 21% w / w of fatty acids, the three different species of seeds being cumin, caraway, and fennel, with a weight ratio of 1:1:1 to 1:1:3, the seed powder having a particle size distribution value calculated as Dv50 of 15 μm to 500 μm, and the seed powder having a specific surface area of ​​25 m² 2 / kg~600m 2 It has / kg and the seed powder is JPEG2026097789000017.jpg1136 The above-mentioned lubricant has a span value of 1.5 to 3, expressed as follows.

Claims

1. A mixture consisting of one or more fruit or seed species containing powdered seeds and natural gum powder, or a mixture of at least three different species of powdered seeds, wherein the fruit or seed containing powdered seeds from each of the species constitutes more than 45% w / w of the total fatty acids. １６ ~C １８ The mixture contains fatty acids and at least 21% w / w of fatty acids, and the fruit or seeds containing seeds in powder form are cumin, caraway and fennel.

2. The mixture according to claim 1, wherein the fruit or seed powders containing cumin, caraway, and fennel seeds have a weight ratio of 1:1:1 to 1:1:3, preferably 1:1:

1.

3. - Caraway fruit or seeds, including seeds in powder form, in a weight ratio of 1:1 to 1:8, preferably 1:5 to 1:7, and gum arabic powder, and / or - Fennel fruit or seeds in powder form, including seeds, in a weight ratio of 1:1 to 1:8, preferably 1:5 to 1:7, and gum arabic powder, and / or - Cumin fruit or seeds in powder form, including seeds, in a weight ratio of 1:1 to 1:8, preferably 1:5 to 1:7, and gum arabic powder. A mixture according to claim 1 or 2, comprising the above.

4. The mixture according to any one of claims 1 to 3, comprising a fruit or seed powder containing caraway, fennel, and cumin seeds in a weight ratio of 1:1:1 to 1:1:3, preferably 1:1:1, and powdered gum arabic in a weight ratio of 1:1 to 1:8, preferably 1:5 to 1:

7.

5. The mixture according to any one of claims 1 to 4, wherein the fruit containing seeds or the powder of seeds has a particle size distribution value calculated as Dv50 of 15 μm to 500 μm, preferably 150 μm to 350 μm.

6. The fruit containing seeds or the powder of the seeds has a specific surface area of ​​25 m². ２ / kg ~ 600m ２ / kg, preferably 25m ２ / kg ~ 70m ２ A mixture according to any one of claims 1 to 5, having a concentration of / kg.

7. The fruit containing seeds or the powder of seeds, [Math 1] The mixture according to any one of claims 1 to 6, having a span value of 1.5 to 3 expressed as.

8. The mixture according to any one of claims 1 to 7, wherein the natural gum is gum arabic and / or karaya gum.

9. The natural gum powder has a Dv50 value in the range of 60 μm to 70 μm, 100 m ２ / Kg to 150 m ２ / Kg range, preferably 137 m ２ / Kg specific surface area, and a span value in the range of 1 to 1.8, preferably 1.75, the mixture according to any one of claims 1 to 8.

10. A lubricant for tableting comprising the mixture described in any one of claims 1 to 9.

11. A capsule, tablet, or solid composition comprising a mixture according to any one of claims 1 to 9, or the lubricant according to claim 10 as the sole lubricant.

12. The capsule, tablet, or solid composition according to claim 11, wherein the mixture according to any one of claims 1 to 9, or the lubricant according to claim 10, is present in a concentration of 1% to 35% w / w, preferably 3% to 4.5%.

13. The capsule, tablet, or solid composition according to claim 11 or 12, wherein the capsule, tablet, or composition consists of ingredients of 100% natural origin.

14. A pharmaceutical product, cosmetic product, nutritional supplement, medical device, dietary supplement, or food product comprising a capsule, tablet, or solid composition according to any one of claims 11 to 13.

15. Use of the mixture according to any one of claims 1 to 9 as a lubricant in the preparation of tablets, capsules, and solid compositions.

16. The use according to claim 15, wherein the mixture is the sole lubricant contained in the product in the form of tablets, capsules or a solid composition, and / or is used for lubricating machinery suitable for preparing the product form.

17. The use of natural gum, preferably gum arabic or karaya gum, as a lubricant in the preparation of tablets, capsules, and solid compositions.

18. The use according to claim 17, wherein the natural gum is present in an amount of 1% to 35% by weight of the tablet, capsule, or solid composition.

19. The aforementioned natural gum powder has a Dv50 value in the range of 60 μm to 70 μm, and 100 μm ２ / kg ~ 150m ２ A range of / kg, preferably 137m ２ The use according to claim 17 or 18, having a specific surface area of ​​ / kg and a span value in the range of 1 to 1.8, preferably 1.

75.

20. A method for producing capsules, tablets, or solid compositions, comprising the step of mixing the mixtures described in claims 1 to 9 with a suitable formulation preparation, wherein the mixture is the only lubricant used in the method.

21. A method for producing capsules, tablets, or solid compositions, comprising the following steps: i) A step of preparing one or more fruits or seed species and / or natural gums containing powdered seeds, wherein the fruits or seeds containing powdered seeds from each of the species have a proportion of C higher than 45% w / w with respect to total fatty acids. １６ ~C １８ A step comprising fatty acids, and a step comprising fatty acids in a proportion of at least 21% w / w, ii) A step of mixing one or more seeds of a fruit or seeds containing powdered seeds and / or the natural gum with a suitable formulation for a time of 2 to 30 minutes, preferably 5 to 15 minutes, and more preferably 5 minutes, iii) A step of compressing or sealing the product obtained in step ii) The method comprising, wherein the components used in steps i) and ii) constitute the sole lubricant used in the method.

22. The method according to claim 20 or 21, further comprising between steps i) and ii) a step of granulating the one or more fruit or seed species, including seeds in powder form, and / or the natural gum.

23. Step ii) is as follows: ii) A step of granulating the compound preparation together with natural gum, iib) Mix the granular material obtained in step ii) and the one or more fruits or seeds containing the powdered seeds prepared in step i) for 2 to 30 minutes, preferably 5 to 15 minutes, and more preferably 5 minutes, until a homogeneous mixture is obtained. A method for producing capsules, tablets, or solid compositions according to claim 21 or 22, which is replaced by the method described

24. The method according to claim 23, wherein the granular material obtained in step iiia) is dried before mixing in iib) until a relative humidity between 23% and 26% is reached.

25. The method according to any one of claims 22 to 24, wherein the granulation is dry granulation, wet granulation, dry pneumatic granulation, reverse wet granulation, steam granulation, moisture-activated dry granulation, thermal adhesive granulation, melt granulation, freeze granulation, or foam granulation.

26. The method according to any one of claims 20 to 25, wherein the one or more fruit or seed species and / or natural gum, including seeds in powder form, are present in the capsule, tablet or solid composition at a total concentration of 1% to 35% by weight.

27. The method according to any one of claims 20 to 26, wherein the natural gum is gum arabic and / or karaya gum.

28. A capsule, tablet, or solid composition that can be obtained by the method described in any one of claims 2 to 27.

Images